[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"autonomy\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:autonomy":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,44,73,106,139,169],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100568735","translation-and-validation-of-the-limbs-pain-autonomy-depression-anxiety-and-quality-of-life-scales-in-albanian-100568735",false,"NCT06685094","Translation and Validation of the Limbs, Pain, Autonomy, Depression, Anxiety and Quality of Life Scales in Albanian","Cross-cultural Adaptation, Translation and Validation of the Assessment Scales of the Upper and Lower Limbs, Pain, Autonomy, Depression, Anxiety and Quality of Life for Use in the Albanian-speaking Population","Inclusion Criteria:\n\n* articular and muscular pain\n* back pain\n* presence of rheumatologic symptoms\n* functional misbalance\n* scoliosis\n* musculoskeletal disorders\n\nExclusion Criteria:\n\n* no native albanian language\n* severe trauma to the lumbar spine or hip(s)\n* tumor\n* metabolic disease",true,"ALL","18 Years","80 Years",{"count":21,"type":22},300,"ESTIMATED","OBSERVATIONAL","The cross-cultural adaptation will be performed according to the internationally recommended methodology, using the following guidelines: translation, back-translation; revision by a committee, questionnaire diffusion and data collection and analyzing.\n\nThe psychometric properties will be evaluated by administering the questionnaire to approximately 300 participants. Reliability will be estimated through stability and homogeneity assessment",[26,27,28,29,30],"Musculoskeletal Pain","Autonomy","Healthy","Upper Limb Injury","Lower Limb Injury","RECRUITING","2026-06-02",{"date":34,"type":35},"2026-06-04","ACTUAL",{"date":37,"type":35},"2025-06-30",{"date":39,"type":22},"2027-09-01",{"name":41,"class":42},"Universidad Católica San Antonio de Murcia","OTHER",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":50,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":17,"minAge":52,"maxAge":4,"enrollmentInfo":53,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":55,"conditions":56,"keywords":60,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":43},"100640901","validation-of-the-french-version-of-the-new-mobility-score-nms-100640901","NCT07622095","Validation of the French Version of the New Mobility Score (NMS)","Validation of the French Version of the New Mobility Score (NMS) in Hospitalized Patients With Hip Fracture","MOB-SCORE","Inclusion Criteria:\n\n* Patients aged 75 years and older admitted to a hospital department following a hip fracture and treated surgically (osteosynthesis or arthroplasty).\n* Type of fracture: pertrochanteric fracture or femoral neck fracture.\n* Sufficient proficiency in French to complete the questionnaires.\n* Patients affiliated with a health insurance scheme.\n* No objection to participate from the patient or the caregiver in case of cognitive impairment.\n\nExclusion Criteria: no exclusion criteria","75 Years",{"count":54,"type":22},100,"The incidence of hip fractures in France is 50,000 cases per year among women and 16,000 among men, with a 1-year mortality rate of 20-24%. After a fracture, 10-30% of patients become functionally dependent. The increasing aging of the population and the rise in dependency are likely to worsen the situation of older patients in hospital settings.\n\nSeveral tools are available to assess functional independence, including the New Mobility Score (NMS), which evaluates mobility through three domains: mobility indoors, mobility outdoors, and shopping activities. The NMS has shown good performance in predicting patient mortality and functional recovery, and its use is recommended in clinical practice. However, the French version of the NMS has not yet been validated.