[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"asymptomatic-hyperuricemia\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:asymptomatic-hyperuricemia":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,40],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":28,"lastUpdatePostDateStruct":29,"startDateStruct":32,"completionDateStruct":34,"leadSponsor":36,"locationsCount":39},"100642683","study-on-the-effects-and-mechanisms-of-probiotic-supplementation-in-ameliorating-uric-acid-metabolism-in-asymptomatic-hyperuricemic-individuals-100642683",false,"NCT07650214","Study on the Effects and Mechanisms of Probiotic Supplementation in Ameliorating Uric Acid Metabolism in Asymptomatic Hyperuricemic Individuals","Inclusion Criteria:\n\n* Men and women aged 18-65;\n* Residents who have lived in Guangdong for more than one year;\n* According to the \"Chinese Multidisciplinary Expert Consensus on the Diagnosis and Treatment of Hyperuricemia-Related Diseases (2023 Edition)\", asymptomatic HUA is defined as a fasting serum uric acid level \\>420 umol \u002FL and no history of gout symptoms such as gouty arthritis;\n* Consent to be randomly assigned to the intervention or control group;\n* Willing to consume the probiotic products provided by the study;\n\nExclusion Criteria:\n\n* Secondary HUA caused by disease or drugs;\n* Within 3 months before participating in the study, or currently taking drugs that affect uric acid metabolism, such as azathioprine, thiazide diuretics, prednisone, etc., and unwilling to stop taking them during the study;\n* Taking or currently taking medication for gout within 3 months before participating in the study and unwilling to stop taking it during the study;\n* Abnormal liver function (AST or ALT levels are more than 3 times the upper limit of normal), abnormal renal function (glomerular filtration rate less than 60mL\u002Fmin\u002F1.73m\\^2);\n* Abnormal blood test results (such as white blood cell count \\\u003C 3.5x10\\^9 \u002FL, platelet count \\\u003C 100x10\\^9 \u002FL, hemoglobin \\\u003C 90g\u002FL) or other blood system diseases;\n* Suffering from severe cardiovascular, kidney, gastrointestinal, hepatal, and malignant tumor diseases;\n* Long-term or current use of nonsteroidal anti-inflammatory drugs, antibiotics, antihistamines, or immunomodulatory drugs, and inability to stop using these drugs within 72 hours before the start of the study;\n* Currently taking anticoagulants, anabolic steroids, hydrocortisone and other hormonal drugs;\n* Use of probiotic supplements within one month prior to participating in the study, and was unwilling to discontinue taking them during the study;\n* Frequent use (more than once a day) of multivitamins, antioxidants, herbal supplements, dietary fiber-containing supplements, and other nutritional supplements (such as inulin, fish oil, soy lecithin, niacin, dietary fiber, flaxseed, phytoestrogens, sterols, etc.), or products containing prebiotics, probiotics, synbiotics, postbiotics, etc. (such as yogurt, fermented milk, beverages, or other fermented products) within 3 months prior to study participation, and unwilling to stop taking them;\n* Self-reported weight loss of more than 7 kg or 10% in the 6 months prior to enrollment;\n* Suffering from eating disorders (such as anorexia and bulimia), dysphagia, or difficulty swallowing food or medication;\n* Unable to consume the probiotic products provided by the study as required during the study period;\n* Drink more than 2 times a day, more than 14 times a week, and are unwilling to stop drinking during the study;\n* Intolerance or food allergy related to the investigational product, drug allergy, or other issues that may affect food intake;\n* Poor venous access;\n* Women who have given birth in the past year, are pregnant, or plan to become pregnant within 6 months, or are breastfeeding;\n* Participating or planning to participate in other dietary intervention studies, drug use studies, or cosmetic or pharmaceutical application studies in the next three months;\n* Participated in clinical trials in the past 3 months;\n* Any other condition that is deemed unsuitable for the trial by a physician.","ALL","18 Years","65 Years",{"count":19,"type":20},68,"ESTIMATED","INTERVENTIONAL",[23],"NA","This study aims to utilize a randomized controlled trial in asymptomatic hyperuricemic individuals to clarify the effects of four probiotic strains including Lactobacillus acidophilus on serum uric acid levels, pathways of uric acid synthesis, degradation and excretion, hyperuricemia-induced oxidative stress and chronic inflammatory responses, uric acid-related metabolites, gut microbiota composition and diversity.",[26],"Asymptomatic Hyperuricemia","NOT_YET_RECRUITING","2026-06-11",{"date":30,"type":31},"2026-06-16","ACTUAL",{"date":33,"type":20},"2026-07-01",{"date":35,"type":20},"2027-12-31",{"name":37,"class":38},"Sun Yat-sen University","OTHER",1,{"id":41,"slug":42,"hasResults":11,"nctId":43,"briefTitle":44,"officialTitle":45,"acronym":46,"eligibilityCriteria":47,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":48,"targetDuration":4,"studyType":21,"phases":50,"briefSummary":51,"conditions":52,"keywords":53,"overallStatus":58,"whyStopped":4,"lastUpdateSubmitDate":59,"lastUpdatePostDateStruct":60,"startDateStruct":62,"completionDateStruct":64,"leadSponsor":66,"locationsCount":39},"100579444","manual-acupuncture-ma-for-asymptomatic-hyperuricemia-hua-100579444","NCT06824376","Manual Acupuncture (MA) for Asymptomatic Hyperuricemia (HUA)","Efficacy and Safety Study of Manual Acupuncture (MA) on Serum Uric Acid (SUA) Outcomes in Patients With Asymptomatic Hyperuricemia (HUA): a Multi-center, Randomized, Sham-controlled Trial","HUA，SUA，MA","Inclusion Criteria:\n\n* With serum uric acid (SUA) level \\>7 mg\u002FdL after 1 month of a low-purine diet.\n* No history of gouty arthritis.\n* Has not received uric acid-lowering drug treatment or stopped uric acid- lowering drug treatment ≥ 12 weeks.\n* 18.5kg\u002Fm2 ≤ body mass index (BMI) ≤ 30.0 kg\u002Fm2.\n* Can write informed consent.\n\nExclusion Criteria:\n\n* Patients with poorly controlled hypertension: systolic blood pressure (SBP) ≥ 160mmHg, diastolic blood pressure (DBP) ≥ 100 mmHg.\n* Patients with poorly controlled diabetes (hemoglobin A1c ≥ 8.4%).\n* Patients with severe liver and kidney damage: chronic kidney disease (CKD) ≥ stage 2 or a serum creatinine, urea, alanine, or aspartate aminotransferase level more than twice of the upper limit.\n* Patients with blood system diseases, such as acute and chronic leukemia, polycythemia, multiple myeloma, hemolytic anemia, lymphoma, or undergoing chemotherapy for multiple solid tumors.\n* Patients with stroke, coronary heart disease, or severe neuropsychological diseases.\n* Patients who are pregnant.\n* Illiterate or unwilling to accept acupuncture treatment.",{"count":49,"type":20},260,[23],"Assess the effectiveness of manual acupuncture in modulating serum uric acid levels among patients diagnosed with asymptomatic hyperuricemia.",[26],[54,55,56,57],"MA","HUA","SUA","deqi","RECRUITING","2025-03-28",{"date":61,"type":31},"2025-03-30",{"date":63,"type":31},"2025-03-25",{"date":65,"type":20},"2026-12",{"name":67,"class":38},"Shenghao Tu"]