[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"atelectases-postoperative-pulmonary\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:atelectases-postoperative-pulmonary":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,53,81,107,128],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":41,"lastUpdatePostDateStruct":42,"startDateStruct":45,"completionDateStruct":47,"leadSponsor":49,"locationsCount":52},"100643703","bedside-assessment-of-right-ventricular-output-lying-in-prone-or-supine-position-100643703",false,"NCT07632027","Bedside Assessment of Right Ventricular Output Lying in Prone Or Supine Position","The BAROLO Study Bedside Assessment of Right Ventricular Output Lying in Prone Or Supine Position. Hemodynamic Changes Due to Prone Position in Patients After Cardiac Surgery - a Prospective Randomized Controlled Trial Evaluating the Effect of Prone Position on Right Heart Function","BAROLO","Inclusion Criteria:\n\n* Scheduled for cardiac surgery using cardiopulmonary bypass\n\nExclusion Criteria:\n\n* BMI \\>40\n* Emergency surgery\n* In need of secondary surgery\n* Advanced grown up congenital heart disease\n* Pulmonary disease\n* Hemodynamic instability with Norepinephrine \\>0.4mcg\u002Fkg\u002Fmin\n* Any condition which, in the judgement of the investigator, might increase the risk to the patient","ALL","18 Years",{"count":20,"type":21},80,"ESTIMATED","INTERVENTIONAL",[24],"NA","Right ventricular failure (RVF) is a common complication to cardiac surgery, which is associated to mortality, kidney failure, stroke, prolonged mechanical ventilation and ICU stay. The right ventricle is particularly vulnerable to an increased afterload. By increasing pulmonary vascular resistance (PVR), atelectasis might mitigate a negative effect on the right ventricle.\n\nRecruitment maneuvers have been shown to resolve atelectasis and improve hemodynamics by increasing cardiac output and lowering PVR. However these maneuvers transiently raise airway pressures, which in turn increases right ventricular afterload, a situation often poorly tolerated by patients with RVF.\n\nProne position is used in patients with respiratory failure and has been shown to decrease mortality in patients with ARDS. Prone position decreases atelectasis and moves ventilation dorsally. In ARDS it also seems to mediate beneficial hemodynamic effects such as an increase in cardiac output and a decrease in PVR.\n\nThe investigators hypothesis is that prone position early after cardiac surgery will increase cardiac output by recruitment of atelectasis and thereby decrease PVR.",[27,28,29,30,31,32,33,34,35,36,37,38,39],"Right Ventricular Function","Prone Position","Atelectasis","Atelectases, Postoperative Pulmonary","Cardiac Output","Vasoconstriction","Heart Failure","Recruitment Maneuver","Respiratory Mechanics","Pulmonary Arterial Pressure","Cardiac Surgery","Cardiac Surgery Recovery","Cardiopulmonary Bypass","NOT_YET_RECRUITING","2026-06-03",{"date":43,"type":44},"2026-06-08","ACTUAL",{"date":46,"type":21},"2026-09",{"date":48,"type":21},"2028-10",{"name":50,"class":51},"Sahlgrenska University Hospital","OTHER",1,{"id":54,"slug":55,"hasResults":11,"nctId":56,"briefTitle":57,"officialTitle":58,"acronym":4,"eligibilityCriteria":59,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":60,"enrollmentInfo":61,"targetDuration":4,"studyType":22,"phases":62,"briefSummary":64,"conditions":65,"keywords":67,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":52},"100639358","early-phase-1-the-role-intraoperative-salbutamol-inhaler-in-preventing-atelectasis-100639358","NCT07591558","The Role Intraoperative Salbutamol Inhaler in Preventing Atelectasis","The Role Intraoperative Salbutamol Inhaler Usage as Part of Intraoperative Regimen in