[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"back-pain-low\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:back-pain-low":32},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,55,95,118],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":4,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":43,"lastUpdatePostDateStruct":44,"startDateStruct":47,"completionDateStruct":49,"leadSponsor":51,"locationsCount":54},"100640820","phase-1-hormones-outcomes-and-pain-pathways-in-exercise-study-100640820",false,"NCT07579182","Hormones, Outcomes, and Pain Pathways in Exercise Study","Mechanical and Non-mechanical Contributions to Chronic Neck, Shoulder, Arm, and Back Pain in Full-busted Women","HOPE","Inclusion Criteria:\n\n1. Able to provide informed consent\n2. Age of 18 to 60 years\n3. Assigned female sex at birth\n4. Right-handed by self-declaration\n5. Willing to participate in one online testing session and up to four in-person testing sessions\n6. Bra band size between 32-40\"\n7. International Physical Activity Questionnaire - Short Form (IPAQ-SF) score of 2 or higher\n8. An answer of \"NO\" to any item of the general health questions of the PARQ+\n9. No history of surgery to the: back, neck, or shoulders or joint replacement\n10. No history of implanted pacemakers or other stimulation devices\n11. No history of spinal cord injury (SCI)\n\nExclusion Criteria:\n\n1. Inability to provide informed consent\n2. Age 17 years old or younger or 61 years or older\n3. Assigned male sex at birth\n4. Left-handed by self-declaration\n5. Not willing to participate in one online testing session and up to four in-person testing sessions\n6. Bra band size greater than 40\" or less than 32\"\n7. IPAQ-SF score of 1 or lower\n8. An answer of \"YES\" to any item of the general health questions of the PARQ+\n9. History of limb amputation (upper or lower extremity)\n10. Presence of open pressure sores on the upper or lower extremities\n11. Currently pregnant or lactating\u002Fbreastfeeding\n12. History of surgery to the: back, neck, or shoulders or joint replacement\n13. History of breast cancer and\u002For mastectomy\n14. History of implanted pacemakers or other stimulation devices\n15. History of spinal cord injury (SCI)\n16. History of joint disease including osteoarthritis and\u002For Rheumatoid Arthritis\n17. History of the following neurological diseases: Cerebrovascular accident (CVA, stroke), Alzheimer's Disease (AD), Dementia (of any form), Huntington's Disease, Traumatic Brain Injury (TBI), Spinal cord injury (SCI), Multiple Sclerosis (MS), Parkinson's Disease (PD), Polio, Paraproteinaemic Demyelinating Neuropathy (PDN) and\u002For Monoclonal Gammopathy of Undetermined Significance (MGUS), Myasthenia Gravis, Muscular Dystrophy, Guillain-Barré Syndrome, Scoliosis, Charcot-Marie-Tooth Disorder or other hereditary neuropathies\n\nAdditional Inclusion Criteria for Intervention Group:\n\na. Self-declared breast size of D-I cup (US sizes: D, E, F, G, H)\n\nAdditional Inclusion Criteria for the Control Group:\n\na. Self-declared breast size of A-C cup (US sizes: AA, A, B, C)",true,"FEMALE","18 Years","60 Years",{"count":22,"type":23},140,"ESTIMATED","INTERVENTIONAL",[26],"PHASE1","The goal of the proposed project is to evaluate a mechanical intervention (sports bras designed specifically for full busted women) to alleviate neck, shoulder, arm, and back pain in full-busted women and investigate the contribution of non-mechanical pathways associated with this type of pain in women. Specifically, the investigators will investigate how sex-hormones, inflammation, and remapping of specific regions of the brain contribute to the manifestation of neck, shoulder, arm, and back pain in full-busted women across the lifespan.",[29,30,31,32,33,34,35,36,37,38,39,40,41],"Breast Pain","Mastalgia","Back Pain","Back Pain, Low","Neck Pain","Chest Pain","Activity, Motor","Healthy Aging","Weight, Body","Inflammation","Gonadal Steroid Hormones","Neuronal Plasticity","Neuromuscular Manifestations","RECRUITING","2026-05-28",{"date":45,"type":46},"2026-06-02","ACTUAL",{"date":48,"type":46},"2026-05-17",{"date":50,"type":23},"2029-09",{"name":52,"class":53},"University of Houston","OTHER",1,{"id":56,"slug":57,"hasResults":11,"nctId":58,"briefTitle":59,"officialTitle":60,"acronym":61,"eligibilityCriteria":62,"healthyVolunteers":11,"sex":63,"minAge":19,"maxAge":4,"enrollmentInfo":64,"targetDuration":4,"studyType":24,"phases":66,"briefSummary":68,"conditions":69,"keywords":79,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":89,"completionDateStruct":91,"leadSponsor":93,"locationsCount":54},"100579522","auriculotherapy-neuroimaging-100579522","NCT06825390","AuriculoTherapy NeuroImaging","Mechanistic Clinical Trial of Auricular Stimulation and Cryogenic Auriculotherapy in Patients With Chronic Low-back Pain, Using Functional Near-infrared Spectroscopy and Magnetic Resonance Imaging","ATNI","Inclusion Criteria:\n\n1. Adult, at least 18 years old\n2. Episodes of chronic low back pain at least daily for at least 6 months, with an average pain score within the last week of 3\u002F10.