[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"asthenozoospermia\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:asthenozoospermia":32},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,56,82,110,135,154],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":34,"overallStatus":43,"whyStopped":4,"lastUpdateSubmitDate":44,"lastUpdatePostDateStruct":45,"startDateStruct":48,"completionDateStruct":50,"leadSponsor":52,"locationsCount":55},"100621793","effect-of-daily-intake-of-gazpacho-on-semen-quality-and-oxidative-stress-100621793",false,"NCT07375238","Effect of Daily Intake of Gazpacho on Semen Quality and Oxidative Stress","Effect of Daily Intake of Gazpacho on Semen Quality and Oxidative Stress in Men With Altered Semen Parameters: A Randomized Controlled Study","G-OXSEM","Inclusion Criteria:\n\n* Men aged 18 to 45 years\n* Andrological profile including altered semen parameters such as oligozoospermia, asthenozoospermia and\u002For teratozoospermia (O±A±T)\n* No clinical indication for sperm DNA fragmentation testing or advanced sperm selection techniques\n* Willingness and ability to comply with the study protocol, including adherence to a standardized Mediterranean diet\n* Signed and dated written informed consent form\n\nExclusion Criteria:\n\n* Use of antioxidant supplements during the three months prior to study start.\n* Active smokers or men who have stopped smoking within the last three months.\n* Diagnosis of azoospermia, leucocytospermia or necrozoospermia.\n* Presence of severe systemic diseases or chronic conditions that could interfere with semen quality or adherence to the study.\n* Known allergy or intolerance to any ingredient of the gazpacho used in the study.\n* Any medical, psychological or social condition that, in the investigator's judgement, could compromise the subject's ability to participate fully or comply with the protocol requirements.\n* Simultaneous participation in another clinical study.","MALE","18 Years","45 Years",{"count":21,"type":22},80,"ESTIMATED","INTERVENTIONAL",[25],"NA","The goal of this clinical trial is to learn whether drinking a daily serving of gazpacho can improve semen quality in men with reduced sperm quality. The study will also examine how this dietary intervention affects oxidative stress and whether it is well tolerated.\n\nThe main questions this study aims to answer are:\n\n* Does daily consumption of gazpacho improve semen quality in men with altered semen parameters?\n* Does this dietary intervention affect levels of oxidative stress in semen?\n* Is daily gazpacho intake feasible and well tolerated as part of a Mediterranean diet?\n\nResearchers will compare a Mediterranean diet plus daily gazpacho intake with a Mediterranean diet alone to determine whether adding gazpacho provides additional benefits for male reproductive health.\n\nParticipants will:\n\n* Follow a standardized Mediterranean diet for 12 weeks\n* Drink 330 mL of gazpacho every day or follow the diet without gazpacho\n* Provide semen samples at the start of the study and after 12 weeks\n* Complete a short diary to record adherence to the dietary intervention\n* Be followed for up to 18 months to record reproductive outcomes",[28,29,30,31,32,33],"Male Infertility","Oxidative Stress","Subfertility","Oligozoospermia","Asthenozoospermia","Teratozoospermia",[35,36,37,38,39,40,41,42],"Mediterranean diet","Gazpacho","sperm quality","Male infertility","Altered semen parameters","oxidative stress","OxiSperm II","Randomized trial","RECRUITING","2026-03-11",{"date":46,"type":47},"2026-03-13","ACTUAL",{"date":49,"type":47},"2026-03-02",{"date":51,"type":22},"2029-09-01",{"name":53,"class":54},"Ginefiv","OTHER",1,{"id":57,"slug":58,"hasResults":11,"nctId":59,"briefTitle":60,"officialTitle":61,"acronym":62,"eligibilityCriteria":63,"healthyVolunteers":64,"sex":17,"minAge":18,"maxAge":65,"enrollmentInfo":66,"targetDuration":4,"studyType":68,"phases":4,"briefSummary":69,"conditions":70,"keywords":4,"overallStatus":43,"whyStopped":4,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":81},"100573142","efficacy-and-safety-of-a-new-sperm-capacitation-method-100573142","NCT06742437","Efficacy and Safety of a New Sperm Capacitation Method","Efficacy and Safety of a New Sperm Capacitation Method: a Prospective in Vitro Study on Semen Samples","HyperSperm01","Inclusion Criteria:\n\n* Ability to provide a semen sample