[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"atelectasis\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:atelectasis":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,18,0,[8,44,70,104,127,161,191,223,247,272,298,323,349,382,416,443,471,492],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100637976","pneumoperitoneum-pressure-and-lung-ultrasound-atelectasis-100637976",false,"NCT07609615","Pneumoperitoneum Pressure and Lung Ultrasound Atelectasis","Effects of Different Pneumoperitoneum Pressures on Perioperative Atelectasis Assessed by Lung Ultrasound in Laparoscopic Cholecystectomy: A Prospective Randomized Single-Blind Controlled Trial","Inclusion Criteria:\n\n* Patients aged between 18 and 65 years\n* ASA physical status I-II\n* Scheduled for elective laparoscopic cholecystectomy under general anesthesia\n* Body mass index (BMI) \\\u003C30 kg\u002Fm²\n* Ability to provide written informed consent\n\nExclusion Criteria:\n\n* Chronic pulmonary disease\n* Recent respiratory tract infection\n* Thoracic deformity or previous thoracic surgery\n* Preoperative pulmonary pathology\n* Morbid obesity\n* Pregnancy\n* Emergency surgery\n* Conversion to open surgery\n* Requirement for protocol-violating pneumoperitoneum pressure modification\n* Refusal to participate in the study","ALL","18 Years","65 Years",{"count":20,"type":21},112,"ESTIMATED","INTERVENTIONAL",[24],"NA","Elective laparoscopic cholecystectomy may lead to perioperative atelectasis due to pneumoperitoneum-related diaphragmatic elevation and impaired respiratory mechanics. Lung ultrasound (LUS) provides a noninvasive bedside method for evaluating perioperative aeration loss. This prospective randomized controlled study aims to compare the effects of low-pressure (10 mmHg) and standard-pressure (14 mmHg) pneumoperitoneum on perioperative atelectasis assessed by LUS in patients undergoing laparoscopic cholecystectomy under general anesthesia. Changes in LUS scores, respiratory mechanics, oxygenation, and postoperative clinical outcomes will also be evaluated.",[27,28,29],"Atelectasis","Perioperative Complication","Pneumoperitoneum",[27,29,28],"RECRUITING","2026-06-22",{"date":34,"type":35},"2026-06-23","ACTUAL",{"date":37,"type":35},"2026-06-01",{"date":39,"type":21},"2026-09-01",{"name":41,"class":42},"Engin Çetin","OTHER_GOV",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":4,"eligibilityCriteria":50,"healthyVolunteers":51,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":52,"targetDuration":4,"studyType":54,"phases":4,"briefSummary":55,"conditions":56,"keywords":58,"overallStatus":60,"whyStopped":4,"lastUpdateSubmitDate":61,"lastUpdatePostDateStruct":62,"startDateStruct":63,"completionDateStruct":65,"leadSponsor":67,"locationsCount":43},"100641321","surgical-positions-and-postoperative-atelectasis-a-lung-ultrasound-study-100641321","NCT07654153","Surgical Positions and Postoperative Atelectasis: A Lung Ultrasound Study","Evaluation of the Effect of Surgical Positions Under General Anesthesia on Postoperative Atelectasis Using Lung Ultrasonography","Inclusion Criteria:\n\n* Being between 18-65 years of age\n* Having ASA I-III status\n* Planning elective surgery under general anesthesia\n* Agreeing to participate in the study and signing the consent form\n\nExclusion Criteria:\n\n* Patients requiring emergency surgery\n* Patients with ASA IV or higher\n* Presence of a known serious preoperative lung disease (COPD, Asthma, Pneumonia, Pleural effusion, Pneumothorax, Interstitial lung disease, Bronchiectasis, etc.)\n* History of neuromuscular disease\n* Body Mass Index (BMI) \\> 35 kg\u002Fm² (Morbid obesity)\n* Presence of chest wall deformity or skin lesions that would obstruct LUS imaging\n* Cases with an operative duration of less than 60 minutes or more than 300 minutes\n* Patients with a history of thoracotomy, sternotomy, or prior open thoracic surgery\n* Patients with alcohol or drug dependence\n* Patients with significant anemia\n* Patients who are pregnant or lactating\n* Patients who develop laryngospasm following extubation\n* Refusal to provide consent or inability to cooperate",true,{"count":53,"type":21},100,"OBSERVATIONAL","The aim of this study is to prospectively evaluate the effect of surgical position on the development of postoperative atelectasis in patients undergoing surgery in supine, prone, lateral decubitus, and lithotomy positions using lung ultrasonography (LUS), and to investigate whether there is a difference between these positions.",[57,27],"Lung Ultrasound",[59],"lung ultrasound","NOT_YET_RECRUITING","2026-06-18",{"date":32,"type":35},{"date":64,"type":21},"2026-07-20",{"date":66,"type":21},"2027-08-01",{"name":68,"class":69},"Cumhuriyet University","OTHER",{"id":71,"slug":72,"hasResults":11,"nctId":73,"briefTitle":74,"officialTitle":75,"acronym":76,"eligibilityCriteria":77,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":78,"targetDuration":4,"studyType":22,"phases":80,"briefSummary":81,"conditions":82,"keywords":4,"overallStatus":60,"whyStopped":4,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":43},"100643703","bedside-assessment-of-right-ventricular-output-lying-in-prone-or-supine-position-100643703","NCT07632027","Bedside Assessment of Right Ventricular Output Lying in Prone Or Supine Position","The BAROLO Study Bedside Assessment of Right Ventricular Output Lying in Prone Or Supine Position. Hemodynamic Changes Due to Prone Position in Patients After Cardiac Surgery - a Prospective Randomized Controlled Trial Evaluating the Effect of Prone Position on Right Heart Function","BAROLO","Inclusion Criteria:\n\n* Scheduled for cardiac surgery using cardiopulmonary bypass\n\nExclusion Criteria:\n\n* BMI \\>40\n* Emergency surgery\n* In need of secondary surgery\n* Advanced grown up congenital heart disease\n* Pulmonary disease\n* Hemodynamic instability with Norepinephrine \\>0.4mcg\u002Fkg\u002Fmin\n* Any condition which, in the judgement of the investigator, might increase the risk to the patient",{"count":79,"type":21},80,[24],"Right ventricular failure (RVF) is a common complication to cardiac surgery, which is associated to mortality, kidney failure, stroke, prolonged mechanical ventilation and ICU stay. The right ventricle is particularly vulnerable to an increased afterload. By increasing pulmonary vascular resistance (PVR), atelectasis might mitigate a negative effect on the right ventricle.\n\nRecruitment maneuvers have been shown to resolve atelectasis and improve hemodynamics by increasing cardiac output and lowering PVR. However these maneuvers transiently raise airway pressures, which in turn increases right ventricular afterload, a situation often poorly tolerated by patients with RVF.\n\nProne position is used in patients with respiratory failure and has been shown to decrease mortality in patients with ARDS. Prone position decreases atelectasis and moves ventilation dorsally. In ARDS it also seems to mediate beneficial hemodynamic effects such as an increase in cardiac output and a decrease in PVR.