[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"back-pain-lower-back-chronic\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:back-pain-lower-back-chronic":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,10,0,[8,46,71,106,137,159,197,223,251,281],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100623966","evaluation-of-the-short-term-effectiveness-of-spinal-manipulation-to-treat-acute-and-subacute-low-back-pain-100623966",false,"NCT07403500","Evaluation of the Short-term Effectiveness of Spinal Manipulation to Treat Acute and Subacute Low Back Pain.","Evaluation of the Short-term Effectiveness of Spinal Manipulation to Treat Acute and Subacute Low Back Pain. An Open-label Randomized Controlled Multicenter Trial.","MeLoPe","Inclusion Criteria:\n\n* Patients seeking treatment for low back pain present for less than 3 months, with an average intensity greater than 50 on a visual analog scale of 0-100 in the previous 48 hours.\n* Patients able to complete online questionnaires.\n* Patients who have given their free and informed consent.\n* Patients who are affiliated with or beneficiaries of a health insurance plan.\n\nExclusion Criteria:\n\n* Patients with a history of back surgery, undergoing corticosteroid or morphine treatment, with acute or chronic inflammatory diseases, with psychiatric illness, or with low back pain lasting more than 3 months.\n* Patients who have already undergone spinal manipulation for low back pain with the investigator.\n* Patients participating or having participated in a therapeutic or drug study in the 3 months prior to their inclusion in this protocol.\n* Patients in a period of exclusion determined by another study.\n* Patients under legal protection, guardianship, or conservatorship.\n* Patients unable to give their consent.\n* Patients for whom it is impossible to provide informed consent.\n* Pregnant or breastfeeding patients.","ALL","18 Years",{"count":20,"type":21},416,"ESTIMATED","INTERVENTIONAL",[24],"NA","Low back pain is the second most common reason for medical consultation in France and affects 60 to 80% of the working population. Patients with acute episodes of non-specific low back pain recover within 6 to 8 weeks, but recurrence is common and 7 to 10% of patients will experience persistent pain and disability for more than 3 months. Given their low efficacy and the risks associated with nonsteroidal anti-inflammatory drugs or opioids (nearly 60% of all opioids prescribed in the United States), the scientific literature does not support the use of pharmacological treatments. The international recommendations strongly suggest using non-pharmacological therapies, including physical exercise, rehabilitation, and spinal manipulation.Spinal manipulation (SM) is a common choice of therapy in primary care. In the patient's imagination \"getting manipulated when in pain leads to heavy use of these manual therapies in a medical (manual medicine and medical osteopathy) or non-medical setting (manual therapy, osteopathy, and chiropractic). However, the evidence of effectiveness is weak in the chronic phase (only in the short term) and contradictory for the acute or subacute phases of low back pain. Pain and function are improved at 6 weeks, but the results are not clinically relevant. There is a lack of evidence regarding efficacy because the trials on spinal manipulations are of poor quality. A meta-analysis has recently reported that SMs are associated with a very limited risk of harm, making them a reasonable treatment option. Therefore, it seems necessary to demonstrate the specific effect of MVs in order to justify their use in primary care, support their wider use around the world, and reinforce recommendations for non-pharmacological treatment of low back pain.",[27],"Back Pain Lower Back Chronic",[29,30,31,32],"Back","Pain","Chronic","Spinal manipulation","NOT_YET_RECRUITING","2026-05-28",{"date":36,"type":37},"2026-05-29","ACTUAL",{"date":39,"type":21},"2026-07-01",{"date":41,"type":21},"2027-03-31",{"name":43,"class":44},"Centre Hospitalier Universitaire de