[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"autonomous-cortisol-secretion\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:autonomous-cortisol-secretion":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,42,71],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":27,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100589505","study-on-the-incidence-of-adrenal-insufficiency-after-surgery-in-primary-aldosteronism-patients-concurrent-with-or-without-autonomous-cortisol-secretion-100589505",false,"NCT06955286","Study on the Incidence of Adrenal Insufficiency After Surgery in Primary Aldosteronism Patients Concurrent With or Without Autonomous Cortisol Secretion","* A confirmed diagnosis of primary aldosteronism or autonomous cortisol secretion;\n\n  ② Completion of unilateral adrenal surgery;\n\n  ③ Voluntary participation and obtaining informed consent. (2) Exclusion criteria\n* Patients with typical clinical manifestations of Cushing's syndrome;\n\n  * Patients suspected of having bilateral cortisol over-secretion, such as PBMAH or PPNAD; ③ Patients with severe surgical complications, unstable postoperative condition (not due to cortical insufficiency), and difficulty completing the ACTH stimulation test;\n\n    * History of ACTH allergy;\n\n      * Patients requiring long-term hormone therapy for other diseases (such as autoimmune diseases);\n\n        * Severe liver and kidney dysfunction (ALT ≥ 3 times the upper limit of normal; patients undergoing dialysis or with an estimated glomerular filtration rate \\\u003C 30 ml\u002Fmin\u002Fm2); ⑦ History of contralateral adrenal surgery; ⑧ Patients with poor compliance who are unable to complete the study.","ALL","18 Years","70 Years",{"count":19,"type":20},521,"ESTIMATED","OBSERVATIONAL","To evaluate the incidence of adrenal insufficiency after surgery in Primary aldosteronism (PA) patients concurrent with or without autonomous cortisol secretion (ACS). To assess the recovery time of postoperative adrenal insufficiency in patients. And to explore the clinical characteristics and predictive indicators of patients requiring postoperative hormone replacement therapy.",[24,25,26],"Primary Aldosteronism","Autonomous Cortisol Secretion","Adrenal Insufficiency",[24,25,26,28],"ACTH stimulation test","RECRUITING","2026-04-29",{"date":32,"type":33},"2026-05-01","ACTUAL",{"date":35,"type":33},"2025-01-02",{"date":37,"type":20},"2028-12-31",{"name":39,"class":40},"Qifu Li","OTHER",1,{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":4,"eligibilityCriteria":48,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":49,"targetDuration":4,"studyType":51,"phases":52,"briefSummary":54,"conditions":55,"keywords":56,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":41},"100580141","68ga-pentixafor-petct-versus-adrenal-vein-sampling-in-diagnosing-unilateral-subtype-of-primary-aldosteronism-concurrent-with-autonomous-cortisol-secretion-predict-100580141","NCT06833437","68Ga-Pentixafor PET\u002FCT Versus Adrenal Vein Sampling in Diagnosing Unilateral Subtype of Primary Aldosteronism Concurrent With Autonomous Cortisol Secretion (PREDICT)","68Ga-Pentixafor PET\u002FCT Versus Adrenal Vein Sampling in Diagnosing Unilateral Subtype of Primary Aldosteronism Concurrent With Autonomous Cortisol Secretion (PREDICT): a Randomized Cross-over Trial","Inclusion Criteria:\n\n* Getting the written informed consent;\n* PA conccurent with autonomous cortisol secretion;\n* Patients with hypertension aged 18-70 years;\n* CT or MRI scan of the adrenal glands with adenoma. Exclusion criteria\n\nExclusion Criteria:\n\n* Unable to complete 68Ga-Pentixafor PET\u002FCT or AVS;\n* Refusal of surgery or contraindications for surgery;\n* PA patients who meet the by-passing AVS criteria \\[i.e., younger than 35 years old, spontaneous hypokalemia, adrenal CT indicated unilateral low-density adenoma (≥1cm), plasma aldosterone \\>300pg\u002Fml\\]\n* Suspicion of familial hyperaldosteronism or Liddle syndrome. \\[i.e., age \\\u003C20 years, hypertension and hypokalemia, or with family history\\];\n* Suspicion of pheochromocytoma or adrenal carcinoma;\n* Patients with actively malignant tumor;\n* Patients who have adrenalectomy history;\n* Long-term use of glucocorticoids;\n* Pregnant or lactating women; with alcohol or drug abuse and mental disorders;\n* Congestive heart failure with New York Heart Association (NYHA) Functional Classification III or IV; History of serious cardiovascular or cerebrovascular