[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"atlantoaxial-dislocation\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:atlantoaxial-dislocation":23},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,37,65],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":4,"briefSummary":21,"conditions":22,"keywords":4,"overallStatus":24,"whyStopped":4,"lastUpdateSubmitDate":25,"lastUpdatePostDateStruct":26,"startDateStruct":29,"completionDateStruct":31,"leadSponsor":33,"locationsCount":36},"100575440","conservative-treatment-for-atlantoaxial-dislocation-patients-without-neurological-deficit-100575440",false,"NCT06772311","Conservative Treatment for Atlantoaxial Dislocation Patients Without Neurological Deficit","Clinical Efficacy of Surgical Vs. Conservative Treatment for Atlantoaxial Dislocation Patients Without Neurological Deficit: a Prospective, Multicenter, Observational Study","Inclusion Criteria:\n\n* The patients meet the diagnostic criteria for atlantoaxial dislocation, that is, the ADI exceeds the normal range: it is over 3 mm in adults and over 5 mm in children.\n* The patients have no clinical manifestations of the nervous system, including occipital neuralgia, manifestations of cranial nerve impairment (such as dysphagia, dysarthria, nystagmus, etc.) and manifestations of spinal cord impairment (such as unsteadiness in holding objects, unsteady gait, decreased limb muscle strength, etc.).\n* After fully understanding their own conditions as well as the advantages, disadvantages and risks of both conservative treatment and surgical treatment, the patients can choose the initial treatment method on their own. If they choose conservative treatment, they will be included in the conservative treatment. If they choose surgical treatment, they will be included in the surgical intervention group.\n\nExclusion Criteria:\n\n* Patients who have undergone surgeries in the cranio-cervical junction previously.\n* Patients with infections or tumors in the cranio-cervical junction.\n* Patients with fresh fractures in the cranio-cervical junction.\n* Patients with clinical manifestations of nerve deficit.\n* Patients with severe diseases in other spinal regions such as the thoracic and lumbar spine that affect their clinical symptoms; patients with motor neuron diseases like amyotrophic lateral sclerosis and other severe neurological diseases.\n* Patients who have participated in other clinical trials within the recent three months.\n* Patients with mental disorders whose cognitive impairments (or those of their legal guardians) prevent them from giving full informed consent.\n* Patients who refuse to participate in this study.","ALL",{"count":18,"type":19},300,"ESTIMATED","OBSERVATIONAL","The goal of this observational study was to learn about the long-term clinical efficacy of conservative treatment in atlantoaxial dislocation patients without neurological deficit. The main question it aims to answer is:\n\nIs surgical intervention always necessary in atlantoaxial dislocation patients without nerve deficit?\n\nPatients who refuse surgical intervention will continue to be treated conservatively. Clinical outcomes will be summarized over five years of follow-up",[23],"Atlantoaxial Dislocation","NOT_YET_RECRUITING","2025-01-08",{"date":27,"type":28},"2025-01-13","ACTUAL",{"date":30,"type":19},"2025-01-15",{"date":32,"type":19},"2030-12-31",{"name":34,"class":35},"Peking University Third Hospital","OTHER",1,{"id":38,"slug":39,"hasResults":11,"nctId":40,"briefTitle":41,"officialTitle":42,"acronym":4,"eligibilityCriteria":43,"healthyVolunteers":11,"sex":16,"minAge":44,"maxAge":45,"enrollmentInfo":46,"targetDuration":4,"studyType":48,"phases":49,"briefSummary":51,"conditions":52,"keywords":53,"overallStatus":24,"whyStopped":4,"lastUpdateSubmitDate":57,"lastUpdatePostDateStruct":58,"startDateStruct":60,"completionDateStruct":62,"leadSponsor":64,"locationsCount":36},"100568245","minimally-invasive-atlantoaxial-lateral-mass-joint-fusion-mis-palf-as-a-surgical-treatment-of-atlantoaxial-dislocation-100568245","NCT06678711","Minimally Invasive Atlantoaxial Lateral Mass Joint Fusion (MIS-PALF) As a Surgical Treatment of Atlantoaxial Dislocation","Randomized Controlled Study of Minimally Invasive Atlantoaxial Mass Fusion and Open Atlantoaxial Fusion in the Treatment of Atlantoaxial Dislocation","Inclusion Criteria:\n\n1. Age range from 0 to 80 years old, regardless of gender\n2. Diagnosed with atlantoaxial dislocation, suitable for posterior surgical treatment\n3. Index of assessment integrity\n4. Agree to participate in the study and sign the informed consent\n\nExclusion Criteria:\n\n1. Atlantoaxial