\n\nThe French validation of the NMS is important to facilitate its implementation in clinical practice and research, particularly because of its simplicity and the need for rapid assessment tools for healthcare professionals. A French version of the NMS has been translated, and the MOB-SCORE study aims to assess its reliability and validity among healthcare professionals caring for patients with hip fractures.",[57,58,59,27],"Hip Fractures","Mobility Limitation","Independence",[61,62,63],"New Mobility Score","Validation","Inter-rater reliability","NOT_YET_RECRUITING","2026-05-28",{"date":32,"type":35},{"date":68,"type":22},"2026-07",{"date":70,"type":22},"2028-02",{"name":72,"class":42},"Hospices Civils de Lyon",{"id":74,"slug":75,"hasResults":11,"nctId":76,"briefTitle":77,"officialTitle":78,"acronym":79,"eligibilityCriteria":80,"healthyVolunteers":16,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":81,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":83,"conditions":84,"keywords":89,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":100,"completionDateStruct":102,"leadSponsor":104,"locationsCount":43},"100617090","impact-evaluation-of-breizh-fabribus-intervention-for-personalized-assistive-technology-creation-or-adaptation-100617090","NCT07314099","Impact Evaluation of Breizh Fabribus Intervention for Personalized Assistive Technology Creation or Adaptation","Évaluation d'Impact de l'Intervention du Breizh Fabribus Pour la création ou l'Adaptation d'Aide Technique personnalisée (BFB-IMPACT)","BFB-IMPACT","Inclusion Criteria:\n\n* Any person who has received assistance from BFB for the creation or adaptation of assistive technology\n\nExclusion Criteria:\n\n* objection to the use of their data\n* Sollicitation but no delivery of technical assistance by BFB",{"count":82,"type":22},70,"In France, more than 14 million individuals report severe functional limitations, and nearly 5 million struggle with essential daily activities. Traditional barriers to assistive technology-high costs, lengthy funding delays, lack of information, and poorly fitting off-the-shelf solutions-frequently lead to underuse, dissatisfaction, and environmental waste The BFB-IMPACT study evaluates the real-world effectiveness of Breizh Fabribus, a mobile workshop equipped with 3D printing and laser-cutting that produces and customizes assistive devices on site for people with disabilities in Finistère, France region. This retrospective, single-center investigation includes all service recipients from January 2024 to December 2025 and measures changes in users' ability to perform targeted activities at three months post-intervention. Secondary outcomes include user satisfaction and device utilization. Data collection occurs from October 2025 to May 2026, with analysis anticipated in June 2026 and results published in the second half of 2026.",[85,86,87,88,27],"Amputation","Functional Limitation","Autonomy of Older People","Handicaps Physical",[90,91,92,93,94,95,96],"mobile workshop","3D printing","laser cutting","personalized devices","user satisfaction","functionnal autonomy","disability","2025-12-17",{"date":99,"type":35},"2026-01-02",{"date":101,"type":22},"2025-12",{"date":103,"type":22},"2026-11",{"name":105,"class":42},"Fondation Ildys",{"id":107,"slug":108,"hasResults":11,"nctId":109,"briefTitle":110,"officialTitle":111,"acronym":112,"eligibilityCriteria":113,"healthyVolunteers":11,"sex":17,"minAge":114,"maxAge":4,"enrollmentInfo":115,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":117,"conditions":118,"keywords":124,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":130,"lastUpdatePostDateStruct":131,"startDateStruct":133,"completionDateStruct":135,"leadSponsor":137,"locationsCount":43},"100612893","predictors-of-emergency-department-use-in-frail-patients-100612893","NCT07259499","Predictors of Emergency Department Use in Frail Patients","Towards an Integrated Care System for the Assistance of Patients With Chronic Diseases, Multimorbidity, Frailty, and Polypharmacy","THE-Spoke 10","Inclusion Criteria:\n\n* fluency in Italian language,\n* age higher than 64 years,\n* loss of autonomies of daily living as assessed by the Katz Activities of Daily Living or in the Lawton Instrumental Activities of Daily Living questionnaires,\n* having performed routinary blood exams in the 6 months prior to recruitment\n* having performed head neuroimaging feasable for cerebrovascular burden assessment, i.e., Magnetic Resonance Imaging (MRI) or computed tomography (CT), in the 6 months prior to recruitment.