[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"aspiration\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:aspiration":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,8,0,[8,42,76,105,123,141,166,200],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":4,"maxAge":16,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":21,"briefSummary":23,"conditions":24,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100401206","effect-of-thickened-feeds-on-swallow-physiology-in-children-with-dysphagia-100401206",false,"NCT04504227","Effect of Thickened Feeds on Swallow Physiology in Children With Dysphagia","Inclusion Criteria:\n\n* Age 0 to 21 years\n* Admitted to Boston Children's Hospital after experiencing first lifetime BRUE, or with dysphagia symptoms such that they would be at risk for BRUE or other symptoms of swallowing difficulty\n* Have had videofluoroscopic swallow study performed or might have future videofluoroscopic swallow study performed.\n\nExclusion Criteria:\n\n* Any pre-existing medical diagnoses that exclude brief resolved unexplained event diagnosis including seizure disorders and cyanotic congenital heart disease\n* Any nasal\u002Fpharyngeal\u002Fesophageal anomalies that might affect safe placement of the pharyngeal motility catheter\n* Children fed exclusively by enteral tube\n* Allergy to rice cereal or Gelmix thickener, which will be used to adjust liquid viscosity","ALL","21 Years",{"count":18,"type":19},200,"ESTIMATED","INTERVENTIONAL",[22],"NA","This study will examine the effects of varying liquid viscosity on swallow physiology in infants with oropharyngeal dysphagia and brief resolved unexplained event (BRUE) and other children with dysphagia that would be at risk for symptoms of swallow dysfunction.",[25,26,27,28],"Dysphagia","Aspiration","Brief Resolved Unexplained Event (BRUE)","Apparent Life Threatening Event (ALTE)","RECRUITING","2026-03-16",{"date":32,"type":33},"2026-03-18","ACTUAL",{"date":35,"type":33},"2021-04-01",{"date":37,"type":19},"2026-08-31",{"name":39,"class":40},"Boston Children's Hospital","OTHER",1,{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":48,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":15,"minAge":50,"maxAge":4,"enrollmentInfo":51,"targetDuration":4,"studyType":20,"phases":53,"briefSummary":54,"conditions":55,"keywords":59,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":75},"100555352","non-inferiority-of-continuing-oral-intake-versus-fasting-in-patients-with-acute-respiratory-failure-100555352","NCT06510972","Non-inferiority of Continuing Oral Intake Versus Fasting in Patients With Acute Respiratory Failure","Continuation of Oral Intake Compared With Fasting in Patients With Acute Respiratory Failure Before Intubation : a Non-inferiority Randomized Clinical Trial","JEUN-TUBE","Inclusion Criteria:\n\n* Male or female ≥ 18 years old\n* Participant affiliated to a social security scheme\n* Express oral consent of the participant, or failing that of the trusted support person, or failing that of the next of kin\n* Patient hospitalised in an intensive care unit or in a continuous surveillance unit or in an intensive care unit for less than 24 hours.\n* Criteria for acute hypoxaemic respiratory failure defined as.\n\n  * Respiratory rate \\> 25 cpm or indifferent if SARS-CoV-2 (Severe acute respiratory syndrome coronavirus 2) infection occurred ≥ 1 time since admission.\n  * PaO2\u002FFiO2 \\\u003C 200 mmHg or equivalent SpO2 (oxygen saturation)\u002FFiO2 (fraction of inspired oxygen) i.e. \\\u003C 235 (measured under at least 10 L\u002Fmin high concentration mask)\n\nExclusion Criteria:\n\n* Patient with criteria for immediate intubation:\n\n  * Persistent or worsening respiratory failure (respiratory rate \\> 40\u002Fmin, respiratory failure on physical examination, respiratory acidosis with pH (hydrogen potential ) \\\u003C 7.25, copious tracheal secretions, hypoxia with SpO2 \\\u003C 90% despite FiO2 \\> 80% for more than 5 minutes without technical dysfunction).\n  * Major haemodynamic failure (need for increasing vasopressor support with instability and hypoperfusion).\n  * Neurological failure (Glasgow score \\\u003C 8).