[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"athletes\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:athletes":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,12,0,[8,46,78,105,132,165,244,272,303,331,361,388],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":29,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":4},"100642465","the-effect-of-muscular-fatigue-on-lower-limb-kinematics-during-single-leg-drop-landing-in-female-athletes-100642465",false,"NCT07648537","The Effect of Muscular Fatigue on Lower Limb Kinematics During Single-Leg Drop Landing in Female Athletes","SLD","Inclusion Criteria:\n\n* Female volleyball players aged 20-25 years\n* Practice professional volleyball training or competition experience of at least 2 years\n* typically engage in a high volume of training, with regular participation in at least five training sessions per week\n* Willingness to adhere to fatigue protocol and provide informed consent\n\nExclusion Criteria:\n\n* Current or recent (within the past 6 months) lower limb injury or medical condition\n* History of lower limb surgeries\n* Neurological disorders or balance impairments .\n* Experiencing pain or discomfort during jumping or landing tasks\n* Body mass index (BMI) greater than 30 kg\u002Fm²\n* Inability to comply with the fatigue protocol or follow instructions for the landing tasks",true,"FEMALE","20 Years","25 Years",{"count":21,"type":22},35,"ESTIMATED","INTERVENTIONAL",[25],"NA","this study will be conducted to investigate the effect of muscular fatigue on lower limb kinematics during single-leg drop landing in female professional volleyball players using a mobile-based motion analysis application.",[28],"Athletes",[30,31,32,33],"Muscular Fatigue","Lower Limb Kinematics","Single-Leg Drop Landing","Female Athletes","NOT_YET_RECRUITING","2026-06-10",{"date":37,"type":38},"2026-06-15","ACTUAL",{"date":40,"type":22},"2026-06-30",{"date":42,"type":22},"2026-12-20",{"name":44,"class":45},"Cairo University","OTHER",{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":52,"eligibilityCriteria":53,"healthyVolunteers":16,"sex":54,"minAge":18,"maxAge":55,"enrollmentInfo":56,"targetDuration":58,"studyType":59,"phases":4,"briefSummary":60,"conditions":61,"keywords":64,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":4},"100635117","understanding-the-relationship-of-body-composition-and-metabolism-in-adult-and-older-filipino-endurance-and-strength-athletes-in-the-philippines-100635117","NCT07548515","Understanding the Relationship of Body Composition and Metabolism in Adult and Older Filipino Endurance and Strength Athletes in the Philippines","Understanding the Relationship of Body Composition and Metabolism in Adult and Older Filipino Endurance and Strength Athletes in the Philippines (NPOWER P1)","NPOWER P1","Inclusion Criteria (Athletes):\n\n* Male or female athletes aged 20-40 (early and mid-adults) and 60-69 (older adults)\n* Natural-born Filipinos with maternal and paternal Filipino heritage\n* Current and former national and professional athletes, actively participating in endurance or strength sports events or recreational sports events\n* Current off-season athletes undergoing training or former professional athletes who played \\\u003C3 years ago\n* With ≥3 years of formal, structured athletic training\n* Apparently healthy (no cardiovascular conditions, respiratory diseases, musculoskeletal disorders, neurological conditions and metabolic disorders)\n* Ambulatory and can perform physical activity exercises such as treadmill walking\u002Frunning and stationary bike\n* Cleared by a physician to participate in exercise testing; for older adults, clearance must be based on electrocardiogram (ECG) results.\n\nInclusion Criteria (Non-Athletes):\n\n* Age (+3 years) and sex-matched community-dwelling participants\n* Natural-born Filipinos with maternal and paternal Filipino heritage\n* Not involved in structured or competitive exercise training\n* Apparently healthy (no cardiovascular conditions, respiratory diseases, musculoskeletal disorders, neurological conditions and metabolic disorders)\n* Ambulatory and can perform physical activity exercises such as treadmill walking\u002Frunning and stationary bike\n* Cleared by a physician to participate in exercise testing; for older adults, clearance must be based on electrocardiogram (ECG) results.\n\nExclusion Criteria (Athletes and Non-Athletes):\n\n* Unable to comprehend and answer the questions\n* Presence of metal implants and\u002For pacemaker\n* Has limited mobility and a history of orthopedic surgery (that may limit their mobility)\n* With medically diagnosed severe diseases that could affect body composition or metabolism (i.e., cardiovascular diseases, diabetes, cancer, renal diseases, thyroid disorders)\n* Experienced minor or major injury in the past 3 months that will inhibit the performance\n* Taking prohibited sports substances banned by the World Anti-Doping Program that may influence the performance of exercise\n* Taking medications that can affect metabolism (e.g., mood stabilizers, GLP-1 receptor agonists etc.)