[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"athlete-heart\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:athlete-heart":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,46,76],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":27,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100620928","interaction-between-intraventricular-flow-and-cardiac-mechanics-using-3d-echocardiography-in-athletes-and-sedentary-subjects-100620928",false,"NCT07363993","Interaction Between Intraventricular Flow and Cardiac Mechanics Using 3D Echocardiography in Athletes and Sedentary Subjects","CARDIO-3D","Inclusion criteria for athletes:\n\n\\- Athlete practicing at least 10 hours of endurance training per week for a minimum of 5 years.\n\nInclusion criteria for controls:\n\n\\- Individual not training in more than 3 hours of physical activity per week.\n\nExclusion Criteria for both groups:\n\n* History of known heart disease;\n* Current cardiac rhythm disorder;\n* Individual with one or more cardiovascular risk factors (smoking, diabetes, hypertension, body mass index \\> 30 kg\u002Fm²);\n* Individual in a period of relative exclusion in relation to another protocol, or for whom the annual maximum compensation amount of €4,500 has been reached;\n* Individual not affiliated with a social security system, or not benefiting from such a system;\n* Pregnant or breastfeeding woman; patient unable to give informed consent; protected adults; vulnerable persons;\n* Individual deprived of liberty by judicial or administrative decision.\n\nExclusion criteria for athletes:\n\n\\- Use of substances listed on the prohibited substances list of the French Anti-Doping Agency",true,"ALL","18 Years","45 Years",{"count":21,"type":22},160,"ESTIMATED","OBSERVATIONAL","Exercise-induced cardiac remodeling, known as the \"athlete's heart,\" corresponds to morphological and functional adaptations of the left ventricle in response to prolonged physical training. It is characterized in particular by physiological hypertrophy and improved myocardial function.\n\nIntraventricular blood flow interacts with cardiac mechanics. Regional shape (e.g., sphericity, wall curvature) and myocardial deformations guide flow patterns to create an optimal hemodynamic environment. The interaction between these different parameters in the athlete's heart remains insufficiently explored. In this context, 3D echocardiography makes it possible to combine indices derived from fluid dynamics, regional myocardial function, and cardiac geometry, enabling a comprehensive assessment of cardiac performance.\n\nPrimary and secondary objectives:\n\nIn this context, the aim of this project is to investigate the relationship between intraventricular flow and cardiac mechanics based on combined measurements of intraventricular flow (e.g., vorticity, pressure gradients), regional myocardial function (e.g., myocardial strain), and global\u002Fregional LV geometry (e.g., sphericity, wall curvature) in the athlete's heart. Since these parameters are interdependent, analyzing their interaction through the development of new echocardiographic tools based on 4D assessments will enable a comprehensive evaluation of functional improvements in the athlete's heart.\n\nThe secondary objectives are to analyze the impact of dyssynchrony on intraventricular flow, to evaluate the influence of primary and secondary deformations on intraventricular flow, and to study cardiac function from an energetic perspective using non-invasive reconstruction of pressure-volume loops for cardiac work estimation.\n\nMethodology:\n\nThe study will include 80 endurance athletes (ENT group) and 80 control subjects (CONT group). The main inclusion criteria common to both groups are: men and women aged 18-45 years, with no known heart disease and no cardiovascular risk factors (e.g., body mass index \\> 30 kg\u002Fm², arterial hypertension). Athletes must train at least 10 hours per week for the past 5 years. Control subjects must not engage in more than 3 hours of physical activity per week.\n\nAthletes will be recruited from elite groups of various federations, during local long-distance races, or during clinical evaluations at Montpellier University Hospital (Dr. C. Hédon's department). Control subjects will be recruited in the Avignon area and in the cardiology department of Montpellier University Hospital during routine visits.\n\nEchocardiographic examinations will be performed in the left lateral decubitus position using Vivid systems with 4D probes. 4D and tri-plane acquisitions with color Doppler will allow assessment of cardiac structure and intraventricular flow. Data analysis will be performed using TOMTEC software, and scripts developed in Matlab and RStudio will process information related to shape, mechanical dispersion, and dyssynchrony. Intraventricular hemodynamics will be analyzed in collaboration with the CREATIS laboratory (D. Garcia), particularly through measurements of intraventricular pressure gradients and vorticity indices.",[26],"Athlete Heart",[28,29,30,31,32],"regional myocardial function","intraventricular flow","cardiac geometry","echo-3D","athlete's heart","RECRUITING","2026-01-16",{"date":36,"type":37},"2026-01-23","ACTUAL",{"date":39,"type":37},"2025-12-01",{"date":41,"type":22},"2027-08-31",{"name":43,"class":44},"University of Avignon","OTHER",2,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":52,"eligibilityCriteria":53,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":54,"enrollmentInfo":55,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":57,"conditions":58,"keywords":62,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":75},"100555912","risk-of-sudden-cardiac-death-in-un-athletes-100555912","NCT06518252","Risk of Sudden Cardiac Death in UN Athletes","Detection of the Risk of Sudden Cardiac Death in Athletes From the Universidad Nacional de Colombia","Suddendeath","Inclusion Criteria:\n\n* Athletes belonging to the sports teams of the National University of Colombia, Bogotá campus.