Nīmes","OTHER",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":50,"acronym":51,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":53,"targetDuration":4,"studyType":22,"phases":55,"briefSummary":56,"conditions":57,"keywords":58,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":45},"100635654","a-comparative-study-of-erector-spinae-fascia-esf-injection-and-dry-needling-combined-with-functional-rehabilitation-fr-in-patients-with-chronic-low-back-pain-who-have-undergone-spinal-surgery-spin-need-100635654","NCT07555496","A Comparative Study of Erector Spinae Fascia (ESF) Injection and Dry Needling Combined With Functional Rehabilitation (FR) in Patients With Chronic Low Back Pain Who Have Undergone Spinal Surgery (SPIN-NEED)","SPIN-NEED","Inclusion Criteria:\n\n* Patient with chronic back pain, with previous surgery\n\nExclusion Criteria:\n\n* Patients with specific or common low back pain\n* Patients receiving posterior subcutaneous spinal cord stimulation\n* Patients with a life expectancy of less than 12 months\n* Patients with a contraindication to corticosteroid injections (coagulation disorder)\n* Pregnant or breastfeeding patients\n* Patients with cognitive and\u002For psychobehavioral disorders",{"count":54,"type":21},120,[24],"Chronic low back pain represents a major public health issue, with an estimated prevalence of up to 23% in the adult population and a significant impact on quality of life and functional capacity. Among these patients, a significant proportion undergo spinal surgery-including laminectomy, discectomy, or spinal fusion-when conservative treatment has failed to provide adequate relief. Current treatment strategies involve functional spinal rehabilitation (FSR). Due to the multifaceted and complex pathophysiology of this chronic pain condition, we have previously addressed the spinal syndrome in terms of its functional and muscular component: the myofascial expression. In our clinical practice, we have introduced a minimally invasive paravertebral procedure, guided by ultrasound, targeting the fascia of the erector spinae muscles in the lower lumbar region. The goal of this procedure is to provide pain relief to the patient, enabling them to better adhere to the rehabilitative treatment (functional restoration of the spine) and ultimately improve the patient's quality of life within their environment. This evaluation of professional practices highlights a clear clinical indication in favor of infiltration of the erector spinae fascia, with a significant majority of patients reporting improved pain relief and better adherence to rehabilitation.\n\nThus, within a coordinated, multidisciplinary care approach, this intervention appears to address patient expectations regarding comfort and leads us to consider the myofascial component of the complaint. The proposed paravertebral intervention is also appropriate in accordance with the updated recommendations, which are very restrictive in the context of a surgically treated spine (PSPS-2). This assessment of current practices justifies the implementation of a prospective controlled study. Through this study, we aim to investigate the treatment's effects and evaluate its pharmacological (via the anti-inflammatory action of corticosteroids) and mechanical (via needle-induced muscle stimulation) components.",[27],[59,60,61],"chronic back pain","infiltration","epineurium of the erector spinae muscles","2026-04-21",{"date":64,"type":37},"2026-04-29",{"date":66,"type":21},"2026-05",{"date":68,"type":21},"2029-03-31",{"name":70,"class":44},"Clinique de la Côte d'Emeraude",{"id":72,"slug":73,"hasResults":11,"nctId":74,"briefTitle":75,"officialTitle":76,"acronym":77,"eligibilityCriteria":78,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":79,"enrollmentInfo":80,"targetDuration":4,"studyType":22,"phases":82,"briefSummary":83,"conditions":84,"keywords":89,"overallStatus":96,"whyStopped":4,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":100,"completionDateStruct":102,"leadSponsor":104,"locationsCount":45},"100618643","retrolaminar-analgesia-for-lumbar-surgery-100618643","NCT07334288","Retrolaminar