\n\nThe investigators hypothesis is that prone position early after cardiac surgery will increase cardiac output by recruitment of atelectasis and thereby decrease PVR.",[83,84,27,85,86,87,88,89,90,91,92,93,94],"Right Ventricular Function","Prone Position","Atelectases, Postoperative Pulmonary","Cardiac Output","Vasoconstriction","Heart Failure","Recruitment Maneuver","Respiratory Mechanics","Pulmonary Arterial Pressure","Cardiac Surgery","Cardiac Surgery Recovery","Cardiopulmonary Bypass","2026-06-03",{"date":97,"type":35},"2026-06-08",{"date":99,"type":21},"2026-09",{"date":101,"type":21},"2028-10",{"name":103,"class":69},"Sahlgrenska University Hospital",{"id":105,"slug":106,"hasResults":11,"nctId":107,"briefTitle":108,"officialTitle":109,"acronym":4,"eligibilityCriteria":110,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":111,"targetDuration":4,"studyType":22,"phases":113,"briefSummary":114,"conditions":115,"keywords":117,"overallStatus":60,"whyStopped":4,"lastUpdateSubmitDate":119,"lastUpdatePostDateStruct":120,"startDateStruct":122,"completionDateStruct":123,"leadSponsor":125,"locationsCount":4},"100640158","bronchoscopic-airway-clearance-for-improving-lung-aeration-in-mechanically-ventilated-patients-with-atelectasis-100640158","NCT07594379","Bronchoscopic Airway Clearance for Improving Lung Aeration in Mechanically Ventilated Patients With Atelectasis","Effect of Bedside Flexible Bronchoscopy-Guided Airway Clearance on Lung Aeration in Mechanically Ventilated Patients With Atelectasis: A Multicenter Randomized Controlled Trial","Inclusion Criteria:\n\n1. Age 18 years or older\n2. Receiving invasive mechanical ventilation for at least 48 hours\n3. Presence of atelectasis confirmed by chest computed tomography, chest X-ray, or lung ultrasound\n4. High airway secretion burden, defined as requiring airway suctioning at least twice per hour during the previous 8 hours\n5. Written informed consent obtained from the participant or legally authorized representative\n\nExclusion Criteria:\n\n1. Expected duration of artificial airway maintenance less than 5 days\n2. Untreated tension pneumothorax Known or suspected aspiration\n3. Active intrapulmonary hemorrhage\n4. Severe dysfunction of other organs with expected short-term mortality within 7 days or need for palliative care\n5. Any other condition judged by the medical team to make the participant unsuitable for the study\n6. Informed consent not obtained",{"count":112,"type":21},104,[24],"The goal of this clinical trial is to learn whether bedside flexible bronchoscopy-guided airway clearance can improve lung aeration in adult patients who are receiving invasive mechanical ventilation and have atelectasis with a high airway secretion burden.\n\nThe main questions it aims to answer are:\n\nDoes bedside flexible bronchoscopy-guided airway clearance reduce the proportion of nonaerated lung tissue from baseline to day 5? Does this treatment improve other lung aeration measures, respiratory mechanics, arterial blood gas parameters, pulmonary infection score, ventilator-free days, intensive care unit length of stay, and safety outcomes?\n\nResearchers will compare usual airway care plus bedside flexible bronchoscopy-guided airway clearance with usual airway care alone to see if bronchoscopy-guided airway clearance improves lung aeration and clinical outcomes.\n\nParticipants will be randomly assigned to one of two groups. Participants in the usual care group will receive standard airway management, which may include airway suctioning, postural drainage, humidification, chest physiotherapy, and other routine respiratory care. Participants in the bronchoscopy group will receive the same usual care, plus bedside flexible bronchoscopy-guided airway clearance when predefined criteria for high airway secretion burden are met.\n\nParticipants will have clinical assessments during the study, including chest imaging, respiratory mechanics measurements, arterial blood gas tests, pulmonary infection score assessment, and safety monitoring. The main assessment will compare quantitative chest computed tomography findings at baseline and day 5 to evaluate changes in nonaerated lung tissue.",[27,116],"Mechanical Ventilation",[27,116,118],"Airway Secretion Retention","2026-05-21",{"date":121,"type":35},"2026-05-27",{"date":37,"type":21},{"date":124,"type":21},"2028-06-01",{"name":126,"class":69},"Southeast University, China",{"id":128,"slug":129,"hasResults":11,"nctId":130,"briefTitle":131,"officialTitle":132,"acronym":133,"eligibilityCriteria":134,"healthyVolunteers":11,"sex":16,"minAge":135,"maxAge":18,"enrollmentInfo":136,"targetDuration":4,"studyType":22,"phases":138,"briefSummary":139,"conditions":140,"keywords":144,"overallStatus":60,"whyStopped":4,"lastUpdateSubmitDate":119,"lastUpdatePostDateStruct":153,"startDateStruct":155,"completionDateStruct":157,"leadSponsor":159,"locationsCount":43},"100638373","effect-of-positioning-and-acbt-on-pulmonary-complications-after-cardiac-surgery-100638373","NCT07612033","Effect of Positioning and ACBT on Pulmonary Complications After Cardiac Surgery","Effect of Positioning Combined With Active Cycle of Breathing Techniques on Pulmonary Complications After Cardiac Surgeries","P-ACBT","Inclusion Criteria:\n\n* Adult patients (aged from 20 years to 65 years old).\n* Undergoing elective cardiac surgery (Coronary Artery bypass Grafting (CABG) or valves surgeries) via median sternotomy.\n* Hemodynamically stable postoperatively (no high-dose vasopressor support).\n* Fully conscious and capable of following complex verbal instructions.\n\nExclusion Criteria:\n\n* • Patients undergoing emergency cardiac surgery.\n\n  * History of chronic respiratory diseases such as chronic obstructive pulmonary disease (COPD), bronchial asthma, or bronchiectasis\n  * Pre-existing pulmonary complications (e.g., pneumonia, atelectasis, pleural effusion) prior to surgery\n  * Neuromuscular disorders affecting respiratory muscles\n  * Severe obesity (e.g., BMI ≥35 kg\u002Fm²)\n  * Cognitive impairment or inability to follow instructions\n  * Any contraindication to physiotherapy techniques (e.g., unstable sternum, severe pain not controlled)","20 Years",{"count":137,"type":21},124,[24],"The goal of this quasi-experimental clinical trial is to learn if position management combined with the Active Cycle of Breathing Techniques (ACBT) works to reduce postoperative pulmonary complications in adult patients undergoing elective cardiac surgery. It will also evaluate the individual effects of each technique compared to routine care.\n\nThe main questions it aims to answer are:\n\nDoes the combination of positioning and ACBT significantly lower the incidence and severity of postoperative pulmonary complications (like atelectasis, pneumonia, and respiratory failure) within the first 7 days after surgery? Does the combination of these techniques reduce the length of hospital stay compared to using each technique alone or routine care? Does the application of ACBT alone lower the rate of respiratory infections? Does position management alone improve oxygenation parameters (such as SpO\\_{2} and PaO\\_{2})?\n\nResearchers will compare four groups of patients to determine the most effective nursing approach:\n\nGroup 1 (Control Group): Participants will receive routine postoperative hospital care only.\n\nGroup 2 (ACBT Group): Participants will perform the Active Cycle of Breathing Techniques (breathing control, thoracic expansion, and huffing) three times daily for 10-15 minutes over 5 postoperative days.\n\nGroup 3 (Positioning Group): Participants will receive structured position management exclusively, shifting from head elevation (30-45) early after surgery to a semi-recumbent position (approx60) during waking hours, alongside other positions like lateral or forward-leaning as tolerated.\n\nGroup 4 (Combined Group): Participants will receive both structured position management and perform the ACBT sessions according to the same schedules.