\n\nExclusion Criteria:\n\n1. active lesions, skin disruptions, or neuropathy of either ear;\n2. recent (\\\u003C1 month) analgesic procedures or surgery;\n3. recent (\\\u003C1 month) start of new analgesic or psychoactive medication (including marijuana, opioids, tramadol, methadone, gabapentinoids, anti-depressants, anti-epileptics, mood-stabilizers, anti-psychotics, or stimulants);\n4. history of chronic pain in shoulder or thumb (to avoid confounding at control stimulation points);\n5. recent (\\\u003C 3 months) illicit drug use;\n6. prior substance misuse\u002Fabuse;\n7. cold-activated diseases (including: agammaglobulinemia, cold urticaria, cold agglutinin disease, cryofibrinogenemia, cryoglobulinemia, immunosuppression, Raynaud's disease, collagen or autoimmune diseases, multiple myeloma, platelet deficiency disorders, pyoderma gangrenosum.)\n\n   \\- MRI-specific exclusions additionally include:\n8. Pregnancy or active attempts at conception;\n9. Implanted metal or electronic device;\n10. severe claustrophobia","ALL",{"count":65,"type":23},60,[67],"NA","This is a clinical study of patients who have low back pain (for at least 6 months). The goal is to understand, with brain imaging, how auriculotherapy (an acupuncture-like stimulation of the ear) may work to relieve pain. There are 4 total study visits, divided into two pairs of visits that occur before and 5-7 days after receiving either a real or sham auriculotherapy treatment. The cryo-IQ device will be used, to stimulate 7 small areas on both ears with a focused jet of cold as a small amount of compressed gas is released. This is generally not painful, and less invasive, compared to using needles for auriculotherapy.",[70,71,32,72,73,74,75,76,77,78],"Low Back Pain","Chronic Low-back Pain","Lumbar Disc Disease","Lumbar Discogenic Pain","Lumbar Pain Syndrome","Lumbar Post-Laminectomy Syndrome","Back Pain Lower Back Chronic","Back Pain Without Radiation","Pain;Back Low;Chronic",[80,81,82,83,84,85],"auriculotherapy","auricular stimulation","functional near-infrared spectroscopy","functional magnetic resonance imaging","functional connectivity","cryo-auriculotherapy","2026-02-13",{"date":88,"type":46},"2026-02-18",{"date":90,"type":46},"2025-07-30",{"date":92,"type":23},"2029-04-30",{"name":94,"class":53},"Keith M Vogt",{"id":96,"slug":97,"hasResults":11,"nctId":98,"briefTitle":99,"officialTitle":100,"acronym":4,"eligibilityCriteria":101,"healthyVolunteers":11,"sex":63,"minAge":19,"maxAge":102,"enrollmentInfo":103,"targetDuration":4,"studyType":24,"phases":105,"briefSummary":107,"conditions":108,"keywords":4,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":109,"lastUpdatePostDateStruct":110,"startDateStruct":112,"completionDateStruct":114,"leadSponsor":116,"locationsCount":54},"100504718","phase-4-duloxetine-for-lbp-100504718","NCT05851976","Duloxetine for LBP","Duloxetine for Patients With Low Back Pain Who Fail to Improve With Oral NSAIDs. A Randomized Placebo-controlled Exploratory Study","Inclusion Criteria:\n\n* Present to Emergency Department (ED) primary for management of LBP, defined as pain originating between the lower border of the scapulae and the upper gluteal folds. Flank pain, that is pain originating from tissues lateral to the paraspinal muscles, will not be included.\n* Musculoskeletal etiology of low back. Patients with non-musculoskeletal etiologies such as urinary tract infection, ovarian cysts, or influenza like illness will be excluded. The primary clinical diagnosis, at the conclusion of the ED visit, must be a diagnosis consistent with non-traumatic, non-radicular, musculoskeletal LBP.\n* Patient is to be discharged home. Patients admitted to the hospital are more likely to be treated with parenteral medication and therefore are not appropriate for this study.\n* Age 18-64 Enrollment will be limited to adults younger than 65 years because of the increased risk of adverse medication effects in older patients.\n* Non-radicular pain. Patients will be excluded if the pain radiates below the gluteal folds in a radicular pattern.