\n* Current smoker or Electronic Nicotine Delivery System (ENDS; vape, e-cigarette) smoker","ALL","69 Years",{"count":57,"type":22},120,"3 Days","OBSERVATIONAL","This study aims to address the gap by investigating the correlation between body composition and metabolism in adult and older Filipino endurance and strength athletes. It seeks to offer significant insights that can guide age- and sport-specific training programs, nutritional strategies, and health interventions adapted to the requirements of Filipino athletes. The results may help enhance the wider discussion on fostering healthy aging and athletic longevity in the Philippines.",[62,28,63],"Nutrition Physiology","The Focus of This Study is to Describe the Body Composition and Metabolism of Athletes and Non-athletes",[65,66,67,28],"Body composition","metabolism","aerobic capacity","2026-04-21",{"date":70,"type":38},"2026-04-23",{"date":72,"type":22},"2026-05-01",{"date":74,"type":22},"2027-01-31",{"name":76,"class":77},"Food and Nutrition Research Institute, Philippines","OTHER_GOV",{"id":79,"slug":80,"hasResults":11,"nctId":81,"briefTitle":82,"officialTitle":83,"acronym":4,"eligibilityCriteria":84,"healthyVolunteers":11,"sex":54,"minAge":85,"maxAge":86,"enrollmentInfo":87,"targetDuration":4,"studyType":23,"phases":89,"briefSummary":90,"conditions":91,"keywords":4,"overallStatus":94,"whyStopped":4,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":104},"100567316","bone-stimulator-for-spondylolysis-100567316","NCT06666608","Bone Stimulator for Spondylolysis","The Efficacy of Bone Stimulator in Treatment and Return-to-Sport for Spondylolysis","Inclusion Criteria:\n\n* Patients between the ages of 16 to 40 years of age diagnosed with symptomatic spondylolysis by one of the investigators\n* Patients who plan to attend prescribed physical therapy\n* Patients who participate in a regular sport whether that be professional, collegiate or recreational\n\nExclusion Criteria:\n\n* Any condition which in the investigator's opinion, would interfere with the subject's ability to comply with study instructions\n* Patients with contraindications to bone stimulator therapy\n* Patients with pacemaker and implantable cardioverter defibrillator\n* Patients with previous spine surgery\n* Patients with metabolic bone conditions\n* Patients who use nicotine products\n* Vulnerable populations\n* Non-English speaking services","16 Years","40 Years",{"count":88,"type":22},48,[25],"This prospective study aims to investigate the effectiveness of bone stimulator therapy as adjunct treatment of spondylolysis in athletic populations. By evaluating its impact on pain reduction, functional improvement, osseous bony union and return-to-sport time, the investigators seek to provide valuable insights into the role of bone stimulation therapy as a potential treatment modality for this challenging condition.",[92,93,28],"Spondylolysis","Symptomatic Spondylolysis","RECRUITING","2026-03-24",{"date":97,"type":38},"2026-03-25",{"date":99,"type":38},"2025-12-03",{"date":101,"type":22},"2029-12",{"name":103,"class":45},"The Methodist Hospital Research Institute",1,{"id":106,"slug":107,"hasResults":11,"nctId":108,"briefTitle":109,"officialTitle":110,"acronym":4,"eligibilityCriteria":111,"healthyVolunteers":11,"sex":54,"minAge":112,"maxAge":113,"enrollmentInfo":114,"targetDuration":4,"studyType":23,"phases":116,"briefSummary":117,"conditions":118,"keywords":4,"overallStatus":94,"whyStopped":4,"lastUpdateSubmitDate":123,"lastUpdatePostDateStruct":124,"startDateStruct":126,"completionDateStruct":128,"leadSponsor":130,"locationsCount":104},"100611439","acute-effects-of-different-warm-up-protocols-in-competitive-young-swimmers-100611439","NCT07240597","Acute Effects of Different Warm-Up Protocols in Competitive Young Swimmers","Acute Effects of Different Potentiation Protocols During Warm-Up in Competitive Young Swimmers: A Randomized Crossover Trial","Inclusion Criteria:\n\n* Active participation in competitive training programs (at least 10 hours per week), at least one year of experience in competitions organized by the Italian Swimming Federation, and no recent injuries.\n* Experience of resistance training for at least 6 months\n\nExclusion Criteria:\n\n* Irregular training participation\n* History of injuries in the 6 months prior to the study","11 Years","18 Years",{"count":115,"type":22},15,[25],"Several warm-up strategies are commonly employed by athletes to optimize athletic performance and minimize the risk of injury. Recently, Post-Activation Performance Enhancement (PAPE) has been demonstrated to be effective in improving athletic performance. Nevertheless, the difference with the general warm-up is still unclear and poorly studied. Conventionally, short-term performance improvements achieved after brief periods of maximal activity have been attributed to PAP, a muscle memory mechanism that generates involuntary and short-lived effects (\\~28 seconds). This condition appears to be activated only by a history of localized maximal contractions. In the literature, various conditioning protocols with differing durations and intensities have been explored, often finding conflicting results in terms of athletic performance. In swimming, few PAPE warm-up protocols outside the pool have been studied, despite their potential usefulness considering the waiting times before competitions.