[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"asplenia\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:asplenia":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,48,79,109,132],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":28,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100625851","development-of-an-italian-questionnaire-for-splenectomized-patients-using-a-delphi-consensus-method-100625851",false,"NCT07428005","Development of an Italian Questionnaire for Splenectomized Patients Using a Delphi Consensus Method","Development of an Italian Questionnaire to Assess Awareness and Knowledge of Infectious Risk Prevention Strategies in Splenectomized Patients Using a Delphi Consensus Method","Inclusion Criteria:\n\n* Healthcare professionals working at Fondazione Policlinico Universitario A. Gemelli IRCCS\n* Professional experience in vaccination or infection prevention\n* Clinical involvement in care of patients with asplenia or related conditions\n* Italian native language proficiency\n* Provision of informed consent\n\nExclusion Criteria:\n\n* Participation in the expert panel is restricted to individuals who meet all predefined inclusion criteria. Failure to satisfy any inclusion criterion automatically results in exclusion from the study population",true,"ALL","18 Years",{"count":20,"type":21},20,"ESTIMATED","OBSERVATIONAL","This study aims to develop an Italian-language questionnaire assessing awareness, knowledge of infectious risk prevention strategies, and vaccination attitudes among splenectomized individuals. The questionnaire will be developed through a structured Delphi consensus process involving a multidisciplinary panel of healthcare professionals experienced in infection prevention and vaccination strategies. Two Delphi rounds will be conducted online to evaluate item relevance and clarity. Items reaching predefined consensus thresholds will be included in the final questionnaire. The resulting tool will support future studies assessing preventive care awareness and vaccination uptake among splenectomized patients.",[25,26,27],"Splenectomy; Status","Asplenia","Splenectomized Patients",[29,30,31,32,33,34],"splenectomy","asplenia","vaccination","infection prevention","delphi study","questionnaire development","RECRUITING","2026-04-02",{"date":38,"type":39},"2026-04-08","ACTUAL",{"date":41,"type":39},"2026-01-01",{"date":43,"type":21},"2026-04-01",{"name":45,"class":46},"Fondazione Policlinico Universitario Agostino Gemelli IRCCS","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":56,"targetDuration":58,"studyType":22,"phases":4,"briefSummary":59,"conditions":60,"keywords":62,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":78},"100620228","evaluation-of-the-effectiveness-of-an-educational-intervention-in-splenectomized-patients-100620228","NCT07354893","Evaluation of the Effectiveness of an Educational Intervention in Splenectomized Patients","Evaluation of an Educational Intervention on Knowledge and Awareness of Infectious Risk in Splenectomized Patients and on Their Satisfaction With Vaccination Management in an Intra-hospital Outpatient Setting.","SPLE-VAC","Inclusion Criteria:\n\n* Adult patients (≥18 years old)\n* Patients splenectomized at FPG for whom a vaccination consultation is requested during hospitalization\n* Patients who provide signed informed consent to participate in the study and for the processing of personal data for research purposes\n\nExclusion Criteria:\n\n* Minor patients\n* Lack of signed informed consent for participation in the study and for the processing of personal data for research purposes\n* Patients splenectomized at other healthcare facilities",{"count":57,"type":21},100,"24 Months","The absence or dysfunction of the spleen is associated with a substantially increased risk of invasive infections that may rapidly progress to fulminant sepsis, including overwhelming post-splenectomy infection (OPSI), a medical emergency with high mortality. Although the risk is greatest in the first two years after splenectomy, it persists lifelong. Preventing infections in patients with anatomical or functional asplenia requires an integrated strategy that includes patient education, early recognition of symptoms, behavioral measures, antibiotic prophylaxis when indicated, and vaccination.\n\nPost-splenectomy immunization has been shown to reduce OPSI incidence. Regional and international guidelines recommend vaccination against pneumococcus, Haemophilus influenzae type b, meningococcus (B and ACWY), herpes zoster, diphtheria-tetanus-pertussis, measles-mumps-rubella-varicella, and annual influenza. However, adherence to these recommendations is frequently suboptimal, often due to limited awareness among patients and healthcare professionals.\n\nThis study involves the intra-hospital vaccination team providing structured vaccination consultations to splenectomized patients hospitalized at the Fondazione Policlinico Universitario \"A. Gemelli\" IRCCS. During ward consultations, patients receive an educational intervention on asplenia-related infectious risks and preventive measures, supported by standardized informational materials. Effectiveness is evaluated using a pre-post questionnaire assessing knowledge and awareness. Patients completing the vaccination pathway at the outpatient clinic also complete a questionnaire assessing their experience with vaccination management in an intra-hospital setting.",[27,61,25,26],"Splenectomy",[63,64,65,66,67,30,29,68,69],"OPSI","infection risk","Infection Prevention","Preventive measures","Vaccination","splenectomized patients","post splenectomy