[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"atherosclerosis-and-calcific-aortic-stenosis-with-and-without-diabetes\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:atherosclerosis-and-calcific-aortic-stenosis-with-and-without-diabetes":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":4,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":27,"lastUpdatePostDateStruct":28,"startDateStruct":31,"completionDateStruct":33,"leadSponsor":35,"locationsCount":5},"100542004","potential-role-of-sirtuins-as-epigenetic-biomarkers-of-the-patient-with-atherosclerosis-or-calcific-aortic-stenosis-100542004",false,"NCT06337227","Potential Role of Sirtuins As Epigenetic Biomarkers of the Patient with Atherosclerosis or Calcific Aortic Stenosis","Potential Role of Sirtuins As Epigenetic Biomarkers for the Clinical Management of the Patient with Atherosclerosis or Calcific Aortic Stenosis","Inclusion Criteria:\n\n* Patients with atherosclerosis or calcific aortic stenosis with and without diabetes older than 18 years of either sex;\n* Patients without atherosclerosis undergoing surgical procedure for endocarditis;\n* Patients who will have signed informed consent\n\nExclusion Criteria:\n\n* Patients for whom biological material cannot be recovered for study purposes;\n* Patients who refuse to participate in the study",true,"ALL","18 Years",{"count":20,"type":21},3,"ESTIMATED","OBSERVATIONAL","The project aims to shed light on the role of Sirtuins, enzymes belonging to the third class of histone deacetylases (class III) involved in epigenetic modifications (deacetylation), focusing mainly on Sirtuin 6 (SIRT6), as a regulator of atherosclerosis and severe aortic valve stenosis through molecular-based and epigenetic studies in human VSMC cells.",[25],"Atherosclerosis and Calcific Aortic Stenosis with and Without Diabetes","RECRUITING","2025-03-07",{"date":29,"type":30},"2025-03-11","ACTUAL",{"date":32,"type":30},"2023-10-19",{"date":34,"type":21},"2026-10",{"name":36,"class":37},"IRCCS SYNLAB SDN","OTHER"]