Analgesia for LuMbar Surgery","Efficacy of Ultrasound-Guided Retrolaminar Block Combined With Standard Multimodal Analgesia for Postoperative Pain Management in Lumbar Spine Surgery: A Randomized Controlled Trial","REALM","Inclusion Criteria:\n\n* Adult patients aged 18-80 years\n* Scheduled for elective lumbar spine surgery (with instrumentation)\n* American Society of Anesthesiologists (ASA) physical status I-III\n* Willing and able to provide written informed consent\n* Able to use patient-controlled analgesia (PCA) device\n\nExclusion Criteria:\n\n* Refusal to participate in the study\n* Known allergy to local anesthetics (bupivacaine - levobupivacaine - lidocaine) or any study medication\n* Contraindication to regional anesthesia (infection at injection site, coagulopathy)\n* Chronic opioid use (daily use for \\>3 months prior to surgery)\n* Severe psychiatric disorder that precludes informed consent\n* Emergency surgery\n* Diabetes mellitus with preoperative glucose \\>180 mg\u002Fdl\n* Pregnancy or breastfeeding\n* Body mass index (BMI) \\>40 kg\u002Fm²\n* Reoperation or revision of the same level of previous spinal surgery","80 Years",{"count":81,"type":21},50,[24],"This randomized controlled trial evaluates the effectiveness of ultrasound-guided retrolaminar nerve block in addition to standard multimodal analgesia for postoperative pain management in patients undergoing lumbar spine surgery. Fifty patients will be randomly assigned to receive either the retrolaminar block combined with standard pain management or standard pain management alone. The primary outcome is total opioid consumption in the first 24 hours after surgery. Secondary outcomes include pain intensity at multiple time points, time to first rescue analgesia, duration of sensory block, incidence of postoperative nausea and vomiting, length of hospital stay, patient satisfaction, and chronic pain development at 3 and 6 months follow-up.",[85,86,27,87,88],"Postoperative Pain","Lumbar Surgery","Opioid Analgesia","Regional Anaesthesia",[90,91,92,93,94,95],"retrolaminar block","regional anesthesia","lumbar spine surgery","Multimodal analgesia","opioid consumption","Ultrasound-guided nerve block","RECRUITING","2026-04-10",{"date":99,"type":37},"2026-04-13",{"date":101,"type":37},"2026-03-01",{"date":103,"type":21},"2027-06-01",{"name":105,"class":44},"Universidad de los Andes, Chile",{"id":107,"slug":108,"hasResults":11,"nctId":109,"briefTitle":110,"officialTitle":111,"acronym":112,"eligibilityCriteria":113,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":114,"targetDuration":4,"studyType":22,"phases":116,"briefSummary":117,"conditions":118,"keywords":122,"overallStatus":96,"whyStopped":4,"lastUpdateSubmitDate":128,"lastUpdatePostDateStruct":129,"startDateStruct":131,"completionDateStruct":133,"leadSponsor":135,"locationsCount":45},"100603530","psychological-options-for-wellness-and-recovery-power-trial-for-veterans-with-chronic-backneck-pain-100603530","NCT07137715","Psychological Options for Wellness and Recovery (POWeR) Trial for Veterans With Chronic Back\u002FNeck Pain","Pain Reprocessing Therapy for Veterans With Chronic Back Pain: Comparative Efficacy and Facilitators and Barriers to Implementation","POWeR","Inclusion Criteria:\n\n* Adults (18 and older)\n* Be veterans\n* Have a history of chronic back or neck pain defined as pain at least half the days of the last 6 months.\n* Have moderate or greater pain, defined as pain intensity ≥4 in the past week\n\nExclusion Criteria:\n\nClinical presentation suggestive of back pain that is secondary or peripheral in nature, including self-reported leg pain that is worse than back pain (indicative of radiculopathy or sciatica), spine surgery within the past 6 months, fall, motor vehicle accident or other trauma related to back pain in the past 6 months, back pain due to an inflammatory disorder, infection, or malignant etiology as determined per medical provider review, known sensory abnormality in trunk or legs, recent large (\\>20 lbs) unexplained weight loss, difficulty controlling bowels (to screen out cauda equina syndrome), and self-reported diagnoses of specific inflammatory disorders (rheumatoid arthritis, polymyalgia rheumatica, scleroderma, Lupus, and polymyositis).