\n\nTherefore, this study explores the effects of three different warm-up protocols in young swimmers. Specifically, different exercise protocols will be included in the athletes' usual warm-up routine, aimed at improving athletic performance through PAPE effects. In line with existing literature, the performance parameters examined are the countermovement jump (CMJ) and the times recorded for covering race distances ( 25 m, 50 m, 100 m). In addition, skin temperature, heart rate (HR), muscle oxygen saturation (SmO2), and perceived exertion (RPE) are also measured after the protocols to investigate possible relationships with performance measures. Nevertheless, the primary aim of this study is to compare different warm-up protocols in young swimmers to maximize their athletic performance.",[28,119,120,121,122],"Post Activation Potentiation","Countermovement Jump","Performance","Warm-up","2025-11-16",{"date":125,"type":38},"2025-11-21",{"date":127,"type":22},"2025-12-02",{"date":129,"type":22},"2026-02",{"name":131,"class":45},"University of Palermo",{"id":133,"slug":134,"hasResults":11,"nctId":135,"briefTitle":136,"officialTitle":137,"acronym":4,"eligibilityCriteria":138,"healthyVolunteers":16,"sex":54,"minAge":139,"maxAge":140,"enrollmentInfo":141,"targetDuration":4,"studyType":23,"phases":143,"briefSummary":144,"conditions":145,"keywords":148,"overallStatus":94,"whyStopped":4,"lastUpdateSubmitDate":156,"lastUpdatePostDateStruct":157,"startDateStruct":159,"completionDateStruct":161,"leadSponsor":163,"locationsCount":104},"100593097","the-effects-of-scapular-stabilization-exercises-in-traditional-archery-athletes-100593097","NCT07002008","The Effects of Scapular Stabilization Exercises in Traditional Archery Athletes","The Effects of Scapular Stabilization Exercises on Shooting Accuracy and Upper Extremity Performance in Traditional Archery Athletes: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Aged 15 to 35 years\n\nLicensed traditional archers with at least 2 years of experience\n\nRegular participation in training programs\n\nWillingness to participate and provide informed consent\n\nExclusion Criteria:\n\n* History of upper extremity orthopedic surgery in the past year\n\nExisting musculoskeletal disorders in the upper extremity\n\nPresence of any neurological disease","15 Years","35 Years",{"count":142,"type":22},30,[25],"This randomized controlled trial aims to investigate the effects of an 8-week scapular stabilization exercise program on shooting accuracy and upper extremity performance in athletes engaged in traditional archery. Thirty licensed archers aged between 15 and 35, with at least 2 years of experience, will be randomly assigned to an intervention group or a control group. The intervention group will receive scapular stabilization exercises in addition to their regular training, while the control group will continue their usual training routine. Pre- and post-intervention evaluations will assess upper extremity strength, stability, proprioception, and shooting performance.",[28,146,147],"Exercise","Archery",[149,150,151,152,153,154,155],"traditional archery","scapular stabilization","shooting performance","strength","balance","endurance","proprioception","2025-07-04",{"date":158,"type":38},"2025-07-10",{"date":160,"type":38},"2025-05-01",{"date":162,"type":22},"2025-07",{"name":164,"class":45},"Karabuk University",{"id":166,"slug":167,"hasResults":11,"nctId":168,"briefTitle":169,"officialTitle":169,"acronym":170,"eligibilityCriteria":171,"healthyVolunteers":16,"sex":54,"minAge":113,"maxAge":172,"enrollmentInfo":173,"targetDuration":4,"studyType":23,"phases":175,"briefSummary":177,"conditions":178,"keywords":215,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":236,"lastUpdatePostDateStruct":237,"startDateStruct":239,"completionDateStruct":241,"leadSponsor":242,"locationsCount":104},"100565622","phase-1-evaluating-the-efficacy-and-safety-of-prosomnia-sleep-therapy-in-patients-with-sleep-deprivation-and-chronic-insomnia-100565622","NCT06644573","Evaluating the Efficacy and Safety of PROSOMNIA Sleep Therapy™ in Patients With Sleep Deprivation and Chronic Insomnia","PSHW","By adhering to the following criteria, the study aims to select a population that can safely undergo the PROSOMNIA Sleep therapy and for whom the therapy is most likely to be beneficial, ensuring the reliability and validity of the study outcomes.\n\nINCLUSION CRITERIA:\n\n1. Age Range: 18-65 years of age Reason: This age range includes adults who are most likely to benefit from the PROSOMNIA Sleep therapy and who can provide informed consent. It also excludes children and older adults who may have different physiological responses or additional health risks.\n2. Diagnosed or Undiagnosed Chronic Insomnia:\n\n   Reason: Included subjects have a consistent pattern of sleep disturbances that PROSOMNIA Sleep Therapy aims to treat.\n3. Diagnosed or Undiagnosed Sleep Deprivation:\n\n   Reason: Includes individuals who are not getting enough sleep quantity, which is a key condition that the PROSOMNIA Sleep Therapy aims to address.\n4. Diagnosed or Undiagnosed REM Sleep Inconsistencies:\n\n   Reason: Includes individuals who are not getting enough sleep quality and those with specific REM sleep phase issues that the PROSOMNIA Sleep Therapy is designed to improve.\n5. Failure to Respond to Conventional Sleep Treatments:\n\n   Reason: Focuses on subjects who have not found relief from existing sleep therapies, ensuring that the study population represents those in need of alternative solutions.\n6. Ability to Provide Informed Consent:\n\nReason: Ensures that participants understand the study and agree to participate voluntarily.\n\nEXCLUSION CRITERIA:\n\n1. Severe Obesity (BMI \\> 40):\n\n   Reason: Severe obesity can increase the risk of complications with anesthesia and may affect sleep patterns in ways that could confound study results.\n2. Cardiovascular Conditions:\n\n   Reason: Patients with significant heart conditions are at higher risk for complications during anesthesia.