\n\nAll participants will undergo daily respiratory assessments using a standardized scoring system for 7 days post-surgery or until hospital discharge.",[141,142,27,143],"Postoperative Pulmonary Complications (PPCs)","Cardiac Surgery With Sternotomy","Postoperative Pneumonia",[145,146,147,148,149,150,151,152],"Position management","Active Cycle of Breathing Techniques ACBT","Postoperative pulmonary complications (PPCs)","Cardiac surgery (Open heart surgery)","Median sternotomy","Respiratory rehabilitation","Atelectasis prevention","Nursing-driven intervention",{"date":154,"type":35},"2026-05-28",{"date":156,"type":21},"2026-06-15",{"date":158,"type":21},"2027-01-01",{"name":160,"class":69},"Assiut University",{"id":162,"slug":163,"hasResults":11,"nctId":164,"briefTitle":165,"officialTitle":166,"acronym":4,"eligibilityCriteria":167,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":168,"targetDuration":4,"studyType":54,"phases":4,"briefSummary":170,"conditions":171,"keywords":176,"overallStatus":60,"whyStopped":4,"lastUpdateSubmitDate":183,"lastUpdatePostDateStruct":184,"startDateStruct":186,"completionDateStruct":188,"leadSponsor":190,"locationsCount":4},"100634623","bedside-lung-ultrasound-to-monitor-lung-recruitment-in-obese-patients-100634623","NCT07542093","Bedside Lung Ultrasound to Monitor Lung Recruitment in Obese Patients","Use of Bedside Lung Ultrasound to Monitor Lung Recruitment Maneuvers During Mechanical Ventilation in Obese Patients","Inclusion Criteria:\n\n* Adult patients aged \\>18 years\n* BMI ≥ 33 kg\u002Fm² (morbid obesity)\n* Intubated and receiving invasive mechanical ventilation for any indication (elective surgery, respiratory failure, post-operative ICU admission)\n* Expected duration of mechanical ventilation ≥ 6 hours\n* Hemodynamically stable at enrollment: Mean Arterial Pressure (MAP) ≥ 65 mmHg without escalating vasopressor support\n* SpO₂ ≥ 85% on current ventilator settings\n* Written informed consent obtained from patient or legal guardian\n\nExclusion Criteria:\n\n* Known or suspected pneumothorax or bullous emphysema (contraindication to recruitment maneuvers)\n* Severe hemodynamic instability: MAP \\\u003C 60 mmHg or requiring high-dose vasopressors (norepinephrine \\> 0.3 mcg\u002Fkg\u002Fmin)\n* Active bronchopleural fistula\n* Recent thoracic or cardiac surgery (within 48 hours) where high airway pressures are contraindicated\n* Raised intracranial pressure (ICP) or known severe traumatic brain injury\n* Confirmed ARDS with PaO₂\u002FFiO₂ ratio \\\u003C 100 mmHg (severe ARDS, where recruitment strategy differs significantly)\n* Chest wall deformity or subcutaneous emphysema that precludes reliable lung ultrasound assessment\n* Refusal of consent",{"count":169,"type":21},45,"Patients with morbid obesity who require a breathing machine (mechanical ventilator) in the Intensive Care Unit (ICU) frequently experience partial lung collapse. This happens because the extra weight of the chest and abdomen presses on the lungs, reducing their capacity and making it difficult to maintain adequate oxygen levels. To address this, doctors often perform a standard lung recruitment maneuver, which involves temporarily increasing the air pressure from the ventilator to gently pop open the collapsed lung areas. However, standard bedside monitoring tools make it difficult to see exactly how well the different regions of the lungs are reopening.\n\nThis prospective observational study aims to evaluate the use of Bedside Lung Ultrasound (LUS), which is a safe, radiation-free imaging tool, to monitor how well the lungs respond to these maneuvers in real-time.\n\nDuring the study, researchers will use a standardized 12-zone ultrasound scan to examine the lungs of mechanically ventilated adult patients (BMI ≥ 33 kg\u002Fm²) before, during, and after a step-by-step lung recruitment maneuver. By calculating a \"Total Lung Ultrasound Score,\" the medical team can directly visualize and measure the transition from collapsed tissue to normal, aerated lung tissue. Furthermore, the ultrasound will be used during a step-down pressure phase to help identify the patient's \"optimal PEEP\" (Positive End-Expiratory Pressure), which is the exact customized pressure needed to keep the lungs open after the maneuver is complete, thereby improving oxygenation and minimizing the risk of lung injury.",[172,173,174,27,175],"Morbid Obesity","Obesity","Respiratory Failure","Ventilator-Induced Lung Injury (VILI)",[177,178,179,116,180,181,182],"Lung Ultrasound (LUS)","Lung Ultrasound Score","Lung Recruitment Maneuvers (LRM)","Positive End-Expiratory Pressure (PEEP)","Optimal PEEP","Decremental PEEP Titration","2026-04-14",{"date":185,"type":35},"2026-04-21",{"date":187,"type":21},"2026-05",{"date":189,"type":21},"2027-06",{"name":160,"class":69},{"id":192,"slug":193,"hasResults":11,"nctId":194,"briefTitle":195,"officialTitle":196,"acronym":4,"eligibilityCriteria":197,"healthyVolunteers":11,"sex":16,"minAge":198,"maxAge":4,"enrollmentInfo":199,"targetDuration":4,"studyType":22,"phases":201,"briefSummary":202,"conditions":203,"keywords":207,"overallStatus":60,"whyStopped":4,"lastUpdateSubmitDate":215,"lastUpdatePostDateStruct":216,"startDateStruct":217,"completionDateStruct":219,"leadSponsor":221,"locationsCount":43},"100633570","high-flow-nasal-cannula-after-major-abdominal-surgery-to-prevent-postoperative-pulmonary-complications-100633570","NCT07528404","High-Flow Nasal Cannula After Major Abdominal Surgery to Prevent Postoperative Pulmonary Complications","High-Flow Nasal Cannula for Prevention of Early Postoperative Pulmonary Complications After Major Abdominal Surgery: A Prospective Single-Center Randomized Controlled Trial","Inclusion Criteria:\n\n* Adults aged 19 years or older.\n* Undergoing major abdominal surgery under general anesthesia.\n* Major abdominal surgery is defined as one of the following:\n\n  1. Upper gastrointestinal surgery: total gastrectomy, distal gastrectomy, proximal gastrectomy, or esophagogastric junction surgery.\n  2. Lower gastrointestinal surgery: right or left hemicolectomy, low anterior resection, anterior resection, total colectomy, abdominoperineal resection, or segmental small bowel resection with anastomosis.\n  3. Hepatobiliary and pancreatic surgery: hepatic resection (≥1 segment), right or left hepatectomy, central hepatectomy, distal pancreatectomy, pancreaticoduodenectomy (Whipple procedure), or bile duct resection with reconstruction.\n  4. Other moderate-to-major intra-abdominal procedures involving major organ resection or reconstruction, as determined by the investigator (e.g., complex cholecystectomy with extensive adhesiolysis, intra-abdominal tumor resection).\n* Actual anesthetic duration ≥ 3 hours, confirmed at the end of surgery.\n* Able to undergo immediate extubation at the end of surgery and be transferred to the post-anesthesia care unit or intensive care unit with spontaneous breathing.\n* Provided written informed consent before surgery. Final enrollment will occur only if the actual surgical procedure and anesthetic duration meet all eligibility criteria after surgery.\n\nExclusion Criteria:\n\n* Requirement for postoperative invasive mechanical ventilation. Failed extubation immediately after surgery.\n* Severe intraoperative instability preventing routine postoperative recovery (e.g., major hemodynamic instability, massive bleeding, or cardiopulmonary resuscitation).