[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"astigmatism\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:astigmatism":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,24,0,[8,44,74,96,117,138,159,184,205,228,252,271,294,314,349,369,390,421,443,463,480,501,525,553],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":29,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100641841","corneal-epithelial-thickness-mapping-by-anterior-segment-optical-coherence-tomography-in-patients-with-refractive-errors-100641841",false,"NCT07647146","Corneal Epithelial Thickness Mapping by Anterior Segment Optical Coherence Tomography in Patients With Refractive Errors","Inclusion Criteria:\n\n* Age ≥ 18 years-\n* Patients diagnosed with myopia or hyperopia by refraction\n* Clear cornea with no evidence of corneal pathology\n* Ability to undergo reliable anterior segment imaging\n\nExclusion Criteria:\n\n* Inability to fixate or follow instructions\n* Family history of keratoconus\n* Glaucoma,Cataract\n* Previous ocular surgery including refractive surgery\n* Keratoconus or suspected corneal ectasia\n* Corneal opacities or scars\n* Contact lens wear within the last two weeks\n* Ocular trauma\n* systemic disease affecting the cornea ( Such as diabetes)",true,"ALL","18 Years","99 Years",{"count":20,"type":21},360,"ESTIMATED","OBSERVATIONAL","This study evaluates corneal epithelial thickness using anterior segment optical coherence tomography (AS-OCT) in patients with refractive errors. It aims to assess the relationship between epithelial thickness patterns and different types of refractive errors.",[25,26,27,28],"Myopia","Hyperopia","Astigmatism","Emmetropia",[30],"Corneal epithelial thickness, AS-OCT, anterior segment optical coherence tomography, refractive errors, myopia, hyperopia, astigmatism, cornea","NOT_YET_RECRUITING","2026-06-09",{"date":34,"type":35},"2026-06-15","ACTUAL",{"date":37,"type":21},"2026-07-01",{"date":39,"type":21},"2027-05-01",{"name":41,"class":42},"Sohag University","OTHER",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":4,"eligibilityCriteria":50,"healthyVolunteers":11,"sex":16,"minAge":51,"maxAge":4,"enrollmentInfo":52,"targetDuration":4,"studyType":54,"phases":55,"briefSummary":57,"conditions":58,"keywords":60,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":73},"100631574","clareon-truplus-study-100631574","NCT07502456","Clareon TruPlus Study","Clareon TruPlus Single-Arm Study","Key Inclusion Criteria:\n\n* Diagnosed with bilateral cataracts and planned bilateral cataract extraction by routine phacoemulsification.\n* Potential postoperative BCDVA of 0.2 logMAR or better in each eye in the expert medical opinion of the investigator.\n* Astigmatism suitable for correction with available toric IOL models.\n* Other protocol-specified inclusion criteria may apply.\n\nKey Exclusion Criteria:\n\n* Age-related macular degeneration (AMD), glaucoma, diabetic retinopathy, and other eye conditions as specified in the protocol.\n* Moderate to severe dry eye that would affect study measurements.\n* Other protocol-specified exclusion criteria may apply.","22 Years",{"count":53,"type":21},122,"INTERVENTIONAL",[56],"NA","The purpose of this research study is to generate safety and performance data for Clareon TruPlus Monofocal Intraocular Lenses (IOLs). IOLs are medical devices that are implanted in the eye during cataract surgery to restore clear vision after the cloudy natural lens has been removed. IOLs are intended to remain in the eyes for the duration of the patient's lifetime.",[59,27],"Aphakia",[61],"Cataract","RECRUITING","2026-06-01",{"date":65,"type":35},"2026-06-03",{"date":67,"type":35},"2026-05-26",{"date":69,"type":21},"2028-06",{"name":71,"class":72},"Alcon Research","INDUSTRY",5,{"id":75,"slug":76,"hasResults":11,"nctId":77,"briefTitle":78,"officialTitle":79,"acronym":4,"eligibilityCriteria":80,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":81,"enrollmentInfo":82,"targetDuration":4,"studyType":54,"phases":84,"briefSummary":85,"conditions":86,"keywords":4,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":43},"100637867","nomogram-for-astigmatism-correction-of-klex-100637867","NCT07605221","Nomogram for Astigmatism Correction of KLEx","Nomogram Optimization for Astigmatism Precision Correction of Corneal Refractive Correction","Inclusion Criteria:\n\n* age ≥18 years; preoperative sphere -0.50 D to -10.00 D; preoperative cylinder -1.50 D to -5.00 D; stable refraction (±0.50 D) for 1 year; normal corneal topography; central corneal thickness \\>500 μm or predicted residual stromal bed \\>280 μm; intraocular pressure \\\u003C21 mmHg\n\nExclusion Criteria:\n\n* ocular or systematic disease","45 Years",{"count":83,"type":21},100,[56],"The goal of this clinical trial is to learn if nomogram could promote treatment outcomes in astigmatism correction. The main question it aims to answer is:\n\ndoes the nomogram could promote treatment outcomes in astigmatism correction? If there is a comparison group: Researchers will compare non-nomogram adopted to see if the outcome acceptable.\n\nParticipants will ask to complete 3-month follow-up of manifest refraction and visual acuity test.",[27],"2026-05-18",{"date":89,"type":35},"2026-05-22",{"date":91,"type":35},"2025-02-18",{"date":93,"type":21},"2027-12-31",{"name":95,"class":42},"Tianjin Eye Hospital",{"id":97,"slug":98,"hasResults":11,"nctId":99,"briefTitle":100,"officialTitle":100,"acronym":4,"eligibilityCriteria":101,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":102,"targetDuration":4,"studyType":54,"phases":104,"briefSummary":105,"conditions":106,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":108,"lastUpdatePostDateStruct":109,"startDateStruct":111,"completionDateStruct":113,"leadSponsor":115,"locationsCount":43},"100635772","optimization-for-toric-contact-lenses-100635772","NCT07557030","Optimization for Toric Contact Lenses","Inclusion Criteria:\n\n1. They are at least 18 years of age.\n2. They understand their rights as a research participant and are willing and able to sign a Statement of Informed Consent.\n3. They have spherical refractive error at the corneal plane between +4.00 to -7.00DS\n4. They have refractive astigmatism at the corneal plane of 0.75 to 2.25DC in one eye.\n5. They are able to achieve distance HCHL visual acuity of +0.10 logMAR or better in each eye\n6. They are a current soft contact lens wearer or have previous experience of successful soft contact lens wear in the past 3 years.\n\nExclusion Criteria:\n\n1. Is participating in any concurrent clinical or research trial.\n2. They have an ocular disorder which would normally contra-indicate contact lens wear.\n3. They have a systemic disorder which would normally contra-indicate contact lens wear.\n4. They are pseudophakic or aphakic.\n5. They have had corneal refractive surgery.\n6. They have any corneal distortion resulting from previous hard or rigid lens wear or have keratoconus.