\n\nAdditionally, patients who meet any of the following criteria are ineligible due to anticipated difficulties complying with study procedures:\n\n* Moderate or severe cognitive impairment\n* Unstable or severe untreated mental health condition, including active suicidal ideation\n* Unstable or end-stage medical disease including active cancer\n* Back surgery planned within the next 6 months\n* Inability to communicate by telephone or video, including inability due to housing instability\n* Current pain-related litigation outside the VA (service connection-related applications are not excluded)\n* Having engaged in CBT or PRT for chronic pain in the past 6 months\n* Participants may be excluded based on the discretion of PIs Ashar and Frank",{"count":115,"type":21},360,[24],"The goal of this clinical trial is to learn which treatment works better for veterans with chronic neck or back pain. This study is comparing three treatments: Pain Reprocessing Therapy (PRT), Cognitive Behavioral Therapy (CBT), and usual care (whatever a person is already doing to cope with their pain).\n\nThe main questions the study aims to answer are:\n\n1. Which treatment works better for lowering pain: PRT, CBT, or usual care?\n2. How do the effects of PRT compare with CBT and usual care in terms of pain relief and other factors such as emotional functioning, quality of life, anxiety, and pain medication use?\n\nParticipants will:\n\n1. Be randomly assigned to receive either PRT, CBT, or usual care.\n2. Complete questionnaires about their pain and health.\n3. If in the PRT or CBT group, have nine weekly therapy sessions over video calls with a therapist.",[119,120,27,121],"Chronic Pain","Back Pain","Neck Pain",[123,124,119,125,121,120,126,127],"Pain Reprocessing Therapy (PRT)","PRT","Veterans","Cognitive Behavioral Therapy (CBT)","CBT","2026-03-30",{"date":130,"type":37},"2026-03-31",{"date":132,"type":37},"2026-03-27",{"date":134,"type":21},"2028-09",{"name":136,"class":44},"University of Colorado, Denver",{"id":138,"slug":139,"hasResults":11,"nctId":140,"briefTitle":141,"officialTitle":142,"acronym":4,"eligibilityCriteria":143,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":144,"targetDuration":4,"studyType":22,"phases":146,"briefSummary":147,"conditions":148,"keywords":4,"overallStatus":96,"whyStopped":4,"lastUpdateSubmitDate":151,"lastUpdatePostDateStruct":152,"startDateStruct":153,"completionDateStruct":155,"leadSponsor":157,"locationsCount":45},"100477120","impowr-me-project-1-trial-of-yoga-and-physical-therapy-onsite-at-opioid-treatment-programs-100477120","NCT05492825","IMPOWR-ME Project 1: Trial of Yoga and Physical Therapy Onsite at Opioid Treatment Programs","Randomized Trial of Yoga and Physical Therapy Onsite at Opioid Treatment Programs for Patients With Chronic Back Pain and Opioid Use Disorder","Inclusion Criteria:\n\n1. age ≥18 years old\n2. English or Spanish proficiency (i.e., be able to participate in study interventions and interviews in English or Spanish)\n3. receiving methadone or buprenorphine treatment for OUD in the Montefiore OTP network for at least 12 weeks, with no dose change in 14 days\n4. Chronic low or mid back pain, with at least moderate pain severity (score of ≥4 on the Pain, Enjoyment of Life and General Activity (PEG) Scale)\n5. Willingness to participate in all study components\n6. ability to provide informed consent, assessed using consent teach-back\n\nExclusion Criteria:\n\n1. severe disabling conditions that could make participation in yoga or PT hazardous (e.g., spinal canal stenosis; severe scoliosis; vertebral fracture, history of spine surgery, or joint surgery in the past six months; severe or progressive neurological deficits, or cardiovascular or neurological disease requiring hospitalization in the past six months; unable to stand for at least 60 seconds; regular use of a wheelchair or motorized scooter, or regular use of a walker and inability to walk at least 4 steps without