[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"autism-or-autistic-traits\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:autism-or-autistic-traits":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,49,73,98,120],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":33,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100546822","baker-gordon-syndrome-natural-history-study-100546822",false,"NCT06399952","Baker Gordon Syndrome Natural History Study","A Prospective, Longitudinal and Observational Natural History Study for Children and Adults With Baker Gordon Syndrome - Genetic Autism Alliance","BAGOS","Inclusion Criteria:\n\n* Genetically confirmed diagnosis of Baker Gordon syndrome.\n* 0-99 years\n* Ability to send medical records and diagnostic test results.\n* Ability to complete tests and questionnaires.\n\nExclusion Criteria:\n\n• The presence of another condition or co-morbidity unrelated to Baker Gordon syndrome, that affects neurodevelopment.\n\nIn this study, the primary caregivers\u002FLAR for each participant diagnosed Baker Gordon Syndrome will be also considered participants.\n\nCaregivers\u002FLAR will have to meet the following inclusion criteria:\n\n* \\>18 years.\n* Legal caregiver of the patient diagnosed with a Baker Gordon Syndrome.\n* Willingness to follow study procedures, as assessed by the research team.\n* Willingness to sign the consent form.\n* Ability to understand all the information regarding the study, as assessed by the research team.\n\nCaregivers\u002FLAR Exclusion Criteria:\n\n• Less than 18 years old.","ALL","0 Years","99 Years",{"count":21,"type":22},50,"ESTIMATED","OBSERVATIONAL","The goal of this study is to conduct a prospective, longitudinal assessment of the natural clinical progression of children and adults with Synaptotagmin1-Associated Neurodevelopmental Disorder also known as Baker Gordon Syndrome (BAGOS). This will be performed by acquiring baseline measurements and developing effective outcome measures and diagnostic tools for the disorder, to prepare the healthcare system for future clinical trials.",[26,27,28,29,30,31,32],"Rare Diseases","Autism or Autistic Traits","Development Delay","SYT-SSX Fusion Protein Expression","Sleep Disorder","Epilepsy, Generalized","Motor Delay",[34,15,35],"Baker Gordon Syndrome","Synaptotagmin 1-Associated Neurodevelopmental Disorder","RECRUITING","2026-06-01",{"date":39,"type":40},"2026-06-03","ACTUAL",{"date":42,"type":40},"2024-04-30",{"date":44,"type":22},"2027-05-05",{"name":46,"class":47},"University of Missouri-Columbia","OTHER",1,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":53,"acronym":4,"eligibilityCriteria":54,"healthyVolunteers":55,"sex":17,"minAge":56,"maxAge":57,"enrollmentInfo":58,"targetDuration":60,"studyType":23,"phases":4,"briefSummary":61,"conditions":62,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":48},"100541390","development-of-prosocial-behaviors-and-related-brain-network-in-infants-of-high-and-low-risk-of-asd-100541390","NCT06329245","Development of Prosocial Behaviors and Related Brain Network in Infants of High and Low Risk of ASD","Inclusion Criteria:\n\n* Subjects were enrolled as high-risk if they had an older sibling with a clinical diagnosis of ASD confirmed on the Autism Diagnostic Observation Schedule, second edition (ADOS-2) or Autism Diagnostic Interview (ADI-R).\n* Subjects were enrolled in the low-risk group if they had an older sibling without evidence of ASD and no family history of a first or second-degree relative with ASD.\n\nExclusion Criteria:\n\n1. diagnosis or physical signs strongly suggestive of a genetic condition or syndrome (e.g., fragile X syndrome) reported to be associated with ASDs;\n2. a significant medical or neurological condition affecting growth, development or cognition (e.g., CNS infection, seizure disorder, congenital heart disease);\n3. sensory impairment such as vision or hearing loss;\n4. low birth weight (\\\u003C2000 grams) or prematurity (\\\u003C37 weeks gestation);\n5. possible perinatal brain injury from exposure to in-utero exogenous compounds reported to likely affect the brain adversely in at least some individuals (e.g., alcohol, selected prescription medications);\n6. contraindication for MRI (e.g., metal implants);\n7. a family history of intellectual