\n7. Is using any systemic or topical medications that in the opinion of the investigator may affect contact lens wear or a study outcome variable.",{"count":103,"type":21},45,[56],"The aim of this study is to evaluate the agreement between subjective and objective toric lens prescriptions.",[27,107],"Ametropia","2026-05-04",{"date":110,"type":35},"2026-05-06",{"date":112,"type":21},"2026-05",{"date":114,"type":21},"2026-08",{"name":116,"class":72},"CooperVision International Limited (CVIL)",{"id":118,"slug":119,"hasResults":11,"nctId":120,"briefTitle":121,"officialTitle":121,"acronym":4,"eligibilityCriteria":122,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":123,"enrollmentInfo":124,"targetDuration":4,"studyType":54,"phases":126,"briefSummary":127,"conditions":128,"keywords":4,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":129,"lastUpdatePostDateStruct":130,"startDateStruct":132,"completionDateStruct":134,"leadSponsor":136,"locationsCount":43},"100616308","wear-experience-with-daily-disposable-contact-lenses-for-astigmatism-over-a-long-wear-day-100616308","NCT07303920","Wear Experience With Daily Disposable Contact Lenses for Astigmatism Over a Long-Wear Day","Inclusion Criteria:\n\n* Current soft toric contact lens wearer with long hours of wear\n* Willing to follow the contact lens wearing schedule required by the study\n* Vision 20\u002F25 or better with current soft toric contact lenses\n* Self-report completion of a comprehensive eye examination in the past two years\n\nExclusion Criteria:\n\n* Have a history of corneal ocular surgery\n* Have current ocular inflammation or infection as assessed by the study investigator who will complete the study\n* Are past rigid contact lens wearers\n* Have a history of being diagnosed with dry eye or ocular allergies\n* Have known systemic health conditions that are thought to alter tear film physiology\n* Have a history of viral eye disease\n* Have a history of ocular surgery\n* Have a history of severe ocular trauma\n* Have a history of corneal dystrophies or degenerations\n* Have active ocular infection or inflammation\n* Are currently using isotretinoin-derivatives or ocular medications\n* Are pregnant or breast feeding","40 Years",{"count":125,"type":21},40,[56],"The purpose of this study to assess the wear experience of people who have astigmatism when wearing a daily disposable contact lens for astigmatism over long days of wear.",[27],"2026-03-23",{"date":131,"type":35},"2026-03-25",{"date":133,"type":35},"2026-03-04",{"date":135,"type":21},"2026-06-30",{"name":137,"class":42},"Ohio State University",{"id":139,"slug":140,"hasResults":11,"nctId":141,"briefTitle":142,"officialTitle":143,"acronym":4,"eligibilityCriteria":144,"healthyVolunteers":11,"sex":16,"minAge":123,"maxAge":4,"enrollmentInfo":145,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":147,"conditions":148,"keywords":4,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":150,"lastUpdatePostDateStruct":151,"startDateStruct":153,"completionDateStruct":155,"leadSponsor":157,"locationsCount":43},"100614851","comfort-and-vision-with-total30-multifocal-lenses-100614851","NCT07284966","Comfort and Vision With TOTAL30 Multifocal Lenses","Evaluation of Wear Comfort and Vision With Total 30 Multifocal Lenses Over 16 Hours of Wear","Inclusion Criteria:\n\nSubjects are eligible for the study if they meet the following criteria:\n\n* Subjects who currently wear soft multi-focal contact lenses and score \\\u003C12 on an entering CLDEQ-8 survey.\n* Subjects who are \\>= 40 years old.\n* Subjects who can and are willing to wear their lenses for 13 hours per day during the study period, and 16 hours per day when questionnaires are being taken.\n* Willing to insert their contact lenses between 6:00 am and 8:00 am on the days when questionnaires will be taken.\n* Vision correctable in soft multi-focal contact lenses to 20\u002F25 (0.10 log MAR) or better in each eye at 6M.\n* Must be able to be successfully fit into the prescription parameters available for Total30 MF contact lenses.\n* Required to have a smartphone and receive push notifications.\n* Willing to attend all study visits.\n* Willing to be diligent about answering the timed surveys in a prompt manner.\n\nExclusion Criteria:\n\nIf any of the following exclusion criteria are applicable, the subject should not be enrolled in the study.\n\n* Ocular anterior segment infection, inflammation, abnormality, or active disease that would contraindicate contact lens wear.\n* Use of systemic or ocular medications for which contact lens wear could be contraindicated as determined by the investigator.\n* Use of isotretinoin-derivatives.\n* Use of lubricating drops.\n* Monocular patients or patients fit with only 1 multifocal lens.\n* Prior refractive surgery.\n* History of herpetic keratitis, ocular surgery, or irregular cornea.\n* Pregnant or lactating.\n* Having participated in a clinical trial in the past 30 days.\n* High-ADD habitual wearers using a different fitting approach than Alcon's multifocal fitting guide (e.g., J\\&J or CooperVision's fitting guide adopting a modified monovision approach).\n* Are past rigid CL wearers.\n* Have a history of being diagnosed with dry eye or ocular allergies.\n* Have history of severe ocular trauma.",{"count":146,"type":21},36,"This study is a single-arm, prospective, observational study conducted at one site to evaluate the comfort and vision of the TOTAL30 Multifocal (T30MF) contact lenses over the course of long wear days. The study will assess the proportion of positive subjective Visual Analog Scale (VAS) assessments of comfort and vision at 10, 12, 14, and 16 hours of wear on Days 1, 7, 14, and 30. Additionally, the study will explore subjective assessments of lens comfort using the CLDEQ-8 survey and measure logMAR visual acuity at both distance and near at Visit 1, Visit 2, and after 1 month of lens wear. Participants will undergo three site visits, with at-home surveys conducted at specified intervals to gather real-time data on comfort and vision.",[25,149,27],"Presbyopia","2026-02-06",{"date":152,"type":35},"2026-02-09",{"date":154,"type":35},"2026-02-05",{"date":156,"type":21},"2027-01-21",{"name":158,"class":42},"Scripps Poway Eyecare and Optometry",{"id":160,"slug":161,"hasResults":11,"nctId":162,"briefTitle":163,"officialTitle":164,"acronym":165,"eligibilityCriteria":166,"healthyVolunteers":11,"sex":16,"minAge":167,"maxAge":4,"enrollmentInfo":168,"targetDuration":4,"studyType":54,"phases":170,"briefSummary":171,"conditions":172,"keywords":4,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":175,"lastUpdatePostDateStruct":176,"startDateStruct":178,"completionDateStruct":180,"leadSponsor":182,"locationsCount":43},"100615600","improving-visual-quality-in-patients-with-irregular-corneas-using-asymmetrical-toric-intraocular-lenses-100615600","NCT07294716","Improving Visual Quality in Patients With Irregular Corneas Using Asymmetrical Toric Intraocular Lenses","VITAL - \"Visual Improvement With Toric Asymmetrical Lenses\": Enhancing Vision in Irregular Corneas","VITAL","Inclusion Criteria:\n\n* Age 21 years or older\n* Scheduled cataract surgery\n* At least 1.75 D of total astigmatism in the CASIA2 measurement\n* At least 0.75 D of asymmetry or higher order irregularity within the 6mm zone of the real (total) index corneal refractive map of the CASIA2 measurements\n\nExclusion Criteria:\n\n* Relevant central corneal scars\n* PEX, previous ocular surgery, severe trauma or any pathology that could lead to an unstable capsular bag\n* Combined surgery (cataract plus glaucoma\u002Fvitreoretinal\u002Fcorneal surgery)\n* Postoperative best corrected distance visual acuity below 0.3 Snellen decimal\n* Pregnancy","21 Years",{"count":169,"type":21},15,[56],"Cataract surgery in patients with irregular corneas presents unique challenges, primarily due to the high variability in keratometry and corneal tomography measurements, which complicates accurate intraocular lens (IOL) calculations. In these patients, therapeutic options are currently limited to either non-toric IOLs and rigid contact lenses postoperatively or conventional toric IOLs for the reduction of total astigmatism within cataract surgery. While conventional toric IOLs may be beneficial in selected cases with a stable astigmatic pattern and clear axis, their effectiveness is largely limited, as