[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"ataxia-cerebellar\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:ataxia-cerebellar":31},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,58,89],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":35,"overallStatus":45,"whyStopped":4,"lastUpdateSubmitDate":46,"lastUpdatePostDateStruct":47,"startDateStruct":50,"completionDateStruct":52,"leadSponsor":54,"locationsCount":57},"100608487","at-home-use-of-stimulation-suits-for-managing-ms-symptoms-100608487",false,"NCT07202195","At Home Use of Stimulation Suits for Managing MS Symptoms","Home-Based Neuromodulation Suits for Reducing Spasticity and Ataxia in Multiple Sclerosis: A Multi-center RCT","HANDS-MS","Inclusion Criteria:\n\n* Eligible participants must have ataxia or spasticity alongside impairments in upper or lower extremity physical function. MAS score ≥ 1 will be used as an inclusion criterion to determine the presence of spasticity. SARA score ≥ 4 will be used as an inclusion criterion to determine the presence of ataxia. Note: one of the two criteria (MAS score or SARA score) must be fulfilled for a pwMS to be eligible.\n* The patient must have the cognitive abilities to understand instructions and to be able to complete the questionnaires adequately\n* Diagnosis of multiple sclerosis.\n\nExclusion Criteria:\n\n* Implanted devices (like pacemaker, Baclofen pump, neurostimulator, defibrillator, shunts, ECG equipment, electronic life support, high frequency operation equipment )\n* Change in disease modifying treatment within the last 3 months\n* Use of Botuline Toxine A within the last 3months\n* Recent relapse within the last 3 months\n* Acute musculoskeletal problems that hinder the test performance,\n* Pregnancy\n* Sizes bigger than 3XL (triple eXtra Large)\n* Skin eruptions and\u002For skin areas in the stimulation zone that are swollen, infected or inflamed.","ALL","18 Years",{"count":20,"type":21},70,"ESTIMATED","INTERVENTIONAL",[24],"NA","This study is being carried out at Multiple Sclerosis (MS) centers to evaluate whether a full-body stimulation suit at home can help people with Multiple Sclerosis (pwMS) reduce symptoms like spasticity (muscle stiffness) and ataxia (poor coordination), and improve daily functioning.\n\nCan pwMS who experience spasticity or ataxia benefit from using a stimulation suit for 6 weeks?\n\nResearchers will compare two groups: an intervention group (who will use the suit) and a control group (who will not use the suit).\n\nParticipants in the intervention group will:\n\n* Wear the suit for 6 weeks in total every day or every other day (1 week during their MS center admission and 5 weeks at home).\n* Receive their usual care in addition to wearing the suit.\n* Undergo clinical tests at the MS center after 1 week and 6 weeks of stimulation.\n\nParticipants in the control group will:\n\n* Receive their usual care.\n* Undergo clincial tests at the same time points as the other group.",[27,28,29,30,31,32,33,34],"Multiple Sclerosis","MS (Multiple Sclerosis)","Spasticity With Multiple Sclerosis","Ataxia - Other","Ataxia, Cerebellar","Ataxia, Motor","Spasticity","Home Based Care",[36,37,38,39,40,41,42,43,44],"ataxia","spasticity","multiple sclerosis","MS","neuromodulation suit","stimulation suit","exopluse molli suit","home-based rehabilitation","symptom management","RECRUITING","2026-02-04",{"date":48,"type":49},"2026-02-06","ACTUAL",{"date":51,"type":21},"2026-03",{"date":53,"type":21},"2027-09",{"name":55,"class":56},"Daphne Kos","OTHER",2,{"id":59,"slug":60,"hasResults":11,"nctId":61,"briefTitle":62,"officialTitle":62,"acronym":63,"eligibilityCriteria":64,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":65,"targetDuration":4,"studyType":67,"phases":4,"briefSummary":68,"conditions":69,"keywords":74,"overallStatus":79,"whyStopped":4,"lastUpdateSubmitDate":80,"lastUpdatePostDateStruct":81,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":4},"100599041","structural-validity-and-inter-rater-reliabitiliy-of-the-ataxia-trunk-lower-and-upper-extremity-scale-atlas-100599041","NCT07079332","Structural Validity and Inter-rater Reliabitiliy of the Ataxia Trunk, Lower And Upper Extremity Scale (ATLAS)","ATLASReVa","Inclusion Criteria:\n\n* Be adults\n* Be able to provide written informed consent\n* Be able to understand