via masturbation\n\nExclusion Criteria:\n\n* Current diagnosis of a sexually transmitted infection (STI)\n* Previous diagnosis of hepatitis A, B, C, D, or HIV\n* Prior participation in this study\n* Participation in a clinical trial involving an intervention within the last 3 months",true,"60 Years",{"count":67,"type":22},300,"OBSERVATIONAL","Prospective, multicenter research study with a split-sample design on semen samples, without intervention, to evaluate the efficacy and safety of HyperSperm, a new sperm capacitation method, in 300 semen samples with various characteristics and abnormalities, in an in vitro study over 12 months.",[71,28,32,31,33],"Reproductive Issues","2026-02-24",{"date":74,"type":47},"2026-02-27",{"date":76,"type":47},"2025-01-14",{"date":78,"type":22},"2026-06",{"name":80,"class":54},"Fecundis Lab SL",4,{"id":83,"slug":84,"hasResults":11,"nctId":85,"briefTitle":86,"officialTitle":87,"acronym":4,"eligibilityCriteria":88,"healthyVolunteers":11,"sex":17,"minAge":89,"maxAge":19,"enrollmentInfo":90,"targetDuration":4,"studyType":23,"phases":92,"briefSummary":93,"conditions":94,"keywords":96,"overallStatus":43,"whyStopped":4,"lastUpdateSubmitDate":101,"lastUpdatePostDateStruct":102,"startDateStruct":104,"completionDateStruct":106,"leadSponsor":108,"locationsCount":55},"100619502","probiotics-on-sperm-quality-in-male-infertility-patients-100619502","NCT07345455","Probiotics on Sperm Quality in Male Infertility Patients","Effect of Probiotics on Sperm Quality in Male Infertility Patients","Inclusion Criteria:\n\n* Males aged 20 to 45 years\n* Diagnosis of unexplained oligozoospermia, asthenozoospermia, or oligoasthenoteratozoospermia\n* Sperm concentration \\\u003C 5 x 10\\^6\u002FmL\n* Sperm total motility \\\u003C 40%\n* Sperm morphology (Kruger strict criteria) \\\u003C 4%\n\nExclusion Criteria:\n\n* History of hormonal disorders or epididymo-orchitis\n* Substance abuse, including drugs or excessive alcohol consumption\n* Diabetes mellitus\n* Kidney disease (defined as a doubling of creatinine levels or more)\n* Chronic liver disease\n* Varicocele\n* Current use of medications that interfere with hormones\n* Occupational or environmental exposure to pesticides, heavy metals, or solvents\n* Intake of antioxidant supplements within the past three months\n* Body Mass Index (BMI) of 30 kg\u002Fm\\^2 or higher","20 Years",{"count":91,"type":22},60,[25],"This randomized, placebo-controlled pilot study aims to evaluate the effects of probiotic supplementation on sperm quality in male patients diagnosed with infertility. Male infertility accounts for approximately 40% of all infertility cases and is closely related to abnormalities in sperm count, motility, and morphology. Factors such as oxidative stress, inflammation, and DNA fragmentation are known to impact sperm function and subsequent fertilization potential negatively.\n\nProbiotics are microorganisms that confer health benefits by improving the intestinal microenvironment and regulating immunity. Emerging research suggests that probiotics may reduce oxidative stress and DNA fragmentation in men with asthenozoospermia; however, clinical data on human sperm remains limited. This study seeks to determine whether specific probiotic strains can improve sperm parameters and function in patients with unexplained oligozoospermia, asthenozoospermia, or oligoasthenoteratozoospermia.\n\nThe study will enroll 60 male participants aged 20 to 45 who meet specific inclusion criteria, including a sperm concentration of less than 50 million\u002FmL, motility less than 40%, and normal morphology (Kruger) less than 4%. Participants will be randomly assigned to either an experimental group receiving probiotics or a control group receiving a placebo for approximately 100 days.