[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"atrial-flutter-with-rapid-ventricular-response\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:atrial-flutter-with-rapid-ventricular-response":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,45,69],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100643816","phase-3-magnesium-with-metoprolol-for-rate-control-in-atrial-fibrillation-100643816",false,"NCT07632157","MAGNEsium With meToprolol for Rate Control In Atrial Fibrillation","MAGNEsium With meToprolol for Rate Control In Atrial Fibrillation (MAGNETIC-AF)","MAGNETIC-AF","Inclusion Criteria:\n\n* Age \\> 18 years or older\n* Able to provide informed consent\n* Primary diagnosis atrial fibrillation or atrial flutter with rapid ventricular response (AFF RVR) greater than or equal to 120 beats per minute\n* Metoprolol as rate control agent\n* English speaking\n\nExclusion Criteria:\n\n* Hemodynamically unstable patients (SBP \\\u003C90, MAP \\\u003C65)\n* Impaired consciousness\n* Acute heart failure exacerbation based on clinical diagnosis, physician exam, bedside echo, and\u002For additional imaging\n* Patient in AFF RVR that is highly suspected to be a compensatory mechanism for an alternative clinical diagnosis\n* Rhythms other than atrial fibrillation, such as sick sinus syndrome or wide-complex ventricular response\n* Acute myocardial infarction\n* Contraindications to magnesium sulfate (including myasthenia gravis)\n* Allergy or sensitivity to any study drugs\n* Previously enrolled in this trial during a different patient encounter\n* Withdrew from study","ALL","18 Years",{"count":20,"type":21},196,"ESTIMATED","INTERVENTIONAL",[24],"PHASE3","The purpose of this research study is to find out if the use of magnesium in addition to Metoprolol, a rate controlling medication that you would be offered in the Emergency Department today unrelated to this study, will help reduce your high heart rate (rapid ventricular response).",[27],"Atrial Flutter With Rapid Ventricular Response",[29,30,31],"AFF RVR","intravenous magnesium","atrial flutter","NOT_YET_RECRUITING","2026-06-24",{"date":35,"type":36},"2026-06-29","ACTUAL",{"date":38,"type":21},"2026-10",{"date":40,"type":21},"2028-12",{"name":42,"class":43},"Wake Forest University Health Sciences","OTHER",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":51,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":53,"targetDuration":4,"studyType":22,"phases":55,"briefSummary":56,"conditions":57,"keywords":4,"overallStatus":60,"whyStopped":4,"lastUpdateSubmitDate":61,"lastUpdatePostDateStruct":62,"startDateStruct":64,"completionDateStruct":66,"leadSponsor":68,"locationsCount":44},"100545055","phase-3-comparing-magnesium-2g-versus-4g-versus-placebo-in-the-incidence-of-treating-aff-rvr-100545055","NCT06376916","Comparing Magnesium 2g Versus 4g Versus Placebo in the Incidence of Treating AFF RVR","Atrial Tachycardia Reduction With Intravenous Use of Magnesium (ATRIUM) Study: Comparing Magnesium 2g Versus 4g Versus Placebo in the Incidence of Treating AFF RVR","ATRIUM","Inclusion Criteria:\n\n* Age \\> 18 years or older\n* Able to provide informed consent\n* Primary diagnosis AFF RVR greater than or equal to 120 bpm\n* Diltiazem as rate control agent\n* English speaking\n\nExclusion Criteria:\n\n* Hemodynamically unstable patients (SBP \\\u003C90, MAP \\\u003C65)\n* Impaired consciousness\n* End stage renal disease on hemodialysis or peritoneal dialysis\n* Acute heart failure exacerbation based on clinical diagnosis, physician exam, bedside echo, and\u002For additional imaging\n* Patient in AFF RVR that is highly suspected to be a compensatory mechanism for an alternative clinical diagnosis\n* Rhythms other than AF, such as sick sinus syndrome or wide-complex ventricular response\n* Acute myocardial infarction\n* Pregnancy defined as a positive urine HCG (human chorionic gonadotropin)\n* Contraindications to magnesium sulfate (including myasthenia gravis)\n* Allergy or sensitivity to any study drugs\n* Previously enrolled in this trial during a different patient encounter\n* Withdrew from study",{"count":54,"type":21},153,[24],"The purpose of this prospective, randomized, double-blinded study is to further evaluate the safety and efficacy of varying doses of intravenous magnesium in the treatment of AFF RVR.",[58,59,27],"Tachycardia Atrial","Atrial