[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"athlete\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:athlete":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,14,0,[8,54,87,115,142,181,208,236,271,301,331,360,386,405],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":32,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":42,"lastUpdatePostDateStruct":43,"startDateStruct":46,"completionDateStruct":48,"leadSponsor":50,"locationsCount":53},"100634963","effects-of-cistanche-supplementation-on-anaerobic-exercise-performance-and-recovery-in-men-with-different-athletic-training-levels-100634963",false,"NCT07546513","Effects of Cistanche Supplementation on Anaerobic Exercise Performance and Recovery in Men With Different Athletic Training Levels","Effects of Cistanche Supplementation on Anaerobic Exercise Performance and Recovery in Men With Different Athletic Training Levels: A Double-Blind, Randomized, Placebo-Controlled Trial","Inclusion Criteria:\n\n* Male, aged 18 to 25 years\n* Body mass index (BMI) between 18.5 and 25.0 kg\u002Fm²\n* Able and willing to provide written informed consent\n* Willing to comply with study procedures, supplementation, training, and assessments\n* Belonging to one of the following athletic training strata:\n* High-level elite stratum: Chinese National Level-1 Athlete standard in sprint-related events, regular training in past 12 months and active during study\n* Amateur stratum: regular exercise-training background in past 12 months without National Level-1 status\n\nExclusion Criteria:\n\n* Use of steroids or ergogenic supplements during study\n* Known cardiovascular, metabolic, musculoskeletal, or other conditions making participation unsafe or affecting outcomes\n* Current use of medications affecting muscle growth, recovery, hormones, or high-intensity performance\n* Current injury or limitation preventing safe participation\n* Known allergy or intolerance to supplement\u002Fplacebo ingredients\n* Participation in another clinical trial or structured intervention during study period\n* Inability or unwillingness to comply with protocol\n* Any other condition deemed unsuitable by investigators",true,"MALE","18 Years","25 Years",{"count":21,"type":22},56,"ESTIMATED","INTERVENTIONAL",[25],"NA","This study is a double-blind, randomized, placebo-controlled trial designed to examine whether 8 weeks of Cistanche deserticola supplementation, when combined with a standardized anaerobic training program, can improve anaerobic exercise performance, recovery, and selected body composition outcomes in young adult men with different athletic training levels.\n\nParticipants will be assigned to receive either Cistanche deserticola extract or a matched placebo while completing the same supervised anaerobic training program. The study will assess changes in anaerobic performance, including Wingate test outcomes and jump performance, as well as recovery-related indicators such as blood lactate, creatine kinase, malondialdehyde, testosterone, cortisol, and the testosterone-to-cortisol ratio. Body composition outcomes, including body fat percentage and skeletal muscle mass, will also be evaluated.\n\nThe purpose of this study is to determine whether Cistanche deserticola supplementation provides additional benefits beyond training alone, and whether these effects differ between highly trained and recreationally trained participants.",[28,29,30,31],"Athlete","Elite Athlete","Sport Performance","Exercise Recovery",[33,34,35,36,37,38,39,40],"Cistanche","anaerobic performance","exercise recovery","explosive power","lactate","muscle damage","body composition","randomized controlled trial","NOT_YET_RECRUITING","2026-06-30",{"date":44,"type":45},"2026-07-02","ACTUAL",{"date":47,"type":22},"2026-06-25",{"date":49,"type":22},"2026-09-15",{"name":51,"class":52},"Beijing Sport University","OTHER",1,{"id":55,"slug":56,"hasResults":11,"nctId":57,"briefTitle":58,"officialTitle":59,"acronym":60,"eligibilityCriteria":61,"healthyVolunteers":16,"sex":62,"minAge":18,"maxAge":63,"enrollmentInfo":64,"targetDuration":4,"studyType":66,"phases":4,"briefSummary":67,"conditions":68,"keywords":71,"overallStatus":77,"whyStopped":4,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":81,"completionDateStruct":83,"leadSponsor":85,"locationsCount":53},"100637725","effects-of-the-menstrual-cycle-and-oral-contraceptive-use-on-health-and-performance-in-athletes-100637725","NCT07591818","Effects of the Menstrual Cycle and Oral Contraceptive Use on Health and Performance in Athletes","Menstrual Cycle and Oral Contraceptive Use in Athletic Performance and Health-related Hydration and Energy Balance Status","Flow2Perform","Inclusion Criteria:\n\n* Cisgender female individuals (biologically female, not undergoing gender-transition therapy)\n* Age between 18 and 30 years;\n* Classified as at least Tier 2 athletes;\n* Minimum of 1 year of federated sports participation;\n* Menarche occurred at least 3 years prior to enrollment;\n\nAdditional inclusion criteria for the natural menstrual cycle group:\n\n* Menstrual cycle length between 21 and 35 days with at least nine consecutive cycles in the previous year;\n* Confirmed ovulatory cycle (luteinizing hormone surge and progesterone \\>16 nmol\u002FL);\n\nAdditional inclusion criteria for the oral contraceptive group:\n\n* Use of combined monophasic oral contraceptives with a 21-day regimen;\n* Use of the same oral contraceptive for at least 3 months prior to enrollment;\n\nExclusion Criteria:\n\n* Pregnancy or child birth within the previous 12 months;\n* Active smoking;\n* Diagnosis of metabolic, cardiovascular, or respiratory disease:\n* Use of continuous or extended-cycle oral contraceptives.","FEMALE","30 Years",{"count":65,"type":22},40,"OBSERVATIONAL","A review of the sports medicine literature reveals a clear underrepresentation of female athletes in research. In the current era of