significant irregularity and higher order aberrations reduce predictability, accuracy of formulae, and refractive outcomes. Therefore, the development of a reliable method to reduce total astigmatism - including irregular components - would represent a major advancement, potentially improving both visual function and patient quality of life. The aim of this exploratory study is to evaluate the effectiveness of customized toric intraocular lenses (AMILens Individual, AMIPLANT GmbH, Germany) in reducing total corneal astigmatism in patients with a significant irregular astigmatic component. These lenses are designed to address corneal aberrations up to the 6th Zernike order, thereby extending correction beyond the capabilities of conventional toric IOLs. To our knowledge, no clinical study has yet investigated this novel approach.",[173,27,174],"Irregular Astigmatism","Cataract and IOL Surgery","2026-01-22",{"date":177,"type":35},"2026-01-26",{"date":179,"type":35},"2026-01-20",{"date":181,"type":21},"2027-06",{"name":183,"class":42},"Johannes Kepler University of Linz",{"id":185,"slug":186,"hasResults":11,"nctId":187,"briefTitle":188,"officialTitle":189,"acronym":4,"eligibilityCriteria":190,"healthyVolunteers":15,"sex":16,"minAge":51,"maxAge":191,"enrollmentInfo":192,"targetDuration":4,"studyType":54,"phases":194,"briefSummary":195,"conditions":196,"keywords":197,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":179,"lastUpdatePostDateStruct":200,"startDateStruct":201,"completionDateStruct":202,"leadSponsor":203,"locationsCount":43},"100599000","wavefront-guided-lasik-surgery-compared-to-ray-tracing-guided-lasik-surgery-100599000","NCT07078799","Wavefront-guided LASIK Surgery Compared to Ray Tracing-Guided LASIK Surgery","A Prospective Randomized Comparison of Wavefront-guided LASIK Surgery to Ray Tracing-Guided LASIK Surgery","Inclusion Criteria:\n\n1. Age 22 and older\n2. People with healthy eyes:\n\n   1. No abnormal corneal shape\n   2. No excessively thin corneas\n   3. No eye diseases such as glaucoma or cataracts\n3. Nearsightedness between -1.00 diopters and -10.00 diopters.\n4. Subjects with less than or equal to 3.00 diopters of astigmatism.\n5. Subjects must have similar levels of nearsightedness in each eye.\n\nExclusion Criteria:\n\n1. Subjects under the age of 22.\n2. Subjects with excessively thin corneas.\n3. Subjects with topographic evidence of keratoconus.\n4. Subjects with ectactic eye disorders.\n5. Subjects with autoimmune diseases.\n6. Subjects who are pregnant or nursing at the time of surgery. (The FDA-approved labelling indications for LASIK specifically excludes patients who are pregnant or nursing. There is no strict prohibition not to become pregnant during the one year study period)\n7. They can not be more than 1.5 diopter of difference between eyes.\n8. Subjects with more than 3.00 diopters of astigmatism\n9. Subjects with disimilar levels of astigmatism in each eye (They can not have more than 0.75 diopters of difference between eyes) -","59 Years",{"count":193,"type":21},70,[56],"We are enrolling participants aged 22 and older to have LASIK surgery in both eyes. We will perform wavefront-guided LASIK in one eye and ray tracing-guided LASIK in the fellow eye of each participant. We are trying to see if there are any differences in the efficacy between the two types of LASIK procedures.",[25,27],[198,199],"Ray tracing-guided LASIK","Wavefront-guided LASIK",{"date":175,"type":35},{"date":179,"type":35},{"date":93,"type":21},{"name":204,"class":42},"Stanford University",{"id":206,"slug":207,"hasResults":11,"nctId":208,"briefTitle":209,"officialTitle":210,"acronym":4,"eligibilityCriteria":211,"healthyVolunteers":11,"sex":16,"minAge":167,"maxAge":4,"enrollmentInfo":212,"targetDuration":4,"studyType":54,"phases":214,"briefSummary":216,"conditions":217,"keywords":4,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":218,"lastUpdatePostDateStruct":219,"startDateStruct":221,"completionDateStruct":223,"leadSponsor":225,"locationsCount":227},"100603756","phase-4-arcuate-incisions-with-light-adjustable-lens-for-astigmatism-correction-in-lens-surgery-100603756","NCT07140653","Arcuate Incisions With Light Adjustable Lens for Astigmatism Correction in Lens Surgery","Evaluation of Arcuate Incisions for Correcting Pre-Existing Corneal Astigmatism in Combination With the Light Adjustable Lens for Cataract and Refractive Lens Exchange Surgery","Inclusion Criteria:\n\n1. Subject must be aged ≥ 21 years at the time of eligibility visit.\n2. Subject must have a vector difference of 0.50 D or less in magnitude of pre-operative anterior corneal astigmatism as measured by the Pentacam AXL and the Zeiss IOLMaster 700 (Carl Zeiss Meditec).\n3. Subject must be able and willing to comply with the study examination procedures.\n4. Astigmatic treatment must require paired arcs \\\u003C45mm in length.\n5. Subject must be willing to complete the approved informed consent form.\n6. Subject must have elected to undergo lens extraction and Light Adjustable Lens (LAL) implantation.\n7. Subject must be willing and able to return for scheduled pre-op and follow-up examinations.\n8. Subject must have central 7 mm of clear cornea without vascularization.\n\nExclusion Criteria:\n\n1. Subject who has undergone previous corneal or intraocular surgery in the eye to be treated.\n2. Subject with a history, signs or symptoms of ocular disease or atypical findings that would be contraindicated under standard of care for lens extraction surgery.\n3. Subject with neuro-ophthalmic disease.\n4. Diabetic or hypertensive subject with clinical evidence of retinal pathology that the investigator believes will significantly affect visual outcomes.\n5. Subject with macular degenerative pathology identified at the preoperative visit that the investigator believes will significantly affect visual outcomes.\n6. Subject with a history of steroid-responsive rise in intraocular pressure (IOP), preoperative IOP \\>25 mmHg, or uncontrolled glaucoma in either eye.\n7. Subject with known lens\u002Fzonular instability.\n8. Subject who cannot achieve dilated pupillary diameter \\> 6 mm.\n9. Subject with abnormal corneal topography, including evidence of forme fruste keratoconus, keratoconus or pellucid marginal degeneration.\n10. Subject with posterior segment disease or degeneration.\n11. Subject with corneal disease or pathology that precludes an adequate view for imaging or transmission of laser wavelength of light.\n12. Subject with known sensitivity to planned perioperative standard of care medications.\n13. Subject participating in any other ophthalmic drug or device clinical trial during the time of this clinical assessment.\n14. Subject with known sensitivity to planned assessment concomitant medications.\n15. Subjects with severe dry eye syndrome (DES) or history of ocular inflammation that may impact visual outcomes.