disability, psychosis, schizophrenia or bipolar disorder in a first-degree relative.",true,"0 Months","18 Months",{"count":59,"type":22},100,"30 Months","The goal of this observational study is to compare the developmental trajectories of prosocial behaviors and functional network connections in infants and toddlers at high and low risk of autism spectrum disorder (ASD). The main questions it aims to answer are what the differences in prosocial behaviors and related brain network connections between infants\u002Ftoddlers at high and low risk of ASD are. Participants will receive developmental and social communicational assessments (Griffiths Mental Developmental Scales, Peabody Developmental Motor Scales, The Communication and Symbolic Behavior Scales Developmental Profile Infant-Toddler Checklist), resting-state EEG and MRI in a natural sleeping state.",[27,63],"Healthy","2026-03-13",{"date":66,"type":40},"2026-03-16",{"date":68,"type":40},"2024-04-01",{"date":70,"type":22},"2029-07-01",{"name":72,"class":47},"Children's Hospital of Fudan University",{"id":74,"slug":75,"hasResults":11,"nctId":76,"briefTitle":77,"officialTitle":77,"acronym":4,"eligibilityCriteria":78,"healthyVolunteers":11,"sex":17,"minAge":79,"maxAge":80,"enrollmentInfo":81,"targetDuration":4,"studyType":83,"phases":84,"briefSummary":86,"conditions":87,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":48},"100554176","effects-of-multiple-session-transcranial-direct-current-stimulation-tdcs-on-behavioral-physiological-and-electrophysiological-measures-with-adults-with-autism-spectrum-disorder-asd-100554176","NCT06495684","Effects of Multiple-Session Transcranial Direct Current Stimulation (tDCS) on Behavioral, Physiological, and Electrophysiological Measures With Adults With Autism Spectrum Disorder (ASD)","Inclusion Criteria:\n\n1. Age 18-35 years\n2. Proficient in English\n3. Classification of autism or autism spectrum disorder on Autism Diagnostic Observation Scale, 2nd Edition (ADOS-2) or score of \\>= 17 on Autism Quotient (AQ)\n4. Good or corrected vision and hearing\n5. Right-handed based on the Edinburgh Handedness Inventory\n6. Score of \\>= 85 on Shipley-2\n\nExclusion Criteria\n\n1. No known loss of consciousness for \\> 5 minutes\n2. No immediate biological family members with a history of epilepsy or seizure disorder\n3. No major medical needs (e.g., neurological disorders such as a seizure disorder; long-term illness)\n4. No surgically implanted metal above the neck (example: metal pins or plates, cochlear implants, aneurysm clips, brain electrodes)\n5. No hospitalization for depression, anxiety, or substance abuse in the past 12 months\n6. No individuals who are currently pregnant\n7. No pacemakers\n8. No history of neurological disorders such as stroke, multiple sclerosis, bipolar disorder, encephalitis, epilepsy, seizure disorder, or amyotrophic lateral sclerosis","18 Years","35 Years",{"count":82,"type":22},20,"INTERVENTIONAL",[85],"NA","The purpose of this clinical trial is to investigate the effects of multiple sessions of transcranial direct current stimulation (tDCS) delivered while participants complete tasks that target social learning with high functioning adults with ASD and\u002For high traits of ASD.\n\nThe main question it aims to answer is:\n\nWhat are the effects of multiple sessions of active compared to sham tDCS, with tDCS simultaneously paired with social learning tasks, from employing a within-subject, cross-over randomized controlled trial design?\n\nParticipants will:\n\n* Complete a randomly assigned block of 5 sessions of active and a block of 5 sessions of sham tDCS, with a four-week break occurring between the two blocks.\n* Complete social learning tasks simultaneously during receipt of tDCS at each session (whether receiving active or sham tDCS).\n* Complete behavioral, physiological, and electrophysiological testing before and after each block of active or sham tDCS.