Preventing Atelectasis Following Thoracic, Abdominal and Spinal Surgery in Diabetics Population","Inclusion Criteria:\n\n* The study will include patients aged 18-70 years\n* American Society of Anesthesiologists (ASA) physical status of I or II\n* Will undergo thoracic, abdominal or spinal surgery\n\nExclusion Criteria:\n\n* cardiac conditions other than hypertension like arrhythmia\n* previous cardiac surgeries and valvular heart diseases","70 Years",{"count":20,"type":21},[63],"EARLY_PHASE1","Atelectasis is considered a common complication in the perioperative period, especially following surgeries under general anesthesia. Postoperative atelectasis could occur anytime during the perioperative period from intraoperative period to 24 hours postoperative and contribute to a variety of other complications, including hypoxemia and pneumonia. In the literature, several methods were utilized to combat this phenomenon, therefore, we investigate the role of intraoperative salbutamol in reducing the incidence of atelectasis. It is well known that salbutamol could be an adjunctive bronchodilator medication used in the intraoperative anesthetic regimens.",[30,66],"Diabete Mellitus",[68,69,70,71],"atelectasis","salbutamol","pulmonary","bronchodilator","2026-05-11",{"date":74,"type":44},"2026-05-15",{"date":76,"type":21},"2026-06",{"date":78,"type":21},"2026-12",{"name":80,"class":51},"King Abdullah University Hospital",{"id":82,"slug":83,"hasResults":11,"nctId":84,"briefTitle":85,"officialTitle":86,"acronym":4,"eligibilityCriteria":87,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":88,"enrollmentInfo":89,"targetDuration":4,"studyType":22,"phases":91,"briefSummary":92,"conditions":93,"keywords":4,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":100,"completionDateStruct":102,"leadSponsor":104,"locationsCount":4},"100621788","ori-guided-fio-titration-in-prone-spine-surgery-impact-on-postoperative-atelectasis-assessed-by-lung-ultrasound-100621788","NCT07375173","ORI-Guided FiO₂ Titration in Prone Spine Surgery: Impact on Postoperative Atelectasis Assessed by Lung Ultrasound","Oxygen Reserve Index-Guided FiO₂ Titration in Prone Spine Surgery: Impact on Postoperative Atelectasis Assessed by Lung Ultrasound","Inclusion Criteria:\n\n1. Adults aged 18 to 80 years\n2. Patients with an ASA physical status of I, II, or III\n3. Individuals with a body mass index (BMI) between 18 and 35 kg\u002Fm²\n\nExclusion Criteria:\n\n1. History of or active upper or lower respiratory tract infection within the past month\n2. Pulmonary emphysematous\u002Fbullous disease or COPD\n3. Pre-existing significant atelectasis or consolidation (Preoperative LUS showing a score of 3 consolidation or ≥2 regions with a score ≥2)\n4. Severe obstructive sleep apnea requiring CPAP therapy\n5. NYHA class III-IV heart failure, EF \\\u003C35%, or severe valvular disease\n6. Severe arrhythmia or hemodynamic instability requiring high-dose vasopressors\n7. Body mass index (BMI) \\>35 kg\u002Fm²\n8. Severe anemia (Hb \\\u003C9 g\u002FdL) or polycythemia (Hb \\>18 g\u002FdL)\n9. Non-diagnostic or unclear preoperative lung ultrasound images\n10. Preoperative SpO₂ ≤ 94%\n11. Inability to apply the sensor due to finger deformity, or inadequate signal caused by digital hypoperfusion","80 Years",{"count":90,"type":21},74,[24],"Atelectasis is a frequent pulmonary complication after general anesthesia, often triggered by preoxygenation and intraoperative hyperoxia. High inspiratory oxygen fractions (FiO₂) can promote absorption atelectasis, ventilation-perfusion mismatch, hemodynamic alterations, and oxidative injury.