\n16. Subject with irregular astigmatism in the eye to be treated.",{"count":213,"type":21},60,[215],"PHASE4","This study aims to evaluate the safety and effectiveness of femtosecond laser arcuate corneal relaxing incisions (AK) combined with Light Adjustable Lens (LAL) implantation for correcting pre-existing corneal astigmatism in patients undergoing cataract or refractive lens exchange surgery. Postoperative assessments will focus on residual refractive astigmatism, visual outcomes, patient satisfaction, and the incidence of adverse events. Arcuate keratotomy and toric IOLs are well-established methods for astigmatism correction, and this study will compare their combined effectiveness using advanced femtosecond laser technology.",[27],"2025-12-18",{"date":220,"type":35},"2025-12-22",{"date":222,"type":35},"2025-09-02",{"date":224,"type":21},"2026-09-02",{"name":226,"class":42},"Center For Sight",2,{"id":229,"slug":230,"hasResults":11,"nctId":231,"briefTitle":232,"officialTitle":233,"acronym":4,"eligibilityCriteria":234,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":235,"targetDuration":237,"studyType":22,"phases":4,"briefSummary":238,"conditions":239,"keywords":242,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":243,"lastUpdatePostDateStruct":244,"startDateStruct":246,"completionDateStruct":248,"leadSponsor":250,"locationsCount":4},"100611430","assessing-the-turkish-ddivat-for-visual-acuity-measurement-100611430","NCT07240480","Assessing the Turkish DDIVAT for Visual Acuity Measurement","Validation of the Turkish Version of the DDIVAT Visual Acuity Measuring Device in a Turkish-speaking Population","Inclusion Criteria:\n\n* Adults aged 18 years or older\n\nTurkish-speaking individuals able to understand the study purpose\n\nWillingness to participate and provide written informed consent\n\nParticipants with or without refractive errors (e.g., myopia, hyperopia, astigmatism)\n\nExclusion Criteria:\n\n* Age below 18 years\n\nIndividuals unable to complete visual acuity testing\n\nPresence of severe ocular pathology (e.g., corneal opacity, retinal detachment) that prevents accurate measurement\n\nCognitive or communication difficulties preventing informed consent",{"count":236,"type":21},200,"1 Day","The goal of this observational methodological study is to validate the Turkish version of the DDIVAT visual acuity measuring device in a Turkish-speaking adult population.\n\nThe main questions it aims to answer are:\n\nDoes the Turkish version of the DDIVAT provide reliable and valid visual acuity measurements in Turkish speakers?\n\nAre the results of the DDIVAT comparable to those obtained with the standard Snellen chart used in clinical practice?\n\nResearchers will compare DDIVAT visual acuity test results with Snellen chart results to see if both methods produce consistent measurements.\n\nParticipants will:\n\nBe adults aged 18 years or older, including both patients and healthy volunteers.\n\nUndergo visual acuity testing using the DDIVAT system displayed on a smart TV connected to the university server.\n\nHave their visual acuity re-measured using the standard Snellen optotype under the same conditions.\n\nNo medication or invasive procedure will be used. The study carries no risk to participants.",[240,241,25,26,27],"Visual Acuity","Refractive Errors",[240,241],"2025-11-26",{"date":245,"type":35},"2025-12-04",{"date":247,"type":21},"2025-12-01",{"date":249,"type":21},"2026-05-31",{"name":251,"class":42},"Trakya University",{"id":253,"slug":254,"hasResults":11,"nctId":255,"briefTitle":256,"officialTitle":257,"acronym":4,"eligibilityCriteria":258,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":259,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":261,"conditions":262,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":243,"lastUpdatePostDateStruct":263,"startDateStruct":265,"completionDateStruct":266,"leadSponsor":268,"locationsCount":270},"100576430","revive-toric-rwe-study-100576430","NCT06785194","Revive Toric RWE Study","Samfilcon B Custom Toric Lens Real-World Observational Study","Inclusion Criteria:\n\n1. Be 18 years or older on the date the ICF is signed\n2. Have the capacity to read, understand, and provide written voluntary informed consent\n3. Have physiologically normal anterior segments not exhibiting clinically significant biomicroscopy findings\n4. Have no active ocular disease or allergic conjunctivitis\n5. Not be using any topical ocular medications\n6. Be willing and able to follow instructions\n7. Have signed a statement of informed consent\n8. Be an experienced soft contact lens wearer (have previously used soft contact lenses)\n9. Meet the indications per the Instructions for Use (IFU) and have a suitable prescription for treatment with the device\n\nExclusion Criteria:\n\n1. Is participating in another research study\n2. Is considered by the Investigator to not be a suitable candidate for participation\n3. Is not eligible for treatment with the study lens per the IFU (contraindicated)\n4. Has had previous ocular surgery\n5. Is taking\u002Fusing ocular, systemic, or topical medications that, in the Investigator's opinion, could potentially affect ocular physiology or lens\u002Fsolution performance",{"count":260,"type":21},30,"This is a post-market observational clinical investigation. The objective of this observational study is to evaluate the visual performance and HCP satisfaction of REVIVE samfilcon B custom toric contact lenses.",[27],{"date":264,"type":35},"2025-11-28",{"date":112,"type":21},{"date":267,"type":21},"2026-07",{"name":269,"class":72},"Bausch & Lomb Incorporated",3,{"id":272,"slug":273,"hasResults":11,"nctId":274,"briefTitle":275,"officialTitle":276,"acronym":4,"eligibilityCriteria":277,"healthyVolunteers":11,"sex":16,"minAge":167,"maxAge":4,"enrollmentInfo":278,"targetDuration":4,"studyType":54,"phases":280,"briefSummary":281,"conditions":282,"keywords":4,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":284,"lastUpdatePostDateStruct":285,"startDateStruct":287,"completionDateStruct":289,"leadSponsor":291,"locationsCount":293},"100610825","a-planned-study-at-multiple-sites-is-being-done-to-compare-the-results-of-two-types-of-trifocal-toric-intraocular-lenses-used-in-cataract-surgery-100610825","NCT07232615","A Planned Study at Multiple Sites is Being Done to Compare the Results of Two Types of Trifocal Toric Intraocular Lenses Used in Cataract Surgery","A Prospective, Multicenter Clinical Study Comparing Outcomes of Two Trifocal Toric Intraocular Lens","Inclusion Criteria:\n\n1. Age of patient \\>21 Years\n2. Patient diagnosed with cataract.\n3. Patient must have preoperative regular corneal astigmatism between 0.75 to 4.5 D as per corneal topography or keratometry\n4. Calculated IOL power is within the range of investigational IOLs.\n5. Patient willing to sign inform consent form.\n6. Clear intraocular media other than cataract.\n7. Female participants of childbearing potential must be willing to ensure that they use effective contraception during the study.\n\nExclusion Criteria:\n\n1. Previous intraocular or corneal surgery.\n2. Traumatic cataract\n3. Pregnancy (as stated by patient) or lactation.\n4. Concurrent participation in another drug or device investigation.\n5. Irregular astigmatism.\n6. Patient receiving chlorquine treatment.\n7. Subjects with any systemic disease that could increase operative risk or confound the outcome.\n8. Active ocular disease in the operative eye other than cataract.\n9. Vulnerable subjects as defined in section 12.3.9.