\n  * Cardiac or respiratory arrest\n* Chronic lung disease: chronic obstructive pulmonary disease (GOLD grade 3 or 4: Global Initiative for Chronic Obstructive Lung Disease) or other chronic lung disease requiring long-term oxygen or ventilation (this does not include a patient undergoing continuous positive nocturnal pressure for sleep apnoea syndrome).\n* Contraindications to oral nutrition: known previous swallowing problems or inability to swallow, digestive sutures, admission for inhalation pneumonia, exclusive parenteral nutrition, etc.\n* Patients with a nasogastric or orogastric tube, a jejunostomy or a feeding ileostomy\n* Patient already on invasive mechanical ventilation on admission\n* Limitation of therapies including a decision not to intubate\n* Incapacitated adult (guardianship or curators)\n* Pregnant, parturient or breast-feeding women\n* Tracheostomised patient\n* Patient already included for the first time in this study","18 Years",{"count":52,"type":19},754,[22],"Fasting in intensive care is mainly studied in mechanically ventilated patients or those in the weaning phase. Recent research challenge the common assumption of fasting and suggests that continuing enteral nutrition before extubation may be beneficial. Fasting is also practiced before procedures (e.g., tracheostomy, endoscopy) or surgeries, based on anesthetic guidelines. Yet, no data address fasting in non-intubated ICU patients with acute respiratory failure, despite frequent caloric deficits and inadequate nutritional intake.\n\nAspiration risk often justifies fasting, but studies indicate that swallowing reflexes remain intact in patients receiving high-flow nasal oxygen or non-invasive ventilation. Moreover, although intubation carries a 2-5.9% aspiration risk, rapid sequence induction mitigates this, questioning the necessity of preventive fasting. Despite its prevalence, this practice lacks scientific validation and guideline support.\n\nPatient discomfort is also significant. Hunger and thirst are major sources of distress, and evidence from anesthesiology suggests that allowing fluid intake pre-anesthesia reduces discomfort. Extrapolating these findings to ICU patients could improve well-being.\n\nIn conclusion, fasting in ICU patients may contribute to discomfort, dehydration, and malnutrition, while its protective benefits remain uncertain. We hypothesize that maintaining oral intake does not increase the risk of intubation or aspiration-related complications.",[56,57,25,58,26],"Respiratory Insufficiency","Fasting","Swallowing Disorder",[60,61,62,63,64,65],"acute respiratory failure","fasting","oral intake","aspiration","intubation","high-flow nasal oxygen","2026-02-13",{"date":68,"type":33},"2026-02-18",{"date":70,"type":33},"2025-02-05",{"date":72,"type":19},"2028-03",{"name":74,"class":40},"University Hospital, Tours",14,{"id":77,"slug":78,"hasResults":11,"nctId":79,"briefTitle":80,"officialTitle":81,"acronym":4,"eligibilityCriteria":82,"healthyVolunteers":11,"sex":15,"minAge":83,"maxAge":16,"enrollmentInfo":84,"targetDuration":4,"studyType":20,"phases":86,"briefSummary":88,"conditions":89,"keywords":92,"overallStatus":96,"whyStopped":4,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":100,"completionDateStruct":102,"leadSponsor":104,"locationsCount":4},"100616304","phase-4-the-use-of-high-bile-binding-foods-to-reduce-upper-gastrointestinal-bile-acid-concentrations-aim-2-100616304","NCT07303868","The Use of High Bile-binding Foods to Reduce Upper Gastrointestinal Bile Acid Concentrations (Aim 2)","The Use of High Bile-Binding Foods to Reduce Upper Gastrointestinal Bile Acid Concentrations: A Novel Intervention for Children at Risk for Aspiration-Associated Complications (Aim 2)","Pediatric patients ages 5 to 21 in the randomized arm Inclusion criteria\n\n* receive at least 80% of their nutritional needs via gastrostomy\n* receive blenderized feeds or will start receiving blenderized feeds\n* have no known allergies to ingredients in blenderized feeds;\n* receive their bolus feeds within 30 minutes or less\n* can receive their feeds by syringe push Exclusion criteria\n* have undergone anti-reflux surgery\n* receive post-pyloric feeds\n* are allergic to any component of the administered diets\n* cannot receive their gastrostomy feeds over 30 minutes\n* require a feeding pump for feed administration (as the H-BBB is too thick for pump administration).