it; 3 or more falls in the prior year with at least one being non-mechanical;; or other severe disabling conditions deemed by the study clinician or MPI to preclude safe or adequate participation in the study)\n2. acute exacerbation of psychiatric conditions that preclude the ability to participate in the study (e.g., acute mania, active suicidality\u002Fhomicidality, psychosis)\n3. cancer pain related to malignancy\n4. yoga practice or PT in the prior 60 days",{"count":145,"type":21},180,[24],"This is a pragmatic, open label, randomized controlled trial with 1:1:1 allocation to 12 weeks of: (1) onsite yoga at opioid treatment programs (OTPs), (2) onsite physical therapy (PT) at OTPs, or (3) treatment as usual (TAU). Participants will be 180 individuals with chronic back pain receiving treatment for opioid use disorder (OUD) in community-based OTPs. Through research visits at screening, baseline, and months 1, 2, 3, 6, and 9, the investigators will evaluate pain and opioid use outcomes and implementation outcomes.",[149,119,150,27],"Substance Use Disorders","Opioid Use Disorder","2026-03-26",{"date":130,"type":37},{"date":154,"type":37},"2023-02-27",{"date":156,"type":21},"2026-11-02",{"name":158,"class":44},"Albert Einstein College of Medicine",{"id":160,"slug":161,"hasResults":11,"nctId":162,"briefTitle":163,"officialTitle":164,"acronym":165,"eligibilityCriteria":166,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":167,"targetDuration":4,"studyType":22,"phases":169,"briefSummary":170,"conditions":171,"keywords":181,"overallStatus":96,"whyStopped":4,"lastUpdateSubmitDate":188,"lastUpdatePostDateStruct":189,"startDateStruct":191,"completionDateStruct":193,"leadSponsor":195,"locationsCount":45},"100579522","auriculotherapy-neuroimaging-100579522","NCT06825390","AuriculoTherapy NeuroImaging","Mechanistic Clinical Trial of Auricular Stimulation and Cryogenic Auriculotherapy in Patients With Chronic Low-back Pain, Using Functional Near-infrared Spectroscopy and Magnetic Resonance Imaging","ATNI","Inclusion Criteria:\n\n1. Adult, at least 18 years old\n2. Episodes of chronic low back pain at least daily for at least 6 months, with an average pain score within the last week of 3\u002F10.\n\nExclusion Criteria:\n\n1. active lesions, skin disruptions, or neuropathy of either ear;\n2. recent (\\\u003C1 month) analgesic procedures or surgery;\n3. recent (\\\u003C1 month) start of new analgesic or psychoactive medication (including marijuana, opioids, tramadol, methadone, gabapentinoids, anti-depressants, anti-epileptics, mood-stabilizers, anti-psychotics, or stimulants);\n4. history of chronic pain in shoulder or thumb (to avoid confounding at control stimulation points);\n5. recent (\\\u003C 3 months) illicit drug use;\n6. prior substance misuse\u002Fabuse;\n7. cold-activated diseases (including: agammaglobulinemia, cold urticaria, cold agglutinin disease, cryofibrinogenemia, cryoglobulinemia, immunosuppression, Raynaud's disease, collagen or autoimmune diseases, multiple myeloma, platelet deficiency disorders, pyoderma gangrenosum.)\n\n   \\- MRI-specific exclusions additionally include:\n8. Pregnancy or active attempts at conception;\n9. Implanted metal or electronic device;\n10. severe claustrophobia",{"count":168,"type":21},60,[24],"This is a clinical study of patients who have low back pain (for at least 6 months). The goal is to understand, with brain imaging, how auriculotherapy (an acupuncture-like stimulation of the ear) may work to relieve pain. There are 4 total study visits, divided into two pairs of visits that occur before and 5-7 days after receiving either a real or sham auriculotherapy treatment. The cryo-IQ device will be used, to stimulate 7 small areas on both ears with a focused jet of cold as a small amount of compressed gas is released. This is generally not painful, and less invasive, compared to using needles for auriculotherapy.",[172,173,174,175,176,177,178,27,179,180],"Low Back Pain","Chronic Low-back Pain","Back Pain, Low","Lumbar Disc Disease","Lumbar Discogenic Pain","Lumbar Pain Syndrome","Lumbar Post-Laminectomy