[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"atrophic-maxilla\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:atrophic-maxilla":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,56,84,121],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":31,"overallStatus":43,"whyStopped":4,"lastUpdateSubmitDate":44,"lastUpdatePostDateStruct":45,"startDateStruct":48,"completionDateStruct":50,"leadSponsor":52,"locationsCount":55},"100590543","buccal-fat-pad-vs-palatal-rotation-scarf-grafts-for-soft-tissue-management-around-zygomatic-implants-100590543",false,"NCT06968780","Buccal Fat Pad vs. Palatal Rotation Scarf Grafts for Soft Tissue Management Around Zygomatic Implants","Buccal Pad of Fat Graft vs. Palatal Rotation Scarf Graft for Soft Tissue Enhancement and Prevention of Dehiscence Around Zygomatic Implants Placed in Patients With Severely Atrophic Maxilla: A Randomized Clinical Trial","RCT BFP ZAGA","Inclusion Criteria:\n\n1. Patient of age 18 years or more, who can understand and sign an informed consent.\n2. Patients with severely atrophic edentulous upper arch (Cawood \\& Howell class IV, V, VI) that could not be restored by standard axial implants without augmentation.\n3. Patients with severely atrophic edentulous upper arch (Bedrossian classification inadequate bone in zones II or III or all three zones) that could not be restored by standard axial implants without augmentation.\n4. Good systemic health (ASA score I-II)\n5. Highly motivated patients with good compliance to oral hygiene habits.\n\nExclusion Criteria:\n\n1. Patients with cardiovascular disease or pulmonary disease or medical systemic condition that does not permit the surgical procedure under general anesthesia (ASA III, IV, V and VI).\n2. Patients with conditions contraindicating implant placement (e.g.: radiation to the head and neck, intra-venous bisphosphonates, uncontrolled Diabetes mellitus).\n3. Heavy smokers. (\\> 20 cigarettes daily)\n4. Patient with psychiatric problems, severe bruxism, or other parafunctional habits.\n5. Acute maxillary sinus infection or untreated maxillary sinus cyst.\n6. Malignancy or pathology in Maxilla or Zygoma.","ALL","18 Years",{"count":20,"type":21},8,"ESTIMATED","INTERVENTIONAL",[24],"NA","Over the past 20 years, the demand for oral rehabilitation among edentulous patients has steadily increased. Traditionally, individuals with edentulous maxillae were treated using removable complete dentures. However, these often result in poor patient satisfaction due to instability and functional limitations. Dental rehabilitation with implants in the maxillary arch presents unique challenges, primarily due to the anatomical complexity of the maxilla and the need for adequate residual ridge dimensions for successful implant placement.\n\nFollowing the extraction of maxillary teeth, patients experience rapid and progressive alveolar bone loss in both vertical and horizontal dimensions. This resorption is largely attributed to the absence of teeth and periodontal ligament fibers support, which are essential for transmitting mechanical forces that maintain bone homeostasis. In addition, the loss of maxillary molars accelerates pneumatization\u002Fexpansion of the maxillary sinus, further reducing available bone volume. Contributing factors such as ill-fitting dentures and systemic health conditions can exacerbate this process, complicating implant placement even further.