\n\nThis study evaluates the effect of two intraoperative oxygen management strategies-oxygen reserve index (ORI)-guided FiO₂ titration versus fixed 50% FiO₂-on postoperative atelectasis in patients undergoing thoracolumbar spine surgery under general anesthesia. Atelectasis severity will be assessed using lung ultrasonography (LUS), scored across 12 thoracic regions (0-3 per region, total 0-36), while respiratory function changes will be examined via preoperative and 24-hour postoperative spirometry (FVC, FEV₁, FEV₁\u002FFVC).\n\nBecause postoperative spirometry may be influenced by pain, Numeric Rating Scale (NRS) scores will be recorded to help distinguish true restrictive patterns from pain-limited respiratory effort.\n\nThe study aims to determine whether ORI-guided FiO₂ titration can reduce postoperative atelectasis and improve respiratory outcomes compared with a fixed FiO₂ approach.",[30,28,94,95,96],"Spine Surgery","Lung Ultrasound","Oxygen Reserve Index","2026-01-24",{"date":99,"type":44},"2026-01-29",{"date":101,"type":21},"2026-03-15",{"date":103,"type":21},"2026-11-30",{"name":105,"class":106},"Ankara Etlik City Hospital","OTHER_GOV",{"id":108,"slug":109,"hasResults":11,"nctId":110,"briefTitle":111,"officialTitle":111,"acronym":4,"eligibilityCriteria":112,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":113,"enrollmentInfo":114,"targetDuration":4,"studyType":22,"phases":116,"briefSummary":117,"conditions":118,"keywords":4,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":119,"lastUpdatePostDateStruct":120,"startDateStruct":122,"completionDateStruct":124,"leadSponsor":126,"locationsCount":52},"100614781","prevention-and-treatment-of-early-postoperative-atelectasis-using-the-metaneb-system-in-patients-underwent-esophagectomy-100614781","NCT07284056","Prevention and Treatment of Early Postoperative Atelectasis Using The MetaNeb System in Patients Underwent Esophagectomy","Inclusion Criteria:\n\n1. Age between 18 and 85 years.\n2. Patients who are scheduled for ICU admission after esophagectomy for esophageal cancer.\n\nExclusion Criteria:\n\n1. Presence of an artificial airway at the time of ICU admission.\n2. Planned ICU stay less than 24 hours.\n3. Patients with contraindications to the use of the MetaNeb® System, or those unable to cooperate due to organic or psychiatric conditions.","85 Years",{"count":115,"type":21},178,[24],"The goal of this clinical trial is to evaluate whether the MetaNeb® System can effectively prevent and treat early postoperative atelectasis in adult patients admitted to ICU after esophagectomy for esophageal cancer.\n\nThe main question it aims to answer is: can the MetaNeb® system significantly reduce the lung ultrasound score (LUSS) indicating atelectasis on postoperative days 1 and 2? Participants will be randomly assigned to either the standard treatment or MetaNeb group, undergo lung ultrasound and electrical impedance tomography (EIT) assessments on postoperative days 1 and 2, receive at least 4 sessions of MetaNeb therapy on postoperative day 1 if in the intervention group, be monitored for oxygenation indices, ICU stay duration, incidence of mechanical ventilation, need for bronchoscopic intervention, and adverse events like pneumothorax.",[30],"2025-12-15",{"date":121,"type":44},"2025-12-16",{"date":123,"type":21},"2026-01-01",{"date":125,"type":21},"2026-12-31",{"name":127,"class":51},"Shanghai Zhongshan Hospital",{"id":129,"slug":130,"hasResults":11,"nctId":131,"briefTitle":132,"officialTitle":133,"acronym":4,"eligibilityCriteria":134,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":135,"targetDuration":4,"studyType":22,"phases":137,"briefSummary":138,"conditions":139,"keywords":144,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":151,"lastUpdatePostDateStruct":152,"startDateStruct":154,"completionDateStruct":155,"leadSponsor":157,"locationsCount":4},"100538192","cpap-in-patients-with-severe-obesity-after-anesthesia-100538192","NCT06287632","CPAP