\n* Requirement for continuous oxygen therapy, noninvasive ventilation, or invasive mechanical ventilation before surgery.\n* Thoracic surgery within 4 weeks before the index surgery. Inability to receive HFNC because of upper airway or nasal anatomical limitations.\n* Planned reoperation at the completion of the index surgery.\n* Inability to complete study participation or follow-up because of impaired decision-making capacity or practical inability to complete follow-up.\n* Any condition that, in the investigator's judgment, makes study participation inappropriate.","19 Years",{"count":200,"type":21},580,[24],"Major abdominal surgery is associated with a substantial risk of early postoperative pulmonary complications, including atelectasis, hypoxemia, pneumonia, and increased need for respiratory support. High-flow nasal cannula (HFNC) provides warmed and humidified oxygen at high flow rates and may improve oxygenation, reduce respiratory workload, and support lung volume during the immediate postoperative period. However, whether routine prophylactic HFNC after major abdominal surgery reduces clinically significant postoperative pulmonary complications remains uncertain.\n\nThis prospective, single-center, randomized controlled trial will evaluate whether prophylactic HFNC applied for 24 hours immediately after extubation reduces postoperative pulmonary complications compared with standard postoperative respiratory care in adult patients undergoing major abdominal surgery under general anesthesia with an actual anesthetic duration of 3 hours or longer.",[204,27,205,206],"Postoperative Complications","Pneumonia","Respiratory Insufficiency",[208,209,210,211,212,213,214],"High-flow nasal cannula","HFNC","PPC","Major abdominal surgery","Postoperative respiratory support","Postoperative pulmonary complications","Randomized controlled trial","2026-04-07",{"date":183,"type":35},{"date":218,"type":21},"2026-07-01",{"date":220,"type":21},"2027-12-31",{"name":222,"class":69},"Uijeongbu St. Mary Hospital",{"id":224,"slug":225,"hasResults":11,"nctId":226,"briefTitle":227,"officialTitle":228,"acronym":4,"eligibilityCriteria":229,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":230,"targetDuration":4,"studyType":22,"phases":232,"briefSummary":233,"conditions":234,"keywords":236,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":238,"lastUpdatePostDateStruct":239,"startDateStruct":241,"completionDateStruct":243,"leadSponsor":245,"locationsCount":43},"100617991","effects-of-periodic-recruitment-maneuvers-on-atelectasis-and-respiratory-mechanics-during-elective-spine-surgery-assessed-by-lung-ultrasonography-100617991","NCT07325812","Effects of Periodic Recruitment Maneuvers on Atelectasis and Respiratory Mechanics During Elective Spine Surgery Assessed by Lung Ultrasonography","Evaluation of the Effects of Periodic Recruitment Maneuvers on Atelectasis and Respiratory Mechanics in Elective Spine Surgery Using Lung Ultrasonography","Inclusion Criteria:\n\n* Adults aged 18 to 65 years\n* Scheduled for elective lumbar spine surgery under general anesthesia\n* Surgery planned to be performed in the prone position\n* Expected surgical duration of at least 2 hours\n* American Society of Anesthesiologists (ASA) physical status I-II\n* Ability to provide written informed consent\n\nExclusion Criteria:\n\n* Body mass index (BMI) greater than 30 kg\u002Fm²\n* History of thoracic surgery\n* Known or suspected chronic pulmonary disease (e.g., chronic obstructive pulmonary disease, restrictive lung disease)\n* Clinically significant cardiac disease\n* Pregnancy or breastfeeding\n* Known airway anomalies\n\nIntraoperative surgical duration shorter than 2 hours\n\nRefusal or inability to provide informed consent",{"count":231,"type":21},60,[24],"During general anesthesia, particularly in patients undergoing spine surgery in the prone (face-down) position, increased intrathoracic and abdominal pressure may reduce lung compliance and promote the development of atelectasis (partial lung collapse). Atelectasis can impair intraoperative oxygenation and may increase the risk of postoperative pulmonary complications. Alveolar recruitment maneuvers (ARM) are routinely used in anesthesia practice to reopen collapsed lung regions; however, it remains unclear whether periodic application of ARM throughout surgery provides additional benefit compared with standard single-time application.\n\nThis prospective, randomized controlled clinical study aims to evaluate whether periodic alveolar recruitment maneuvers applied during elective spine surgery in the prone position reduce intraoperative atelectasis and improve respiratory mechanics compared with the standard approach of performing ARM only after positioning and before extubation. Adult patients undergoing elective spine surgery under general anesthesia will be randomly assigned to either a periodic ARM group or a standard ARM group.\n\nLung aeration will be assessed using lung ultrasound, a non-invasive and radiation-free bedside imaging method. The primary outcome is the incidence of intraoperative atelectasis assessed before extubation. Secondary outcomes include lung ultrasound aeration scores, respiratory mechanics parameters (such as airway pressures and compliance), oxygenation indices, and the occurrence of transient intraoperative respiratory or hemodynamic events.\n\nThe findings of this study may help optimize intraoperative ventilation strategies in prone spine surgery and contribute to improved perioperative respiratory safety.",[27,116,235,84],"General Anesthesia",[27,237,57,84,90],"Alveolar Recruitment Maneuver","2026-04-02",{"date":240,"type":35},"2026-04-08",{"date":242,"type":21},"2026-04",{"date":244,"type":21},"2026-07",{"name":246,"class":69},"Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization",{"id":248,"slug":249,"hasResults":11,"nctId":250,"briefTitle":251,"officialTitle":252,"acronym":4,"eligibilityCriteria":253,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":254,"targetDuration":4,"studyType":22,"phases":255,"briefSummary":256,"conditions":257,"keywords":258,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":262,"lastUpdatePostDateStruct":263,"startDateStruct":265,"completionDateStruct":267,"leadSponsor":269,"locationsCount":271},"100627651","the-effect-of-oscillation-and-lung-expansion-ole-therapy-in-prolonged-mechanical-ventilated-patients-with-atelectasis-evaluated-in-multiple-methods-100627651","NCT07451405","The Effect of Oscillation and Lung Expansion (OLE) Therapy in Prolonged Mechanical Ventilated Patients With Atelectasis Evaluated in Multiple Methods","The Efficacy of Oscillation and Lung Expansion (OLE) Therapy Evaluated by Compterized Tomography (CT) and Electrical Impedance Tomography（EIT）in Prolonged Mechanical Ventilated Patients With Atelectasis: A Multicenter Randomized Contralled Trial","Inclusion Criteria:\n\n* Age ≥18 years old\n* The following characteristics of high mucus secretion in the airway occur along with pulmonary infection: coughing up a large amount of white sticky phlegm, yellow phlegm or yellow purulent phlegm; Phlegm sounds can be heard in the lungs. The frequency of sputum aspiration is higher than once every 4 hours\n* Tracheotomy time ≥7 days\n* Vital signs are stable.\n\nExclusion Criteria:\n\n* Hemodynamic instability\n* Inhaled oxygen concentration (FiO2) \\> 60%\n* Untreated pneumothorax\n* Patients who have undergone total pneumonectomy\n* Hemoptysis\n* Pulmonary bullae, etc.