\n3. Neurological Disorders:\n\n   Reason: These diagnosed conditions and medications such as epilepsy could interfere with sleep patterns and responses to sleep therapy.\n4. Other Health Conditions Contraindicating Anesthesia:\n\n   Reason: Includes any condition that would make the use of anesthesia unsafe.\n5. Greater than ASA II Status:\n\n   Reason: The American Society of Anesthesiologists (ASA) physical status classification system classifies patients based on their pre-anesthesia medical conditions. Excluding those above ASA II ensures that only patients with mild systemic disease are included, to minimize risks.\n6. Current Use of Prohibited Medications:\n\n   Reason: Medications that could interfere with the combined use of anesthesia including, but not limited to sedatives and hypnotics; such as benzodiazepines, Z-drugs and barbiturates.\n7. Pregnancy or Breastfeeding:\n\nReason: Ensures the safety of the fetus or infant, as the effects of the PROSOMNIA Sleep therapy on pregnancy or lactation are unknown.","65 Years",{"count":174,"type":22},100,[176],"PHASE1","This clinical trial aims to evaluate the safety and efficacy of PROSOMNIA Sleep Therapy (PSTx) for individuals suffering from chronic insomnia, sleep deprivation, and REM sleep disorders. Chronic insomnia, characterized by difficulty falling or staying asleep, significantly affects patients and quality of life, mood, and cognitive function. REM sleep disorders, in which the body struggles to enter or maintain restful REM sleep, can worsen these issues. The trial introduces a novel therapy using anesthesia-induced sleep, targeting sleep homeostasis and improving sleep architecture.\n\nObjectives: The primary goals of the trial are to determine:\n\n1. Whether PROSOMNIA Sleep Therapy increases the quality of REM sleep.\n2. Whether PSTx increases the duration of REM and\u002For NREM sleep.\n3. Whether PSTx decreases the time it takes participants to fall asleep (sleep onset latency).\n\nParticipants will receive ONE (1) PROSOMNIA Sleep Therapy session lasting between 60-120 minutes. Each session uses Diprivan\u002FPropofol to induce sleep, and is monitored via an EEG to ensure proper sleep stages, particularly REM sleep.\n\nParticipant Criteria:\n\nInclusion: Adults aged 18-65 with diagnosed or undiagnosed chronic insomnia or sleep deprivation.\n\nExclusion: Patients with severe obesity, significant cardiovascular, neurological, or psychiatric conditions, or those with an ASA status above II.\n\nStudy Design: This trial is non-randomized, single-arm and open-label, with all participants receiving the PSTx. The trial does not include a comparison group, as the focus is on evaluating the immediate, direct effects of the therapy.\n\nParticipants will undergo continuous EEG monitoring during therapy sessions, allowing researchers to track brain activity and sleep stages in real-time. This method ensures that sleep cycles, particularly REM sleep, are optimized for therapeutic benefit.\n\nTherapy Methodology:\n\nPROSOMNIA Sleep Therapy leverages anesthesia to mimic natural sleep patterns and enhance the efficiency of REM sleep. Diprivan\u002FPropofol is used to induce REM sleep, while EEG monitoring tracks and maintains proper sleep architecture throughout the session. The therapy promotes the clearance of adenosine, a compound that builds up during wakefulness and drives the need for sleep. Adenosine is cleared during REM sleep, reducing sleep pressure and improving cognitive function.\n\nOutcome Measures:\n\nPrimary Outcomes: Researchers will measure the increase in REM sleep duration, improvement in sleep quality (via self-reported questionnaires), and a reduction in sleep onset latency.\n\nSecondary Outcomes: These include changes in mood, cognitive function, and blood serum uric acid levels. Patient-reported outcomes will also be tracked through tools like the PROSOMNIA Sleep Quiz, which is specifically designed for PSTx.\n\nSignificance: Chronic insomnia and REM sleep disorders affect millions globally, leading to cognitive impairment, mood disturbances, and poor overall health. Traditional treatments, including pharmacological approaches and Cognitive Behavioral Therapy for Insomnia (CBT-I), often provide suboptimal results for many individuals. PSTx offers a novel, therapeutic approach to restoring sleep balance and enhancing the overall quality of sleep, particularly for those who have not responded to conventional treatments.\n\nStudy Process:\n\nRecruitment and Baseline Assessments: Participants undergo a comprehensive sleep assessment, including sleep questionnaires and polysomnography, to establish a baseline for sleep quality and duration. Blood serum uric acid levels will also be measured to track any biochemical changes due to therapy.\n\nTherapy Sessions: Only one (1) PROSOMNIA Sleep Therapy session will be administered, with the session lasting between 60-120 minutes. Diprivan\u002FPropofol is used to induce sleep, and EEG will monitor brain activity to ensure the proper balance of sleep stages.\n\nPost-Therapy Follow-up: Follow-up assessments will occur at 24 hours, 7 days, and 30 days post-treatment. Researchers will analyze the therapy effects on REM sleep, mood, cognitive function, and other health indicators.\n\nPotential Implications: If successful, this trial could revolutionize how we treat sleep disorders by targeting the underlying mechanisms of sleep pressure and REM sleep disruption. PROSOMNIA Sleep Therapy may offer a safe, effective, and immediate alternative for patients who have exhausted other treatment options.