\n\nExclusion Criteria:\n\n* withdrawal of the informed consent","65 Years",{"count":116,"type":22},110,"When admitted to the emergency department (ED), elderly non-autonomous patients show high risk of adverse health outcomes. The prompt identification of ED use risk factors in such population is hence needed. While cognitive impairment is a known clinical risk factor, biomarkers of most prevalent dementias have been scarcely investigated as possible ED use predictors. Within this context, this prospective study aims at exploring whether plasma phospho-tau181 and cerebrovascular burden can predict ED use at 6 months in elderly non-autonomous patients, irrespective of frailty.",[119,120,121,122,123,27],"Alzheimer s Disease","Vascular Dementia","Frailty","Elderly","Emergency Department Visits",[125,126,127,121,128,122,129],"phosphorylated tau 181","dementia","Emergency Department","Autonomies","cerebrovascular","2025-11-20",{"date":132,"type":35},"2025-12-02",{"date":134,"type":35},"2023-11-19",{"date":136,"type":22},"2025-12-31",{"name":138,"class":42},"University of Pisa",{"id":140,"slug":141,"hasResults":11,"nctId":142,"briefTitle":143,"officialTitle":144,"acronym":4,"eligibilityCriteria":145,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":146,"enrollmentInfo":147,"targetDuration":4,"studyType":149,"phases":150,"briefSummary":152,"conditions":153,"keywords":156,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":160,"lastUpdatePostDateStruct":161,"startDateStruct":163,"completionDateStruct":165,"leadSponsor":167,"locationsCount":43},"100608114","repetitive-transcranial-magnetic-stimulation-primed-self-controlled-practice-on-motor-learning-100608114","NCT07197346","Repetitive Transcranial Magnetic Stimulation Primed Self-controlled Practice on Motor Learning","The Effects of Repetitive Transcranial Magnetic Stimulation Primed Self-controlled Practice on Motor Learning and Motivation","Inclusion Criteria:\n\n1. Healthy adults aged 18-35 years\n2. Right-handed (per Edinburgh Handedness Inventory)\n3. Normal or corrected-to-normal vision and hearing\n4. Eligible for non-invasive brain stimulation per safety screening (no contraindications to TMS)\n5. Able to understand study procedures and provide written informed consent in Chinese\n6. Willing to comply with all study visits and tasks, including TBS\u002FrTMS and motor practice\n7. For yoked pairing: able to be matched to a counterpart participant for practice parameters\n\nExclusion Criteria:\n\n1. History of epilepsy, seizures, or unexplained fainting; family history of epilepsy in first-degree relatives\n2. Any intracranial metal or implanted medical devices (e.g., cochlear implant, deep brain stimulator, aneurysm clips); non-removable metallic objects in head\u002Fneck\n3. Cardiac pacemaker or other implanted electronic devices\n4. Current or past major neurological or psychiatric disorders (e.g., stroke, traumatic brain injury, multiple sclerosis, major depression, bipolar disorder, schizophrenia)\n5. Current use of medications lowering seizure threshold or affecting cortical excitability (e.g., tricyclic antidepressants, bupropion, clozapine, lithium, stimulant or sedative-hypnotic abuse); or unstable psychotropic regimens\n6. Active migraine with aura or chronic severe headaches\n7. Pregnancy or planning pregnancy during participation; breastfeeding (if your site policy excludes)\n8. Substance or alcohol use disorder within the past 12 months; positive alcohol\u002Fdrug screen on visit days\n9. Sleep deprivation (\\\u003C5 hours) on the day before stimulation, or excessive caffeine (\\>400 mg) within 6 hours pre-stimulation\n10. Dermatologic conditions or open wounds at stimulation or EMG\u002Felectrode sites\n11. Prior extensive training on the specific motor task used in this study (risk of ceiling effects)\n12. Concurrent participation in another interventional study or received brain stimulation (TMS\u002FtDCS) within the past 3 months\n13. Any condition that, in the investigator's judgment, makes participation unsafe or data unreliable","35 Years",{"count":148,"type":22},72,"INTERVENTIONAL",[151],"NA","This study aims to investigate the additive effects of combining self-controlled practice with repetitive transcranial magnetic stimulation (rTMS) pretreatment on motivation enhancement and motor learning performance in healthy young adults. According to the \"Optimizing Performance Through Intrinsic Motivation and Attention for Learning\" (OPTIMAL) theory, numerous studies have demonstrated that providing learners with autonomy during practice can facilitate intrinsic motivation and motor learning. However, self-controlled practice alone may have limited effects, and further interventions may be required to amplify learning outcomes.