precision medicine, increasing attention has been directed toward the regulatory roles of estrogen and progesterone in athletic performance and health optimization. Regular fluctuations in estrogen and progesterone across menstrual cycle phases (i.e., early follicular, late follicular, and mid-luteal phases) may influence strength performance, hydration status, body composition, and energy balance. However, few studies have examined these outcomes using hormonal confirmation of menstrual cycle phases. Monophasic oral contraceptive use also represents a highly relevant hormonal condition among female athletes, as exogenous hormones suppress endogenous ovarian fluctuations and create distinct hormonal profiles across active pill-consumption and withdrawal phases. Nevertheless, the influence of oral contraceptive phases on strength-related outcomes, hydration markers, body water regulation, body composition, and energy balance remains insufficiently characterized, particularly in comparison with naturally menstruating athletes. In response to these gaps, this longitudinal observational study primarily aims to examine variations in strength-related outcomes across three distinct menstrual cycle phases (early follicular, late follicular, and mid-luteal) in eumenorrheic athletes. Secondary objectives include: (i) conducting within- and between-group comparisons of hydration status, energy balance, and strength outcomes (maximal, endurance, and explosive torque) in naturally menstruating athletes and oral contraceptive users; (ii) testing the reliability of methods used to assess body water, energy expenditure, and body composition across the menstrual cycle; (iii) exploring associations between energy availability, resting energy expenditure, and sex hormone concentrations across menstrual cycle phases; and (iv) testing, validating, and proposing methodological recommendations for the use of bioelectrical impedance analysis in tracking fluid-related changes across hormonal phases. To achieve these goals, the study will use a longitudinal observational design involving 40 female athletes, including 24 naturally menstruating athletes and 16 oral contraceptive users. Naturally menstruating athletes will be assessed during the early follicular, late follicular, and mid-luteal phases of the menstrual cycle, while oral contraceptive users will be assessed across pill-consumption and withdrawal phases. Measurements will be conducted across the three menstrual cycle phases and across oral contraceptive use phases, and will include: i) maximal voluntary isometric strength assessed using handgrip dynamometry, bench press, and leg press; ii) serum estrogen and progesterone; iii) body water and its compartments, and water turnover by dilution techniques; iv) hydration status by plasma osmolality, sodium, and vasopressin; v) energy balance by doubly labeled water and body composition changes; vi) resting energy expenditure by indirect calorimetry.",[69,70,28],"Menstrual Cycle","Oral Contraceptive Use",[72,73,74,75,76],"Muscle Strength","Sex Hormones","Fluid Balance","Energy Expenditure","Body Composition","RECRUITING","2026-05-11",{"date":80,"type":45},"2026-05-18",{"date":82,"type":45},"2026-04-01",{"date":84,"type":22},"2028-06-01",{"name":86,"class":52},"Faculdade de Motricidade Humana",{"id":88,"slug":89,"hasResults":11,"nctId":90,"briefTitle":91,"officialTitle":91,"acronym":4,"eligibilityCriteria":92,"healthyVolunteers":16,"sex":93,"minAge":18,"maxAge":63,"enrollmentInfo":94,"targetDuration":4,"studyType":23,"phases":96,"briefSummary":97,"conditions":98,"keywords":100,"overallStatus":77,"whyStopped":4,"lastUpdateSubmitDate":106,"lastUpdatePostDateStruct":107,"startDateStruct":109,"completionDateStruct":111,"leadSponsor":113,"locationsCount":53},"100615152","effects-of-pulsed-electromagnetic-field-therapy-on-sport-performance-and-recovery-100615152","NCT07288892","Effects of Pulsed Electromagnetic Field Therapy on Sport Performance and Recovery","Inclusion Criteria:\n\n* Exercise at least twice a week in the past 3 months\n* Perform resistance training 1-3 times per week in the past 3 months.\n* Have competed in at least two matches \u002F events in the past one year (e.g. heat and final are counted as two events).\n\nExclusion Criteria:\n\n* History of fracture or surgery over the past year.\n* History of musculoskeletal injury in the last 3 months that required more than 7 days of rest.\n* Currently experiencing any injury, discomfort and\u002For pain at the time of study.","ALL",{"count":95,"type":22},30,[25],"The goal of this clinical trial is to learn if pulsed electromagnetic field (PEMF) therapy works to improve sports performance and recovery in athletes. The main questions it aims to answer are:\n\n* Does PEMF therapy enhance participants' performance during exercise?\n* Does PEMF therapy enhance recovery in participants after exercise? Researchers will compare active PEMF therapy to sham PEMF therapy (using the same device for both, but without any electromagnetic fields) to see if active PEMF therapy is effective in improving sports performance and recovery.\n\nParticipants will:\n\n* Receive active pulsed electromagnetic field therapy or sham pulsed electromagnetic field therapy twice a week for 8 weeks.