\n* Pain duration \\\u003C2 weeks (336 hours).\n* Prior to the acute attack of LBP, back pain cannot occur more frequently than once per week.\n* Functionally impairing back pain: A baseline score of \\> 5 on the Roland-Morris Disability Questionnaire\n\nExclusion Criteria:\n\n* Not available for follow-up\n* Pregnant or breast-feeding\n* Chronic pain syndrome defined as moderate or severe pain anywhere in their body on \\>= 50% of days for at least three months\n* Allergic to or intolerant of investigational medications\n* Contra-indications to non-steroidal anti-inflammatory drugs:\n\n  1. history of hypersensitivity to NSAIDs or aspirin\n  2. active or history of peptic ulcer disease, chronic dyspepsia, or active or history of gastrointestinal bleed\n  3. Severe heart failure (NYHA 2 or worse)\n  4. uncontrolled blood pressure (\\>160\u002F100)\n  5. Glomerular Filtration Rate (GFR) \\\u003C60ml\u002Fmin\n  6. Current use of anti-coagulants\n  7. cirrhosis or acute hepatitis\n* Contra-indication to duloxetine:\n\n  1. alcohol use disorder\n  2. chronic liver disease\n  3. chronic kidney disease\n  4. glaucoma\n  5. Active use of medication for depression\n  6. Score \\> 10 on the Patient Health Questionnaire (PHQ-9) screening instrument or thoughts of suicide, symptoms of feeling down, depressed, or hopeless\n\nPHQ9 score \\>4. Now we would like to exclude patients with a PHQ9 score \\>10 or symptoms of feeling down, depressed, or hopeless","64 Years",{"count":104,"type":23},120,[106],"PHASE4","This research study will help determine whether a medication called duloxetine can improve back pain. It is well documented that many participants who come to the ER with acute low back pain still have low back pain 3 months later. The investigator team will attempt to determine whether duloxetine can help prevent this.",[32],"2025-12-01",{"date":111,"type":46},"2025-12-02",{"date":113,"type":46},"2023-10-04",{"date":115,"type":23},"2027-05",{"name":117,"class":53},"Montefiore Medical Center",{"id":119,"slug":120,"hasResults":11,"nctId":121,"briefTitle":122,"officialTitle":123,"acronym":4,"eligibilityCriteria":124,"healthyVolunteers":11,"sex":63,"minAge":19,"maxAge":125,"enrollmentInfo":126,"targetDuration":4,"studyType":24,"phases":128,"briefSummary":129,"conditions":130,"keywords":4,"overallStatus":131,"whyStopped":4,"lastUpdateSubmitDate":132,"lastUpdatePostDateStruct":133,"startDateStruct":135,"completionDateStruct":137,"leadSponsor":139,"locationsCount":4},"100591730","pulsed-direct-current-electrical-stimulation-for-treatment-of-low-back-pain-100591730","NCT06984224","Pulsed Direct Current Electrical Stimulation for Treatment of Low Back Pain","Efficacy of Pulsed Direct Current Electrical Stimulation (Neubie) on Low Back Pain","Inclusion Criteria:\n\n1. Must show evidence of axial mechanical low back pain at least 3\u002F10 on visual analog scale, without radiation to the lower limbs. Pain has to have been present for at least two weeks or diagnosed as chronic .\n2. Normal lower limb strength\n3. Able to attend twice weekly physical therapy visis for up to 6 weeks\n4. 18 years of age, or older\n\nExclusion Criteria:\n\n1. Currently pregnant\n2. Cardiac pacemaker\n3. Active or recently treated cancer\n4. Active or recent blood clots\n5. Epilepsy\n6. Open wounds\n7. History of lumbar spine fusion surgery\n8. Radicular symptoms suggesting radiculopathy or spinal stenosis.","85 Years",{"count":127,"type":23},40,[67],"The goal of this interventional clinical trail is to determine the efficacy of the use of the Neubie pulsed direct current electrical stimulation device for the treatment of participants experiencing mechanical low back pain. The main question it aims to answer is:\n\nDoes treatment with the Neubie improve symptoms and time to resolution of back pain compared to standard of care?\n\nResearchers will compare a 12 session treatment physical therapy regimen using the Neubie to standard of care to see if there is a difference in symptom severity and time to resolution.\n\nParticipants will:\n\n* Visit the clinic 2 times a week to undergo active physical therapy treatments with or without electrical stimulation from the Neubie.\n* Undergo testing and fill out surveys on evaluation and final session on quality of life, disability, pain, and spinal mobility.",[32],"NOT_YET_RECRUITING","2025-05-19",{"date":134,"type":46},"2025-05-22",{"date":136,"type":23},"2025-06",{"date":138,"type":23},"2026-03",{"name":140,"class":141},"NeuFit - Neurological Fitness and Education","INDUSTRY"]