\n\nSemen samples will be collected and analyzed at three time points: before the intervention (Day 0), during the intervention (Day 60), and at the end of the study (Day 100). The primary objective is to assess changes in sperm concentration, motility, and morphology using the Computer-Aided Sperm Analysis (CASA) system. Secondary objectives include evaluating sperm DNA integrity using the Sperm Chromatin Structure Assay (SCSA) by flow cytometry and assessing sperm function via the acrosome reaction assay. The results of this pilot study will help determine the potential therapeutic role of probiotics in the management of male infertility.",[28,31,32,33,95],"Oligoasthenoteratozoospermia",[97,98,99,100,31,32],"Probiotics","Sperm Motility","Sperm DNA","Sperm Function","2026-01-08",{"date":103,"type":47},"2026-01-15",{"date":105,"type":47},"2023-09-16",{"date":107,"type":22},"2026-12-31",{"name":109,"class":54},"Mackay Memorial Hospital",{"id":111,"slug":112,"hasResults":11,"nctId":113,"briefTitle":114,"officialTitle":115,"acronym":4,"eligibilityCriteria":116,"healthyVolunteers":11,"sex":17,"minAge":89,"maxAge":117,"enrollmentInfo":118,"targetDuration":4,"studyType":23,"phases":120,"briefSummary":121,"conditions":122,"keywords":123,"overallStatus":43,"whyStopped":4,"lastUpdateSubmitDate":126,"lastUpdatePostDateStruct":127,"startDateStruct":129,"completionDateStruct":131,"leadSponsor":133,"locationsCount":55},"100612356","effect-of-pentoxifylline--coq10-vs-coq10-alone-on-sperm-motility-in-subfertile-men-with-asthenozoospermia-100612356","NCT07252518","Effect of Pentoxifylline + CoQ10 vs CoQ10 Alone on Sperm Motility in Subfertile Men With Asthenozoospermia","Effect of Pentoxifylline Plus Coenzyme Q10 Combination Therapy Compared to Coenzyme Q10 Alone on Sperm Motility in Sub-fertile Male With Asthenozoospermia","Inclusion Criteria:\n\n* Sub fertile men with asthenozoospermia(Total motility20% to less than 42%) according to WHO semen analysis,2021.\n* Age 20-50 years.\n\nExclusion Criteria:\n\n* Severe oligoasthenoteratozoospermia\n* Any medical, endocrine and genetic disorders, history of chemotherapy or radiotherapy, genital infection, genital surgery.\n* Antioxidants supplmentation in the last 3 months\n* Drug, alcohol or substance abuse, psycho-sexual abnormalities.\n* Any known hypersensitivity to xanthine related product, recent cerebral or retinal haemorrhage Severe oligoasthenoteratozoospermia\n* Any medical, endocrine and genetic disorders, history of chemotherapy or radiotherapy, genital infection, genital surgery.\n* Antioxidants supplmentation in the last 3 months\n* Drug, alcohol or substance abuse, psycho-sexual abnormalities.\n* Any known hypersensitivity to xanthine related product, recent cerebral or retinal haemorrhage","50 Years",{"count":119,"type":22},56,[25],"The goal of this clinical trial is to learn if drug Pentoxifylline plus Coenzyme Q10 work to treat asthenozoospermia in subfertile male. It will also learn about the safety of drug Pentoxifylline plus Coenzyme Q10. The main questions it aims to answer are:\n\nDoes drug Pentoxifylline plus Coenzyme Q10 increase the motility of sperm in participants? What medical problems do participants have when taking drug Pentoxifylline plus Coenzyme Q10 ? Researchers will compare drug Pentoxifylline plus Coenzyme Q10 combination to Coenzyme Q10 alone to see if drug Pentoxifylline plus Coenzyme Q10 combination works better.\n\nParticipants will:\n\nExperimental Group:Pentoxifylline 400mg twice dailyand Coenzyme Q10 100mg twice daily for 3 months.\n\nComparator Group: Coenzyme Q10 100mg twice daily for 3 months Visit the clinic after three months of treatment for checkups and tests",[32],[32,124,125],"Pentoxifylline","Coenzyme Q10","2025-11-24",{"date":128,"type":47},"2025-11-26",{"date":130,"type":47},"2025-10-01",{"date":132,"type":22},"2027-03-01",{"name":134,"class":54},"Mst.Sumyara Khatun",{"id":136,"slug":137,"hasResults":11,"nctId":138,"briefTitle":139,"officialTitle":140,"acronym":4,"eligibilityCriteria":141,"healthyVolunteers":11,"sex":142,"minAge":18,"maxAge":117,"enrollmentInfo":143,"targetDuration":4,"studyType":68,"phases":4,"briefSummary":144,"conditions":145,"keywords":4,"overallStatus":43,"whyStopped":4,"lastUpdateSubmitDate":146,"lastUpdatePostDateStruct":147,"startDateStruct":149,"completionDateStruct":151,"leadSponsor":152,"locationsCount":55},"100464538","fertility-and-the-microbiome-100464538","NCT05328999","Fertility and the Microbiome","Fertility and the Microbiome: an Observational Study and Randomized Placebo Controlled Double-blind Pilot Trial","Inclusion Criteria:\n\n* Couples (Males and females) with subfertility, primary or secondary infertility, or recurrent pregnancy loss.