\n\nTo overcome these limitations, oral and maxillofacial surgeons have developed a range of advanced techniques, including tilted implants, sinus floor elevation, short implants, pterygoid implants, and most notably, zygomatic implants. Zygomatic implants bypass the atrophic alveolar ridge entirely by anchoring into the dense zygomatic bone, offering a reliable solution for patients with severely resorbed maxillae who are not candidates for conventional implant therapy.",[27,28,29,30],"Zygomatic Implants","Atrophic Maxilla","Soft Tissue Defect","Soft Tissue Healing",[32,27,33,34,35,36,37,28,38,39,40,41,42],"ZAGA","Buccal Fat Pad","BFP","Palatal Rotation Graft","PRG","Scarf Graft","Soft tissue Recession","Dehiscence","RCT","Zygoma","Implant","RECRUITING","2025-12-06",{"date":46,"type":47},"2025-12-12","ACTUAL",{"date":49,"type":47},"2025-06-01",{"date":51,"type":21},"2026-12-01",{"name":53,"class":54},"Cairo University","OTHER",1,{"id":57,"slug":58,"hasResults":11,"nctId":59,"briefTitle":60,"officialTitle":61,"acronym":4,"eligibilityCriteria":62,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":63,"targetDuration":4,"studyType":22,"phases":65,"briefSummary":66,"conditions":67,"keywords":70,"overallStatus":72,"whyStopped":4,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":83},"100612850","nobelzygoma-tiultra-implant-system-study-100612850","NCT07258940","NobelZygoma TiUltra Implant System Study","A 1-year Prospective Multicenter Clinical Investigation to Assess Safety, Performance and Clinical Benefits of the NobelZygoma TiUltra Implant System in the Rehabilitation of Severely Atrophic Maxillae","Inclusion Criteria:\n\n* Participant has signed the informed consent form (ICF).\n* Participant aged ≥ 18 years at the time of treatment.\n* Medical and anatomical conditions are in accordance with the applicable IFU.\n* Participant with a severely atrophic maxilla classified as Cawood and Howell class V or VI\n* Suitable for immediate loading.\n\nExclusion Criteria:\n\n* Presence of acute or chronic maxillary sinusitis.\n* Zygomatic bone pathologies including tumors, infections, or congenital abnormalities\n* History of recurrent sinusitis (≥ 4 occurrences\u002Fyear)\n* Pre-operative LM score of ≥ 1\n* Uncontrolled systemic disorders including poorly controlled hypertension, uncontrolled diabetes, cardiovascular disease.\n* Active malignancy or currently undergoing oncological treatment.\n* History of severe maxillary jaw injury or maxillofacial trauma.\n* Moderate and heavy smokers (defined as \\> 5 cigarettes a day).\n* Severe bruxism or dysfunctional tendencies\n* Previous oro-maxillofacial radiotherapy.\n* Use of bisphosphonates.\n* Pregnant or lactating women\n* Implant loaded \\> 1 week of zygomatic implant placement",{"count":64,"type":21},85,[24],"The goal of this prospective study is to assess short term (12-months) clinical outcomes of NobelZygoma TiUltra implants and Multi-unit Abutment Xeal in the rehabilitation of participants with severely atrophic maxilla treated with zygomatic dental implant procedure. The main goal is to assess the sinusitis occurrence at 12-months after implant insertion. Other objectives are to assess: soft tissue health; biological and technical complication; patient's experience, outcomes (sinonasal symptoms and oral health-related quality of life) and satisfaction; clinician's experience with handling of device and satisfaction; implant, abutment and prosthetic survival and adverse events.\n\nParticipants will be asked to complete questionnaires at pretreatment visit, postoperative visit, and after 6-months and 12-months of implant insertion. At 12-months a radiological exam (CBCT) will be asked for the participant for the evaluation of the radiological condition of the maxillary sinus.",[68,69,28],"Edentulous Maxilla","Maxillary Bone Loss",[71],"\"zygomatic implants\"; \"zygoma implants\"","NOT_YET_RECRUITING","2025-11-21",{"date":75,"type":47},"2025-12-02",{"date":77,"type":21},"2026-06-01",{"date":79,"type":21},"2029-11-01",{"name":81,"class":82},"Nobel Biocare","INDUSTRY",2,{"id":85,"slug":86,"hasResults":11,"nctId":87,"briefTitle":88,"officialTitle":89,"acronym":4,"eligibilityCriteria":90,"healthyVolunteers":91,"sex":17,"minAge":18,"maxAge":92,"enrollmentInfo":93,"targetDuration":4,"studyType":22,"phases":95,"briefSummary":96,"conditions":97,"keywords":99,"overallStatus":72,"whyStopped":4,"lastUpdateSubmitDate":112,"lastUpdatePostDateStruct":113,"startDateStruct":115,"completionDateStruct":117,"leadSponsor":119,"locationsCount":4},"100594026","prospective-study-of-bone-augmentation-with-lateral-sinus-lift-and-osseointegration-of-dental-implants-100594026","NCT07014085","Prospective