\n* Subject's sports history (practice time exceeding 2 years).\n* Individuals aged 18 to 35 years, without discrimination based on biological sex.\n* Training time exceeding 6 hours per week in their sports modality (weekly training record).\n* Personal history of cardiovascular disease (cardiac malformations or previously detected sudden death risk).\n* Athletes who attend at least 90% of the training sessions planned by the coach.\n\nExclusion Criteria:\n\n* Personal history of metabolic (type 1 and 2 diabetes mellitus), neurological (spinal cord injury), or renal disease.\n* Routine consumption of alcohol or psychoactive substances.\n* Use of antihypertensive medications, beta-blockers, or inotropes.\n* Cardiovascular disease diagnosed with previously established pharmacological management.","35 Years",{"count":56,"type":22},250,"The detection of sudden cardiac death risk in athletes is a topic of great relevance in the field of sports physiotherapy and physical activity. High-performance sports practice involves anatomical and physiological changes that can modify the mechanical and electrical properties of the heart, increasing the risk of potentially fatal cardiac events. Therefore, it is essential to implement early detection strategies to identify at-risk athletes and prevent tragedies during sports practice.\n\nMethodology: This study focuses on the prevalence of sudden cardiac death risk, using a 12-lead electrocardiogram as the primary detection tool. This examination will allow for the evaluation of the heart's electrical activity and the detection of potential anomalies that could predispose athletes to adverse cardiac events during sports practice. In addition to the electrocardiogram, cardiovascular screening questionnaires will be administered to collect information on personal and family health histories, as well as other relevant risk factors. In conjunction with the project's researchers, the sports medical team of the Universidad Nacional de Colombia will be responsible for conducting the evaluations, ensuring the precision and reliability of the obtained results. A detailed analysis of the collected data will be performed using statistical tools to identify possible correlations between the evaluated risk factors and the presence of sudden cardiac death risk in athletes. Logistic regression models will be employed to determine the strength of association between the studied variables and cardiovascular risk in this specific population.\n\nExpected Results: It is anticipated that implementing pre-participation evaluations, including the electrocardiogram and cardiovascular screening questionnaires, will enable the identification of athletes at higher risk of sudden cardiac death. These results will allow for the establishment of individualized risk profiles and the design of personalized prevention strategies for each athlete. Additionally, it is expected that the findings of this study will contribute to the development of early detection protocols for sudden cardiac death risk in athletes, which can be effectively implemented in sports settings. The information generated from this study will provide a solid foundation for clinical decision-making and the implementation of preventive measures to benefit the health and well-being of high-performance athletes.",[59,60,26,61],"Death, Sudden, Cardiac","Electrocardiogram QT Prolonged","Athletic Injuries",[63,64,65],"Sudden death of the athlete","Electrocardiogram","University sports.","2024-07-18",{"date":68,"type":37},"2024-07-24",{"date":70,"type":37},"2023-11-24",{"date":72,"type":22},"2025-06-25",{"name":74,"class":44},"Universidad Nacional de Colombia",1,{"id":77,"slug":78,"hasResults":11,"nctId":79,"briefTitle":80,"officialTitle":81,"acronym":82,"eligibilityCriteria":83,"healthyVolunteers":16,"sex":17,"minAge":84,"maxAge":85,"enrollmentInfo":86,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":88,"conditions":89,"keywords":90,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":100,"completionDateStruct":102,"leadSponsor":104,"locationsCount":106},"100451886","prospective-athletes-heart-study-100451886","NCT05164328","Prospective Athlete's Heart Study","Prospective Athlete's Heart Study: Long-term Assessment of the Determinants of Cardiac Remodelling and Its Clinical Consequences in Endurance Athletes","Pro@Heart","Inclusion Criteria:\n\n1. Males and females aged 14-23 years old\n2. Athletes competing in endurance sports at national or international level for at least 2 years. Sports include:\n\n   1. Triathlon\n   2. Cycling\n   3. Distance running (≥ 1500 meters)\n   4. Rowing\n   5. Swimming\n3. Non athletes engaged in \\\u003C 3 hours per week of physical activity\n\nExclusion Criteria:\n\n1. Medical history of cardiovascular disease\n2. Current smoker of past history of smoking\n3. Diabetes mellitus","14 Years","23 Years",{"count":87,"type":22},450,"The Pro@Heart (Prospective Athlete's Heart) study is an international multicentre long-term prospective trial. The primary objective of the Pro@Heart study is to investigate the impact of training load (i.e. accurately evaluated in term of type, frequency, duration and intensity) and genotype on the variability of structural, functional and electrical exercise induced cardiac remodeling (EICR) in young competitive endurance athletes. The second objective is to determine how EICR, training load and genotype are associated with physical performance, health benefits and cardiac pathology (e.g. exercise-related cardiomyopathies and arrhythmias) during follow-up over several decades.",[26],[91,92,93,94,95,96],"Athlete","Atrial fibrillation","Arrhythmias","Cardiac remodelling","Cardiomyopathy","Genetics","2021-12-07",{"date":99,"type":37},"2021-12-20",{"date":101,"type":37},"2015-06-23",{"date":103,"type":22},"2040-06-23",{"name":105,"class":44},"Universitaire Ziekenhuizen KU Leuven",4]