\n* Patients with delirium and restlessness",{"count":231,"type":21},[24],"High frequency chest wall oscillation (HFCWO) is currently one of the most common and widespread mechanical airway clearance techniques (ACTs) in clinical practice in China. As an external airway oscillation technique, it has been proven in previous clinical practices that it can help clear secretions by vibrating the chest wall, loosening the secretions adhering to the airway walls and promoting ciliary movement, thereby improving lung ventilation and re-expansion. However, there are still some groups of patients for whom this technique is not suitable in clinical practice, such as those who are uncomfortable with the oscillation, have damaged skin on the chest and back, have unstable rib fractures, or have poorly positioned tracheostomy tubes. In recent years, integrating multiple techniques into a single treatment has become a trend. Among them, oscillation and lung expansion (OLE) combines continuous positive airway pressure (CPAP), continuous high-frequency oscillation (CHFO), and nebulization, which can effectively clear airway secretions and promote lung re-expansion. Currently, only a few studies have confirmed that OLE has a positive impact on improving respiratory function in patients with acute respiratory failure, severe burns, and after lung surgery.\n\nThis study aims to further compare the effects of the above two mechanical ACTs on improving lung ventilation and re-expansion by electrical impedance tomography (EIT), and optimize the clinical practice of physical therapists.",[27],[259,260,261,27],"oscillation and lung expansion","high frequency chest wall","electrical impedance tomography","2026-02-28",{"date":264,"type":35},"2026-03-05",{"date":266,"type":21},"2026-03-15",{"date":268,"type":21},"2026-10-01",{"name":270,"class":69},"Capital Medical University",2,{"id":273,"slug":274,"hasResults":11,"nctId":275,"briefTitle":276,"officialTitle":277,"acronym":4,"eligibilityCriteria":278,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":279,"enrollmentInfo":280,"targetDuration":4,"studyType":22,"phases":282,"briefSummary":283,"conditions":284,"keywords":285,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":289,"lastUpdatePostDateStruct":290,"startDateStruct":292,"completionDateStruct":294,"leadSponsor":296,"locationsCount":43},"100619835","automated-intraoperative-lung-recruitment-maneuvers-in-major-laparoscopic-surgery-100619835","NCT07349784","Automated Intraoperative Lung Recruitment Maneuvers in Major Laparoscopic Surgery","Effect of Automated Intraoperative Lung Recruitment Maneuvers on Atelectasis in Patients Undergoing Major Laparoscopic Surgery: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Age between 18 and 80 years\n* Scheduled for elective laparoscopic colorectal cancer surgery\n* American Society of Anesthesiologists (ASA) physical status I-III\n\nExclusion Criteria:\n\n* ASA physical status IV or higher\n* Pregnancy\n* Body mass index (BMI) \\> 40 kg\u002Fm²\n* Severe chronic obstructive pulmonary disease (COPD), GOLD stage III-IV\n* Advanced heart failure with left ventricular ejection fraction \\\u003C35%\n* Previous thoracic surgery\n* Preoperative requirement for supplemental oxygen therapy\n* Refusal or inability to provide informed consent\n* Intraoperative conversion to open surgery\n* Development of significant hemodynamic instability during lung recruitment maneuvers","80 Years",{"count":281,"type":21},56,[24],"Laparoscopic colorectal surgery is associated with an increased risk of intraoperative atelectasis due to pneumoperitoneum, Trendelenburg positioning, and prolonged anesthesia duration. Atelectasis developing during surgery may persist into the postoperative period and contribute to postoperative pulmonary complications. Automated lung recruitment maneuvers delivered by modern anesthesia ventilators may offer a standardized method to improve lung aeration and reduce atelectasis. This prospective, randomized, single-center controlled trial aims to evaluate the effect of automated intraoperative lung recruitment maneuvers on atelectasis detected by lung ultrasonography in patients undergoing elective major laparoscopic colorectal cancer surgery. Adult patients will be randomized to receive either automated lung recruitment maneuvers or standard mechanical ventilation without recruitment. Lung ultrasonography will be used to assess atelectasis at predefined perioperative time points. The primary outcome is the incidence of atelectasis detected by lung ultrasound, and secondary outcomes include postoperative pulmonary complications, length of intensive care unit stay, length of hospital stay, and perioperative hemodynamic instability.",[27,141],[286,287,288],"Lung Ultrasound Score (LUS)","Automated Lung Recruitment Maneuvers","Laparoscopic Colorectal Surgery","2026-01-19",{"date":291,"type":35},"2026-01-21",{"date":293,"type":35},"2025-12-13",{"date":295,"type":21},"2026-12",{"name":297,"class":42},"Bakirkoy Dr. Sadi Konuk Research and Training Hospital",{"id":299,"slug":300,"hasResults":11,"nctId":301,"briefTitle":302,"officialTitle":303,"acronym":304,"eligibilityCriteria":305,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":306,"targetDuration":4,"studyType":22,"phases":308,"briefSummary":309,"conditions":310,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":289,"lastUpdatePostDateStruct":315,"startDateStruct":316,"completionDateStruct":318,"leadSponsor":320,"locationsCount":322},"100538848","open-lung-protective-extubation-following-general-anesthesia-100538848","NCT06296173","Open Lung Protective Extubation Following General Anesthesia","Open Lung Protective Extubation Following General Anesthesia: the OLEXT-3 Trial","OLEXT-3","Inclusion Criteria:\n\n* Adult patients (18 years of age or over)\n* Elective intra-abdominal surgery under general anesthesia.\n* Moderate or high risk of postoperative pulmonary complication according to the ARISCAT score (score of 26 or more)\n* Planned postoperative hospitalization\n\nExclusion Criteria:\n\n* Expected or known difficult intubation according to the treating anesthesiologist\n* Postoperative mechanical ventilation (planned or unplanned)\n* General anesthesia performed outside the main operating room",{"count":307,"type":21},270,[24],"Perioperative respiratory complications are a major source of morbidity and mortality. Postoperative atelectasis plays a central role in their development. Protective \"open lung\" mechanical ventilation aims to minimize the occurrence of atelectasis during the perioperative period. Randomized controlled studies have been performed comparing various \"open lung\" ventilation protocols, but these studies report varying and conflicting effects. The interpretation of these studies is complicated by the absence of imagery supporting the pulmonary impact associated with the use of different ventilation strategies. Imaging studies suggest that the gain in pulmonary gas content in \"open lung\" ventilation regimens disappears within minutes after the extubation. Thus, the potential benefits of open-lung ventilation appear to be lost if, at the time of extubation, no measures are used to keep the lungs well aerated. Recent expert recommendations on good mechanical ventilation practices in the operating room conclude that there is actually no quality study on extubation.