Syndrome","Back Pain Without Radiation","Pain;Back Low;Chronic",[182,183,184,185,186,187],"auriculotherapy","auricular stimulation","functional near-infrared spectroscopy","functional magnetic resonance imaging","functional connectivity","cryo-auriculotherapy","2026-02-13",{"date":190,"type":37},"2026-02-18",{"date":192,"type":37},"2025-07-30",{"date":194,"type":21},"2029-04-30",{"name":196,"class":44},"Keith M Vogt",{"id":198,"slug":199,"hasResults":11,"nctId":200,"briefTitle":201,"officialTitle":201,"acronym":202,"eligibilityCriteria":203,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":204,"enrollmentInfo":205,"targetDuration":4,"studyType":207,"phases":4,"briefSummary":208,"conditions":209,"keywords":211,"overallStatus":96,"whyStopped":4,"lastUpdateSubmitDate":214,"lastUpdatePostDateStruct":215,"startDateStruct":217,"completionDateStruct":219,"leadSponsor":221,"locationsCount":45},"100493407","evoke-ecap-controlled-lead-placement-and-programming-in-chronic-pain-patients-100493407","NCT05704751","EVOKE ECAP-Controlled Lead Placement and Programming in Chronic Pain Patients","ECAP","Inclusion Criteria:\n\n1. Be 18-75 years of age or older at the time of enrolment.\n2. Symptoms of chronic predominant back pain for at least 6-months, with a minimum pain intensity of 5\u002F10 in the primary pain area on VAS pain intensity questionnaire.\n3. Be an appropriate candidate for the surgical procedures required in this study based on the clinical judgment of the implanting physician.\n4. Be capable of subjective evaluation, able to read and understand English-written questionnaires, and able to read, understand and sign the written inform consent in English.\n5. Be willing and capable of giving informed consent.\n6. Be willing and able to comply with study-related requirements, procedures, and visits.\n\nExclusion Criteria:\n\nHave a medical condition or pain in other area(s), not intended to be treated with SCS, that could interfere with study procedures, accurate pain reporting, and\u002For confound evaluation of study endpoints, as determined by the Investigator.\n\n2\\. Have evidence of an active disruptive psychological or psychiatric disorder or other known condition significant enough to impact perception of pain, compliance of intervention, and\u002For ability to evaluate treatment outcomes.\n\n3\\. Subjects with chronic alcohol abuse or currently in rehabilitation. 4. Be benefitting within from an interventional procedure and\u002For surgery to treat chronic pain (Subjects should be enrolled at least 30 days from last benefit).\n\n5\\. Have prior experience with SCS. 6. Have an existing drug pump and\u002For another active implantable device such as a pacemaker.\n\n7\\. Have a condition currently requiring or likely to require the use of diathermy.\n\n8\\. Have an active systemic or local infection at the anticipated needle entry site.\n\n9\\. Be pregnant (if female and sexually active, subject must be using a reliable form of birth control, be surgically sterile or be at least 2 years post-menopausal).\n\n10\\. Are currently nursing (if female).\n\n11\\. Be concomitantly participating in another clinical study.","75 Years",{"count":206,"type":21},20,"OBSERVATIONAL","This study is designed to evaluate the feasibility of using intra-operative ECAP and Late-Response (LR) recordings for confirmation of activating the neuronal target of the dorsal column in a single-stage SCS lead placement procedure. The collected ECAP and LR data will be analysed post-hoc to further evaluate its utility for determining the laterality of lead placement with respect to the physiologic midline of the dorsal column.",[27,210],"Spinal Cord Stimulation",[212,213,59],"closed loop","spinal cord stimulation","2026-01-07",{"date":216,"type":37},"2026-01-08",{"date":218,"type":37},"2023-10-27",{"date":220,"type":21},"2026-04-01",{"name":222,"class":44},"Barts & The London NHS