\n10. Corneal Astigmatism \\> 4.5 D",{"count":279,"type":21},138,[56],"To evaluate the clinical outcomes and patient satisfaction of two commercially available trifocal toric intraocular lenses Primary Objective: To compare the distance-corrected intermediate visual acuity between the two trifocal toric intraocular lenses. Secondary Objectives: To assess and compare the safety of two trifocal toric intraocular lenses.",[283,27,61],"Presbyopia Correction","2025-11-14",{"date":286,"type":35},"2025-11-18",{"date":288,"type":35},"2021-11-22",{"date":290,"type":21},"2027-02",{"name":292,"class":72},"Biotech Healthcare Holding Gmbh",6,{"id":295,"slug":296,"hasResults":11,"nctId":297,"briefTitle":298,"officialTitle":299,"acronym":4,"eligibilityCriteria":300,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":301,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":303,"conditions":304,"keywords":4,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":305,"lastUpdatePostDateStruct":306,"startDateStruct":308,"completionDateStruct":310,"leadSponsor":312,"locationsCount":43},"100602764","clinical-evaluation-of-wavelight-plus-lasik-100602764","NCT07127757","Clinical Evaluation of WaveLight Plus LASIK","Clinical Evaluation of Visual Outcomes With the Wavelight Plus Excimer Laser in Normal and Dim Lighting","Inclusion Criteria:\n\n* Subject must be able to understand and sign an IRB approved Informed consent form\n* Willing and able to attend all scheduled study visits as required per protocol\n* Minimum of 18 years of age\n* Myopia up to -8.00 D, astigmatism up to -3.00 D, with SE more than -1.00D and up to -9.00D, based on Sightmap measured refraction\n* Best corrected photopic distance visual acuity of 20\u002F20-2 or better (≤ 0.04 logMAR)\n* Mesopic pupil size ≥ 4.5mm\n* Less than 0.75 D manifest refraction spherical equivalent difference between Sightmap refraction and subjective manifest refraction\n* Stable refraction (within ± 0.50 D) as determined by manifest refraction spherical equivalent for a minimum of 12 months prior to surgery, verified by consecutive subjective refractions or medical records or prescription history\n* If currently wearing contact lenses:\n\n  * Soft CTL wearers discontinue for minimum 3 days prior to first refraction\n  * RGP or toric soft CTL wearers discontinue for ≥2 weeks prior to first refraction\n\nExclusion Criteria:\n\n* Subjects who are pregnant or nursing\n* Acute or chronic disease or illness that would increase the operative risk or confound the outcomes of the study\n* Patients with flap complications\n* Systemic medications that may confound the outcome of the study or increase the risk to the subject.\n* Ocular condition (other than high myopia) that may predispose the subject to future complications, such as ectasia\n* History or evidence of active or inactive corneal disease (e.g., herpes simplex keratitis, herpes zoster keratitis, recurrent corneal erosion syndrome, corneal dystrophy)\n* Evidence of retinal vascular disease\n* Keratoconus or Keratoconus suspect\n* Glaucoma or glaucoma suspect by exam findings and\u002For family history\n* Previous intraocular or corneal surgery\n* Predicted residual stromal bed thickness \\\u003C 250 μm\n* Intended to have monovision treatment\n* Participation in other current clinical trials",{"count":302,"type":21},50,"This study is a single-site, single-arm, prospective, observational study of subject satisfaction, quality of vision, and quality of life after bilateral LASIK surgery. Subjects will be assessed up to 3 months post-operatively. Clinical evaluations will include refractive outcomes, visual acuity, and administration of the adapted PROWL and Low Luminance Questionnaire (LLQ-32) Questionnaire.",[25,27],"2025-09-29",{"date":307,"type":35},"2025-10-02",{"date":309,"type":35},"2025-08-28",{"date":311,"type":21},"2026-09-01",{"name":313,"class":42},"Laser Defined Vision",{"id":315,"slug":316,"hasResults":11,"nctId":317,"briefTitle":318,"officialTitle":319,"acronym":4,"eligibilityCriteria":320,"healthyVolunteers":15,"sex":16,"minAge":51,"maxAge":321,"enrollmentInfo":322,"targetDuration":4,"studyType":54,"phases":324,"briefSummary":325,"conditions":326,"keywords":327,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":340,"lastUpdatePostDateStruct":341,"startDateStruct":343,"completionDateStruct":345,"leadSponsor":347,"locationsCount":43},"100608418","a-three-phase-contralateral-comparison-of-ray-tracing-guided-lasik-versus-three-other-refractive-surgery-platforms-to-correct-myopia-or-myopia-with-astigmatism-100608418","NCT07201298","A Three-Phase Contralateral Comparison of Ray-Tracing Guided LASIK Versus Three Other Refractive Surgery Platforms to Correct Myopia or Myopia With Astigmatism","A Prospective Contralateral Comparison of Ray-Tracing Guided LASIK (WaveLight® Plus LASIK) vs. Small Incision Lenticule Extraction (SMILE® Pro) Using VisuMax® 800, or Wavefront Optimized LASIK or Topography Guided LASIK (Contoura LASIK): A Three-Phase Visual Outcomes Study.","Inclusion Criteria:\n\n1. Age 22-50 at the time of consent\n2. Diagnosis of myopia or myopia with astigmatism with Preoperative manifest spherical equivalent refraction of ≥ -2.00 and ≤ -9.00 D (-2.00 D through -9.00 D)\n3. Preop Spherical component of ≥ -2.00 and ≤ -8.00 D (-2.00 D through -8.00 D)\n4. Refractive Cylinder of ≤ -3.00 D (0.00 through -3.00 D)\n5. BCVA of 20\u002F20 or better in each eye (83 or more letters on the ETDRS Chart)\n6. Subjects must have a stable refraction which is defined as a change in spherical equivalent no greater than 0.50 D comparing the screening visit manifest refraction to a previous refraction, spectacle Rx, or contact lens Rx, 12 months or older.\n7. Subjects who are contact lens wearers must discontinue the use of soft lenses (spherical or toric) for at least 5 days and hard or gas-permeable lenses for at least 4 weeks prior to the preoperative screening evaluation. Hard or gas-permeable lens wearers must not return to contact lens use before surgery. Soft lens wearers may resume contact lens wear after all preoperative testing is completed, but must discontinue lens use at least 5 days before surgery.\n8. Acceptable preoperative tomography and examination results for refractive procedures as determined by the Principal Investigator.\n9. Surgical plan includes treatment target for emmetropia in both eyes, and no monovision.\n10. Subject is capable and willing to use postoperative medications as prescribed.\n11. Subject has ability to successfully complete all preoperative and postoperative questionnaires, testing, and exam visits.\n12. Subject is willing and able to return for all postoperative examinations.\n\nExclusion Criteria:\n\n1. Clinically significant dry eye on clinical examination, as determined by the investigator\n2. Irregular astigmatism, keratoconus, keratoconus suspect, or abnormal corneal tomography\n3. History of corneal dystrophies or guttata\n4. History of herpetic keratitis or active disease\n5. History of prior refractive surgery\n6. History of glaucoma or glaucoma suspect\n7. History of uncontrolled diabetes, unstable hypertension, or unstable autoimmune disease.\n8. Females who are pregnant, breastfeeding, or intend to become pregnant any time during the study as determined by verbal inquiry.\n9. The Principal Investigator has determined the subject not to be a good candidate for the study.","50 Years",{"count":323,"type":21},120,[56],"This purpose of this study is to compare a new form of LASIK called Ray Tracing Guided LASIK to 3 other forms of corneal refractive surgery: 1. KLEx (KeratoLenticule Extraction) using the Zeiss Visumax 800 Laser, 2. WFO LASIK (Wavefront Optimized LASIK) using the Alcon EX500 Laser, and 3. Topography Guided LASIK (Contoura LASIK) also using the Alcon EX500 Laser.",[25,27],[328,329,330,331,332,333,334,335,336,337,338,339],"refractive surgery","myopia","astigmatism","excimer laser","femtosecond laser","Ray Tracing","Lenticule","SMILE","KLEx","Contoura","Topography Guided LASIK","Wavefront Optimized","2025-09-23",{"date":342,"type":35},"2025-10-01",{"date":344,"type":21},"2025-09",{"date":346,"type":21},"2029-09",{"name":348,"class":42},"Hoopes Vision",{"id":350,"slug":351,"hasResults":11,"nctId":352,"briefTitle":353,"officialTitle":354,"acronym":4,"eligibilityCriteria":355,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":356,"enrollmentInfo":357,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":359,"conditions":360,"keywords":4,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":361,"lastUpdatePostDateStruct":362,"startDateStruct":364,"completionDateStruct":366,"leadSponsor":367,"locationsCount":43},"100599465","patient-reported-outcomes-with-wavelight-plus-lasik-100599465","NCT07084844","Patient