infections","2026-01-29",{"date":72,"type":39},"2026-02-02",{"date":74,"type":39},"2026-01-13",{"date":76,"type":21},"2028-01-13",{"name":45,"class":46},2,{"id":80,"slug":81,"hasResults":11,"nctId":82,"briefTitle":83,"officialTitle":84,"acronym":85,"eligibilityCriteria":86,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":87,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":89,"conditions":90,"keywords":4,"overallStatus":101,"whyStopped":4,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":102,"startDateStruct":104,"completionDateStruct":106,"leadSponsor":108,"locationsCount":4},"100623008","integrating-vaccination-into-hospital-care-pathways-for-vulnerable-patients-100623008","NCT07391046","Integrating Vaccination Into Hospital Care Pathways for Vulnerable Patients","Integrating Vaccination Into Hospital Care Pathways for Vulnerable Patients: A Scalable and Sustainable Model","AMBU-VAX","Inclusion Criteria:\n\n* Adults aged ≥18 years\n* Presence of at least one chronic or immunocompromising condition eligible for vaccination according to national guidelines\n* Written informed consent provided\n\nExclusion Criteria:\n\n* Age \\\u003C18 years\n* Conditions not included among the predefined eligibility criteria",{"count":88,"type":21},1500,"AMBU-VAX is a prospective, single-center observational study designed to develop and implement an organizational model for delivering recommended vaccinations within a hospital setting.\n\nThe study targets adult and elderly patients with chronic diseases or immunocompromising conditions who are eligible for vaccination according to national immunization guidelines. Vaccination is actively proposed during outpatient visits, hospital admissions, or at discharge and, when accepted, administered within the hospital or coordinated with local public health vaccination services.\n\nThe study aims to evaluate the feasibility, uptake, and completion of hospital-based vaccination pathways and to support integration between hospital and territorial prevention services for vulnerable populations.",[91,92,93,94,95,96,97,98,99,26,100],"Chronic Disease","Immunocompromised","HIV Infection","Chronic Kidney Disease","Solid Organ Transplantation","Hematopoietic Stem Cell Transplantation","Cancer","Autoimmune Diseases","Inflammatory Bowel Disease","Frailty","NOT_YET_RECRUITING",{"date":103,"type":39},"2026-02-05",{"date":105,"type":21},"2026-02",{"date":107,"type":21},"2027-02",{"name":45,"class":46},{"id":110,"slug":111,"hasResults":11,"nctId":112,"briefTitle":113,"officialTitle":113,"acronym":4,"eligibilityCriteria":114,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":115,"enrollmentInfo":116,"targetDuration":4,"studyType":118,"phases":119,"briefSummary":121,"conditions":122,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":123,"lastUpdatePostDateStruct":124,"startDateStruct":126,"completionDateStruct":128,"leadSponsor":130,"locationsCount":47},"100226959","phase-2-immunologic-response-to-pneumococcal-polysaccharide-vaccine-in-splenic-injury-patients-100226959","NCT02232191","Immunologic Response to Pneumococcal Polysaccharide Vaccine in Splenic Injury Patients","Inclusion Criteria:\n\n* Adult trauma patients (aged 18 to 65 years old) sustaining a splenic injury.\n\nExclusion Criteria:\n\n* Ages less than 18 and greater than 65\n* Initial planned nonoperative management patient who subsequently undergoes embolization or splenectomy will be withdrawn from the study.","65 Years",{"count":117,"type":21},75,"INTERVENTIONAL",[120],"PHASE2","Persons without a spleen are susceptible to potentially lethal infections from certain bacteria, with pneumococcus being the most prevalent. Vaccines are provided to help protect against these infections, though they do not so with certainty. Trauma patients who sustain an injury to their spleen currently have three treatment options available for the treating surgeon - nonoperative management, embolization, or removal of the spleen. The purpose of this study is to investigate the antibody response to pneumococcal vaccine in patients undergoing these modes of therapy.",[26],"2025-12-03",{"date":125,"type":39},"2025-12-05",{"date":127,"type":4},"2014-12",{"date":129,"type":21},"2026-07",{"name":131,"class":46},"University of California, Davis",{"id":133,"slug":134,"hasResults":11,"nctId":135,"briefTitle":136,"officialTitle":136,"acronym":137,"eligibilityCriteria":138,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":139,"targetDuration":141,"studyType":22,"phases":4,"briefSummary":142,"conditions":143,"keywords":144,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":147,"lastUpdatePostDateStruct":148,"startDateStruct":150,"completionDateStruct":152,"leadSponsor":154,"locationsCount":156},"100377812","assessment-of-complication-risk-factors-in-a-french-national-cohort-of-asplenic-patients-100377812","NCT04199403","Assessment of Complication Risk Factors in a French National Cohort of Asplenic Patients","SPLEEN","Inclusion Criteria:\n\n* ≥18 year-old\n* With asplenia due to splenectomy, splenic artery embolization or radiotherapy\n\nExclusion Criteria:\n\n* Genetic asplenia including sick cell disease",{"count":140,"type":21},6000,"10 Years","Spleen could have been surgically removed for trauma, cancer, auto-immune disease, or to perform a diagnosis. Spleen could be non-functional due to radiotherapy or splenic artery embolism. These patients are at risks of infectious diseases due to encapsulated bacteria, cancer, and thromboembolism disease. The purpose of this study is to assess complications occurring in French patients without spleen and to implement new diagnostic tools for follow-up.",[26],[145,146,29,30],"spleen","asplenic patients","2024-01-30",{"date":149,"type":39},"2024-02-01",{"date":151,"type":39},"2020-01-09",{"date":153,"type":21},"2040-01",{"name":155,"class":46},"Poitiers University Hospital",12]