Trust",{"id":224,"slug":225,"hasResults":11,"nctId":226,"briefTitle":227,"officialTitle":228,"acronym":229,"eligibilityCriteria":230,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":231,"enrollmentInfo":232,"targetDuration":4,"studyType":22,"phases":234,"briefSummary":235,"conditions":236,"keywords":237,"overallStatus":96,"whyStopped":4,"lastUpdateSubmitDate":242,"lastUpdatePostDateStruct":243,"startDateStruct":245,"completionDateStruct":247,"leadSponsor":249,"locationsCount":45},"100512492","yoga-for-patients-with-chronic-back-pain-and-poor-prognosis-100512492","NCT05953155","YOga for Patients with Chronic BACK Pain and Poor PROgnosis","Effectiveness of YOga in Patients with Chronic Low BACK Pain and Poor PROgnosis (YOBACK-PRO Trial): a Randomized Controlled Trial","YOBACK-PRO","Inclusion Criteria:\n\n* report chronic nonspecific LBP, defined as pain and discomfort localized below the costal margin and above the inferior gluteal folds, with or without leg pain and of at least 3 months' duration.\n* score ≥ 50 points (out of 100) in the Orebro Musculoskeletal Pain Questionnaire.\n* have an average back pain intensity of 3 points or more on a 0-10 numerical pain rating scale.\n\nExclusion Criteria:\n\n* serious spine pathology (e.g. tumors, fractures, and inflammatory diseases).\n* nerve root compromise (i.e. at least 2 of the following signs: weakness, reflex change, or sensation loss associated with the same spinal nerve).\n* previos spinal surgery.\n* pregnancy or having given birth within the previous 3 months.\n* any medical condition that prevented being physically active (e.g., serious cardiovascular, kidney or neurological diseases).\n* any other musculoskeletal condition that may affect activity and movement participation in a Yoga program during the last year.\n* not currently receiving other physical activity-based intervention (e.g., Pilates, physical therapy, aquatic exercise).\n* inadequate Portuguese literacy for the study's questionnaires and instructions.","60 Years",{"count":233,"type":21},110,[24],"The goal of this clinical trial is to investigate the effectiveness of yoga for patients with chronic low back pain and high risk of poor prognosis. The main question it aims to answer is:\n\n\\- In patients with back pain and high risk of poor prognosis, what is the effectiveness of yoga plus education on reducing pain and disability compared to a control group receiving education alone?\n\nA total of 110 patients with chronic low back pain and classified as high risk of poor prognosis according to the Orebro Musculoskeletal Pain Screening Questionnaire (i.e. score ≥ 50 points out of 100) will be recruited for this study. Participants will be randomized into two groups: yoga and control. The yoga group will receive a 3-month course of yoga program consisting of two sessions per week and 3 educational classes. The control group will receive 3 educational classes over a 12-week period. Outcome measures will be assessed at baseline, at post-intervention (i.e. 3-months post randomization) and at 6-month follow up (i.e. 6-months post randomization).",[172,173,120,27],[238,239,240,241],"low back pain","chronic low back pain","yoga","poor prognosis","2025-03-13",{"date":244,"type":37},"2025-03-17",{"date":246,"type":37},"2023-07-27",{"date":248,"type":21},"2027-07-30",{"name":250,"class":44},"Federal University of Minas Gerais",{"id":252,"slug":253,"hasResults":11,"nctId":254,"briefTitle":255,"officialTitle":256,"acronym":257,"eligibilityCriteria":258,"healthyVolunteers":259,"sex":17,"minAge":18,"maxAge":231,"enrollmentInfo":260,"targetDuration":4,"studyType":207,"phases":4,"briefSummary":262,"conditions":263,"keywords":264,"overallStatus":96,"whyStopped":4,"lastUpdateSubmitDate":271,"lastUpdatePostDateStruct":272,"startDateStruct":274,"completionDateStruct":276,"leadSponsor":278,"locationsCount":280},"100504658","the-forgotten-role-of-back-muscle-characteristics-to-tailor-exercise-therapy-for-recurrent-non-specific-low-back-pain-100504658","NCT05851196","The Forgotten Role of Back Muscle Characteristics to Tailor Exercise Therapy for Recurrent Non-specific Low Back Pain","Back to Back: the Forgotten Role of Back Muscle Characteristics to Tailor Exercise Therapy for Recurrent Non-specific Low Back Pain","Back-to-Back","Inclusion Criteria:\n\nPatients