\n* Visit the laboratory at baseline, 8 weeks, and 12 weeks for sports performance and recovery assessments.",[30,99,28],"Sport Recovery",[101,102,103,104,105],"PEMF","Sport","Performance","Recovery","Exercise","2026-04-06",{"date":108,"type":45},"2026-04-08",{"date":110,"type":45},"2026-01-19",{"date":112,"type":22},"2026-08-30",{"name":114,"class":52},"Nanyang Technological University",{"id":116,"slug":117,"hasResults":11,"nctId":118,"briefTitle":119,"officialTitle":120,"acronym":4,"eligibilityCriteria":121,"healthyVolunteers":16,"sex":93,"minAge":18,"maxAge":63,"enrollmentInfo":122,"targetDuration":4,"studyType":23,"phases":124,"briefSummary":125,"conditions":126,"keywords":129,"overallStatus":77,"whyStopped":4,"lastUpdateSubmitDate":134,"lastUpdatePostDateStruct":135,"startDateStruct":136,"completionDateStruct":138,"leadSponsor":140,"locationsCount":53},"100632223","augmented-feedback-effects-on-shoulder-rotator-performance-100632223","NCT07510893","Augmented Feedback Effects on Shoulder Rotator Performance","Immediate and Retention Effects of Augmented Feedback on Isometric Peak Force and Rate of Force Development of Shoulder Rotators","Inclusion Criteria:\n\n* Healthy individuals aged between 18 and 30 years,\n* Body Mass Index (BMI) below 30 kg\u002Fm²,\n* An activity level of 5 or higher according to the Tegner Activity Scale,\n* Full active range of motion (ROM) in shoulder flexion, abduction, internal, and external rotation.\n\nExclusion Criteria:\n\n* Resence of current pain complaints,\n* Provocation of symptoms during at least one of the specific shoulder clinical tests (Neer Test, Hawkins-Kennedy Test, Jobe Test, Resisted External Rotation Test, and Apprehension Test),\n* History of any upper extremity injury, pain, or surgical intervention within the past 12 months,\n* Presence or history of hypertension, cardiovascular diseases, peripheral vascular diseases, deep vein thrombosis, neurological disorders, systemic inflammation, diabetes, cancer, or obesity,\n* Unwillingness to participate in the study.",{"count":123,"type":22},20,[25],"The existing literature demonstrates that motor learning strategies are effective in enhancing sports performance. One of these strategies, augmented feedback, is widely used in athletic training to help athletes achieve their goals more effectively, support the learning process, and motivate improvements in performance. Although studies in the literature have demonstrated the positive effects of augmented feedback provided during training on performance, no study has been found that examines the acute effects of such feedback on peak force and rate of force development during isometric training of the shoulder internal and external rotator muscles. The aim of this study is to investigate the acute effects of outcome feedback on isometric peak force and rate of force development during isometric training of the shoulder internal and external rotator muscles, as well as the short-term retention of these effects. It is expected that augmented feedback on isometric peak force and rate of force development, provided during isometric training of the shoulder internal and external rotator muscles, will have both acute and short-term retention effects on strength parameters. Healthy and physically active individuals will participate in isometric strength training targeting the dominant side shoulder internal and external rotator muscles across two separate sessions. Within a randomized crossover design, all participants will perform the isometric training program under two different conditions: with augmented feedback and without augmented feedback. The order of the conditions will be determined using a computer-based randomization program.To minimize potential learning effects, a washout period of 5-7 days will be provided between the two training conditions. Testing and training protocols will be conducted using an isometric dynamometer (ForceFrame, VALD Performance, Australia). The reported intraclass correlation coefficients (ICC) of the ForceFrame dynamometer for shoulder strength measurements range between 0.85 and 0.91, indicating good to excellent test-retest reliability. All testing and training procedures will be performed in accordance with the standard testing positions recommended by the manufacturer.",[127,28,128],"Performance Enhancement","Shoulder",[130,131,132,133,128,103],"Motor learning","Rotator cuff","Muscle strength","Knowledge of result","2026-03-31",{"date":106,"type":45},{"date":137,"type":45},"2026-03-01",{"date":139,"type":22},"2026-11-01",{"name":141,"class":52},"Elif Turgut",{"id":143,"slug":144,"hasResults":11,"nctId":145,"briefTitle":146,"officialTitle":147,"acronym":148,"eligibilityCriteria":149,"healthyVolunteers":16,"sex":93,"minAge":150,"maxAge":151,"enrollmentInfo":152,"targetDuration":4,"studyType":23,"phases":154,"briefSummary":155,"conditions":156,"keywords":167,"overallStatus":77,"whyStopped":4,"lastUpdateSubmitDate":173,"lastUpdatePostDateStruct":174,"startDateStruct":175,"completionDateStruct":177,"leadSponsor":179,"locationsCount":53},"100631596","pain-in-aging-former-athletes-masters-athletes-and-nonathletes-100631596","NCT07502742","Pain in Aging Former Athletes, Master's Athletes, and Nonathletes","Pain in Athletes INtervention (PAIN): A Randomized Crossover Clinical Trial in Aging Former Athletes, Master's Athletes, and Nonathletes","PAIN","Inclusion Criteria (General):\n\n* Age: 35 years through 65 years\n* Current master's athlete, former competitive athletes, or non-athlete control (see details below)\n* Ability to participate in exercise and exercise testing based on the Physical Activity Readiness Questionnaire (PAR-Q+)\n\nExclusion Criteria (General):\n\n* Currently pregnant or planning to become pregnant during the study\n* Currently taking heart rate lowering medications (e.g., betablockers) that would impact exercise testing\n* Contraindications to ice such as Raynaud's, cryoglobulinemia, cold urticaria, and\u002For impaired circulation or sensation\n* Fibromyalgia and\u002For chronic regional pain syndrome (CRPS)\n* Myocardial infarction or pulmonary embolism in the last 12 months, active cancer, a pacemaker, or any additional condition or disease that would preclude the individual from being able to perform the tests safely\n\nParticipants will be enrolled into one of the following three mutually exclusive groups according to the following criteria:\n\n1. Former Competitive Athlete: Prior participation in competitive sports at the Tier 3 level or above as per McKay et al. (2022): i.e., \"national-level