\n\nIn recent years, non-invasive brain stimulation techniques-particularly high-frequency (facilitatory) rTMS applied to the dorsolateral prefrontal cortex (DLPFC)-have been shown to enhance motivational drive and explicit learning performance by strengthening the connectivity of the DLPFC-midbrain dopamine pathway. For example, 10 Hz high-frequency stimulation can significantly improve learners' accuracy and motivation. Interestingly, several sequence learning studies have found that low-frequency (inhibitory) rTMS, when used as a priming intervention, can instead enhance implicit procedural learning. This effect may occur because inhibiting the lateral prefrontal cortex reduces its top-down suppression of implicit learning systems, thereby releasing procedural learning potential.\n\nBased on the theory of metaplasticity, applying facilitatory or inhibitory stimulation beforehand can alter the threshold of synaptic plasticity, thus influencing subsequent learning outcomes. Therefore, this study designed two DLPFC pretreatments-facilitatory and inhibitory-and combined them with self-controlled practice to systematically examine the interaction between different stimulation protocols on motivation and motor learning.\n\nThis cross-sectional experiment plans to recruit 72 healthy participants aged 20 or older, randomly assigned to one of six groups: (1) facilitatory rTMS + self-controlled practice, (2) facilitatory rTMS + yoked control, (3) inhibitory rTMS + self-controlled practice, (4) inhibitory rTMS + yoked control, (5) sham rTMS + self-controlled practice, and (6) sham rTMS + yoked control.\n\nThe experiment will last for seven days. On Day 1, participants will complete baseline testing, followed by facilitatory rTMS, inhibitory rTMS, or sham stimulation over the DLPFC. Immediately afterward, they will engage in a trajectory-tracking learning task (manipulating a joystick to reproduce a sine-wave pattern). After practice, participants will complete a motivation assessment. During the trajectory-tracking task, the self-controlled group can choose when to receive feedback to adjust their learning, whereas the yoked control group will receive feedback at time points matched to their paired counterpart.\n\nOn Day 2, participants will again receive the assigned rTMS (facilitatory, inhibitory, or sham), complete the trajectory-tracking task, and undergo a motivation assessment. After a five-minute rest, they will perform retention and transfer tests, followed by TMS measurement of cortical excitability. On Day 7, participants will return to the laboratory to complete another retention and transfer test, along with cortical excitability measurement via TMS.\n\nThe primary behavioral outcomes are the root mean square error (RMSE) and error estimation (EE) in the trajectory-tracking task. Motivation will be assessed using the Intrinsic Motivation Inventory (IMI). As there have been no prior studies combining DLPFC rTMS pretreatment with practice autonomy, the results of this experimental design are expected to provide new insights and references for enhancing motor learning ability in healthy adults.",[154,27,155],"rTMS Stimulation","Healthy Young Adults",[157,158,159],"motor learning","repetitive transcranial magnetic stimulation","autonomy","2025-09-22",{"date":162,"type":35},"2025-09-29",{"date":164,"type":35},"2025-09-01",{"date":166,"type":22},"2028-12-31",{"name":168,"class":42},"National Taiwan University Hospital",{"id":170,"slug":171,"hasResults":11,"nctId":172,"briefTitle":173,"officialTitle":174,"acronym":175,"eligibilityCriteria":176,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":177,"targetDuration":4,"studyType":149,"phases":179,"briefSummary":180,"conditions":181,"keywords":192,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":196,"lastUpdatePostDateStruct":197,"startDateStruct":199,"completionDateStruct":201,"leadSponsor":203,"locationsCount":43},"100420789","neurorehabilitation-through-hippotherapy-of-a-brain-stroke-100420789","NCT04759326","Neurorehabilitation Through Hippotherapy of a Brain Stroke","Neurorehabilitation Through Hippotherapy on Neurofunctional Sequels of Brain Stroke: (i) Effect on Patient's Functional Independence, Sensorimotor and Cognitive Capacities and Quality of Life (ii) Effect on