\n\nKey Concepts:\n\nHomeostatic sleep drive, (Process S), caused by adenosine buildup during wakefulness, is disrupted by chronic insomnia. This impacts cognitive function health and recovery. Anesthesia-induced REM sleep via PSTx helps regulate this homeostatic sleep stage, offering deeper and more restorative sleep compared to other sleep therapies. The study uses statistical methods like ANOVA and Chi-square to measure outcomes.",[179,180,181,182,183,184,185,186,187,188,189,190,191,192,193,194,195,196,197,198,199,200,201,202,203,204,205,206,207,208,209,210,211,212,213,214,28],"Chronic Insomnia","Sleep Deprivation","REM Behavior Disorder","REM Sleep Behavior Disorder","REM Sleep Measurement","Insomnia","Insomnia Related to Specified Disorder","Insomnia Due to Other Mental Disorder","Insomnia Comorbid to Psychiatric Disorder","Insomnia Due to Anxiety and Fear","Insomnia Related to Another Mental Condition","Insomnia Disorders","Idiopathic Hypersomnia","Sleep Disorders, Circadian Rhythm","Post Trauma Nightmares","PTSD - Post Traumatic Stress Disorder","Sleep Quality","Anesthesia","Anxiety","Depression","Mental Health","Alzheimer Disease or Associated Disorder","Parkinsons","Circadian Rhythm","Circadian Dysregulation","PTSD","Post-Traumatic","Post-Traumatic Stress Disorder Complex","Military Combat Stress Reaction","Sleep","Military Activity","Veterans","Shift Work Sleep Disorder","Menopause Related Conditions","Pain","Cancer Pain",[216,217,218,219,220,221,222,223,224,225,226,227,228,229,230,231,232,233,184,180,234,191,235,204,199,197,198],"SLEEP","PROSOMNIA Sleep","PROSOMNIA Sleep Therapy","PSTx","PROSOMNIA","Anesthesia Sleep","REM Sleep","REM Sleep Therapy","PROSOMNIA Sleep Health","PROSOMNIA Sleep Wellness","PROSOMNIA Sleep Treatment","Nyree","Nyree Penn","Propofol","Propofol Sleep","Diprivan","Diprivan Sleep","PROSOMNIA Sleep Health and Wellness","IH","Sleep Debt","2025-05-27",{"date":238,"type":38},"2025-05-28",{"date":240,"type":22},"2025-11-01",{"date":72,"type":22},{"name":228,"class":243},"INDUSTRY",{"id":245,"slug":246,"hasResults":11,"nctId":247,"briefTitle":248,"officialTitle":249,"acronym":4,"eligibilityCriteria":250,"healthyVolunteers":16,"sex":54,"minAge":4,"maxAge":4,"enrollmentInfo":251,"targetDuration":4,"studyType":23,"phases":253,"briefSummary":255,"conditions":256,"keywords":258,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":265,"lastUpdatePostDateStruct":266,"startDateStruct":267,"completionDateStruct":268,"leadSponsor":270,"locationsCount":104},"100592284","phase-4-effects-of-creasafe-on-kidney-muscle-and-cardiopulmonary-function-in-athletes-and-copd-patients-100592284","NCT06991426","Effects of CreaSafe® on Kidney, Muscle, and Cardiopulmonary Function in Athletes and COPD Patients","Effects of a New Creatine Formulation (CreaSafe®) on Kidney Function, Skeletal Muscles, and Cardiopulmonary Function in Athletes and Patients With COPD","Inclusion Criteria:\n\n* resistance-trained athletes middle- and long-distance runners severe and\u002For very severe COPD\n\nExclusion Criteria:\n\n* Non-athletes and individuals without a diagnosis of COPD",{"count":252,"type":22},140,[254],"PHASE4","Creatine supplementation (CS) offers numerous health benefits, with no proven side effects reported to date. CS positively impacts all organs and systems of the body. However, there is an ongoing effort among several creatine-producing companies to develop increasingly pure creatine formulations that generate fewer renal metabolites. Therefore, this study aims to evaluate the effects of a new creatine formulation, CreaSafe®, synthesized by the Chinese company Wenda®, on kidney function in athletes and patients with chronic obstructive pulmonary disease (COPD), as well as its effects on skeletal muscles and cardiopulmonary function. Regarding the athletes (Study 1), the sample will consist of 80 healthy athletes (40 strength-training athletes and 40 middle- and long-distance runners). Among each group of 40 athletes, 20 will receive CreaSafe® creatine (0.03 g\u002Fkg\u002Fday), while the other 20 will receive a placebo (microcrystalline cellulose; 0.03 g\u002Fkg\u002Fday), for 90 days, orally administered in water in the morning (between 7:00 a.m. and 9:00 a.m.). For the COPD patients (Study 2), 60 patients with severe and\u002For very severe COPD will be recruited. Of these, 30 will receive CreaSafe® creatine (0.03 g\u002Fkg\u002Fday), while the other 30 will receive placebo (microcrystalline cellulose; 0.03 g\u002Fkg\u002Fday), also administered orally in water for 90 days in the morning (between 7:00 a.m. and 9:00 a.m.). The supplementation period for both studies will last 90 days, with assessments performed at baseline and after 90 days. Kidney function will be evaluated through urinalysis (Urine Type I), the balance of pro- vs. anti-inflammatory cytokines, and levels of urea, creatine kinase (CK), and creatinine. Body composition will be assessed using octopolar and multifrequency bioimpedance, along with circumference measurements of body segments. Muscle strength of different muscle groups will be assessed using the E-lastic dynamometer. Biomarkers of skeletal muscle degradation and recovery will also be measured in plasma, including CK, lactate dehydrogenase (LDH), urea, myoglobin, and the levels of IL-1beta, IL-4, IL-6, IL-10, TNF-alpha, Atrogin-1, MuRF-1, and GDF-8 (myostatin). Whole blood analysis (erythrocytes, leukocytes, and