Study of Bone Augmentation With Lateral Sinus Lift and Osseointegration of Dental Implants","Histomorphometric Evaluation of Bone Augmentation Using Xenograft vs Autologous Bone Graft With Dental Implants. A Comparative Clinical Study.","Inclusion Criteria:\n\n* Partially edentulous jaws in the lateral segment with 2 or more nearby lost teeth in the posterior upper jaw (maxilla), where the vertical height is a minimum of 2mm\n* absence of marginal periodontal disease\n* patients in American Society of Anesthesiologists ASA group 1-2 over 18 years.\n\nExclusion Criteria:\n\n* ASA group 3 and above\n* ongoing infection\n* bruxism or abnormal habit\n* poor oral hygiene\n* medical conditions that may compromise healing (uncontrolled diabetes etc)\n* treatments that interfere with healing in the jaw bone (bisphosphonate, steroid therapy) radiotherapy or chemotherapy within the last 5 years\n* alcohol or substance abuse\n* heavy smoking\n* pregnancy\n* desire not to participate",true,"100 Years",{"count":94,"type":21},20,[24],"By using a split-mouth model in the maxilla, lateral sinus lift procedures will be performed using xenograft on one side vs autologous bone augmentation and PRF membranes on the other side. The purpose is to qualify and verify each step of this study to ensure the reliability and validity of the results.",[28,98],"Partial Edentulism",[100,101,102,103,104,105,106,107,108,109,110,111],"bone augmentation","dento alveolar surgery","oral surgery","comparative prospective study","clinical study","lateral sinus lift","dental implants","osseointegration","prf","autologus graft","xenograft","atrophic maxilla","2025-06-23",{"date":114,"type":47},"2025-06-24",{"date":116,"type":21},"2025-07-01",{"date":118,"type":21},"2035-12-31",{"name":120,"class":54},"Maria H. Pham",{"id":122,"slug":123,"hasResults":11,"nctId":124,"briefTitle":125,"officialTitle":126,"acronym":127,"eligibilityCriteria":128,"healthyVolunteers":91,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":129,"targetDuration":4,"studyType":22,"phases":130,"briefSummary":131,"conditions":132,"keywords":4,"overallStatus":43,"whyStopped":4,"lastUpdateSubmitDate":133,"lastUpdatePostDateStruct":134,"startDateStruct":136,"completionDateStruct":138,"leadSponsor":140,"locationsCount":83},"100572747","surgical-guides-effectiveness-100572747","NCT06737289","SURGICAL GUIDES EFFECTIVENESS","PRECISION OF SURGICAL GUIDES FOR PLACEMENT OF EXTRA-LARGE DENTAL IMPLANTS. A PILOT STUDY","ASG-EI","Inclusion Criteria:\n\n• Age between 18-80 years of age, patients who sign the informed consent form and patients who consent to undergo preoperative and postoperative orthopantomography and CT scans.\n\nExclusion Criteria:\n\n* Smoking (more than 10 cigarettes per day).\n* Alcoholism (more than 25g\u002Fday in women and more than 40g\u002Fday in men according to WHO criteria),\n* Oncological treatment (history of treatment in the last 6 months or current treatment with chemotherapy or radiotherapy).\n* History of head and neck radiotherapy.\n* Allergic to anesthetics or antibiotics.",{"count":94,"type":21},[24],"The use of zygomatic implants is a technique that is becoming more and more widespread in daily clinical practice, however, few professionals feel safe and confident in performing this type of procedure. We therefore believe that a line of research focused on simplifying this technique will have an extraordinary impact on the safety of both patients and surgeons. Currently, new surgical guides have emerged that guarantee greater precision in the placement of zygomatic implants. However, no comparative clinical studies have yet been performed to evaluate the degree of accuracy of guided implant placement compared to the conventional freehand technique.",[28],"2024-12-17",{"date":135,"type":47},"2024-12-20",{"date":137,"type":47},"2024-12-11",{"date":139,"type":21},"2025-10-12",{"name":141,"class":54},"Universidad Complutense de Madrid"]