[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"back-pain-with-radiation\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:back-pain-with-radiation":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,49,74],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100494657","phase-4-ibuprofen-with-or-without-dexamethasone-for-acute-radicular-low-back-pain-100494657",false,"NCT05721027","Ibuprofen With or Without Dexamethasone for Acute Radicular Low Back Pain.","Inclusion Criteria:\n\n* Present to ED primarily for management of acute radicular LBP, defined as pain or paresthesia originating from the lower back and radiating to the buttock and or leg in a radicular pattern. Some patients may not have prominent LBP but a radicular symptom--we will include these patients as well.\n* Patient is to be discharged home.\n* Age 18-70 Enrollment will be limited to adults \\\u003C70 years because of the increased risk of adverse medication effects in older adults.\n* Pain duration \\\u003C2 week\n* Prior to the acute attack of radicular LBP, back pain cannot occur more frequently than half of the days in the last 3 months. Patients with more frequent back pain\u002Fsciatica are at increased risk of poor pain and functional outcomes.10\n* Non-traumatic cause of pain: no substantial and direct trauma to the back within the previous month\n* Functionally impairing radicular LBP: A baseline score of \\> 5 on the Roland-Morris Disability Questionnaire\n\nExclusion Criteria:\n\n* Not available for follow-up\n* Pregnant\n* Chronic pain syndrome defined as use of any analgesic medication on a daily or near-daily basis\n* Allergic to or intolerant of investigational medications\n* Chronic steroid use\n* Contra-indications to investigational medications: 1) known peptic ulcer disease, chronic dyspepsia, or history of gastrointestinal bleed 2) Severe heart failure (NYHA 2 or worse) 3) Chronic kidney disease (GFR \\\u003C60ml\u002Fmin) 4) Current use of anti-coagulants 5) cirrhosis (Child Pugh A or worse) or hepatitis (transaminases 2x the upper limit of normal)",true,"ALL","18 Years","70 Years",{"count":20,"type":21},132,"ESTIMATED","INTERVENTIONAL",[24],"PHASE4","This will be a placebo controlled, randomized, double-blind, comparative effectiveness study, in which we patients are enrolled during an emergency department (ED) visit for acute radicular low back pain (LBP) and followed by telephone two and seven days later. Patients will be randomized to receive an oral dose of dexamethasone for 2 consecutive days or placebo during an ED visit for acute radicular LBP. Every patient will receive a 7 day supply of ibuprofen and a low back pain education session.",[27,28,29],"Radiculopathy, Lumbosacral Region","Back Pain With Radiation","Low Back Pain",[31,32,33,34,35],"ibuprofen","dexamethasone","radiculopathy","low back pain","back pain with radiation","RECRUITING","2026-04-07",{"date":39,"type":40},"2026-04-13","ACTUAL",{"date":42,"type":40},"2023-07-05",{"date":44,"type":21},"2027-10",{"name":46,"class":47},"Montefiore Medical Center","OTHER",2,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":4,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":56,"targetDuration":4,"studyType":22,"phases":58,"briefSummary":59,"conditions":60,"keywords":4,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":73},"100630935","phase-4-dose-dependent-steroid-injections-100630935","NCT07494136","Dose Dependent Steroid Injections","Dose Dependent Response to Interlaminar Steroid Injections for Lumbar Radiculopathy","Inclusion Criteria:\n\n* Adults able to consent\n* Lumbar radiculopathy with MRI-confirmed pathology\n* No history of back surgery\n* Use of interlaminar approach lumbar spine injections\n* No use of oral pain medication other than Tylenol or Acetaminophen during the 6 weeks after injection\n\nExclusion Criteria:\n\n* Adults unable to consent\n* Individuals who are not yet adults (infants, children, teenagers)\n* Pregnant women\n* History of back surgery\n* Use of oral pain meds other than Tylenol or Acetaminophen during the 6 weeks after injection",{"count":57,"type":21},150,[24],"This study aims to evaluate the efficacy of interlaminar steroid injections at treating pain in lumbar radiculopathy at varying doses, to