\n\nPediatric patients ages 5 to 21 in the observational arm Inclusion\n\n* receive at least 80% of their nutritional needs via gastrostomy\n* are taking an amino acid formula\n* have not undergone antireflux surgery Exclusion\n* have undergone anti-reflux surgery\n* receive post-pyloric feeds\n* are not receiving an amino acid-based formula.","5 Years",{"count":85,"type":19},66,[87],"PHASE4","Using a four-week randomized, crossover study design, we will assess the impact of 2 weeks of a high bile acid-binding blenderized diet, compared to 2 weeks of a low bile acid-binding blenderized diet, on gastric and salivary bile acid concentrations within individual participants. Four weeks of an amino acid formula will be a comparator group.",[90,91,26],"Feeding Difficulties","Gastrostomy",[93,94,95,63],"blenderized","bile acid","gastrostomy","NOT_YET_RECRUITING","2025-12-23",{"date":99,"type":33},"2025-12-26",{"date":101,"type":19},"2026-07",{"date":103,"type":19},"2030-08",{"name":39,"class":40},{"id":106,"slug":107,"hasResults":11,"nctId":108,"briefTitle":109,"officialTitle":110,"acronym":4,"eligibilityCriteria":111,"healthyVolunteers":11,"sex":15,"minAge":83,"maxAge":16,"enrollmentInfo":112,"targetDuration":4,"studyType":20,"phases":114,"briefSummary":115,"conditions":116,"keywords":117,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":118,"startDateStruct":119,"completionDateStruct":121,"leadSponsor":122,"locationsCount":41},"100616294","phase-4-the-use-of-high-bile-binding-foods-to-reduce-upper-gastrointestinal-bile-acid-concentrations-aim-1-100616294","NCT07303738","The Use of High Bile-binding Foods to Reduce Upper Gastrointestinal Bile Acid Concentrations (Aim 1)","The Use of High Bile-Binding Foods to Reduce Upper Gastrointestinal Bile Acid Concentrations: A Novel Intervention for Children at Risk for Aspiration-Associated Complications (Aim 1)","Inclusion Criteria:\n\n* receive at least 80% of their nutritional needs by gastrostomy\n* receive either an amino acid-based formula, an International Dysphagia Diet Standardization Initiative level 4 commercial blend, or a home blend\n* can receive bolus feeds of 240 cc within 30 minutes or less\n\nExclusion Criteria:\n\n* have received a fundoplication\n* receive post-pyloric feeds\n* require medication\u002Fflush administration during the four-hour study period\n* are allergic to any component of the study diets.\n\nTo participate in this study, if patients are taking acid suppression or motility medications (e.g., erythromycin, azithromycin, prucalopride), they will need to stop these at least 72 hours prior to participation in this aim.",{"count":113,"type":19},60,[87],"We will perform an acute physiology study comparing three different diets-an amino acid-based formula, a low bile acid-binding blenderized diet, or a high bile acid-binding blenderized diet administered through gastrostomy tube. We will determine the differences in gastric and salivary bile acid concentrations between participants over the 4 hour post-prandial timeframe.\n\nParticipants who regularly receive an amino acid-based formula will receive an amino acid-based formula during the study and participants who regularly receive a blenderized feed will receive a blenderized feed during the study. Only participants who regularly receive blenderized feeds will be randomized to receive either the high or low bile acid binding blenderized feed.",[90,26,91],[93,94,95,63],{"date":99,"type":33},{"date":120,"type":33},"2025-12-01",{"date":103,"type":19},{"name":39,"class":40},{"id":124,"slug":125,"hasResults":11,"nctId":126,"briefTitle":127,"officialTitle":128,"acronym":4,"eligibilityCriteria":129,"healthyVolunteers":11,"sex":15,"minAge":83,"maxAge":16,"enrollmentInfo":130,"targetDuration":4,"studyType":132,"phases":4,"briefSummary":133,"conditions":134,"keywords":135,"overallStatus":96,"whyStopped":4,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":136,"startDateStruct":138,"completionDateStruct":139,"leadSponsor":140,"locationsCount":4},"100586303","the-use-of-high-bile-binding-foods-to-reduce-upper-gastrointestinal-bile-acid-concentrations-aim-3-100586303","NCT06913621","The Use of High Bile-Binding Foods to Reduce Upper Gastrointestinal Bile Acid Concentrations (Aim 3)","The Use of High Bile-Binding Foods to Reduce Upper Gastrointestinal Bile Acid Concentrations: A Novel Intervention for Children at Risk for Aspiration-Associated Complications (Aim 3)","Inclusion Criteria:\n\n* receive at least 80% of their nutritional needs via gastrostomy\n* receive an International Dysphagia Diet Standardization Initiative level 4 commercial blend, home blend or amino acid-based formula\n* receive their bolus feeds within 30 minutes or less.