Reported Outcomes With WaveLight Plus LASIK","Patient Reported Outcomes and Satisfaction With Wavelight Plus LASIK","Inclusion Criteria:\n\n* Between the ages of 18 and 39\n* Meet the standard care requirements for LASIK\n* Spherical equivalent (SE) more than -1.00D and up to -9.00 diopters\n* Myopia ≤ -8.00 sphere (in minus cylinder format) and up to -3.00D astigmatism\n* SE difference between the manifest refraction and the Sightmap measured SE being less than 0.75D\n* Minimum residual stromal bed thickness of 250 µm\n* If currently wearing contact lenses:\n\n  * Soft CTL wearers discontinue for minimum 3 days\n  * RGP CTL wearers discontinue for 1 month per decade of wear\n* Stable refraction (2 consecutive manifest refractions within 0.25 SE)\n* Stable K readings (2 consecutive K readings in 2 consecutive visits)\n* Willing and able to complete all post-operative visits\n* Pre-surgery BCDVA of 20\u002F20 (0.00 logMAR) or better in each eye.Mesopic pupil size ≥ 4.5mm\n\nExclusion Criteria:\n\n* Subjects with any prior ocular surgery\n* Subjects with topographic evidence of keratoconus, or ectasia\n* Subjects with autoimmune diseases\n* Subjects who are pregnant or nursing\n* Systemic disease likely to affect wound healing, such as diabetes and severe atopy\n* Any ocular disease (including un-controlled dry eye) which in the investigator's opinion would affect the outcome of refractive surgery","39 Years",{"count":358,"type":21},52,"This study is a single-site, single-arm, prospective, observational study of subject satisfaction, quality of vision, and quality of life after bilateral LASIK surgery. Subjects will be assessed up to 3 months post-operatively. Clinical evaluations will include refractive outcomes, visual acuity, and administration of the adapted PROWL and the Quality-of-Life Impact of Refractive Correction (QIRC) Questionnaire.",[25,27],"2025-09-08",{"date":363,"type":35},"2025-09-15",{"date":365,"type":35},"2025-09-05",{"date":311,"type":21},{"name":368,"class":42},"Mann Eye Institute",{"id":370,"slug":371,"hasResults":11,"nctId":372,"briefTitle":373,"officialTitle":373,"acronym":4,"eligibilityCriteria":374,"healthyVolunteers":11,"sex":16,"minAge":375,"maxAge":376,"enrollmentInfo":377,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":379,"conditions":380,"keywords":4,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":381,"lastUpdatePostDateStruct":382,"startDateStruct":384,"completionDateStruct":386,"leadSponsor":388,"locationsCount":389},"100585455","north-american-comfilcon-a-clinical-study-100585455","NCT06902584","North American Comfilcon A Clinical Study","Inclusion Criteria:\n\n1. Age 8 to 75 years (inclusive).\n2. Current wearer of the Comfilcon A sphere, toric, multifocal, toric multifocal or Energys contact lens for at least 12 months.\n3. At least occasional overnight wear in the last 12 months.\n\nExclusion Criteria:\n\n1\\. Current participation in a contact lens or contact lens care product clinical trial.","8 Years","75 Years",{"count":378,"type":21},182,"The main objective of this study is to demonstrate acceptable safety and effectiveness (performance) of comfilcon A Sphere, Toric, Multifocal, Toric Multifocal and Energys lenses, when used in the general population.",[27,149,107],"2025-08-25",{"date":383,"type":35},"2025-08-27",{"date":385,"type":35},"2025-02-05",{"date":387,"type":21},"2025-12",{"name":116,"class":72},4,{"id":391,"slug":392,"hasResults":11,"nctId":393,"briefTitle":394,"officialTitle":394,"acronym":4,"eligibilityCriteria":395,"healthyVolunteers":15,"sex":16,"minAge":396,"maxAge":397,"enrollmentInfo":398,"targetDuration":4,"studyType":54,"phases":400,"briefSummary":401,"conditions":402,"keywords":408,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":412,"lastUpdatePostDateStruct":413,"startDateStruct":415,"completionDateStruct":417,"leadSponsor":419,"locationsCount":43},"100596484","algorithm-assisted-subjective-refraction-program-dedicated-to-children-100596484","NCT07046065","Algorithm-assisted Subjective Refraction Program Dedicated to Children","Inclusion Criteria:\n\n1. Age between 6 and 12 years\n2. Subject able to recognize and name the letters of the Latin alphabet\n3. Pupillary distance (PD) not less than 49mm\n4. Distance refractive error for spherical equivalence (SE) within the range of \\[-6.00 to +6.00 D\\] maximum of the two absolute values RE and LE; Cyl ≤ 3.00 D\n5. Monocular Visual acuity ≥ +0.30 LogMAR (0.5 Decimal VA) in each eye at distance\n6. Visual acuity difference \\\u003C 0.20 logMAR between right and left eyes at distance\n\nExclusion Criteria:\n\n1. Vulnerability of the subject\n2. Amblyopia\n3. Strabismus\n4. Any current or evolving pathology manifested in the eye or the appendages which might have an influence on vision, or interfere with refractive state\n5. Any previous ocular surgery, which might have an influence on vision or interfere with study assessments (e.g. iridectomy, refractive surgery…)\n6. Any ocular or systemic condition known to affect refractive status (e.g., keratoconus, diabetes, Down's syndrome, etc.)\n7. Any neurological or speech disorders that might interfere with the ability to understand and answer questions or communicate with the ECP\n8. Any untreated and\u002For uncontrolled systemic condition which might have an influence on vision or interfere with study assessments\n9. Current use of ocular or systemic medications, which, in the Investigator's opinion, may significantly affect pupil size, accommodation or refractive state\n10. History of myopia control intervention that may affect refractive assessment (e.g., atropine, orthokeratology, rigid gas permeable lenses (RGP) etc.) except myopia control spectacles\n11. Contraindications of cycloplegia (e.g. high Intra-ocular pressure - more than 22mmHg in either eye, narrow anterior angle, history of allergy to cycloplegic agents or seizures, etc)\n12. Aphakic or pseudoaphakic (intraocular lens),\n13. Prismatic prescription in either Right or Left eye (horizontal or vertical). -","6 Years","12 Years",{"count":399,"type":21},166,[56],"Current refraction assessment in children is dependent on the Eye Care Specialist and lacks standardization. Essilor has developed new algorithm assisted subjective refraction software dedicated to children of 6-12 years old and suitable for use with Vision-S™ and Vision-R™ phoropters, in addition to existing software.\n\nTwo different versions of the software have been developed: the first incorporating only the steps needed to perform an entire subjective refraction process (vA), and the second, identical to the first but incorporating additional steps useful for managing the child's attention and cooperation (vB).