evaluate the efficacy of interlaminar steroid injections at improving quality of life and function in lumbar radiculopathy at varying doses, and to evaluate difference in efficacy between triamcinolone and dexamethasone interlaminar steroid injections at treating pain in lumbar radiculopathy at varying doses, with the overarching hypotheses that there is no difference in reported pain reduction, quality of life, or function among patients receiving low, moderate, or high doses, and no difference in reported pain reduction between triamcinolone and dexamethasone.",[61,62,28],"Lumbar Radiculopathy","Sciatica","NOT_YET_RECRUITING","2026-03-20",{"date":66,"type":40},"2026-03-27",{"date":68,"type":21},"2026-05",{"date":70,"type":21},"2027-05",{"name":72,"class":47},"University of Miami",1,{"id":75,"slug":76,"hasResults":11,"nctId":77,"briefTitle":78,"officialTitle":79,"acronym":4,"eligibilityCriteria":80,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":81,"targetDuration":4,"studyType":22,"phases":83,"briefSummary":85,"conditions":86,"keywords":89,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":73},"100467903","burst-crossover-trial-100467903","NCT05372822","Burst Crossover Trial","Spinal Cord Burst Stimulation for Chronic Radicular Pain Following Lumbar Spine Surgery: a Randomized Double-blind Sham-controlled Crossover Trial","Inclusion Criteria:\n\n* Have undergone ≥1 back surgeries and developed chronic radicular pain that has remained refractory to non-surgical treatment for ≥6 months\n* Minimum pain intensity of 5\u002F10 on the leg pain NRS at baseline\n* Successful two-week SCS testing period with tonic stimulation (≥2 points reduction in leg pain NRS from baseline). This means patients will experience paresthesia during the SCS trial period\n* Mandatory assessment at the Multidisciplinary outpatient clinic for back-, neck- and shoulder rehabilitation, St. Olavs University Hospital\n* Successful two-week SCS testing period with tonic stimulation (≥50% reduction in leg pain NRS from baseline). This means patients will experience paresthesia during the SCS trial period\n\nExclusion Criteria:\n\n* Coexisting conditions that would increase procedural risk (e.g., sepsis, coagulopathy)\n* History of laminectomy or posterior fusion at the thoracolumbar junction, where percutaneous electrode end tips are routinely placed.\n* Abnormal pain behavior and\u002For unresolved psychiatric illness.\n* Unresolved issues of secondary gain or inappropriate medication use.",{"count":82,"type":21},50,[84],"NA","Spinal cord stimulation (SCS) is a widely applied therapy to treat chronic neuropathic pain, and one of the most common indications is persisting radicular neuropathic pain following lumbar spine surgery. In traditional SCS therapies, the objective has been to replace the pain sensation with paresthesia. The anticipation is that the electrical current alters pain processing by masking the sensation of pain with a comfortable tingling or paresthesia. Although patients mostly cope with paresthesia, a significant proportion reports that the sensation is unpleasant.\n\n'Burst' SCS utilizes complex programming to deliver high-frequency stimuli. This SCS technique seems to provide paresthesia-free stimulation, resulting in better pain relief of low back and leg pain then traditional tonic stimulation.\n\nThe widespread use of SCS has not been backed by solid evidence. The absence of placebo-controlled trials has long been an important point of criticism, but due to the nature of the intervention with sensation of paresthesia, studies with placebo control have so far not been considered possible. When 'burst' SCS is used the stimulation is often unnoticed by the patient, allowing comparison with placebo stimulation.\n\nThe aim of this randomized double-blind sham-controlled crossover trial is to evaluate the efficacy of 'burst' spinal cord stimulation for chronic radicular pain following spine surgery.",[87,88],"Back Pain with Radiation","Pain, Postoperative",[90,91,92,93],"Lumbar Vertebrae","Surgery","Postoperational Complications","Spinal Cord Stimulation","2024-12-18",{"date":96,"type":40},"2024-12-24",{"date":98,"type":40},"2021-05-01",{"date":100,"type":21},"2025-08-15",{"name":102,"class":47},"St. Olavs Hospital"]