\n* Complete a social validity questionnaire after completion of the study.",[88,27],"Autism Spectrum Disorder","2026-01-14",{"date":91,"type":40},"2026-01-16",{"date":93,"type":40},"2024-03-12",{"date":95,"type":22},"2027-06-30",{"name":97,"class":47},"University of New Mexico",{"id":99,"slug":100,"hasResults":11,"nctId":101,"briefTitle":102,"officialTitle":102,"acronym":103,"eligibilityCriteria":104,"healthyVolunteers":11,"sex":17,"minAge":57,"maxAge":105,"enrollmentInfo":106,"targetDuration":4,"studyType":83,"phases":108,"briefSummary":109,"conditions":110,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":111,"lastUpdatePostDateStruct":112,"startDateStruct":114,"completionDateStruct":116,"leadSponsor":118,"locationsCount":48},"100481647","autism-caregiver-coaching-in-africa-100481647","NCT05551728","Autism Caregiver Coaching in Africa","ACACIA","Inclusion Criteria:\n\n* Child's age is 18-72 months\n* Child meets DSM-5 criteria for autism spectrum disorder (ASD), informed by Autism Diagnostic Observation Schedule, Second Edition (ADOS-2)\n* Child's caregiver speaks isiXhosa, isiZulu, Afrikaans, or English\n* Child's race is African or Coloured (South African term for mixed race)\n* Caregiver-child dyad live in recruitment area\n* Caregiver is ≥18 years\n\nExclusion Criteria:\n\n* Genetic disorder of known etiology (e.g., fragile X syndrome)\n* Significant sensory or motor impairment that would preclude use of the play materials\n* Major physical abnormalities that would interfere with participation in the intervention\n* History of serious head injury and\u002For neurological disease\n* Caregiver indicates they will be unable to attend assessments and 12 sessions","72 Months",{"count":107,"type":22},320,[85],"Around the world there is a growing need to develop early intervention services in local communities that support a better quality of life for all autistic people. The South African study will test an approach where caregivers are coached by non-specialists in early intervention strategies. Caregivers can then use these strategies during everyday activities with their young autistic child.",[27],"2026-01-07",{"date":113,"type":40},"2026-01-09",{"date":115,"type":40},"2023-04-01",{"date":117,"type":22},"2027-09",{"name":119,"class":47},"Duke University",{"id":121,"slug":122,"hasResults":11,"nctId":123,"briefTitle":124,"officialTitle":125,"acronym":126,"eligibilityCriteria":127,"healthyVolunteers":55,"sex":17,"minAge":128,"maxAge":129,"enrollmentInfo":130,"targetDuration":4,"studyType":83,"phases":132,"briefSummary":133,"conditions":134,"keywords":137,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":139,"lastUpdatePostDateStruct":140,"startDateStruct":142,"completionDateStruct":144,"leadSponsor":146,"locationsCount":48},"100569772","symptom-specific-effects-of-omega-3-across-neurodevelopmental-symptoms-100569772","NCT06698588","Symptom-specific Effects of Omega-3 Across Neurodevelopmental Symptoms","Examining Symptom-Specific Effects of Omega-3 Fatty Acids in Children with ADHD \u002F ASD Symptoms and Sleep Problems: a Network Approach.","SEASONS","Inclusion Criteria:\n\nAutism Spectrum Quotient 10 score \\>5 OR Conners 3 Handscored Short Parent Form T score \\> 64 for either the inattention OR hyperactivity subscales OR Children Sleep Habits Questionnaire SF score \\>30 Able to swallow capsules\n\nExclusion Criteria:\n\nAny major psychiatric condition likely to require hospitalization (e.g., Psychotic Disorders; Eating Disorders), but NB: for representativeness of typical children with ADHD\u002FASD, diagnosed mood\u002Fanxiety\u002Fsleep or other neurodevelopmental disorders will not be exclusion criteria; Severe learning difficulties (e.g., Down syndrome) Any serious medical condition; (d) allergy to any ingredients of the intervention or related substances","5 Years","12 Years",{"count":131,"type":22},200,[85],"Our study aims to determine whether omega-3 fatty acid supplementation can improve sleep, mood, and behavior in children with sleep problems and symptoms of Autism Spectrum Disorder (ASD), Attention-Deficit\u002FHyperactivity Disorder (ADHD), or both. By using a transdiagnostic approach-focusing on specific symptoms rather than diagnostic labels-we aim to identify which children may benefit most from omega-3 supplementation, thereby enhancing inclusivity. Many previous studies have excluded children with both ASD and ADHD, or those without a formal diagnosis.",[135,27,136],"Sleep","ADHD or ADHD Traits",[138],"Randomised Controlled Trial","2024-11-19",{"date":141,"type":40},"2024-11-21",{"date":143,"type":40},"2024-11-07",{"date":145,"type":22},"2025-12-01",{"name":147,"class":47},"Swansea University"]