\n\nExclusion Criteria:\n\n* have undergone anti-reflux surger\n* receive post-pyloric feeds\n* receive regular daily prophylactic antibiotics.",{"count":131,"type":19},138,"OBSERVATIONAL","Using a longitudinal cohort design, we will compare the impact of a high BA-binding blenderized diet compared to a low BA-binding blenderized diet and an amino acid-based formula, on gastrointestinal and pulmonary hospitalization and emergency room visit rates over six months.",[90,91,26],[93,94,95,63],{"date":137,"type":33},"2025-12-30",{"date":101,"type":19},{"date":103,"type":19},{"name":39,"class":40},{"id":142,"slug":143,"hasResults":11,"nctId":144,"briefTitle":145,"officialTitle":146,"acronym":4,"eligibilityCriteria":147,"healthyVolunteers":148,"sex":15,"minAge":50,"maxAge":4,"enrollmentInfo":149,"targetDuration":4,"studyType":20,"phases":150,"briefSummary":151,"conditions":152,"keywords":4,"overallStatus":96,"whyStopped":4,"lastUpdateSubmitDate":157,"lastUpdatePostDateStruct":158,"startDateStruct":160,"completionDateStruct":162,"leadSponsor":164,"locationsCount":4},"100603602","effect-of-the-aspiration-care-bundle-on-preventing-vap-100603602","NCT07138651","Effect of the Aspiration Care Bundle on Preventing VAP","Yoğun Bakım Hastalarına Uygulanan Aspirasyon Bakım Paketinin Ventilatör İlişkili Pnömoni Gelişimini Önlemeye Etkisi: Yarı Deneysel Çalışma","Inclusion Criteria:\n\n* Patients admitted to the pulmonary intensive care unit\n* Aged 18 years or older\n* Connected to mechanical ventilation via ETT\u002FTT\n* Glasgow Coma Scale score: 8 or higher\n* Remaining in the intensive care unit for at least 24 hours\n* Patients who have not previously been diagnosed with ventilator-associated pneumonia will be included in the study.\n\nExclusion Criteria:\n\n* Transferred from the pulmonary intensive care unit to another clinic\n* Diagnosed with ventilator-associated pneumonia within the first 24 hours\n* Glasgow Coma Scale score fell below 8 during the study\n* Deceased at the time of data collection\n* Patients who developed any complications related to aspiration (atelectasis, hypoxemia, bradypnea, etc.) prior to the study will be excluded from the study.",true,{"count":113,"type":19},[22],"Many pharmacological and non-pharmacological interventions are used to prevent ventilator-associated pneumonia (VAP). Nurses are directly responsible for implementing non-pharmacological interventions and therefore have an important role in preventing VAP. The most important non-pharmacological nursing interventions to prevent VAP are hand hygiene and oral care. In addition, the head of the bed should be elevated to 30°-45°, head pressure should be monitored, and subglottic aspiration should be performed. Various care packages have been developed to prevent VAP. It has been determined that these care packages reduce the incidence of VAP. The aim of this study was to investigate the effect of the aspiration care package applied in the intensive care unit on preventing the development of ventilator-associated pneumonia, and it was planned as a quasi-experimental study.",[153,154,155,26,156],"VAP - Ventilator Associated Pneumonia","Care","Bundle Care","Nursing Care","2025-08-23",{"date":159,"type":33},"2025-08-29",{"date":161,"type":19},"2025-09-15",{"date":163,"type":19},"2026-09-15",{"name":165,"class":40},"Akdeniz University",{"id":167,"slug":168,"hasResults":11,"nctId":169,"briefTitle":170,"officialTitle":171,"acronym":4,"eligibilityCriteria":172,"healthyVolunteers":11,"sex":15,"minAge":50,"maxAge":173,"enrollmentInfo":174,"targetDuration":4,"studyType":20,"phases":176,"briefSummary":177,"conditions":178,"keywords":187,"overallStatus":96,"whyStopped":4,"lastUpdateSubmitDate":191,"lastUpdatePostDateStruct":192,"startDateStruct":194,"completionDateStruct":196,"leadSponsor":198,"locationsCount":41},"100522123","assessment-of-laryngopharyngeal-sensation-cancer-survivor-cohort-100522123","NCT06078527","Assessment of Laryngopharyngeal Sensation: Cancer Survivor Cohort","Assessment of Laryngopharyngeal Sensation in Patients With Laryngopharyngeal Disorders","Inclusion Criteria:\n\n1. Age \\\u003C=18 years.