dislocation without surgical treatment\n2. Atlantoaxial dislocation treated by other operation, such as TARP","0 Years","80 Years",{"count":47,"type":19},60,"INTERVENTIONAL",[50],"NA","The conventional treatment for atlantoaxial dislocation is atlantoaxial fixation and fusion using the Goel-Harms technique, which involves a midline incision, dissection of the occipital muscle group, and is associated with disadvantages such as damage to the posterior ligament and muscle, high incidence of postoperative occipital cervical pain, and significant blood loss due to intraoperative bleeding and postoperative drainage. Since 2013, various studies have reported minimally invasive posterior atlantoaxial lateral mass joint fusion techniques through muscle spaces, but previous studies were all case reports, without sufficient reliability and controlled studies. The Department of Orthopedics at Peking University Third Hospital has been using the minimal invasive surgery-posterior atlantoaxial lateral mass joint fusion (Mis-PALF) technique for the treatment of atlantoaxial dislocation since 2015, with preliminary good clinical results. In order to further compare the advantages and disadvantages of the two surgical methods from a larger sample, a randomized controlled study is planned. The patients will be randomly divided into two groups, with the experimental group receiving the Mis-PALF surgery and the control group receiving open atlantoaxial fusion and fixation. There will be a 1-2 year follow-up to compare the safety and effectiveness of the two surgical methods for the treatment of atlantoaxial dislocation.",[23],[54,55,56],"atlantoaxial dislocation","MIS-PALF","minimal invasive surgery","2024-11-05",{"date":59,"type":28},"2024-11-07",{"date":61,"type":19},"2024-11-04",{"date":63,"type":19},"2026-06-30",{"name":34,"class":35},{"id":66,"slug":67,"hasResults":11,"nctId":68,"briefTitle":69,"officialTitle":69,"acronym":4,"eligibilityCriteria":70,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":71,"targetDuration":73,"studyType":20,"phases":4,"briefSummary":74,"conditions":75,"keywords":4,"overallStatus":78,"whyStopped":4,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":82,"completionDateStruct":84,"leadSponsor":86,"locationsCount":36},"100534031","a-study-on-diagnosis-and-treatment-strategies-for-atlantoaxial-dislocation-100534031","NCT06233539","A Study on Diagnosis and Treatment Strategies for Atlantoaxial Dislocation","Inclusion Criteria:\n\n* Patients diagnosed with atlantoaxial dislocation and treated with surgery\n\nExclusion Criteria:\n\n* Disagree to participate in this study.",{"count":72,"type":19},3000,"1 Year","The most effective treatment for atlantoaxial dislocation is surgical treatment, with the principle of achieving reduction, reconstruction, and fusion of the atlantoaxial joint. The surgical strategies mainly include simple anterior approach, simple posterior approach, and combined anterior posterior approach. The investigators have summarized 904 cases of atlantoaxial instability or dislocation from 1998 to 2010 and preliminarily published the diagnosis and treatment strategy tree of the Third Hospital of Beijing Medical University. This strategy is divided into four types based on the severity of atlantoaxial dislocation: unstable, reversible, difficult to recover, and skeletal, and enters different surgical treatment processes. With the increase in the number of cases, accumulation of experience, and technological improvements in the past decade, spinal surgery colleagues have updated their classification diagnosis, diagnosis and treatment processes, and surgical techniques for atlantoaxial instability or dislocation.\n\nHowever, the selection of treatment strategies for atlantoaxial dislocation is mostly based on the surgeon's own experience, and there is a lack of standardized, large-scale, and high-level evidence-based medical research on the safety and effectiveness of current empirical strategies. Based on this, this study intends to adopt a multicenter, retrospective, and prospective study to construct a high-quality clinical cohort of atlantoaxial dislocation, update the classification and diagnosis and treatment strategies of atlantoaxial dislocation. And conduct long-term follow-up on patients to evaluate their safety and effectiveness, guide the surgical treatment of atlantoaxial dislocation, and thus form a recognized diagnostic and treatment standard for atlantoaxial dislocation.",[23,76,77],"Treatment","Diagnostic","RECRUITING","2024-04-01",{"date":81,"type":28},"2024-04-03",{"date":83,"type":28},"2022-12-01",{"date":85,"type":19},"2026-12-31",{"name":34,"class":35}]