in Patients With Severe Obesity After Anesthesia","Assessment of Cardiopulmonary Function in Response to Continuous Positive Airway Pressure in Patients With Severe Obesity After Anesthesia","Inclusion Criteria:\n\n1. Adult patients (≥ 18 years old) scheduled for elective non-cardiothoracic surgery requiring general anesthesia with an endotracheal tube\n2. Planned admission to the post-anesthesia care unit (PACU) after surgery\n3. BMI ≥ 40 kg\u002Fm2\n4. At the time of baseline measurements in the PACU, patients meet the following criteria:\n\n   * Receiving ≤ 6 liters of supplemental nasal cannula oxygen\n   * Alert as defined by a Richmond Agitation Sedation Scale of 0 or -1\n   * Oriented to person, place, and time\n\nExclusion Criteria:\n\n1. Pregnancy, suspected pregnancy or less than six weeks postpartum Known or current pneumothorax\n2. Hemodynamic instability at the time of study assessment in the PACU defined as:\n\n   * systolic blood pressure \\\u003C90 mmHg or \\>180 mmHg\n   * mean blood pressure \\\u003C60 or \\>130 mmHg\n   * Any use of intravenous vasoactive agent\n   * heart rate \\\u003C 50 or \\> 120 beats per minute\n3. Respiratory insufficiency in PACU defined as:\n\n   * Respiratory rate \\> 30\n   * Oxygen saturation \\\u003C 92%\n   * Receiving \\> 6 liters of supplemental oxygen\n4. Known chronic lung disease requiring supplemental oxygen at home\n5. Known systolic heart dysfunction (left ventricular ejection fraction ≤ 30%)\n6. Contraindication for esophageal catheter placement:\n\n   * Known esophageal varices\n   * Known bacterial sinusitis\n   * Recent esophageal, nasopharyngeal, or laryngeal trauma or surgery\n   * Known coagulopathy: including history of thrombocytopenia defined as platelet count \\\u003C50,000; presence of hemophilia; known genetic disorder of coagulation (e.g.,deficits of protein C, protein S, von Willebrand factor) or oral and subcutaneous anticoagulation treatment (e.g., heparin, warfarin, and or other oral anticoagulants)\n7. Contraindication for electrical impedance tomograph belt placement:\n\n   * Pacemaker and\u002For internal cardiac defibrillator\n   * Chest skin injury\n8. Concern for study inclusion by the perioperative nurse or anesthesia team",{"count":136,"type":21},60,[24],"The goal of this study is to compare two continuous positive airway pressure (CPAP) settings on heart and lung function in patients with severe obesity after anesthesia. The main questions it aims to answer are:\n\n1. Does a recruitment maneuver and CPAP set to intrathoracic pressure (ITP) improve cardiopulmonary function compared to standard CPAP settings in patients with severe obesity after anesthesia?\n2. Does the location of adipose tissue influence the response to CPAP settings in patients with severe obesity after anesthesia?\n\nParticipants will undergo monitoring of their intrathoracic pressure using an esophageal catheter. In the recovery area after anesthesia, participants will receive two CPAP settings, each for 20 minutes.\n\n* Intervention 1: Recruitment maneuver and CPAP will set to the level of intrathoracic pressure\n* Intervention 2: CPAP set to home settings (if OSA is present) or between 8-10 cmH20 (if OSA is not present).",[140,141,142,30,143],"Obesity, Abdominal","Anesthesia Morbidity","Apnea, Obstructive Sleep","Ventilator Lung",[145,146,147,148,149,150],"clinical trial","crossover studies","continuous positive airway pressure","electrical impedance tomography","esophageal pressure monitoring","transthoracic echocardiography","2025-11-17",{"date":153,"type":44},"2025-11-18",{"date":76,"type":21},{"date":156,"type":21},"2027-06",{"name":158,"class":51},"Massachusetts General Hospital"]