[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"avoidant-restrictive-food-intake-disorder\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:avoidant-restrictive-food-intake-disorder":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,44],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":4},"100593478","scalable-clinician-supervised-generative-ai-food-chaining-assistant-for-pediatric-arfid-100593478",false,"NCT07006961","Scalable, Clinician-Supervised Generative-AI Food-Chaining Assistant for Pediatric ARFID","Scalable, Clinician-Supervised Generative-AI Food-Chaining Assistant for Pediatric ARFID: A Pilot Randomized Controlled Trial","Inclusion Criteria:\n\n* Children must be aged 3-17 years\n* Children must have caregiver- or participant-reported DSM-5 ARFID diagnosis and\u002For EDYQ-screen-positive Avoidant Restrictive Food Intake Disorder\n* English proficiency.\n\nExclusion Criteria:\n\n* Lack of English proficiency \\[As there is no validated non-English version of the NIAS, we must exclude caregivers who do not have English proficiency\\]\n* Participants must not have been previously treated at Boston Children's for ARFID","ALL","3 Years","17 Years",{"count":20,"type":21},125,"ESTIMATED","INTERVENTIONAL",[24],"NA","Children with Avoidant\u002FRestrictive Food Intake Disorder (ARFID) often lack access to specialty dietitians, and scalable nutritional guidance\u002Ffood chaining tools are currently not available. The investigators will evaluate a web-based, clinician-supervised, generative-AI assistant that produces individualized food-chaining plans.\n\nDevelop an AI assistant that generates ≥15 allergy-safe, evidence-based chaining steps per participant and meets ≥90 % expert agreement for safety\u002Fappropriateness.\n\nValidate the assistant against gold-standard clinician recommendations (Cohen's κ ≥ 0.80).\n\nTest clinical impact in a three-month pilot RCT (n = 96) by comparing change in Nine-Item ARFID Screen (NIAS) scores between intervention and usual-care groups.\n\nHypothesis: AI-generated plans will reduce NIAS scores by ≥3 points relative to controls.",[27],"Avoidant Restrictive Food Intake Disorder",[29,30,31],"ARFID","artificial intelligence","food chaining","NOT_YET_RECRUITING","2025-06-04",{"date":35,"type":36},"2025-06-06","ACTUAL",{"date":38,"type":21},"2025-06-15",{"date":40,"type":21},"2025-10-31",{"name":42,"class":43},"Boston Children's Hospital","OTHER",{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":48,"acronym":49,"eligibilityCriteria":50,"healthyVolunteers":51,"sex":16,"minAge":52,"maxAge":53,"enrollmentInfo":54,"targetDuration":4,"studyType":56,"phases":4,"briefSummary":57,"conditions":58,"keywords":62,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":78},"100561803","eating-disorders-genetics-initiative-2-100561803","NCT06594913","Eating Disorders Genetics Initiative 2","EDGI2","Inclusion Criteria:\n\n* A lifetime history of anorexia nervosa, bulimia nervosa, binge-eating disorder, avoidant restrictive food intake disorders or no history of any disordered eating behavior, based on DSM-5 criteria algorithms\n* Age 12-99 years, depending on country. (US enrollment age is 18-99)\n\nExclusion Criteria:\n\n* History of subthreshold disordered eating behaviors.",true,"12 Years","99 Years",{"count":55,"type":21},20000,"OBSERVATIONAL","The overarching intention of the Eating Disorder Genetics Initiative 2 (EDGI2) is to increase sample size, diversity, and eating disorder phenotypes. The investigators are enrolling 20,000 new participants with anorexia nervosa (AN), bulimia nervosa (BN), binge-eating disorder (BED), avoidant\u002Frestrictive food intake disorder (ARFID), and controls in the US, Mexico, Australia, New Zealand, Sweden, and Denmark. A primary study goal is to enroll at least 30% of participants from underrepresented groups. Participants are asked to complete a series of questionnaires and submit a saliva sample for genotyping. The goal is to better understand eating disorders and how they relate to each other so that better treatments can be developed.",[59,60,61,27],"Anorexia Nervosa","Bulimia Nervosa","Binge-Eating Disorder",[63,64,65,66,67],"severe and enduring eating disorder","genetics","mental health","disordered eating","environmental factors","RECRUITING","2025-05-30",{"date":71,"type":36},"2025-05-31",{"date":73,"type":36},"2024-10-28",{"date":75,"type":21},"2027-08-01",{"name":77,"class":43},"University of North Carolina, Chapel Hill",5]