platelets) will be performed using a fully automated blood analyzer (Sysmex XS 800i). Pulmonary function will be assessed through pre- and post-bronchodilator spirometry, as well as maximal inspiratory (PIMax) and expiratory (PEMax) pressures using a manovacuometer. Cardiovascular function will be evaluated using electrocardiography (ECG) and cardiovascular hemodynamics assessed by impedance cardiography (PhysioFlow). GraphPad Prism 5.0 software will be used for statistical analyses and graph generation. Paired Student's t-tests will be used to compare pre- and post-intervention values within each group, and unpaired Student's t-tests will be used to compare deltas between the CreaSafe® and placebo groups. Statistical significance will be considered at p ≤ 0.05.",[257,28],"Copd",[259,260,261,262,263,264],"creatine","supplementation","kidneys","heart","lungs","hematology","2025-05-23",{"date":238,"type":38},{"date":162,"type":22},{"date":269,"type":22},"2025-10",{"name":271,"class":45},"Federal University of São Paulo",{"id":273,"slug":274,"hasResults":11,"nctId":275,"briefTitle":276,"officialTitle":277,"acronym":278,"eligibilityCriteria":279,"healthyVolunteers":16,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":280,"targetDuration":282,"studyType":59,"phases":4,"briefSummary":283,"conditions":284,"keywords":288,"overallStatus":94,"whyStopped":4,"lastUpdateSubmitDate":295,"lastUpdatePostDateStruct":296,"startDateStruct":298,"completionDateStruct":299,"leadSponsor":301,"locationsCount":104},"100577875","impact-of-delivery-method-elite-athletes-100577875","NCT06803979","Impact of Delivery Method Elite Athletes.","The Impact of Delivery Method on the Performance of Elite Athletes.","IDEA","Inclusion Criteria:\n\n\\- Elite female athletes meeting representation limits and included in national teams organized under the Czech Olympic Committee and individual sports federations.\n\nExclusion Criteria:\n\n\\- Any male",{"count":281,"type":22},500,"100 Years","Labor itself can occur spontaneously vaginally, with the help of extraction methods, or via cesarean section. It can also be planned or awaited for the spontaneous onset of uterine contractions. Each method has its advantages and disadvantages regarding potential damage to the pelvic floor and its stability in vaginal delivery or extraction methods, or concerning the stability of the abdominal wall with subsequent wound healing after a cesarean section.\n\nThe aim of the study is to retrospectively and prospectively determine the impact of the method of delivery on the performance of female athletes through a questionnaire study. Investigators would like to answer the question of whether cesarean delivery means a later return to training for athletes, whether pregnancy is problematic for female athletes in relation to their BMI, and whether pregnancy often signifies the end of a sports career for female athletes. The questionnaire also includes questions regarding overall women's health-menstrual cycle, incontinence, and mental health of female athletes. Prospectively, the questionnaire will be sent to all female athletes who meet representation limits once a year and for two years after retiring from the national team.",[285,121,286,287,28],"Delivery","Caesarean Section","Pregnancy",[289,290,291,292,293,294],"delivery","performance","caesarean section","pregnancy","athletes","women health","2025-03-16",{"date":297,"type":38},"2025-03-18",{"date":295,"type":22},{"date":300,"type":22},"2040-01-01",{"name":302,"class":77},"Faculty Hospital Kralovske Vinohrady",{"id":304,"slug":305,"hasResults":11,"nctId":306,"briefTitle":307,"officialTitle":308,"acronym":4,"eligibilityCriteria":309,"healthyVolunteers":16,"sex":54,"minAge":310,"maxAge":86,"enrollmentInfo":311,"targetDuration":4,"studyType":23,"phases":313,"briefSummary":314,"conditions":315,"keywords":317,"overallStatus":94,"whyStopped":4,"lastUpdateSubmitDate":321,"lastUpdatePostDateStruct":322,"startDateStruct":324,"completionDateStruct":326,"leadSponsor":328,"locationsCount":330},"100517410","effects-of-myofascial-release-technique-on-mobility-sensorimotor-function-and-performance-in-volleyball-players-100517410","NCT06017180","Effects of Myofascial Release Technique on Mobility, Sensorimotor Function and Performance in Volleyball Players","Investigation of the Effects of Myofascial Release Techniques on Shoulder-Elbow Mobility, Sensorimotor Function and Performance in Volleyball Players","Inclusion criteria:\n\n* Being playing volleyball\n* Training at least two hours a week Being between the ages of 13-40\n* Full active movement of the shoulder and elbow in all directions\n* To have at least 3 years of overhead sports activity (volleyball) (Kurt, 2022)\n* Active participation in training and competitions\n* Absence of shoulder pain\n* To be able to complete all the evaluations and applications to be made in the study\n\nExclusion criteria:\n\n* Not wanting to participate in the study and not being able to fulfill its requirements\n* History of upper extremity injury in the last 1 year\n* Any history of surgery or fracture in the upper extremity\n* The occurrence of pain during evaluations and applications\n* Having a diagnosed disease related to the neck and shoulder\n* Having any diagnosed systemic (rheumatological) musculoskeletal disease\n* Have a lower extremity injury (acute and\u002For active) in the last six months\n* Having acne and similar skin problems, open wounds that may prevent the application of rounded myofascial