disease (angina, myocardial infarction or stroke) in the past 3 months; Severe anemia (Hb\\\u003C60g\u002FL); Serious liver dysfunction or chronic kidney disease aspartate aminotransferase (AST) or alanine transaminase (ALT) \\>3 times the upper limit of normal, or estimated glomerular filtration rate (eGFR) \\\u003C 30 ml\u002Fmin\u002F1.73 m2); Systemic Inflammatory Response Syndrome (SIRS); Uncontrolled diabetes (FBG≥13.3 mmol\u002FL); Obesity (BMI≥35 kg\u002Fm²) or Underweight (BMI≤18 kg\u002Fm²); Untreated aneurysm; Other comorbidity potentially interfering with treatment;\n* Suspected PBMAH or PPNAD;\n* Poor compliance or any other reason deemed unsuitable for inclusion by the investigators;\n* Patients with adrenal insufficiency requiring hormone replacement therapy.",{"count":50,"type":20},178,"INTERVENTIONAL",[53],"NA","To validate the accuracy of 68Ga-Pentixafor PET\u002FCT and adrenal venous sampling (AVS) in subtype diagnosis of PA\u002FACS patients with adrenal nodules, based on biochemical and clinical remission outcomes, and to determine whether the diagnostic accuracy of 68Ga-Pentixafor PET\u002FCT is non-inferior to AVS.",[24,25],[57,58,59,60,61,62],"Primary aldosteronism","Autonomous cortisol secretion","Adrenal venous sampling","68Ga-Pentixafor PET\u002FCT","outcome","multicenter randomized crossover trial","2026-02-03",{"date":65,"type":33},"2026-02-05",{"date":67,"type":33},"2024-08-01",{"date":69,"type":20},"2029-12-31",{"name":39,"class":40},{"id":72,"slug":73,"hasResults":11,"nctId":74,"briefTitle":75,"officialTitle":76,"acronym":4,"eligibilityCriteria":77,"healthyVolunteers":78,"sex":15,"minAge":79,"maxAge":80,"enrollmentInfo":81,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":83,"conditions":84,"keywords":87,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":41},"100466724","performances-on-cognitive-functions-and-brain-function-and-follow-up-after-different-treatments-in-patients-with-autonomous-cortisol-secretion-a-single-center-prospective-observational-study-100466724","NCT05357456","Performances on Cognitive Functions and Brain Function and Follow-up After Different Treatments in Patients With Autonomous Cortisol Secretion: a Single-center, Prospective, Observational Study","A Single Center, Prospective, Observational Study to Explore and Evaluate the Differences of Cognitive Function and Brain Function Between Non-functioning Adrenal Adenomas and Autonomous Cortisol Secretion Patients, and the Different Treatments Methods on Cognitive Function and Brain Function in Patients With Autonomous Cortisol Secretion","Inclusion Criteria:\n\n* age 20-65 years;\n* ≥ 6 years of education；\n* right-handed;\n* complete entire cognitive function tests;\n* adrenal lesions ≥ 1 cm in diameter;\n* patients with non-functioning adrenal adenomas;\n* patients with autonomous cortisol secretion.\n\nExclusion Criteria:\n\n* \\\u003C 6 years of education;\n* age \\\u003C 20 years or \\> 65 years;\n* maximum diameter of AI \\\u003C1cm;\n* active malignancies;\n* with a history of thyroid disease;\n* with a history of acute infection in the last month;\n* central nervous system diseases, including brain trauma, intracranial hemorrhage, acute cerebral infarction, etc;\n* contraindications of MRI examination: such as implantation of metal prosthesis in vivo, claustrophobia, etc;\n* adrenal tuberculosis;\n* suspected or diagnosed adrenocortical carcinoma;\n* unable to complete entire cognitive function tests;\n* current use of steroids or any drugs known to alter steroid synthesis or metabolism in the previous 3 months;\n* clinical Cushing syndrome;\n* Cushing disease;\n* primary hyperaldosteronism;\n* pheochromocytoma;\n* severe impairment of heart, liver, kidney and other organs;\n* pregnant and lactating women",true,"20 Years","65 Years",{"count":82,"type":20},62,"This is a single center, prospective, observational study to explore and evaluate the differences on cognitive function and brain function by functional-MRI in autonomous cortisol secretion patients, and the different treatments methods on the cognitive function and brain function in patients with autonomous cortisol secretion",[25,85,86],"Adrenal Incidentaloma","Non-functioning Adrenal Adenomas",[88,89,90],"cognitive function","functional MRI","treatment","2022-04-27",{"date":93,"type":33},"2022-05-02",{"date":95,"type":33},"2021-10-01",{"date":97,"type":20},"2026-10-01",{"name":99,"class":40},"The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School"]