[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"ataxia-gait\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:ataxia-gait":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,45],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":29,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100625817","cerebellar-deep-brain-stimulation-for-the-treatment-of-ataxia-100625817",false,"NCT07427563","Cerebellar Deep Brain Stimulation for the Treatment of Ataxia","Cerebellar Deep Brain Stimulation for the Treatment of Refractory Ataxia and Gait Disorders: Pilot Trial","DBS-Ataxia","Inclusion Criteria:\n\n1. Female or Male patients between age 20-70\n2. Diagnosis of primary ataxia (inclusive of congenital and hereditary subtypes without other neurological compromise)\n3. Head CT scan and cerebral MRI without any structural contraindications for safe DBS\n4. Patient able to give written consent\n5. Able to comply with all testing, follow-ups and study appointments and protocols\n\nExclusion Criteria:\n\n1. Active neurologic disease including but not limited to epilepsy and certain brain tumors\n2. Secondary ataxia (such as due to stroke, medication, autoimmune disease, ischemia, tumor, or other lesion)\n3. Any contraindication to MRI scanning\n4. Likely to relocate or move during the study's one-year duration\n5. Presence of cardiac arrhythmias, or other cardiac, respiratory, renal or endocrine conditions that will result in significant risk from a surgical procedure.","ALL","20 Years","70 Years",{"count":21,"type":22},12,"ESTIMATED","INTERVENTIONAL",[25],"NA","Abnormal gait is often associated with immobility and falls, which in turn lead to loss of functional independence and death. While gait disorders may arise from many different etiologies, dysfunction of the cerebellum (a part of the brain with the function of coordination of movement) leading to gait disorders results in distinct features. Gait ataxia is a specific type of neurological gait disorder and is defined as the presence of abnormal, uncoordinated movements associated with gait. To date, there are limited treatments for ataxia and\u002For gait disorders. Deep brain stimulation (DBS) is a neurosurgical tool that has been widely used for over twenty years, mainly to treat Parkinson's disease, dystonia, and essential tremor. In this study, we aim to implant DBS in patients with ataxia and\u002For gait disorder in the cerebellum area, and electrically stimulate them in a titratable and ultimately reversible manner. This study is divided into 3 phases: pre-operative, operative and post-operative phase. The purpose of this pilot study is to evaluate the safety, feasibility, and to validate the DBS of cerebellar cortical and deep nuclei in patients with treatment refractory ataxia. Twelve(12 ) patients will be enrolled in this study.",[28],"Ataxia, Gait",[30,31],"deep brain stimulation (DBS)","cerebellar","RECRUITING","2026-02-20",{"date":35,"type":36},"2026-02-23","ACTUAL",{"date":38,"type":36},"2023-03-02",{"date":40,"type":22},"2035-12-31",{"name":42,"class":43},"University Health Network, Toronto","OTHER",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":49,"acronym":50,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":17,"minAge":52,"maxAge":4,"enrollmentInfo":53,"targetDuration":4,"studyType":55,"phases":4,"briefSummary":56,"conditions":57,"keywords":64,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":4},"100599041","structural-validity-and-inter-rater-reliabitiliy-of-the-ataxia-trunk-lower-and-upper-extremity-scale-atlas-100599041","NCT07079332","Structural Validity and Inter-rater Reliabitiliy of the Ataxia Trunk, Lower And Upper Extremity Scale (ATLAS)","ATLASReVa","Inclusion Criteria:\n\n* Be adults\n* Be able to provide written informed consent\n* Be able to understand and follow simple physical instructions\n* Have a diagnosis of genetic or hereditary ataxia, or a cerebellar or pontine stroke (either hemorrhagic or ischemic), confirmed by a neurologist\n\nExclusion Criteria:\n\n* Muscle group strength \\\u003C 3 on the Medical Research Council (MRC) scale\n* Spasticity \\> 2 in any muscle on the Modified Ashworth Scale\n* Pain \\> 5 on the Visual Analogue Scale (VAS) in any part of the body","18 Years",{"count":54,"type":22},64,"OBSERVATIONAL","Ataxia is a neurological disorder affecting coordination, caused by damage to the cerebellum, brainstem, or related pathways. It can be hereditary (e.g., Friedreich's ataxia) or acquired (e.g., multiple sclerosis, stroke). Though rare, ataxia significantly impacts quality of life and independence. Treatments are limited and mainly focus on multidisciplinary rehabilitation. Accurate assessment is essential, yet current tools like Scale for the Assessment and Rating of Ataxia (SARA) have limitations. This study aims to validate a new scale, named the Ataxia Trunk, Lower And upper extremity Scale (ATLAS), through Rasch analysis, to develop a shorter, reliable version. It will assess internal consistency, construct validity, and inter-rater reliability.\n\nFor the valitdity part, statistics will be used (1) to see if the different items of the scale are indeed different and complementary to each other, and (2) to compare the results of this scale with other scales already known and valid (SARA, Trunk Impairment Scale (TIS) and Functional Impairment Measurement(FIM)). Secondly, the investigators would like to know whether ATLAS is reliable. In this particular case, the reliability being assessed is inter-rater reliability, i.e. whether all raters give the same score on the items performed by the patient. To carry out such a study, 64 people will be needed to achieve these goals. Each person will complete the 20 items of the ATLAS scale, those of a trunk motor capacity assessment (TIS), and will evaluate his or her functional independence (FIM).",[58,28,59,60,61,62,63],"Ataxia, Cerebellar","Ataxia, Motor","Ataxia","Ataxia, Spinocerebellar","Ataxias, Hereditary","Ataxia - Other",[60,65,66,67,68],"Scale","Validity Study","reliability study","new scale","NOT_YET_RECRUITING","2025-08-07",{"date":72,"type":36},"2025-08-13",{"date":74,"type":22},"2025-09-01",{"date":76,"type":22},"2028-12-31",{"name":78,"class":43},"Haute Ecole de Santé Vaud"]