representatives who are performing structured and\u002For periodized training and are developing proficiency in skills required to perform their sport at the highest level; this tier includes individuals participating in Provincial\u002FState or Academy Programs\" or higher participation in sport; Not currently participating in any recreational or competitive sports over the last 5 years (Tier 2 or above)\n2. Master's Athlete: Currently (within the past year) participating in sports at the Tier 2 level or above (i.e., committed to sports-specific training at least 3 times per week with the intent to compete)(McKay et al., 2022)\n3. Nonathlete Control: No prior participation in sport at the Tier 3 (Highly Trained\u002FNational) Level or above and not currently participating in any competitive sports (i.e., Tier 2 or above) (McKay et al., 2022) for at least 5 years","35 Years","65 Years",{"count":153,"type":22},90,[25],"The goal of this clinical trial is to determine how male and female former athletes experience pain and respond to moderate-intensity exercise (strength versus aerobic) compared with both current master's athletes and nonathletes.\n\nThe main questions this study aims to address are:\n\n1. How do former athletes, master's athletes, and nonathletes experience pain?\n2. How do different types of moderate-intensity exercise (strength versus aerobic exercise) influence pain in former athletes, master's athletes, and nonathletes?\n\nParticipants will complete 3 different testing sessions:\n\n1. Baseline testing including assessments of strength, cardiorespiratory fitness, and pain;\n2. Strength exercise: pain assessments will occur before and after moderate-intensity strength training exercise;\n3. Aerobic exercise: pain assessments will occur before and after moderate-intensity aerobic exercise.\n\nThere will be a washout period of approximately one week or greater between each of the three different testing sessions. The order of conditions (strength versus aerobic exercise) will be randomized (crossover randomized trial design).",[157,158,28,159,160,161,162,163,164,165,166],"Pain","Pain Management","Exercise Training","Sports Medicine","Strength Training Effects","Aerobic Exercise","Strength Training","Aging","Quality of Life","Sports",[168,169,157,170,171,105,172,164,102],"Former Athlete","Master's Athlete","Quantitative Sensory Testing","Randomized Crossover Clinical Trial","Rehabilitation","2026-03-27",{"date":134,"type":45},{"date":176,"type":45},"2026-03-02",{"date":178,"type":22},"2028-05",{"name":180,"class":52},"Marquette University",{"id":182,"slug":183,"hasResults":11,"nctId":184,"briefTitle":185,"officialTitle":185,"acronym":186,"eligibilityCriteria":187,"healthyVolunteers":16,"sex":93,"minAge":188,"maxAge":18,"enrollmentInfo":189,"targetDuration":4,"studyType":23,"phases":190,"briefSummary":191,"conditions":192,"keywords":195,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":200,"lastUpdatePostDateStruct":201,"startDateStruct":203,"completionDateStruct":205,"leadSponsor":206,"locationsCount":53},"100629584","clinical-trial-of-lactiplantibacillus-plantarum-dad-13-on-gut-microbiota-profile-and-performance-in-adolescent-athletes-100629584","NCT07476573","Clinical Trial of Lactiplantibacillus Plantarum Dad-13 on Gut Microbiota Profile and Performance in Adolescent Athletes","Dad-13","Inclusion Criteria:\n\n* Residing in the BPPLOP dormitory of Central Java Province;\n* Having a normal body mass index;\n* Being an athlete in an endurance sport;\n* Having no growth disorders\n\nExclusion Criteria:\n\n* Injury, any health contraindication or failure to perform exercise procedures;\n* Gastrointestinal infections, diseases, disorders;\n* Past history of gastrointestinal surgery;\n* Failure to follow the study protocol;\n* Declared general feeling of being unwell","12 Years",{"count":95,"type":22},[25],"The aim of this research is to analyze the effect of a Lactiplantibacillus plantarum Dad-13 supplementation on the gut microbiota profile and performance of adolescent athletes.",[28,193,103,194],"Probiotic","Gut Microbiota",[196,197,198,199],"athlete","probiotic","performance","gut microbiota","2026-03-19",{"date":202,"type":45},"2026-03-23",{"date":204,"type":22},"2026-04-13",{"date":112,"type":22},{"name":207,"class":52},"Gadjah Mada University",{"id":209,"slug":210,"hasResults":11,"nctId":211,"briefTitle":212,"officialTitle":213,"acronym":214,"eligibilityCriteria":215,"healthyVolunteers":16,"sex":93,"minAge":18,"maxAge":4,"enrollmentInfo":216,"targetDuration":4,"studyType":23,"phases":218,"briefSummary":219,"conditions":220,"keywords":223,"overallStatus":77,"whyStopped":4,"lastUpdateSubmitDate":176,"lastUpdatePostDateStruct":228,"startDateStruct":230,"completionDateStruct":232,"leadSponsor":234,"locationsCount":53},"100603401","preventing-athlete-under-fueling-through-nutrition-100603401","NCT07136038","Preventing Athlete Under-fueling Through Nutrition.","Prevention and Education for RED-S Through Fueling Outcomes and Research in Metabolic Health","PERFORM","Inclusion Criteria:\n\n1. Age range: from 18 years of age and up\n2. Currently active and NCAA-eligible (including academic standing) member of any Case Western Reserve University (CWRU) Athletic Team\n3. Signed Informed Consent\n\nExclusion Criteria:\n\n1. Under 18 years of age\n2. Pregnant women or women who are nursing\n3. Unwilling to provide anthropometrics, questionnaires or other collection needs\n4. History of a diagnosed disordered eating",{"count":217,"type":22},300,[25],"The goal is to improve nutrition screening and support for Division III athletes.\n\nThe study will use standard, low-risk nutrition screening methods, such as measuring height, weight, grip strength, and body composition, as well as having athletes complete questionnaires. Dietitians trained in sports nutrition will provide nutrition advice based on these screenings.