\n\nThe software performance in terms of subjective refraction results will be compared to a conventional subjective refraction method performed with the Vision-R™700 phoropter in manual mode.",[403,404,405,27,406,407],"Refractive Assessment","Refractive Disorders","Hyperopia and Myopia","Refractive Error Correction","Children",[409,410,411],"cycloplegic refraction","non-cycloplegic refraction","subjective refraction","2025-06-23",{"date":414,"type":35},"2025-07-01",{"date":416,"type":35},"2025-05-23",{"date":418,"type":21},"2025-12-31",{"name":420,"class":72},"Essilor International",{"id":422,"slug":423,"hasResults":11,"nctId":424,"briefTitle":425,"officialTitle":425,"acronym":4,"eligibilityCriteria":426,"healthyVolunteers":11,"sex":16,"minAge":81,"maxAge":427,"enrollmentInfo":428,"targetDuration":4,"studyType":54,"phases":430,"briefSummary":431,"conditions":432,"keywords":4,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":434,"lastUpdatePostDateStruct":435,"startDateStruct":437,"completionDateStruct":439,"leadSponsor":441,"locationsCount":43},"100347446","rotation-of-hydrophobic-acrylic-lenses---rayner-ra0800c--alcon-clareon--hoya-nanex--hoya-vivinex-xy1-em--rayone-emv-toric--podeye-toric-100347446","NCT03803852","Rotation of Hydrophobic Acrylic Lenses - Rayner RA0800C & Alcon Clareon & Hoya Nanex & Hoya Vivinex XY1-EM & RayOne EMV Toric & PODEYE Toric","Inclusion Criteria:\n\n* Uni- or bilateral age-related cataract necessitating phacoemulsification extraction and posterior IOL implantation\n* Age: 45 to 95\n* Need for spherical IOL correction between 10.00 and 30.00 D\n* Need for spherical IOL correction between +6.00 and +30.00 D (Alcon Clareon toric group)\n* Need for spherical IOL correction between +10.00 and +25.00 D (Rayner RayOne EMV toric group)\n* Preoperative pupil dilation in mydriasis ≥ 7.0 mm (Hoya, Rayner groups)\n* Astigmatism of at least 1.0 Diopters (Alcon Clareon toric and Rayner RayOne EMV toric groups and PODEYE Toric)\n* Pupil dilation \\>5.5mm (Alcon Clareon toric Rayner RayOne EMV toric group)\n\nExclusion Criteria:\n\n* Preceding ocular surgery or trauma\n\n  * Recurrent intraocular inflammation of unknown etiology\n  * Uncontrolled glaucoma\n  * Uncontrolled systemic or ocular disease\n  * Blind fellow eye\n  * Microphthalmus\n  * Corneal abnormality (Corneal scaring)\n  * History of uveitis\u002Firitis\n  * Iris neovascularization\n  * Proliferative diabetic retinopathy\n  * Pregnancy\n  * Lactation\n  * Females of childbearing age will be asked if pregnancy is possible","95 Years",{"count":429,"type":21},750,[56],"The investigational devices are approved intraocular lenses (IOL) intended to be implanted after phacoemulsification in individuals suffering from age-related cataract with the need of cataract surgery. Within the study, three different IOLs will be investigated and separately evaluated. Cataract surgery with IOL implantation will be performed in subjects who have signed an informed consent form. Postoperative examinations will be postoperative refraction, visual acuity, slitlamp examination, and rotation of the IOL within 1 hour, 1 week, 1 month and 4-7 months.\n\nIn the Alcon Clareon toric, RayOne EMV toric and PODEYE Toric group, patients receive a toric IOL according to their preoperative astigmatism",[433,27],"Age Related Cataracts","2025-05-08",{"date":436,"type":35},"2025-05-14",{"date":438,"type":35},"2019-01-21",{"date":440,"type":21},"2028-01",{"name":442,"class":42},"Medical University of Vienna",{"id":444,"slug":445,"hasResults":11,"nctId":446,"briefTitle":447,"officialTitle":447,"acronym":4,"eligibilityCriteria":448,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":449,"targetDuration":4,"studyType":54,"phases":450,"briefSummary":452,"conditions":453,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":455,"lastUpdatePostDateStruct":456,"startDateStruct":458,"completionDateStruct":460,"leadSponsor":461,"locationsCount":4},"100584976","phase-1-effectiveness-and-safety-of-limbal-relaxing-incisions-for-correcting-post-phacoemulsification-high-astigmatism-100584976","NCT06896357","Effectiveness and Safety of Limbal Relaxing Incisions for Correcting Post Phacoemulsification High Astigmatism","Inclusion Criteria:\n\n* Conventional phacoemulsification was done at least one month earlier.\n* Clear cornea with corneal astigmatism more than 3.0 D.\n\nExclusion Criteria:\n\n* History of corneal surgeries (e.g., keratoplasty, refractive surgery, and corneal wound repair).\n* Ocular trauma.\n* Other intraocular surgery.\n* Patient with corneal opacities.\n* Thin cornea .\n* Any significant ocular disease causing diminution of vision (e.g., optic atrophy, diabetic retinopathy, and age-related macular degeneration), autoimmune disease, and peripheral corneal disease.",{"count":260,"type":21},[451],"PHASE1","To compare the effect of Limbal relaxing incisions (LRIs) plus spectacle correction versus spectacle correction alone on subjective and objective improvement in visual function for correcting post phacoemulsification high astigmatism .",[27,454],"Phacoemulsification","2025-03-24",{"date":457,"type":35},"2025-03-26",{"date":459,"type":21},"2025-05-01",{"date":63,"type":21},{"name":462,"class":42},"Assiut University",{"id":464,"slug":465,"hasResults":11,"nctId":466,"briefTitle":467,"officialTitle":467,"acronym":4,"eligibilityCriteria":468,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":469,"targetDuration":4,"studyType":54,"phases":470,"briefSummary":471,"conditions":472,"keywords":4,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":473,"lastUpdatePostDateStruct":474,"startDateStruct":476,"completionDateStruct":478,"leadSponsor":479,"locationsCount":43},"100569423","application-of-phototherapeutic-keratectomy-mode-to-mark-the-axis-of-astigmatism-100569423","NCT06694051","Application of Phototherapeutic Keratectomy Mode to Mark the Axis of Astigmatism","Inclusion Criteria:\n\n* at least 18 years old\n\nExclusion Criteria:\n\n* ocular disease",{"count":83,"type":21},[56],"Corneal refractive surgery is an effective way to correct refractive error. Modern corneal refractive surgery for the correction of myopia or hyperopia can achieve or close to the expected goal, but to eliminate astigmatism is always one of the major problems of corneal refractive surgery. The key point in the correction of astigmatism is that as a vector parameter, astigmatism has both magnitude and direction. The angle error may be caused by the rotation of the patient's head position and the involuntary rotation of eyes. Phototherapeutic keratectomy can precisely cut the corneal tissue, and is often used in clinic to remove corneal scars or repair corneal surface morphology. In this study, the excimer laser therapeutic keratectomy mode was used to achieve accurate marking of the axis of astigmatism by setting the treatment laser parameters. With the help of the static cyclotorsion of the eye, the precise treatment of astigmatism could realize.",[27],"2024-11-15",{"date":475,"type":35},"2024-11-19",{"date":477,"type":35},"2024-10-01",{"date":418,"type":21},{"name":95,"class":42},{"id":481,"slug":482,"hasResults":11,"nctId":483,"briefTitle":484,"officialTitle":485,"acronym":4,"eligibilityCriteria":486,"healthyVolunteers":15,"sex":16,"minAge":167,"maxAge":487,"enrollmentInfo":488,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":490,"conditions":491,"keywords":4,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":494,"lastUpdatePostDateStruct":495,"startDateStruct":497,"completionDateStruct":499,"leadSponsor":500,"locationsCount":43},"100253327","an-evaluation-of-lasik-smile-and-prk-surgery-in-physicians-100253327","NCT02576483","An Evaluation of LASIK, SMILE and PRK Surgery in Physicians","An Evaluation of Quality of Vision and Quality of Life With LASIK, SMILE and PRK Surgery in Physicians","Inclusion criteria.\n\n* 21 years or older.\n* A physician or medical student.\n* Have the ability to give informed consent.\n* Speak and read English fluently.\n* Have not previously had any form of refractive surgery, including prior LASIK or cataract surgery.\n* May benefit from increased spectacle independence.\n* Have been determined to be a good candidate for the LASIK, SMILE or PRK procedure based on the investigator's assessment of medical and ophthalmic health, general cognitive function, and physical and social limitations.\n* Have a treatment target of bilateral emmetropia.