\n\nExtubation is a very common practice for anesthesiologists as part of their daily clinical practice. It is therefore imperative to generate evidence on good clinical practice during anesthetic emergence in order to potentially identify an effective extubation strategy to reduce postoperative pulmonary complications.",[311,312,313,314,27],"Intra-abdominal Surgery","Anesthesia","Lung Injury","Ventilator-Induced Lung Injury",{"date":291,"type":35},{"date":317,"type":35},"2024-10-08",{"date":319,"type":21},"2027-04-01",{"name":321,"class":69},"Centre hospitalier de l'Université de Montréal (CHUM)",4,{"id":324,"slug":325,"hasResults":11,"nctId":326,"briefTitle":327,"officialTitle":328,"acronym":329,"eligibilityCriteria":330,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":331,"targetDuration":4,"studyType":22,"phases":333,"briefSummary":334,"conditions":335,"keywords":4,"overallStatus":60,"whyStopped":4,"lastUpdateSubmitDate":340,"lastUpdatePostDateStruct":341,"startDateStruct":343,"completionDateStruct":345,"leadSponsor":347,"locationsCount":4},"100619899","the-effect-of-the-5t-teach-back-method-on-respiratory-exercise-and-incentive-spirometer-training-100619899","NCT07350616","The Effect of the 5T Teach-Back Method on Respiratory Exercise and Incentive Spirometer Training","The Effect of the 5T Teach-Back Method in Respiratory Exercise and Incentive Spirometer Training on Knowledge Level, Practical Skills, Respiratory Parameters, and Patient Satisfaction: A Randomized Controlled Study","TEACH-BREATHE","Inclusion Criteria:\n\n* Adults aged 18 years or older\n* Scheduled for abdominal surgery under general anesthesia\n* Postoperative use of respiratory exercises and incentive spirometry is recommended\n* Expected postoperative hospital stay of more than 3 days\n* Able to read and write and able to communicate effectively\n* Conscious, cooperative, and oriented\n* Willing to participate voluntarily and able to provide written informed consent\n\nExclusion Criteria:\n\n* Severe neurological or cognitive impairment\n* Unstable vital signs or hemodynamic instability\n* Anticipated or required postoperative intensive care unit admission\n* Severe pain that prevents participation in education or assessments\n* Visual or communication impairments that limit participation in education",{"count":332,"type":21},76,[24],"Breathing problems after surgery are common and can lead to serious complications such as low oxygen levels, lung collapse, or pulmonary embolism. These problems increase patient risk and place an additional burden on the healthcare system. Breathing exercises and incentive spirometer use are important methods to prevent these complications. However, many patients have difficulty understanding and correctly performing these exercises when education is limited to standard verbal instructions. This randomized controlled study aims to evaluate whether the 5T Teach-Back education method improves patients' understanding, practical skills, respiratory outcomes, and satisfaction compared with standard verbal education. The study will be conducted in a university hospital and will include 76 adult patients undergoing abdominal surgery under general anesthesia. Participants will be randomly assigned to either an intervention group or a control group.\n\nPatients in the intervention group will receive preoperative breathing exercise and incentive spirometer training using the 5T Teach-Back method, which encourages patients to explain the information back in their own words and repeat the skills until they are correctly understood. Patients in the control group will receive routine verbal education provided by clinical nurses. Outcomes will be measured before surgery and again within 24-72 hours after surgery. These outcomes include patients' knowledge level, correct performance of breathing exercises and spirometer use, respiratory rate, oxygen saturation, lung function test results, and patient satisfaction with nursing care. The results of this study are expected to show whether the 5T Teach-Back method is more effective than standard education in improving postoperative respiratory care and patient satisfaction. The findings may help standardize patient education practices and support nurses in delivering more effective respiratory training before surgery.",[336,27,337,338,339],"Postoperative Pulmonary Complications","Patient Education","Respiratory Exercises","Incentive Spirometry","2026-01-10",{"date":342,"type":35},"2026-01-20",{"date":344,"type":21},"2026-01-15",{"date":346,"type":21},"2027-01-15",{"name":348,"class":69},"Suleyman Demirel University",{"id":350,"slug":351,"hasResults":11,"nctId":352,"briefTitle":353,"officialTitle":354,"acronym":4,"eligibilityCriteria":355,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":356,"targetDuration":4,"studyType":22,"phases":358,"briefSummary":359,"conditions":360,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":373,"lastUpdatePostDateStruct":374,"startDateStruct":376,"completionDateStruct":378,"leadSponsor":380,"locationsCount":43},"100557458","clinical-utility-of-portable-dynamic-chest-x-ray-ddr-in-the-icu-100557458","NCT06538376","Clinical Utility of Portable Dynamic Chest X Ray (DDR) in the ICU","Clinical Utility of Portable Dynamic Chest X-Ray (DDR) in the ICU: Clinical Trial to Demonstrate the Feasibility of Deploying DDR Technology in the ICU - A Study to Prove Its Increased Diagnostic Value","Inclusion Criteria: Participants must meet all the following inclusion criteria to participate in this study:\n\n* Adults (at least 18 years of age) including both intubated\u002Fventilated and non-intubated patients\n* Likely to have pathology related to either, abnormal diaphragmatic excursion and lung aeration, pulmonary perfusion, increased lung water content or all the above, as well as for cricopharyngeal dysfunction\u002Fswallowing difficulties at risk for aspiration.\n* The subject or a legally authorized representative has provided written informed consent.\n\nExclusion Criteria: Candidates meeting any of the exclusion criteria at baseline will be excluded from study participation. These criteria are:\n\n* Special populations, including women with known pregnancy, prisoners, or institutionalized individuals\n* Patients where additional radiation is clinically contraindicated\n* Care team does not provide assent for approaching patient\u002Fsurrogate\n* For women of child-bearing potential, defined as premenopausal women, a pregnancy test will be administered to determine pregnancy status and confirm eligibility for the study. A pregnancy test will NOT be administered to women who are post-menopausal or have documentation of surgical sterilization.",{"count":357,"type":21},230,[24],"Dynamic digital radiography (DDR) is a new advanced version of chest radiography that captures dynamic images at a rate of 15 frames per second. It is coupled with an analytical software that allows it to provide more advanced measures of lung motion, ventilation, and perfusion compared to traditional chest radiography. While implementation of DDR fixed machines are beginning elsewhere in the US, this trial involves the first applications of an FDA-approved portable DDR machine, for use at the bedside in the ICU.\n\nThe goal of this clinical trial is to determine the feasibility and safety of portable DDR technology in the ICU, as well as to evaluate the improved clinical diagnostic value of the portable DDR system over current standards of care.