Fibrillation","RECRUITING","2025-10-25",{"date":63,"type":36},"2025-10-28",{"date":65,"type":36},"2024-10-07",{"date":67,"type":21},"2026-12",{"name":42,"class":43},{"id":70,"slug":71,"hasResults":11,"nctId":72,"briefTitle":73,"officialTitle":74,"acronym":75,"eligibilityCriteria":76,"healthyVolunteers":77,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":78,"targetDuration":4,"studyType":22,"phases":80,"briefSummary":81,"conditions":82,"keywords":84,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":44},"100537307","phase-3-oral-bisoprolol-vs-iv-diltiazem-in-atrial-fibrillation-or-flutter-with-rapid-ventricular-rate-100537307","NCT06276127","Oral Bisoprolol Vs IV Diltiazem in Atrial Fibrillation or Flutter With Rapid Ventricular Rate.","Oral Bisoprolol Versus Intravenous Diltiazem in the Management of Atrial Fibrillation or Flutter With Rapid Ventricular Rate in the Emergency Department: A Randomized Controlled Trial","BisoAF","Inclusion Criteria:\n\n* ≥ 18 years old.\n* Atrial fibrillation (RVR) or Atrial flutter on electrocardiogram.\n* Heart rate \\>120 beats\u002Fmin\n* Stable patient with stable vital signs (Defined as having a SBP \\>110 mmHg, oxygen saturation \\> 94% on room air or with a simple face mask, a respiratory rate within normal limits, being conscious and oriented, and not having any concurrent life-threatening conditions such as myocardial infarction (MI) or Class IV heart failure).\n* Mentally competent patient who can understand and sign the consent form.\n\nExclusion Criteria:\n\n* Acute myocardial infarction.\n* Known congenital and acquired valvular defects.\n* Pre-excitation syndromes.\n* Ventricular rate \\> 220beats\u002Fmin.\n* Administration of AV nodal blocking agents within the previous 24 h (beta blockers, non-dihydropyridine calcium channel blockers, digoxin and amiodarone or receiving regular maintains oral dose).\n* Allergy to either bisoprolol or diltiazem.\n* Severe hepatic and renal failure.\n* Pregnancy \u002F breastfeeding.\n* A history of cocaine or methamphetamine use within 24 hours before arrival.\n* Known Asthmatic.",true,{"count":79,"type":21},60,[24],"INTRODUCTION: The study focuses on comparing the effectiveness of oral Bisoprolol, a beta-1 adrenergic receptor blocker, against intravenous Diltiazem, a calcium channel blocker, in treating rapid atrial fibrillation or flutter with rapid ventricular response in an emergency setting. This research aims to fill the gap in empirical evidence regarding the use of oral Bisoprolol for these conditions, potentially offering a convenient, evidence-based alternative for patient management in emergency departments where established protocols are lacking.\n\nMETHOD: This study is a randomized controlled trial targeting patients who present to the emergency room with symptomatic atrial fibrillation or flutter and rapid ventricular response requiring intervention. Participants will be split into two groups and undergo continuous monitoring of vital signs and regular electrocardiograms to ensure safety and document any adverse effects. The primary focus is on patient safety while evaluating the efficacy of the treatments.\n\nAIM: Evaluate the efficacy and safety of oral bisoprolol in treating atrial fibrillation or atrial flutter with rapid ventricular response in an emergency department setting.\n\nPRIMARY OJECTIVES: The primary efficacy outcome will be evaluated by achieving a HR\\\u003C110 beats per minute or a decrease ≥20% of baseline HR at 60 minutes. The primary safety outcome measures are HR \\\u003C 60 bpm and SBP \\\u003C 95 mm Hg.\n\nSECONDARY OBJECTIVES: The use of Rescue medication, proportion of patients who required hospitalization, worsening of heart failure or pulmonary oedema, side effect of medication ( dizziness, headaches, gastrointestinal symptoms)\n\nPATEINT POPULATION: Adults (18 and older) presenting to the emergency department at Sultan Qaboos University Hospital with symptomatic atrial fibrillation or atrial flutter with rapid ventricular response requiring treatment.\n\nINTERVENTION: A single oral dose of 5 mg Bisoprolol (maximum dose of 5 mg) or a single intravenous dose of Diltiazem at 0.25 mg\u002Fkg (to a maximum dose of 30 mg).\n\nCLINICAL MEASURMENT: Heart rate recorded every 15 minutes up to the 90-minute mark, with a 12-lead ECG performed every 30 minutes.\n\nOUTCOME: For therapy to be considered effective, patients must achieve a ventricular rate ≤110\u002Fmin or experience a drop-in ventricular rate of at least 20% at 60 minutes.",[83,27],"Atrial Fibrillation With Rapid Ventricular Response",[85,86,87,88],"Bisoprolol","AF","Diltiazem","Atrial flutter","2025-03-11",{"date":91,"type":36},"2025-03-14",{"date":93,"type":21},"2025-04",{"date":95,"type":21},"2027-06",{"name":97,"class":98},"Oman Medical Speciality Board","OTHER_GOV"]