[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"autonomic-nervous-system-ans-functioning-and-mood-state\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:autonomic-nervous-system-ans-functioning-and-mood-state":31},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,54],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":34,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":42,"lastUpdatePostDateStruct":43,"startDateStruct":46,"completionDateStruct":48,"leadSponsor":50,"locationsCount":53},"100630073","transcutaneous-auricular-vagus-nerve-stimulation-and-spirometry-sham-controlled-randomized-trial-100630073",false,"NCT07482930","Transcutaneous Auricular Vagus Nerve Stimulation and Spirometry: Sham-Controlled Randomized Trial","Acute Effects Transcutaneous Auricular Vagus Nerve Stimulation on Spirometric Parameters in Healthy Individuals: A Sham-Controlled Randomized Study","taVNS-SPIRO","Inclusion Criteria:\n\n* Aged 18-40 years.\n* Healthy volunteers.\n* Able to perform spirometry and follow study instructions.\n* Provided written informed consent.\n\nExclusion Criteria:\n\n* Any cardiovascular disease, cardiac arrhythmia, hypertension, or related condition.\n* Any neurological disorder (e.g., diabetes mellitus, peripheral neuropathy, epilepsy).\n* Any diagnosed psychiatric disorder.\n* Any respiratory disease (e.g., asthma, chronic obstructive pulmonary disease).\n* Pregnancy or suspected pregnancy.\n* Ear conditions that prevent stimulation (infection, open wound, pain\u002Ftenderness) or presence of a piercing at\u002Fnear the stimulation site.\n* Vigorous exercise within 24 hours prior to measurement.\n* Caffeine intake, smoking, or alcohol consumption within 4-6 hours prior to measurement.\n* Marked intolerance or hypersensitivity to the device or the procedure.\n* Inability to follow instructions during measurements or refusal to complete the session.",true,"ALL","18 Years","40 Years",{"count":22,"type":23},50,"ESTIMATED","INTERVENTIONAL",[26],"NA","This study will examine the short-term effects of transcutaneous auricular vagus nerve stimulation (a non-invasive electrical stimulation delivered through the outer ear) on lung function measured by spirometry in healthy adults. The vagus nerve is involved in many automatic body functions, and ear-based stimulation has been used in research to explore its possible effects on different physiological systems. However, it is not clear whether a brief stimulation session can acutely influence breathing test results in people without respiratory disease.\n\nHealthy volunteers aged 18-40 will take part in one laboratory visit. Participants will be randomly assigned to one of two groups: (1) active bilateral stimulation applied to specific ear regions that are known to be innervated by the vagus nerve, or (2) sham stimulation using the same device setup but designed to minimize vagal activation. The stimulation session will last approximately 10 minutes. Before and after the stimulation, participants will perform standard spirometry (breathing) tests. Primary spirometric outcomes will include common measures of lung function such as forced vital capacity (FVC), forced expiratory volume in one second (FEV1), and peak expiratory flow (PEF). Heart rate, heart rate variability, and blood pressure may also be recorded to monitor physiological responses and safety during the visit.\n\nParticipation is voluntary and participants may withdraw at any time. The procedure is considered minimal risk. Possible side effects are usually mild and temporary, such as tingling, warmth, or mild discomfort at the ear. Rarely, participants may feel lightheaded; if this occurs, the procedure will be stopped and the participant will be monitored until symptoms resolve. There is no guaranteed direct benefit to participants. The results may help clarify whether short-term ear-based vagus nerve stimulation can influence spirometric parameters and may inform future studies on autonomic and respiratory interactions.",[29,30,31,32,33],"Vagus Nerve Stimulations","Spirometry","Autonomic Nervous System (ANS) Functioning and Mood State","Blood Pressure Monitoring","Respiratory Function Tests",[35,36,37,38,39,40],"transcutaneous auricular vagus nerve stimulation","spirometry","autonomic nervous system","sham stimulation","pulmonary function test","blood pressure","RECRUITING","2026-03-16",{"date":44,"type":45},"2026-03-19","ACTUAL",{"date":47,"type":45},"2026-03-17",{"date":49,"type":23},"2026-04-25",{"name":51,"class":52},"SEFA HAKTAN HATIK","OTHER",1,{"id":55,"slug":56,"hasResults":11,"nctId":57,"briefTitle":58,"officialTitle":59,"acronym":4,"eligibilityCriteria":60,"healthyVolunteers":11,"sex":61,"minAge":19,"maxAge":4,"enrollmentInfo":62,"targetDuration":4,"studyType":24,"phases":64,"briefSummary":65,"conditions":66,"keywords":4,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":4},"100613856","office-massage-effects-on-hrv-and-stress-100613856","NCT07272031","Office Massage Effects on HRV and Stress","Randomized Controlled Trial to Evaluate the Effectiveness of Three Different 15-Minute Office Massage Types (Head, Cervical Area, Hand) on Autonomic Nervous System Balance and Chronic Stress Reduction Using Heart Rate Variability (HRV)","Inclusion Criteria:\n\nBiological females aged 18 years or older. Currently working in an office job with at least 75% of the working day spent sitting (sedentary work).\n\nMust report a regular menstrual cycle (cycle length 21-35 days) for at least the past 6 months.\n\nAble to attend all scheduled intervention sessions (8 sessions over 4 weeks). Able to provide informed consent to participate in the study.\n\nExclusion Criteria:\n\nUse of hormonal contraceptives or other hormone-containing therapies (e.g., Intrauterine Device (IUDs), patches, birth control pills).\n\nPregnancy, current breastfeeding, or planning pregnancy during the study period.\n\nMenopause (natural or surgically induced). Diagnosis of a severe chronic disease (e.g., heart failure, insulin-dependent diabetes, diagnosed neurological disorder).\n\nActive cancer or history of cancer within the last 5 years. Current diagnosis of a major psychiatric disorder (e.g., major depressive disorder, bipolar disorder).\n\nCurrent use of psychotropic medications that could significantly affect Heart Rate Variability (HRV) (e.g., certain beta-blockers, anti-depressants).\n\nHistory of recent surgery (within the last 3 months) in the neck or upper extremities.\n\nParticipation in another clinical trial simultaneously.","FEMALE",{"count":63,"type":23},140,[26],"This study is a randomized controlled trial designed to investigate which of three short office massage types (head, neck\u002Fshoulder area, or hand) is most effective for reducing chronic stress in women who perform sedentary office work.\n\nMany sedentary female office employees experience long-term tension and work-related strain, which can affect the body's ability to recover. The investigators are testing whether a 15-minute massage, performed twice a week for four weeks, can help restore balance within the body.\n\nThe investigators will evaluate the impact of these massages using Heart Rate Variability (HRV)-an objective measure that shows how well the body manages stress (autonomic nervous system balance)-as well as analyzing participants' self-reported levels of perceived stress, sleep quality, and overall well-being. Participants receiving massage will be compared to a control group engaging in quiet rest.",[67,31,68],"Occupational Health","Stress","NOT_YET_RECRUITING","2025-11-26",{"date":72,"type":45},"2025-12-09",{"date":74,"type":23},"2026-01-05",{"date":76,"type":23},"2027-04",{"name":78,"class":52},"Riga Stradins University"]