\n* Express willingness and potential ability to return for all follow-up examinations through the 12-month follow-up exam under the care of the treating investigator.\n* Are not enrolled in any other research study.\n\nExclusion criteria.\n\n* Subjects under the age of 21.\n* Patients with excessively thin corneas.\n* Patients with topographic evidence of keratoconus.\n* Patients with ectatic eye disorders.\n* Patients with autoimmune diseases.\n* Patients who are pregnant or nursing.","62 Years",{"count":489,"type":21},700,"The principle investigator is evaluating self-reported quality of vision and quality of life in physicians undergoing LASIK, SMILE and PRK surgery.",[492,493,27],"Nearsightedness","Farsightedness","2024-10-21",{"date":496,"type":35},"2024-10-23",{"date":498,"type":35},"2015-07",{"date":440,"type":21},{"name":204,"class":42},{"id":502,"slug":503,"hasResults":11,"nctId":504,"briefTitle":505,"officialTitle":505,"acronym":4,"eligibilityCriteria":506,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":507,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":508,"conditions":509,"keywords":511,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":516,"lastUpdatePostDateStruct":517,"startDateStruct":519,"completionDateStruct":521,"leadSponsor":523,"locationsCount":43},"100308762","accuracy-of-corneal-astigmatism-in-different-region-modes-100308762","NCT03299530","Accuracy of Corneal Astigmatism in Different Region Modes","Inclusion Criteria:\n\n* Age ≥ 18 years\n* Patients who had received phacoemulsification surgery with or without implantation of toric IOL are with a certain amount of corneal astigmatism.\n* Best corrected visual acuity ≥ 0.66 (20\u002F30 Snellen)\n\nExclusion Criteria:\n\n* Corneal diseases or severe irregular astigmatism (e.g., pterygium, keratoconus), existence of corneal opacification;\n* Ocular disease which may affect visual acuity (e.g., glaucoma, uveitis, retinal disease, pathologic myopia);\n* History of ocular surgery or ocular trauma before this cataract surgery;\n* Decentration of IOL \\> 0.3mm or tilt \\> 5°\n* Implantation of multifocal IOL\n* history of wearing of rigid contact lens within the past 4 weeks or soft contact lens within 1 week;",{"count":193,"type":21},"To analyze the difference between measured total corneal astigmatism and actual corneal astigmatism under different region modes and optimize the region setting.",[27,510],"Cornea",[512,513,514,515],"Corneal Astigmatism","Scheimpflug","pupil size","Toric","2024-07-22",{"date":518,"type":35},"2024-07-23",{"date":520,"type":35},"2017-10-10",{"date":522,"type":21},"2026-10-28",{"name":524,"class":42},"Wenzhou Medical University",{"id":526,"slug":527,"hasResults":11,"nctId":528,"briefTitle":529,"officialTitle":530,"acronym":531,"eligibilityCriteria":532,"healthyVolunteers":15,"sex":16,"minAge":533,"maxAge":534,"enrollmentInfo":535,"targetDuration":4,"studyType":54,"phases":536,"briefSummary":537,"conditions":538,"keywords":540,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":544,"lastUpdatePostDateStruct":545,"startDateStruct":547,"completionDateStruct":549,"leadSponsor":551,"locationsCount":270},"100520665","software-refraction-with-mobilerone-versus-retinoscopy-100520665","NCT06059521","Software Refraction With Mobilerone Versus Retinoscopy","Randomized Controlled Study on Subjective Refraction by Software Eye Test Technology Versus Retinoscopy","SRMR","Inclusion Criteria:\n\n* • subject with ametropia on each eye ≤-12.00D\n\n  * subject with best corrected visual acuity ≥ 20\u002F25, no amblyopia\n  * subject with normal transparency of eyes\n  * subject with a healthy fundus that does not reveal major abnormalities that may affect vision due to the fluctuate situations\n  * subject able to cooperate with the screen and the operator\n  * subject without heavy drug treatment that may affect vision as synthetic antimalarials, corticosteroids\n  * non-diabetic subject\n  * non nystagmus subject\n  * non-strabismus subject\n  * subject who has not had eye surgery less than 1 year old\n\nExclusion Criteria:\n\n* • subject with a topography showing an anomaly (keratoconus type or other)\n\n  * subject with hyperopia or presbyopia\n  * subject with mild myopia ≥ -1.00D\n  * subject who cannot speak with the operator including those staff of local optometrists or ophthalmologists","10 Years","46 Years",{"count":323,"type":21},[56],"Software refraction in the mobilerone for myopia and astigmatism is a novel medical device for myopia adults and elder children with or without astigmatism. And the investigators would like to test its accuracy and efficacy as well as safety.",[25,539,27],"Myopia, Moderate",[541,542,411,543,329,330],"software","refraction","mobilerone","2023-09-21",{"date":546,"type":35},"2023-09-28",{"date":548,"type":35},"2023-07-15",{"date":550,"type":21},"2030-12-30",{"name":552,"class":72},"Beijing Airdoc Technology Co., Ltd.",{"id":554,"slug":555,"hasResults":11,"nctId":556,"briefTitle":557,"officialTitle":558,"acronym":4,"eligibilityCriteria":559,"healthyVolunteers":11,"sex":16,"minAge":167,"maxAge":560,"enrollmentInfo":561,"targetDuration":4,"studyType":54,"phases":562,"briefSummary":563,"conditions":564,"keywords":565,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":571,"lastUpdatePostDateStruct":572,"startDateStruct":574,"completionDateStruct":576,"leadSponsor":578,"locationsCount":389},"100476638","contoura-with-phorcides-compared-to-wavefront-optimized-lasik-100476638","NCT05486546","Contoura With Phorcides Compared to Wavefront Optimized LASIK","Comparison of Visual Acuity and Quality of Life Following Contoura With Phorcides Compared to WaveLight Wavefront Optimized LASIK","Inclusion Criteria:\n\n* Patients at least age 21 years of age undergoing LASIK eye surgery\n* Willing and able to comprehend informed consent and complete 1 month post-op visit\n* Potential postoperative BCDVA of 20\u002F20 or better in each eye based on Investigator's medical opinion\n* Candidates for Contoura with Phorcides (Myopic, astigmatism \\\u003C3.0D)\n* Both eyes targeted for plano\n* Pre-operative total corneal Pachymetry 490um or above\n* Stable refractive error \\\u003C0.50D change in preceding year\n* Good general and ocular health\n* Pre-operative exam completed within three months of surgery\n* SCL discontinued 3 days prior to pre-op exam and the procedure\n* Pachymetry above 490 with residual greater than 270um\n* Candidates who, as determined by the investigator, can safely undergo LASIK\n\nExclusion Criteria:\n\n* Patients under 21 years of age\n* Concomitant ocular condition which would limit the BCVA at the discretion of the surgeon\n* Patients with usual relative and absolute contraindications for LASIK surgery (Patients with severe dry eye, recurrent corneal erosion, uncontrolled Glaucoma, collagen vascular disorders, keratoconus or signs of keratoconus, uncontrolled Diabetes, Herpes)\n* Pachymetry below 490\n* Autoimmune or immunodeficiency diseases\n* Pregnant or nursing women\n* Patients with signs of inability to understand consent for study and procedure planned\n* Patients with history of previous ocular surgery\n* Patients with strabismus or amblyopia\n* Patients that have a BCDVA of 20\u002F25 or worse in either eye","38 Years",{"count":323,"type":21},[56],"Comparing post-operative visual acuity and patient reported satisfaction between Contoura with Phorcides and WaveLight Wavefront Optimized.",[25,27],[566,567,568,569,339,570],"Visual acuity","Refractive outcome","LASIK","Contrast sensitivity","Topography-guided","2023-04-24",{"date":573,"type":35},"2023-04-26",{"date":575,"type":35},"2022-08-15",{"date":577,"type":21},"2023-12-01",{"name":579,"class":42},"Daniel Terveen"]