\n\nData will be collected at three points during the season: before the season starts, mid-season, and after the season ends. This study builds on earlier research conducted at Case Western Reserve University that showed nutrition support can improve athletes' health and performance.",[28,221,222],"Relative Energy Deficiency in Sport","Low Energy Availability",[224,225,226,227],"collegiate","sport","lean body mass","fat mass",{"date":229,"type":45},"2026-03-04",{"date":231,"type":45},"2025-08-19",{"date":233,"type":22},"2026-12-31",{"name":235,"class":52},"Case Western Reserve University",{"id":237,"slug":238,"hasResults":11,"nctId":239,"briefTitle":240,"officialTitle":240,"acronym":241,"eligibilityCriteria":242,"healthyVolunteers":16,"sex":93,"minAge":18,"maxAge":4,"enrollmentInfo":243,"targetDuration":4,"studyType":66,"phases":4,"briefSummary":245,"conditions":246,"keywords":251,"overallStatus":77,"whyStopped":4,"lastUpdateSubmitDate":261,"lastUpdatePostDateStruct":262,"startDateStruct":264,"completionDateStruct":266,"leadSponsor":268,"locationsCount":53},"100623223","molecular-indicators-of-systematic-fitness-100623223","NCT07393841","Molecular Indicators of Systematic Fitness","MISFIT","Inclusion Criteria:\n\n* Be ≥18 years old\n* Be able to understand and provide informed consent (English; additional languages may be added via amendment with translated materials)\n* Be willing to complete VO₂max testing, blood draw, and questionnaires.\n* Be able to safely perform maximal\u002Fsymptom-limited exercise testing as determined by: PAR-Q+ screening and investigator review (included as an attachment) and resting vitals screening (heart rate)\n\nExclusion Criteria:\n\n* Conditions that, in the investigator's judgment, or a medical doctor, makes maximal exercise testing unsafe (e.g., unstable cardiovascular symptoms)\n* Contraindications or unwillingness to undergo venipuncture\n* Acute illness (fever, significant respiratory illness) at the time of testing\n* Failure to comply with procedures.",{"count":244,"type":22},250,"The goal of this study is to characterize associations between cardiorespiratory fitness, as measured by VO₂max\u002FVO₂peak, and blood-based molecular measurements in adults. This is an observational study where research staff measures VO₂max\u002FVO₂peak and collects fasted, resting blood samples on the same day. The main questions it aims to answer are:\n\n1. Can a multi-analyte blood panel accurately predict directly measured VO₂max\u002FVO₂peak?\n2. How do these blood-based features vary across age, sex, and self-reported or documented physical activity profiles?\n3. Are the predictor analytes able to capture changes in VO₂max\u002FVO₂peak caused by a self-directed intervention (e.g., training for a marathon)?\n4. What is the analytic reliability of the predictor biomarkers?",[247,248,28,164,249,250],"Healthy Adult","Fitness Testing","Exercise Physiology","Human Performance",[252,253,254,255,256,257,258,259,260],"VO2peak","VO2max","cardiorespiratory fitness","proteomics","blood biomarkers","cardiovascular health","oxygen transport","exercise performance","functional capacity","2026-02-02",{"date":263,"type":45},"2026-02-06",{"date":265,"type":45},"2026-01-05",{"date":267,"type":22},"2028-05-10",{"name":269,"class":270},"VO Health, Inc.","INDUSTRY",{"id":272,"slug":273,"hasResults":11,"nctId":274,"briefTitle":275,"officialTitle":276,"acronym":277,"eligibilityCriteria":278,"healthyVolunteers":11,"sex":93,"minAge":279,"maxAge":150,"enrollmentInfo":280,"targetDuration":4,"studyType":23,"phases":282,"briefSummary":283,"conditions":284,"keywords":287,"overallStatus":77,"whyStopped":4,"lastUpdateSubmitDate":292,"lastUpdatePostDateStruct":293,"startDateStruct":295,"completionDateStruct":297,"leadSponsor":299,"locationsCount":53},"100611665","fractal-vs-isochronous-cueing-in-athletes-after-acl-reconstruction-100611665","NCT07243535","Fractal vs Isochronous Cueing in Athletes After ACL Reconstruction","Comparison Between a Session of Walking Synchronized to Fractal- VS Isochronous-Based Cues on Gait Variability and Corticospinal Measures in Athletes With a Reconstructed Anterior Cruciate Ligament: A Crossover Randomized Controlled Trial","SyncGait","Inclusion Criteria:\n\n* Undergone unilateral ACL reconstruction less than 2 years ago;\n* Have medical release for the full load on the injury limb for at least 2 weeks;\n* Be independently pain-free walking;\n* Being sports athletes according to an athlete description: Training regularly to improve performance, actively participating in competitions or formally registering in a sports federation or association;\n* Must be able to understand and perform the requested task.\n\nExclusion Criteria:\n\n* Participants with previous surgery on either knee;\n* Those with more than 3 months between ACL injury and surgery;\n* More than 2 weeks between surgery and the start of physical therapy;\n* Had another musculoskeletal injury in the lower limb within the past 6 months;\n* Another musculoskeletal surgery within the past 18 months;\n* Participants with a history of movement system pathologies, such as nervous system, cardiovascular, pulmonary, integumentary, or endocrine conditions;\n* Participants with vestibular or somatosensory system pathologies or visual impairments limiting their ability to see the metronome required for the task;\n* Use of medications that could affect locomotion and balance.","15 Years",{"count":281,"type":22},36,[25],"Anterior cruciate ligament (ACL) injuries are among the most prevalent and functionally limiting knee injuries in sports, particularly those that involve pivoting movements. Despite advancements in surgical reconstruction and physical rehabilitation, many athletes continue to exhibit persistent motor control deficits and increased gait variability, both of which are closely linked to a heightened risk of re-injury and long-term joint degeneration. These