relaxation\n* Previous application of similar rounded myofascial relaxation\n* Diagnosis of diabetes mellitus and peripheral neuropathy\n* Having been diagnosed with osteoporosis\n* Having a diagnosis of vertigo\n* Having a cardiovascular disease\n* Being pregnant","13 Years",{"count":312,"type":22},54,[25],"Sports that require overhead activities (volleyball, tennis, basketball) include components such as rapid displacement, strength and movement control.Volleyball is also called as an overhead sport in terms of the way it is played. In the realization of these sports; Sub-parameters such as proprioceptive sense, strength, throwing rate, flexibility play a role. During these activities, the shoulder and elbow joints are overloaded. To meet this load, the joint must provide the necessary mobility and stability. Proprioceptive sense in increasing the quality and width of movement as well as providing dynamic joint stability in overhead sports; Increasing the range of motion of the joint, reducing muscle stiffness and thus increasing flexibility are effective in providing mobility. That's why it's important to develop them. Likewise, muscle strength should be increased in order to maintain movement performance and prevent injuries. The use of myofascial release techniques as an exercise method has increased in recent years. Application; The effects on parameters such as strength, performance and flexibility were investigated. Studies have focused more on the lower extremities and acute effects. There is no study on the subject examining proprioceptive sensation in volleyball players in the upper extremity. Therefore, our aim is to examine the chronic effects of the application on shoulder and elbow joint mobility, sensorimotor function and performance.",[28,316],"Volleyball",[318,319,155,320,152,290],"foam rolling","volleyball","upper extremity","2025-02-04",{"date":323,"type":38},"2025-02-06",{"date":325,"type":38},"2023-09-30",{"date":327,"type":22},"2026-12-30",{"name":329,"class":45},"Dokuz Eylul University",2,{"id":332,"slug":333,"hasResults":11,"nctId":334,"briefTitle":335,"officialTitle":336,"acronym":337,"eligibilityCriteria":338,"healthyVolunteers":16,"sex":17,"minAge":113,"maxAge":339,"enrollmentInfo":340,"targetDuration":4,"studyType":59,"phases":4,"briefSummary":342,"conditions":343,"keywords":346,"overallStatus":94,"whyStopped":4,"lastUpdateSubmitDate":353,"lastUpdatePostDateStruct":354,"startDateStruct":356,"completionDateStruct":358,"leadSponsor":359,"locationsCount":104},"100511238","quantum-menstrual-health-monitoring-study-100511238","NCT05936840","Quantum Menstrual Health Monitoring Study","Quantitative Hormonal Biomarkers of Menstrual Health in Normal and Abnormal Cycles","QMHMS","Inclusion Criteria:\n\n* Regularly menstruating, PCOS or athlete participants aged 18-45\n* Negative pregnancy test at the beginning and at the end of each cycle\n* Cycle lengths 24-34 days\n* Knowledge of previous 3 cycle lengths\n* Able to travel to Calgary Clinic for regular ultrasounds during the study period\n\nExclusion Criteria:\n\n* For regular cycles\n\n  * Anovulation in the last 3 cycles\n  * Currently or in the previous 3 months, on medications that are known to impair or stimulate ovulation (e.g. oral contraceptives, ovulation stimulants, etc)\n  * Known conditions that impair ovulation or fertility: polycystic ovarian syndrome, endometriosis, pelvic inflammatory disease in the last year, pituitary adenomas, exclusively breastfeeding\n  * Previous surgeries impacting the menstrual cycle: hysterectomy, bilateral oophorectomy\n  * Currently pregnant\n* For PCOS and athlete groups:\n\n  * Currently or in the previous 3 months, on medications that are known to impair or stimulate ovulation (e.g. oral contraceptives, ovulation stimulants, etc)\n  * Known conditions that impair ovulation or fertility: pelvic inflammatory disease in the last year, pituitary adenomas, exclusive breastfeeding\n  * Previous surgeries impacting the menstrual cycle: hysterectomy, bilateral oophorectomy\n  * Currently pregnant","55 Years",{"count":341,"type":22},150,"The Quantum Menstrual Health Monitoring Study will measure four key reproductive hormones in the urine to characterize patterns that predict and confirm ovulation, referenced to serum hormones and the gold-standard of the ultrasound day of ovulation in participants with regular cycles. These normal cycles will provide a reference for comparison to irregular cycles in polycystic ovarian syndrome (PCOS) and athletes. Clinical signs in the menstrual cycle (e.g. menstrual bleeding, temperature) as well as vital sign and sleep patterns will also be referenced to hormonal changes.",[344,345,28],"Menstrual Cycle Abnormal","Polycystic Ovary Syndrome",[347,348,349,350,351,352],"Quantitative urinary hormones","Follicle-stimulating hormone","Luteinizing hormone","Estrone-3-glucuronide","Pregnanediol glucuronide","Ultrasound","2024-10-24",{"date":355,"type":38},"2024-10-28",{"date":357,"type":38},"2024-05-01",{"date":72,"type":22},{"name":360,"class":243},"Quanovate Tech Inc.",{"id":362,"slug":363,"hasResults":11,"nctId":364,"briefTitle":365,"officialTitle":366,"acronym":4,"eligibilityCriteria":367,"healthyVolunteers":16,"sex":54,"minAge":113,"maxAge":368,"enrollmentInfo":369,"targetDuration":4,"studyType":23,"phases":371,"briefSummary":372,"conditions":373,"keywords":374,"overallStatus":94,"whyStopped":4,"lastUpdateSubmitDate":379,"lastUpdatePostDateStruct":380,"startDateStruct":382,"completionDateStruct":384,"leadSponsor":386,"locationsCount":104},"100534529","acute-effects-of-foam-rolling-and-proprioceptive-neuromuscular-facilitation-stretching-100534529","NCT06240013","Acute