and follow simple physical instructions\n* Have a diagnosis of genetic or hereditary ataxia, or a cerebellar or pontine stroke (either hemorrhagic or ischemic), confirmed by a neurologist\n\nExclusion Criteria:\n\n* Muscle group strength \\\u003C 3 on the Medical Research Council (MRC) scale\n* Spasticity \\> 2 in any muscle on the Modified Ashworth Scale\n* Pain \\> 5 on the Visual Analogue Scale (VAS) in any part of the body",{"count":66,"type":21},64,"OBSERVATIONAL","Ataxia is a neurological disorder affecting coordination, caused by damage to the cerebellum, brainstem, or related pathways. It can be hereditary (e.g., Friedreich's ataxia) or acquired (e.g., multiple sclerosis, stroke). Though rare, ataxia significantly impacts quality of life and independence. Treatments are limited and mainly focus on multidisciplinary rehabilitation. Accurate assessment is essential, yet current tools like Scale for the Assessment and Rating of Ataxia (SARA) have limitations. This study aims to validate a new scale, named the Ataxia Trunk, Lower And upper extremity Scale (ATLAS), through Rasch analysis, to develop a shorter, reliable version. It will assess internal consistency, construct validity, and inter-rater reliability.\n\nFor the valitdity part, statistics will be used (1) to see if the different items of the scale are indeed different and complementary to each other, and (2) to compare the results of this scale with other scales already known and valid (SARA, Trunk Impairment Scale (TIS) and Functional Impairment Measurement(FIM)). Secondly, the investigators would like to know whether ATLAS is reliable. In this particular case, the reliability being assessed is inter-rater reliability, i.e. whether all raters give the same score on the items performed by the patient. To carry out such a study, 64 people will be needed to achieve these goals. Each person will complete the 20 items of the ATLAS scale, those of a trunk motor capacity assessment (TIS), and will evaluate his or her functional independence (FIM).",[31,70,32,71,72,73,30],"Ataxia, Gait","Ataxia","Ataxia, Spinocerebellar","Ataxias, Hereditary",[71,75,76,77,78],"Scale","Validity Study","reliability study","new scale","NOT_YET_RECRUITING","2025-08-07",{"date":82,"type":49},"2025-08-13",{"date":84,"type":21},"2025-09-01",{"date":86,"type":21},"2028-12-31",{"name":88,"class":56},"Haute Ecole de Santé Vaud",{"id":90,"slug":91,"hasResults":11,"nctId":92,"briefTitle":93,"officialTitle":94,"acronym":4,"eligibilityCriteria":95,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":96,"targetDuration":4,"studyType":67,"phases":4,"briefSummary":98,"conditions":99,"keywords":105,"overallStatus":45,"whyStopped":4,"lastUpdateSubmitDate":111,"lastUpdatePostDateStruct":112,"startDateStruct":114,"completionDateStruct":116,"leadSponsor":118,"locationsCount":120},"100333672","natural-history-study-of-leukoencephalopathy-with-brainstem-and-spinal-cord-involvement-and-lactate-elevation-lbsl-100333672","NCT03624374","Natural History Study of Leukoencephalopathy With Brainstem and Spinal Cord Involvement and Lactate Elevation (LBSL)","Characterization of the Natural History of Leukoencephalopathy With Brainstem and Spinal Cord Involvement and Lactate Elevation","Inclusion Criteria:\n\n1. Confirmed DARS2 mutation through genetic analysis\n2. Ability of the caregiver or participant to speak and understand English at an 8th-grade level\n\nExclusion Criteria:\n\n* The vulnerable populations of prisoners, non-viable neonates, pregnant women, adults lacking the capacity to consent, non-English speakers or children who are in foster care or wards of the state.",{"count":97,"type":21},100,"In this study, we will conduct retrospective chart and imaging reviews and prospective longitudinal virtual assessments of individuals with LBSL.",[100,101,102,103,31,104],"Leukoencephalopathies","LBSL","Leukoencephalopathy With Brainstem and Spinal Cord Involvement and Lactate Elevation","White Matter Disease","Genetic Disease",[106,107,108,109,110],"Natural History Study","Kennedy Krieger Institute","Virtual assessment","DARS2","Johns Hopkins Hospital","2024-07-01",{"date":113,"type":49},"2024-07-03",{"date":115,"type":49},"2018-04-01",{"date":117,"type":21},"2029-05",{"name":119,"class":56},"Hugo W. Moser Research Institute at Kennedy Krieger, Inc.",1]