with non-specific low back pain:\n\n* Aged 18-60 years\n* Non-specific low back pain without radicular leg pain\n* Mechanical low back pain with episodes of \\\u003C4 on the numerical pain rating scale and episodes of \\>6 on the numerical pain rating scale\n* Non-specific low back pain for three months or more\n* Score of 20% or more on the Modified Low Back Pain Disability Questionnaire\n* Informed consent to participate\n\nHealthy controls:\n\n* Aged 18-60 years\n* No history of low back pain needing medical treatment or resulting in a limited activity level\n* No low back pain in the previous six months\n* Informed consent to participate\n\nExclusion Criteria:\n\n* Pregnancy\n* Previous trauma or surgery to the spine, pelvis or lower limbs\n* Structural spinal deformity (e.g., scoliosis)\n* Neurological, neuromuscular, respiratory or systemic disease\n* Central sensitization: score of 50\u002F100 or more on the Central Sensitization Inventory\n* Specific vestibular or balance problems\n* Acute lower limb or neck problems\n* Body mass index of 30 kg\u002Fm² or more",true,{"count":261,"type":21},100,"Patients with non-specific low back pain will be compared to healthy, age- and sex-matched controls to determine the most discriminating back muscle characteristics and to delineate possible phenotypes of patients with non-specific low back pain showing impaired proprioceptive postural control. Additionally, the group of patients with non-specific low back pain will receive a 16-week, high-load proprioceptive training program. The effects of this training program on the different back muscle characteristics and proprioceptive postural control will be evaluated.",[172,27],[265,266,267,268,269,270],"Proprioceptive postural control","Muscle volume","Muscle activation","Muscle oxygenation","Muscle fiber type composition","Proprioceptive training","2024-02-26",{"date":273,"type":37},"2024-02-28",{"date":275,"type":37},"2024-01-15",{"date":277,"type":21},"2027-12-31",{"name":279,"class":44},"Hasselt University",2,{"id":282,"slug":283,"hasResults":11,"nctId":284,"briefTitle":285,"officialTitle":286,"acronym":4,"eligibilityCriteria":287,"healthyVolunteers":259,"sex":17,"minAge":18,"maxAge":288,"enrollmentInfo":289,"targetDuration":4,"studyType":22,"phases":291,"briefSummary":293,"conditions":294,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":297,"lastUpdatePostDateStruct":298,"startDateStruct":300,"completionDateStruct":302,"leadSponsor":304,"locationsCount":4},"100462119","phase-4-efficacy-of-activematrix-on-spinal-ssi-rate-100462119","NCT05297513","Efficacy of ActiveMatrix on Spinal SSI Rate","Efficacy of ActiveMatrix on Spinal Surgical Site Infection (SSI) Reduction: A Single-blinded Randomized Controlled Trial","Inclusion Criteria:\n\n1. Provision of signed and dated informed consent form\n2. Stated willingness to comply with all study procedures and availability for the duration of the study\n3. Male or female, ≥ 18 years of age to 100 years of age\n4. Have a clinical diagnosis of thoracic and or lumbosacral spinal disease indicated for decompression and\u002For fusion\n5. Have no contraindications or allergies to the treatment administered\n\nExclusion Criteria:\n\n1. Subject is involved with a worker's compensation, personal injury, or other legal matters related to their health\n2. Subject does not provide full consent\n3. Known history of allergy to allografts\n4. Pregnancy or lactation\n5. Minimally invasive spinal surgery\n6. Non-fusion instrumented cases requiring drains\n\nThere is no intended distribution or restriction of subjects by racial and ethnic origin. No vulnerable subjects are included in this protocol.","100 Years",{"count":290,"type":21},275,[292],"PHASE4","This clinical trial seeks to provide high level of evidence on the efficacy of ActiveMatrix primarily on spinal surgical site infection rate.",[295,296,27],"Spinal Stenosis Lumbar","Surgical Site Infection","2022-03-30",{"date":299,"type":37},"2022-04-07",{"date":301,"type":21},"2022-07",{"date":303,"type":21},"2026-07",{"name":305,"class":44},"Baylor College of Medicine"]