\n2. Individuals without a laryngopharyngeal disorder (health controls) or with a laryngopharyngeal disorder. Laryngopharyngeal disorder includes but is not limited to: presbylarynx, aspiration; spasmodic dysphonia; globus pharynges; vocal fold paralysis; iatrogenic injury to the larynx; muscle tension dysphonia; neurogenic dysphagia; laryngeal sensory neuropathy; and laryngopharyngeal disorders resulting from prior radiation therapy in individuals with a history of head and neck cancer who have completed radiation therapy as primary or adjuvant cancer treatment\n3. Ability and willingness to comply with study procedures.\n4. Ability to understand a written informed consent document, and the willingness to sign it.\n\nExclusion Criteria:\n\n1. Non-English speaking.\n2. Laryngopharyngeal structures are not accessible on exam.\n3. Known contraindication to any study-related procedure, or history of being unable to tolerate laryngoscopy.\n4. Vocal fold immobility or severe hypomobility on adduction.\n5. For head and neck cancer survivors only: Currently undergoing radiation therapy for head and neck cancer (i.e., primary\u002Fadjuvant radiation therapy treatment plan is not yet completed).","85 Years",{"count":175,"type":19},40,[22],"A previous study completed in 2022 (NCT05158179) was conducted using cohorts of healthy controls, and adults with general laryngopharyngeal disorders. This study will expand on the previous research to include a separate cohort of adults being seen in clinic for an existing laryngopharyngeal disorder resulting from previous radiation or other cancer treatments.",[179,26,180,181,182,183,184,185,186],"Presbylarynx","Spasmodic Dysphonia","Globus Pharyngeus","Larynx Paralysis","Laryngeal Disease","Vocal Cord Paralysis","Iatrogenic Injury","Sensory Neuropathy",[188,189,190],"Cancer survivors","Previous cancer treatment","Laryngopharyngeal disorders","2025-07-21",{"date":193,"type":33},"2025-07-23",{"date":195,"type":19},"2025-10-01",{"date":197,"type":19},"2028-01-31",{"name":199,"class":40},"University of California, San Francisco",{"id":201,"slug":202,"hasResults":11,"nctId":203,"briefTitle":204,"officialTitle":205,"acronym":4,"eligibilityCriteria":206,"healthyVolunteers":11,"sex":15,"minAge":50,"maxAge":4,"enrollmentInfo":207,"targetDuration":4,"studyType":20,"phases":209,"briefSummary":210,"conditions":211,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":212,"lastUpdatePostDateStruct":213,"startDateStruct":215,"completionDateStruct":217,"leadSponsor":219,"locationsCount":221},"100447627","aspiration-in-acute-respiratory-failure-survivors-2-100447627","NCT05108896","Aspiration in Acute Respiratory Failure Survivors 2","Aspiration in Acute Respiratory Failure Survivors","Inclusion Criteria:\n\n1. Admission to an ICU.\n2. Mechanical ventilation with an endotracheal tube for greater than 48 hours.\n\nExclusion Criteria:\n\n1. Likely persistent contraindications to enteral\u002Foral nutrition administration.\n2. Pre-existing history of dysphagia or aspiration.\n3. Pre-existing or acute primary central or peripheral neuromuscular disorder.\n4. Presence of a chronic tracheostomy (present prior to ICU admission).\n5. Pre-existing head and neck cancer or surgery.\n6. Coagulopathy resulting in uncontrolled nasal or pharyngeal bleeding.\n7. Delirium for more than 96 hours after extubation as assessed by Confusion Assessment Method (CAM-ICU).\n8. Extubated for greater than 96 hours.\n9. Inability to obtain informed consent from patient or an appropriate surrogate.\n10. Age \\\u003C 18 years.",{"count":208,"type":19},855,[22],"The purpose of this study is to learn more about problems with swallowing that could develop in patients who are very sick and need a machine to help them breathe.",[25,26],"2024-10-07",{"date":214,"type":33},"2024-10-08",{"date":216,"type":33},"2021-12-15",{"date":218,"type":19},"2025-12-15",{"name":220,"class":40},"University of Colorado, Denver",5]