Caregivers' Quality of Life","HippoPostCVA","Inclusion Criteria:\n\n* Age ≥ 18 years old\n* Ischemic or haemorrhagic stroke according to ICD 10 I61-I69 (30)\n* Inclusion \\> 3 months post-stroke\n* Deficit still existing (Rankin score ≥ 3 and ≤ 4 at inclusion)\n* Existing declaration of informed consent\n* Affiliation of the patient to a social security scheme\n* Minimal abduction of the hip of 25 degrees bilateral with no history of hip dislocation and\u002For dysplasia\n* Certificate of non-contraindication issued by the referring physician\n\nExclusion Criteria:\n\n* Major cognitive impairment affecting comprehension (Mini Mental State Examination test \\\u003C 24 points)\n* Global or sensory aphasia\n* Neurological or psychiatric co-morbidity (other than mild-to-moderate post-stroke depression)\n* Evidence of an uncontrolled seizure disorder\n* Substance abuse\n* History of uncontrolled pain\n* History of allergic reactions to dust and\u002For horsehair, or severe asthma\n* Overweight (≥ 110 kg)\n* Contraindications to physical activity\n* Inability or medical contraindication to travel to the Equiphoria Institute by personal car or taxi\n* History of horse riding or hippotherapy care during the last 6 months\n* Pregnant or lactating women\n* Patients participating in other biomedical research or in a period of exclusion",{"count":178,"type":22},52,[151],"Cerebrovascular accident \\[CVA\\] (medical term for stroke) is a high burden worldwide disorder and the second leading cause of disability. As illustrated by the number of survivors that remain disabled after a CVA (2 out of 3 according to the US National Stroke Association), recovery is limited, and novel neurorehabilitation approaches are urgently needed. Hippotherapy is an emerging specialized rehabilitation approach, performed by accredited health professionals on a specially trained horse via its movement. A body of scientific evidence has gradually emerged in recent years, showing robust benefits of hippotherapy in various massive neurological disabling conditions including brain stroke.\n\nThe aim of the study is to analyze the effect of a hippotherapy program of several cycles delivered during 22 weeks in total, on the functional and global evolution of post-stroke patients (with a score of Rankin ≥ 3 at inclusion) during the outpatient rehabilitation phase. A second purpose is to measure the impact of the intervention on the quality of life of their close caregivers.\n\nA prospective clinical trial on the effectiveness of hippotherapy versus conventional outpatient rehabilitation alone will be carried out. The 22-weeks program includes three cycles of hippotherapy as follows: an initial 2-weeks cycle, an intermediate 1-week cycle and a final 1-week cycle. One-hour daily sessions will be conducted during each cycle exclusive additional rehabilitation care. After each cycle, the patients will have a 9-weeks rest period where they will continue their conventional therapy. A battery of clinical tests will measure both functional and psychological outcome. The primary end point will be the functional independence of the patient. The secondary end points will consider the patient's sensorimotor and cognitive function, the severity of stroke and the quality of life, as well as the caregivers' burden and quality of life.\n\nProgram evaluation is important in neurorehabilitation to ensure that patients are achieving meaningful outcomes from the care. A primary question is how do stroke patients clinically evolve after being discharged from the hospital and how stable is the achieved rehabilitation outcome. Hippotherapy optimizes brain plasticity and has a strong impact on the global rehabilitation process and functional outcome of these patients. A remaining question concerns the improvement of the caregivers' quality of life.",[182,183,184,185,186,187,188,189,27,190,191],"Cerebrovascular Accident","Neurorehabilitation","Neuroplasticity","Hippotherapy","Silent Neurofunctional Barriers","Functional Deficit","Cognitive Deficit","Psychological Trauma","Quality of Life","Caregiver Burnout",[193,194,195],"NeuroRehabilitation through hippotherapy","Brain plasticity","Functional recovery","2024-07-30",{"date":198,"type":35},"2024-07-31",{"date":200,"type":35},"2022-04-27",{"date":202,"type":22},"2026-03",{"name":204,"class":42},"Alliance Equiphoria"]