\n\nExclusion Criteria:\n\n* unable to consent\n* diseases or conditions that might impact investigation\n* intake of probiotics, antibiotics within last 3 months\n* intake of nutritional supplements\n* chemo therapy or radiation therapy\n* excess alcohol intake\n* smoking","ALL",{"count":67,"type":22},"With this study, the investigators want to investigate the microbiome and human papilloma virus (HPV) status of couples with subfertility. The investigators want to gain information about association of female and male microbiome and its impact on fertility. HPV prevalence is high, and its impact on fertility has not been studied intensively. The investigators want to find out whether there is an association between HPV status and subfertility, vaginal and seminal microbiome and HPV status and the prevalence among our subfertile couples.\n\nAs part of this study, the investigators will perform a randomized placebo controlled double blind pilot study to investigate the association between altered sperm quality (impaired motility and elevated DNA fragmentation index), the seminal microbiome and whether intake of probiotics alters these parameters.",[30,32],"2024-07-23",{"date":148,"type":47},"2024-07-24",{"date":150,"type":47},"2022-08-10",{"date":107,"type":22},{"name":153,"class":54},"Medical University of Graz",{"id":155,"slug":156,"hasResults":11,"nctId":157,"briefTitle":158,"officialTitle":158,"acronym":4,"eligibilityCriteria":159,"healthyVolunteers":64,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":160,"targetDuration":4,"studyType":68,"phases":4,"briefSummary":162,"conditions":163,"keywords":166,"overallStatus":43,"whyStopped":4,"lastUpdateSubmitDate":169,"lastUpdatePostDateStruct":170,"startDateStruct":171,"completionDateStruct":173,"leadSponsor":175,"locationsCount":177},"100487584","the-association-of-gut-microbiota-and-spermatogenic-dysfunction-100487584","NCT05628987","The Association of Gut Microbiota and Spermatogenic Dysfunction","Inclusion Criteria:\n\n* Aged 18 to 45 years, males\n* Body Mass Index (BMI):18.5-29.9 kg\u002Fm\\^2\n* After an abstinence period of 2-7 days, two abnormal semen analysis, the absence of spermatozoa from both replicates will be included in the azoospermia group, the total sperm number (\\\u003C39\\*10\\^6 per ejaculate) or the sperm concentration ( \\\u003C 15 \\* 10\\^6 per ml) will be oligozoospermia group, the progressive motility (PR) (\\\u003C 32%) will be asthenozoospermia group; the percentage of morphologically normal spermatozoa (\\\u003C4%) will be teratozoospermia group\n* Willing to provide feces, urine, blood samples, able to complete study questionnaires aimed at lifestyle factors (cigarette smoking, high temperature environment and others ) and other data collection instruments (e.g. physical activity, food frequency questionnaire, stress and others)\n\nExclusion Criteria:\n\n* Age \\\u003C 18 or \\> 45 years\n* History of Zocanidin, Vitamin E, antibiotics, clyster, gastrointestinal endoscope in the past 30 days, or other drugs known to interact with semen quality or gut microbiota, history of high alcohol consumption (liquor over 200 ml, beer over 1000 ml) in the past 7 days or drinking every week in the past month\n* A known genetic cause of male factor spermatogenesis dysfunction, including chromosomal or gene disorders (e.g. Y chromosome deletions, CFTR mutation)\n* History of male reproductive system (e.g. testis, epididymis, seminiferous duct and others) damage, surgery, tumor or infection\n* History of Crohn's disease, ulcerative colitis, acute gastrointestinal disease, renal failure, liver cirrhosis, hypoplasia, X-rays exposure and other diseases related to spermatogenic dysfunction, history of intestinal gastrointestinal surgery (exclude appendix surgery)\n* History of psychoses or other mental conditions that would result in cognitive impairment and inability to participate in any part of this study including the informed consent process",{"count":161,"type":22},306,"This is a multicenter, case-control study that aims to investigate the relationship between microbiota and sperm quality via stool, blood, and urine microbiome, metabolomics, and collected clinical metadata. The results of the spermatogenic dysfunction, including aspermia, oligozoospermia, asthenozoospermia, and teratozoospermia, will be compared to normal basic semen analysis utilizing the World Health Organization (WHO) semen analysis procedure 5th edition.",[164,165,31,32,33],"Infertility, Male","Azoospermia",[167,164,168],"Microbiota","Sperm","2024-07-22",{"date":148,"type":47},{"date":172,"type":47},"2023-02-20",{"date":174,"type":22},"2025-06-30",{"name":176,"class":54},"Zhujiang Hospital",3]