\n\nParticipants will receive one to three sets of DDR images, which will then be compared to their clinical gold standard exams (such as chest x-rays, CTs, or VQ scans) to assess and improve the precision and accuracy of measurements such as diaphragmatic motion, lung movement, and perfusion.",[361,205,27,362,363,364,365,366,367,368,369,370,371,372],"Pulmonary Edema","Pleural Effusion","Acute Rejection of Lung Transplant (Disorder)","Airway Obstruction","Rib Fractures","Acute Copd Exacerbation","Asthma COPD","Pulmonary Embolism","Hemothorax","Pneumothorax","Mesothelioma","Diaphragmatic Paralysis","2025-10-28",{"date":375,"type":35},"2025-10-29",{"date":377,"type":35},"2023-12-12",{"date":379,"type":21},"2027-11",{"name":381,"class":69},"Brigham and Women's Hospital",{"id":383,"slug":384,"hasResults":11,"nctId":385,"briefTitle":386,"officialTitle":387,"acronym":388,"eligibilityCriteria":389,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":279,"enrollmentInfo":390,"targetDuration":4,"studyType":22,"phases":392,"briefSummary":393,"conditions":394,"keywords":404,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":407,"lastUpdatePostDateStruct":408,"startDateStruct":410,"completionDateStruct":412,"leadSponsor":414,"locationsCount":43},"100609205","intraoperative-paravertebral-block-and-postoperative-complications-100609205","NCT07211529","Intraoperative Paravertebral Block and Postoperative Complications","Perioperative Paravertebral Block Reduces Postoperative Complications in Thoracic Surgery: An Observational Study","IPVB and POCs","Inclusion Criteria:\n\n1. Male or female participants aged 18 years or older.\n2. Scheduled to undergo thoracic surgery via Video-Assisted Thoracoscopic Surgery (VATS) or Robotic-Assisted Thoracoscopic Surgery (RATS), including wedge resection, segmentectomy, lobectomy, or mediastinal surgery.\n3. Signed informed consent obtained prior to study participation. -\n\nExclusion Criteria:\n\n1. Patients who refuse to provide informed consent.\n2. Anesthesiologists who have not received training in ultrasound-guided paravertebral block (PVB-US).\n3. History of ipsilateral thoracic surgery.\n4. Conversion to open thoracotomy during the procedure.\n5. Patients who did not complete the scheduled surgery due to disease progression or medical reasons.\n6. Patients who are lost to follow-up or refuse postoperative follow-up. -",{"count":391,"type":21},500,[24],"This study aims to evaluate the clinical association between intraoperative paravertebral block and the reduction of postoperative complications following thoracic surgery.",[395,396,397,398,399,27,400,370,401,402,403],"Video-assisted Thoracoscopic Surgery (VATS)","Lung Cancer (Diagnosis)","Pulmonary Infections","Respiratory Failure Without Hypercapnia","Pleural Effusion Due to Another Disorder (Disorder)","Bronchospasm","Pulmonary Embolism (Diagnosis)","Bronchopleural Fistula","Acute Respiratory Distress Syndrome (ARDS)",[405,406,204],"Paravertebral Block (PVB)","Video-Assisted Thoracoscopic Surgery (VATS)","2025-09-30",{"date":409,"type":35},"2025-10-08",{"date":411,"type":35},"2025-03-25",{"date":413,"type":21},"2028-12-31",{"name":415,"class":69},"Tongji Hospital",{"id":417,"slug":418,"hasResults":11,"nctId":419,"briefTitle":420,"officialTitle":421,"acronym":422,"eligibilityCriteria":423,"healthyVolunteers":11,"sex":16,"minAge":424,"maxAge":425,"enrollmentInfo":426,"targetDuration":4,"studyType":22,"phases":428,"briefSummary":429,"conditions":430,"keywords":431,"overallStatus":60,"whyStopped":4,"lastUpdateSubmitDate":434,"lastUpdatePostDateStruct":435,"startDateStruct":437,"completionDateStruct":439,"leadSponsor":441,"locationsCount":43},"100606975","vcv-vs-prvc-in-pediatric-anesthesia-an-eit--and-ls-based-study-100606975","NCT07182539","VCV vs PRVC in Pediatric Anesthesia; an EIT- and LS-based Study","Atelectasis in Pediatric Anesthesia: A Randomized Observational Study Comparing Volume-Controlled and Pressure-Regulated Volume Control Ventilation Via Lung Ultrasound and Electrical Impedance Tomography","VentiEIT_ped","Inclusion Criteria:\n\n* Patients requiring intraoperative mechanical ventilation via endotracheal intubation\n* Written informed consent obtained from parents or legal guardians. For children capable of understanding, assent will also be obtained based on age and cognitive ability.\n* ASA (American Society of Anesthesiologists) physical status I-II\n\nExclusion Criteria:\n\n* Patients with significant pre-existing lung disease (e.g., cystic fibrosis, severe bronchopulmonary dysplasia, severe uncontrolled asthma, neuromuscular disease with respiratory compromise).\n* Patients with complex congenital heart disease or significant hemodynamic instability.\n* Patients undergoing thoracic surgery or procedures that could significantly alter lung mechanics (e.g., pre-existing pneumothorax).\n* Refusal of parents\u002Fguardians or patient to participate in the study.\n* History of previous intrathoracic procedure.","3 Years","10 Years",{"count":427,"type":21},88,[24],"The primary objective of this study is to evaluate and compare the incidence and severity of intraoperative pulmonary atelectasis, measured by Lung Ultrasound Score (LUS) and EIT (Electrical Impedance Tomography), between two different modes of mechanical ventilation: Volume Control Ventilation (VCV) and Pressure Regulated Volume Control (PRVC\u002FPCV-VG)",[27],[27,57,432,433],"EIT","Pediatric Anesthesia","2025-09-15",{"date":436,"type":35},"2025-09-19",{"date":438,"type":21},"2025-09",{"date":440,"type":21},"2026-01",{"name":442,"class":69},"Vittore Buzzi Children's Hospital",{"id":444,"slug":445,"hasResults":11,"nctId":446,"briefTitle":447,"officialTitle":448,"acronym":4,"eligibilityCriteria":449,"healthyVolunteers":11,"sex":16,"minAge":135,"maxAge":450,"enrollmentInfo":451,"targetDuration":4,"studyType":22,"phases":453,"briefSummary":454,"conditions":455,"keywords":458,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":462,"lastUpdatePostDateStruct":463,"startDateStruct":465,"completionDateStruct":467,"leadSponsor":469,"locationsCount":43},"100567011","physiological-effects-and-safety-of-continuous-high-frequency-oscillatory-ventilation-in-mechanical-ventilation-patients-100567011","NCT06662630","Physiological Effects and Safety of Continuous High-frequency Oscillatory Ventilation in Mechanical Ventilation Patients","Assessing the Physiological Impact and Safety of Continuous High-Frequency Oscillatory Ventilation in Critically Ill Patients Under Mechanical Ventilation","Inclusion Criteria:\n\n* Patients older than 18 and younger than 90 years;\n* Admitted to the ICU after October 15, 2024, who are intubated and expected to be unable to be extubated within 48 hours due to ARDS, or have atelectasis, or have VAP.\n* Signed informed consent for MetaNeb treatment.\n\nExclusion Criteria:\n\n* Refusal to participate in the proposed study.\n* Age \\\u003C 20 years;\n* Pregnancy;\n* Significant hemodynamic instability defined as an increase of more than 20% in catecholamine doses in the last hour, despite optimization of blood volume, for a target mean blood pressure between 65 and 75 mmHg.