Effects of Foam Rolling and Proprioceptive Neuromuscular Facilitation Stretching","Acute Effects of Foam Rolling and Proprioceptive Neuromuscular Facilitation Stretching During Warm-Up on Muscle Flexibility, Strength and Pain Threshold in Amateur Athletes","Inclusion Criteria:\n\n* Being between the ages of 18-30\n* Being an amateur athlete\n\nExclusion Criteria:\n\n* Hypermobility\n* History of hamstring injury in the last 6 months\n* Diagnosed orthopedic problems\n* Surgery in the lower extremity or spine\n* Back pain\n* Presence of systemic or neurological disorders","30 Years",{"count":370,"type":22},80,[25],"The hamstring muscle is one of the key elements in rehabilitation programs and sports activities that enable the restoration of optimal muscle length. Decreased flexibility in the hamstring muscle may disrupt the biomechanics of the waist and pelvis, leading to low back pain or musculoskeletal disorders.\n\nThis study aims to investigate the acute effects of foam rolling and proprioceptive neuromuscular facilitation stretching during warm-up on muscle flexibility, strength, and pain threshold in amateur athletes. According to our research, there is no study in this field in the literature.\n\nH1: There is a difference between the acute effects of foam rolling exercise and PNF stretching exercise on muscle flexibility during warm-up in amateur athletes.\n\nH2: There is a difference between the effects of foam rolling and PNF stretching exercises used as warm-up exercises on muscle strength.\n\nH3: Foam rolling and PNF stretching exercises applied to the Hamstring muscle as a warm-up exercise make a difference in the pain threshold of the lumbar region and Hamstring muscle.",[28],[375,376,377,378],"Muscle Stretching Exercises","Pain Threshold","Range of Motion, Articular","Muscle Strength","2024-08-13",{"date":381,"type":38},"2024-08-14",{"date":383,"type":38},"2024-04-16",{"date":385,"type":22},"2025-02",{"name":387,"class":45},"Acibadem University",{"id":389,"slug":390,"hasResults":11,"nctId":391,"briefTitle":392,"officialTitle":393,"acronym":4,"eligibilityCriteria":394,"healthyVolunteers":16,"sex":17,"minAge":113,"maxAge":395,"enrollmentInfo":396,"targetDuration":4,"studyType":59,"phases":4,"briefSummary":398,"conditions":399,"keywords":402,"overallStatus":94,"whyStopped":4,"lastUpdateSubmitDate":383,"lastUpdatePostDateStruct":407,"startDateStruct":409,"completionDateStruct":411,"leadSponsor":413,"locationsCount":104},"100545085","identifying-periods-of-high-training-load-considering-the-menstrual-cycle-phases-in-elite-and-non-elite-female-athletes-100545085","NCT06377306","Identifying Periods of High Training Load Considering the Menstrual Cycle Phases in Elite and Non-elite Female Athletes","Identifying Periods of High Training Load Considering the Menstrual Cycle Phases in Elite and Non-elite Female Athletes Using Measures of Strength, Fatigue, Injury, Psychological Parameters, Serum Circulating Metabolites and the Intestinal Microbiome","Inclusion Criteria:\n\n* Elite athletes are defined as participating and competing at national and\u002For international level at their sports.\n* Non-elite athletes are defined as performing at least 3 hours of physical activity per week.\n\nExclusion Criteria:\n\n* Currently pregnant or lactating or planning a pregnancy in the following year.\n* Regular drug use which may affect performance, including but not limited to performance enhancing drugs.\n* Any medical diagnosis, including recent or current injury, which could affect performance and\u002For health under the discretion of the study team.","50 Years",{"count":397,"type":22},200,"Despite a rise in the number of women participating in competitive sports, there remains a gender gap within sport and exercise science literature. Studying females involves potential \"noise\" through the change in hormone concentrations during the different phases of the female menstrual cycle (MC) which can potentially affect physiological parameters, thereby making study design and interpretation of findings difficult. Longitudinal data on the acute and chronic combined effects of training load and MC phases on circulating female hormones in elite and non-elite female athletes is lacking.\n\nThe investigators aim to characterize and track the potential effects of training load and MC phases on performance, anthropometric measures, sport emotions, intestinal microbiome, serum metabolites and injury prevalence in elite and non-elite female athletes.\n\n200 competitive premenopausal female athletes will be recruited. In a longitudinal observational design, each participant will be followed for 1 year, and tested at three time points. At each point, data will be collected on two occasions reflecting distinct phases of the MC.\n\nFinding the possible relationship between the MC phases, training load and performance or specific bio-markers for training load are of utmost importance and can assist professionals to identify periods of high load and over-training, thus preventing injuries and training adjustment.",[400,28,401],"Menstrual Cycle","Physical Activity",[403,404,405,406],"Menstrual cycle","Training load","Microbiome","Elite athletes",{"date":408,"type":38},"2024-04-22",{"date":410,"type":38},"2023-11-05",{"date":412,"type":22},"2027-01-30",{"name":414,"class":45},"Wingate Institute"]