deficits arise from biomechanical impairments and disrupt proprioceptive input that requires cortical reorganization, contributing to maladaptive neuroplasticity. However, conventional rehabilitation strategies often overlook this neural dimension. Recent findings emphasize the importance of fostering motor variability and promoting neuroplasticity through external focus strategies, including sensorimotor synchronization. While isochronous cues, an invariant stimulus, are commonly used, they do not reflect the natural fluctuations of healthy gait and may reduce its complexity. Fractal-based cues, in contrast, introduce structured variability resembling the natural dynamics of locomotion and have been shown to restore gait complexity in clinical populations. However, no study has yet explored their acute effects on gait variability and corticospinal function following ACL reconstruction (ACLR). This crossover randomized controlled trial aims to compare the acute effects of a single session of treadmill walking synchronized to either fractal or isochronous-based visual cues on gait variability and corticospinal measures in athletes with ACLR. The investigators hypothesize that fractal-based cueing will acutely restore gait variability and enhance corticospinal excitability, evidenced by increased corticospinal excitability and intracortical facilitation, and reduced short-interval intracortical inhibition, thus promoting adaptive neuroplasticity. Conversely, isochronous cueing is expected to maintain or decrease gait complexity without improving corticospinal measures. This study may provide insights that could be highly valuable as a way to promote neuroplasticity and optimize gait rehabilitation after ACLR, also allowing an objective quantification and aiming to restore variability to levels close to those observed in healthy individuals, thus contributing to reducing the re-injury rate.",[285,286,28],"Anterior Cruciate Ligament Reconstruction","Anterior Cruciate Ligament Reconstruction Rehabilitation",[288,289,290,291,172],"Complexity","Excitability","Metronome","Neuroplasticity","2025-11-17",{"date":294,"type":45},"2025-11-24",{"date":296,"type":45},"2025-10-03",{"date":298,"type":22},"2026-02",{"name":300,"class":52},"Egas Moniz - Cooperativa de Ensino Superior, CRL",{"id":302,"slug":303,"hasResults":11,"nctId":304,"briefTitle":305,"officialTitle":306,"acronym":307,"eligibilityCriteria":308,"healthyVolunteers":16,"sex":93,"minAge":18,"maxAge":4,"enrollmentInfo":309,"targetDuration":4,"studyType":66,"phases":4,"briefSummary":310,"conditions":311,"keywords":316,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":322,"lastUpdatePostDateStruct":323,"startDateStruct":325,"completionDateStruct":327,"leadSponsor":329,"locationsCount":53},"100594064","using-heart-electrical-signals-to-study-how-well-treatments-prevent-dangerous-heart-rhythms-in-active-people-100594064","NCT07014579","Using Heart Electrical Signals to Study How Well Treatments Prevent Dangerous Heart Rhythms in Active People","Utilizing LifeMap To Investigate Malignant Arrhythmia Therapeutic Efficacy in Athletes","ULTIMATE-A","Inclusion Criteria:\n\n* Age 18 and over.\n* Participates in regular physical activity for at least 3 hours or greater weekly.\n* Having Implantable cardioverter defibrillator insitu (cases).\n* Having a cardiac pacemaker (control).\n* Having no cardiac device (control).\n* Sufficient capacity and agreement to participate orally and signed written consent forms.\n* Understanding of written and spoken English language.\n\nExclusion Criteria:\n\n* Pregnancy, as detected by positive urine pregnancy test result.\n* Inability to comply with study protocols.\n* Any iatrogenic cardiac pathology (stents, CABG etc).\n* Unstable ventricular tachycardia (\\>30 seconds).\n* Any unstable malignant arrhythmia.\n* Fever or presence of a clinically diagnosed febrile illness",{"count":65,"type":22},"The goal of this observational study is to learn if two specific heart electrical signal patterns can help in detecting the risk of dangerous heart rhythms in athletes, and to see if exercise-based tests can be used instead of invasive hospital procedures to record this electrical signals.\n\nThe main questions it aims to answer are:\n\n1. Can special ECG action potential duration markers (R2I2 and PERS) identify athletes who are at higher risk of sudden heart rhythm problems.\n2. Can an exercise test give the same information as a non-invasive electrophysiology study.\n\nResearchers will compare athletes who have an implanted heart device (ICD) with athletes who do not, to see if there are differences in these heart signals.\n\nParticipants will undergo:\n\n1. ECG recordings during rest and exercise.\n2. If they have an ICD or pacemaker, an ECG will be recorded during a non invasive stimulation.\n3. A continuous 24 hour ECG.",[312,313,314,28,315],"Inherited Cardiac Conditions","Sudden Cardiac Arrest","Ventricular Arrhythmia","Ventricular Fibrillation",[317,318,319,320,314,315,321],"ULTIMATE-Athlete","LifeMap","R2I2","PERS","Sudden Cardiac Death","2025-06-09",{"date":324,"type":45},"2025-06-11",{"date":326,"type":22},"2025-06-01",{"date":328,"type":22},"2026-07-31",{"name":330,"class":52},"University of Leicester",{"id":332,"slug":333,"hasResults":11,"nctId":334,"briefTitle":335,"officialTitle":336,"acronym":337,"eligibilityCriteria":338,"healthyVolunteers":16,"sex":93,"minAge":18,"maxAge":151,"enrollmentInfo":339,"targetDuration":4,"studyType":66,"phases":4,"briefSummary":341,"conditions":342,"keywords":345,"overallStatus":77,"whyStopped":4,"lastUpdateSubmitDate":351,"lastUpdatePostDateStruct":352,"startDateStruct":354,"completionDateStruct":356,"leadSponsor":358,"locationsCount":53},"100583854","lifestyle-and-nutrition-evaluation-in-physically-active-people-and-athletes-100583854","NCT06881745","Lifestyle and Nutrition Evaluation in Physically Active People and Athletes","NUTRI_ACTIVE