\n* Participation in another trial within 30 days prior to meeting eligibility criteria;\n* Severe chronic respiratory disease requiring long-term oxygen therapy or home mechanical ventilation;\n* Pneumothorax;\n* Expected duration of mechanical ventilation \\\u003C 48 hours\n* Decision to refuse life-sustaining treatment.","90 Years",{"count":452,"type":21},30,[24],"Mechanical ventilation is an important treatment modality for intensive care unit (ICU) patients, but it also brings a series of problems such as ventilator-associated pneumonia, ventilator-induced lung injury, and atelectasis. Continuous High-Frequency Oscillation (CHFO )is often considered to have a protective effect on the lungs. CHFO provides effective gas exchange at supraphysiological frequencies while minimizing pressure fluctuations, producing tidal volumes smaller than dead space and adjusting around a continuously expanding pressure to optimize end-expiratory lung volume (EELV) by achieving and maintaining lung recruitment. However, the physiological effects and safety of CHFO in critically ill patients on mechanical ventilation lack relevant research. The objective of this research is to assess the feasibility, safety, and efficacy of CHFO in a population of mechanically ventilated critically ill patients.",[27,456,457],"Acute Respiratory Distress Syndrome","VAP - Ventilator Associated Pneumonia",[459,460,432,461],"mechanical ventilation","HFOV","FRC","2024-11-18",{"date":464,"type":35},"2024-11-20",{"date":466,"type":21},"2024-11-19",{"date":468,"type":21},"2026-10-14",{"name":470,"class":69},"Shanghai Zhongshan Hospital",{"id":472,"slug":473,"hasResults":11,"nctId":474,"briefTitle":475,"officialTitle":476,"acronym":477,"eligibilityCriteria":478,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":479,"targetDuration":481,"studyType":54,"phases":4,"briefSummary":482,"conditions":483,"keywords":4,"overallStatus":60,"whyStopped":4,"lastUpdateSubmitDate":484,"lastUpdatePostDateStruct":485,"startDateStruct":486,"completionDateStruct":488,"leadSponsor":490,"locationsCount":4},"100564633","to-assess-the-effectiveness-of-three-distinct-mechanical-assisted-sputum-evacuation-apparatuses-in-the-treatment-of-patients-with-mechanical-ventilation-induced-atelectasis-100564633","NCT06631716","To Assess the Effectiveness of Three Distinct Mechanical Assisted Sputum Evacuation Apparatuses in the Treatment of Patients With Mechanical Ventilation-induced Atelectasis","Evaluation of the Effectiveness of Mechanically Assisted Sputum Excretion","EOTEOMASE","Inclusion Criteria:\n\n* ≥18 years old.\n* patients who were diagnosed as obstructed airway secretion clearance and required mechanical sputum evacuation in Sir Run Run Shaw Hospital, Zhejiang University School of Medicine. Among them, patients using CVT were included in the CVT cohort, patients using Metaneb were included in the Metaneb cohort, and patients using high-frequency chest wall oscillation (HFCWO) were included in the high-frequency chest wall oscillation (HFCWO) cohort.\n* voluntarily participated in this study and signed the informed consent. If the subjects were unable to read and sign the informed consent form due to incapacity or other reasons, their guardians were required to act for them during the informed consent process and sign the informed consent form. If the subjects were unable to read the informed consent form (e.g., illiterate subjects), witnesses were required to witness the informed consent process and sign the informed consent.\n* Invasive mechanical ventilation ≥48 hours.\n* Atelectasis was confirmed by chest CT, chest X-ray or lung ultrasound.\n\nExclusion Criteria:\n\n* BMI≥40kg\u002Fm2.\n* Severe spinal and thoracic deformity.\n* Known or suspected diaphragmatic dysfunction such as phrenic nerve rupture, neuromuscular disease, etc.\n* untreated tension pneumothorax.\n* Active bleeding in the lung.\n* Severe hemodynamic instability (increased dose of vasoactive drugs within 2 hours or MAP≤65mmHg).\n* Severe other organ dysfunction was expected to result in short-term death (7 days) or palliative treatment.\n* Other reasons considered by the medical team not suitable for treatment.\n* Pregnancy status.",{"count":480,"type":21},84,"1 Month","Retention of airway secretions is a common clinical problem in patients with mechanical ventilation. Effective removal of airway secretions requires a balance between the production and removal of airway secretions through the mucociliary transport system. Effective removal of airway secretions is the basic measure to maintain airway patency and normal alveolar ventilation and oxygenation. At present, a variety of mechanical assisted expectoration devices have been used to remove airway secretions in critically ill patients, including The MetaNeb® System(MetaNeb), High Frequency Chest Wall Oscillation(HFCWO) and (Cycloid Vibration Therapy)CVT. However, there is still a lack of sufficient evidence to evaluate the clinical efficacy of these three different mechanical assisted expectoration devices in airway management of patients with mechanical ventilation. This study aims to observe the clinical efficacy of three different mechanical assisted sputum evacuation devices in airway management of patients with mechanical ventilation atelectasis, and to provide a basis for optimizing the airway management scheme of patients with mechanical ventilation.",[116,27],"2024-10-06",{"date":317,"type":35},{"date":487,"type":21},"2024-11-01",{"date":489,"type":21},"2025-12-01",{"name":491,"class":69},"Sir Run Run Shaw Hospital",{"id":493,"slug":494,"hasResults":11,"nctId":495,"briefTitle":496,"officialTitle":497,"acronym":4,"eligibilityCriteria":498,"healthyVolunteers":11,"sex":499,"minAge":4,"maxAge":4,"enrollmentInfo":500,"targetDuration":4,"studyType":54,"phases":4,"briefSummary":501,"conditions":502,"keywords":504,"overallStatus":60,"whyStopped":4,"lastUpdateSubmitDate":510,"lastUpdatePostDateStruct":511,"startDateStruct":513,"completionDateStruct":515,"leadSponsor":516,"locationsCount":43},"100531129","effect-of-epidural-analgesia-on-regional-lung-ventilation-in-parturient-women-as-assessed-by-thoracic-impedance-100531129","NCT06195774","Effect of Epidural Analgesia on Regional Lung Ventilation in Parturient Women as Assessed by Thoracic Impedance","Impact on Respiratory Function Associated to Epidural Analgesia in Parturient Women as Assessed by Electrical Impedance Tomography: a Monocentric Prospective Study","Inclusion Criteria:\n\n* At-term pregnancy (at least 36 weeks)\n* ASA class I-II\n\nExclusion Criteria:\n\n* American Society of Anesthesiologists (ASA) Class III or more\n* BMI\\>35 before pregnancy\n* Contraindication to routinely administrated drugs (levobupivacaine, lidocaine, sufentanil)\n* Contraindication to epidural analgesia\n* Pregnancy-related complications (including pre-eclampsia)\n* Respiratory system diseases\n* Severe psychiatric disorders\n* Twin pregnancy\n* Skin lesions in correspondence to the position of the Electric impedance tomography belt\n* Pacemaker or Implantable Cardioverter Defibrillator (ICD)\n* Language barrier","FEMALE",{"count":53,"type":21},"The goal of this observational study is to learn more about the effect of obstetric epidural anesthesia on regional lung ventilation in healthy parturient women. The main question it aims to answer is whether the initiation or epidural analgesia improves or not regional lung ventilation in healthy women at term during labor.\n\nParticipants will be subject to measurements of pulmonary impedance by electric impedance tomography before and after the start of epidural analgesia. No change will be applied to clinical care as a result of this measurement.",[503,27],"Pregnancy Complications",[505,506,507,508,509],"pregnancy","labor","at term","electric impedance tomography","pulmonary impedance","2023-12-23",{"date":512,"type":35},"2024-01-08",{"date":514,"type":21},"2024-01",{"date":295,"type":21},{"name":517,"class":69},"Erasme University Hospital"]