Study: Lifestyle and Nutrition Evaluation in Physically Active People and Athletes","NUTRI_ACTIVE","Inclusion Criteria:\n\n* Age: ≥ 18 years old and ≤ 65 years old\n* Regular physical activity (at least 150 minutes of moderate-intensity aerobic physical activity; or at least 75 of vigorous-intensity aerobic physical activity; or an equivalent combination of moderate- and vigorous-intensity activity throughout the week)\n* All genders\n\nExclusion Criteria:\n\n* Sedentary population: \\\u003C 150 minutes of moderate-intensity aerobic physical activity or \\\u003C 75 minutes of vigorous-intensity aerobic physical activity throughout the week\n* Age: \\\u003C 18 years old and \\> 65 years old\n* Presence of diseases (i.e. diabetes, hypertension, dyslipidemia, metabolic syndrome, neurological diseases,…) and\u002For injuries",{"count":340,"type":22},181,"The goal of this observational study is to explore the dietary intake, nutrition knowledge and body composition in Italian athletes and physically active adults. This is a nonprofit study aimed at improving clinical practice. The main questions it aims to answer are:\n\n* Assessment of level of adherence to Mediterranean Diet using MEDI-LITE questionnaire\n* Assessment of nutrition knowledge\n* Current dietary intake and eating habits evaluation and comparison to the recommendations, according to sport practised\n* Eating behaviour assessment\n\nParticipants will undergo the following assessments: anthropometric and body composition assessments, Resting Metabolic Rate measurement, Dietary intake assessment, Nutrition knowledge, Lifestyle and behaviour, Physical activity assessment.",[343,344,76,28],"Dietary Habits","Nutritional Status",[346,347,348,349,350],"Mediterranean Diet","Physical Activity","Athletes","Nutritional status","Nutrition knowledge","2025-03-11",{"date":353,"type":45},"2025-03-18",{"date":355,"type":45},"2024-07-05",{"date":357,"type":22},"2026-02-28",{"name":359,"class":52},"University of Pavia",{"id":361,"slug":362,"hasResults":11,"nctId":363,"briefTitle":364,"officialTitle":365,"acronym":4,"eligibilityCriteria":366,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":367,"enrollmentInfo":368,"targetDuration":4,"studyType":23,"phases":370,"briefSummary":371,"conditions":372,"keywords":373,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":377,"lastUpdatePostDateStruct":378,"startDateStruct":380,"completionDateStruct":382,"leadSponsor":384,"locationsCount":4},"100573840","the-effect-of-inspiratory-muscle-warm-up-on-decreased-diffusing-capacity-for-carbon-monoxide-after-maximal-exercise-in-athletes-100573840","NCT06751511","The Effect of Inspiratory Muscle Warm-up on Decreased Diffusing Capacity for Carbon Monoxide After Maximal Exercise in Athletes","The Effect of Inspiratory Muscle Warm-up on Decreased Diffusing Capacity for Carbon Monoxide After Maximal Exercise in Athletes: a Randomized, Placebo-controlled, Double-blind and Crossover Study","Inclusion Criteria:\n\n* Age between 18-24 years.\n* A training history of at least six years.\n* Regular training frequency of at least four sessions per week.\n\nExclusion Criteria:\n\n* History of smoking.\n* History of physical disability or acute respiratory or cardiovascular disease within the past three months.\n* Diagnosis of SARS-CoV-2 within the past three months.\n* Pulmonary function measurements outside the normal clinical range (≤ 80%).","24 Years",{"count":369,"type":22},28,[25],"This study aims to examine the effects of inspiratory muscle warm-up (IMW) on the gas exchange capacity of the lungs (DLCO) and its potential contribution to recovery and athletic performance in elite athletes from various disciplines. The study hypothesizes that the decline in respiratory muscle capacity following high-intensity exercise, which negatively affects ventilation, diffusion, and oxygen transport, may be ameliorated through specific IMW protocol. A placebo-controlled, randomized, crossover, and double-blind design will be utilized, involving 28 elite male athletes from endurance, power, skill-based, and mixed disciplines.\n\nParticipants will complete three warm-up protocols: General Warm-up (GW), General Warm-up combined with IMW at 40% resistance intensity (GW+IMW40%), and a placebo condition (GW+IMWplacebo). Measurements will include respiratory muscle strength, DLCO (assessed at post-2, 30, 60, 90, and 120 minutes), respiratory function, and cardiorespiratory parameters during maximal exercise. This study is unique as it aims to detail the micro-level effects of IMW on pulmonary diffusion mechanisms and performance outcomes, providing novel insights into the ameliorative effects of IMW on respiratory function post-exercise. Additionally, it seeks to expand understanding of the mechanistic basis of IMW's benefits on both pulmonary diffusion capacity and athletic performance.",[28],[374,375,376],"warm-up","inspiratory muscle warm-up","respiratory muscle warm-up","2024-12-27",{"date":379,"type":45},"2024-12-30",{"date":381,"type":22},"2025-01-15",{"date":383,"type":22},"2025-01-30",{"name":385,"class":52},"Emre Karaduman",{"id":387,"slug":388,"hasResults":11,"nctId":389,"briefTitle":390,"officialTitle":391,"acronym":4,"eligibilityCriteria":366,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":367,"enrollmentInfo":392,"targetDuration":4,"studyType":23,"phases":394,"briefSummary":395,"conditions":396,"keywords":398,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":400,"lastUpdatePostDateStruct":401,"startDateStruct":402,"completionDateStruct":403,"leadSponsor":404,"locationsCount":4},"100572666","the-effect-of-respiratory-muscle-warm-up-on-pulmonary-diffusion-capacity-in-athletes-100572666","NCT06736236","The Effect of Respiratory Muscle Warm-up on Pulmonary Diffusion Capacity in Athletes","Effects of Inspiratory Muscle Warm-up on Diffusion Capacity for Carbon Monoxide, Cardiorespiratory, Perceptual and Performance Outcomes During High-intensity Exercise in Elite Athletes from Different Disciplines: a Randomized, Placebo-controlled, Double-blind and Crossover Study",{"count":393,"type":22},35,[25],"Several studies suggest that inspiratory muscle warm-up (IMW) could potentially affect exercise performance; however, its mechanistic basis is still unclear. The aim of this study was to examine the effect of IMW on lung diffusing capacity for carbon monoxide, cardiorespiratory, perceptual and performance outcomes in elite athletes from different disciplines.\n\nThe aim of this study is to evaluate the effects of IMW on diffusion capacity for carbon monoxide, cardiorespiratory, perceptual and performance outcomes during high-intensity exercise in elite athletes from different disciplines. The study will be conducted using a randomized, placebo-controlled, double-blind and crossover study experimental design involving 35 athletes from various sports disciplines, including endurance, strength, skill-based, and mixed disciplines.\n\nParticipants will attend the laboratory on four separate occasions. During the first visit, they will be informed about the study and familiarized with the application and measurement procedures. In the second visit, a general warm-up will be performed. During the third and fourth visits, IMW (IMW40% or IMW placebo) protocols will be applied in addition to the general warm-up. Measurements of DLCO, pulmonary function tests, respiratory muscle strength, and gas analysis during maximal aerobic exercise will be collected both before and after the warm-up protocols.",[397,28],"Healty Male Volunteers",[375,374,399],"DLCO","2024-12-20",{"date":377,"type":45},{"date":379,"type":22},{"date":381,"type":22},{"name":385,"class":52},{"id":406,"slug":407,"hasResults":11,"nctId":408,"briefTitle":409,"officialTitle":409,"acronym":4,"eligibilityCriteria":410,"healthyVolunteers":16,"sex":93,"minAge":411,"maxAge":150,"enrollmentInfo":412,"targetDuration":4,"studyType":23,"phases":413,"briefSummary":414,"conditions":415,"keywords":420,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":422,"lastUpdatePostDateStruct":423,"startDateStruct":425,"completionDateStruct":427,"leadSponsor":429,"locationsCount":53},"100562717","the-effects-of-cervical-and-thoracic-manipulation-therapy-applied-to-weightlifting-athletes-100562717","NCT06606795","The Effects of Cervical and Thoracic Manipulation Therapy Applied to Weightlifting Athletes","Inclusion Criteria:\n\n* Being a weightlifter,\n* Having asymptomatic dysfunction in the cervical and thoracic spine,\n* Not having received any manipulative treatment in the last six months,\n* Individuals who do not have a condition that prevents chiropractic manipulation treatment will be included in the study.\n\nExclusion Criteria:\n\n* Having had an injury related to the musculoskeletal system in the upper and lower extremities in the last month,\n* Having any neurological and psychiatric disorders,\n* Having cervical disc herniations,\n* Having a disorder related to the cardiac and respiratory systems,\n* Having an infectious, rheumatological, metabolic and endocrinological disorder,\n* Having dislocation, osteoporosis, ankylosing spondylitis, discopathy, rheumatoid arthritis,\n* Taking anticoagulant treatment,\n* Individuals who have recently undergone an operation involving the cervical and thoracic regions will not be included in the study.","13 Years",{"count":65,"type":22},[25],"The effects of manipulation therapy on the autonomic nervous system have been examined in the literature and while no sympathetic or parasympathetic changes were found after upper thoracic manipulation, a decrease in sympathetic data was observed after lower thoracic manipulation and an increase in parasympathetic data was observed. On the other hand, a different study found that thoracic manipulation did not cause any changes such as an increase or decrease in the autonomic nervous system. Therefore, although there are uncertainties in the autonomic role of manipulation therapy, its effect on respiration is intriguing when positive studies are considered.\n\nIn a study aiming to evaluate the effect of thoracic manipulation on respiratory function, segmental manipulation treatment was applied to healthy individuals by detecting the vertebrae in the thoracic region where normal joint movements were lost, and it was determined that the respiratory functions of the manipulation group improved significantly compared to the group that did not receive treatment. In another study conducted on healthy individuals, the subjects were divided into manipulation group, exercise and manipulation group and control groups. At the end of the study, it was determined that there was a significant increase in the respiratory functions of the participants in the manipulation group, while an additional increase was observed in the group combined with exercise, but this was not significant. No change was observed in the control group.\n\nWhen the literature is examined, it is noteworthy that the effects of manipulation treatments on respiration remain unclear, and especially the inadequacy of studies on Olympic-style weightlifters and the ongoing search for increasing athletic performance in this area.\n\nThis study aims to examine the effects of cervical and thoracic manipulation treatments on respiratory muscle strength, respiratory functions and cervical and thoracic region joint range of motion in weightlifters.\n\nThe main question it aims to answer is:\n\n\\- Is cervical and thoracic manipulation therapy applied to Olympic style weightlifters effective on respiration?",[416,417,418,28,419],"Weightlifting","Breathing","Breath Tests","Spinal Manipulation",[416,421,417,419,28],"Chiropractic","2024-09-19",{"date":424,"type":45},"2024-09-23",{"date":426,"type":22},"2024-10-04",{"date":428,"type":22},"2025-04-01",{"name":430,"class":52},"Selcuk University"]