[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"bacterial-transmission\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:bacterial-transmission":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,57],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":30,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":45,"lastUpdatePostDateStruct":46,"startDateStruct":49,"completionDateStruct":51,"leadSponsor":53,"locationsCount":56},"100644993","breaking-the-cycle-real-time-family-oral-microbial-transmission-patterns-as-intervention-targets-100644993",false,"NCT07674888","Breaking the Cycle: Real-Time Family Oral Microbial Transmission Patterns as Intervention Targets","Inclusion Criteria:\n\n* Families with at least two children aged 5-12 years living in the same household.\n* least one parent or guardian diagnosed with Stage II or III periodontitis requiring non-surgical periodontal therapy.\n* At least one child who has undergone caries treatment and is considered at high risk for disease recurrence.\n* Willingness of all participating household members to provide oral samples and participate in study procedures.\n* Ability of participants or their legal guardians to provide informed consent, and assent from children where applicable.\n\nExclusion Criteria:\n\n* Children living in multiple households or shared-custody arrangements during the study period.\n* Households unable to complete study visits or follow-up procedures.\n* Individuals unwilling or unable to comply with study procedures.\n* Individuals who do not provide informed consent or assent, where applicable.\n* Medical or behavioral conditions that, in the opinion of the investigators, would preclude safe participation in the study.",true,"ALL","5 Years",{"count":19,"type":20},225,"ESTIMATED","INTERVENTIONAL",[23],"NA","This study aims to understand how oral bacteria that cause tooth decay and gum disease spread among family members and whether treating multiple family members can reduce the return of these bacteria after dental treatment.\n\nFamilies with children aged 5-12 years will be recruited from university dental clinics. Participants will be assigned to one of three treatment groups: treatment for the child only, treatment for the child and parents, or treatment for all family members. Researchers will collect oral bacterial samples from family members before and after treatment and will monitor close-contact interactions within the household using wearable proximity-tracking devices.\n\nThe study will also collect information about oral health habits, family interactions, and environmental factors that may influence bacterial transmission. By combining bacterial DNA analysis with information about family contact patterns, researchers hope to better understand how oral bacteria are shared within households and whether family-based treatment approaches can reduce bacterial recolonization after dental therapy.\n\nThe results of this study may help improve strategies for preventing childhood tooth decay and gum disease by addressing family-level sources of bacterial transmission.",[26,27,28,29],"Dental Caries","Periodontitis","Oral Microbiome","Bacterial Transmission",[31,32,33,34,35,36,37,38,39,40,41,42,43],"family microbial transmission","Oral microbiome","Plaque recolonization","Pediatric oral health","Real-time proximity tracking","Ultrawide Band (UWB)","Oral bacterial transmission","Intergenerational pathogen transfer","Biofilm disruption","Periodontal disease","Family-based intervention","Microbial source tracking","Oral Health","NOT_YET_RECRUITING","2026-06-25",{"date":47,"type":48},"2026-06-30","ACTUAL",{"date":50,"type":20},"2026-09-30",{"date":52,"type":20},"2028-06-30",{"name":54,"class":55},"University of Alberta","OTHER",1,{"id":58,"slug":59,"hasResults":11,"nctId":60,"briefTitle":61,"officialTitle":62,"acronym":63,"eligibilityCriteria":64,"healthyVolunteers":11,"sex":16,"minAge":65,"maxAge":4,"enrollmentInfo":66,"targetDuration":4,"studyType":21,"phases":68,"briefSummary":69,"conditions":70,"keywords":73,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":84,"completionDateStruct":86,"leadSponsor":88,"locationsCount":56},"100644051","oral-protect-i-oral-asepsis-preventing-transmission-during-intubation-100644051","NCT07669064","ORAL-PROTECT I: Oral Asepsis Preventing Transmission During Intubation","ORAL-PROTECT I: Oral Asepsis for Preoperative Reduction Of Tracheal Bacterial Establishment, Colonization, and Transmission","ORAL-PROTECT I","Inclusion Criteria:\n\n* Age ≥ 60 years\n* Elective surgery under general anesthesia with endotracheal intubation\n* Expected duration of surgery ≥ 2 hours\n* Ability to provide written informed consent\n\nExclusion Criteria:\n\n* Systemic antibiotic therapy within 7 days before surgery\n* Planned postoperative systemic antibiotic therapy\n* Known hypersensitivity or allergy to chlorhexidine\n* Pneumonia or clinically relevant respiratory infection within 7 days before surgery\n* Inability to perform the study intervention as intended\n* Preoperative oral hygiene on the day of surgery, less than four hours prior to induction of the general anesthesia","60 Years",{"count":67,"type":20},60,[23],"Postoperative respiratory complications, such as bacterial pneumonia, are common and serious problems after general anesthesia. They can lead to longer hospital stays, more complications, and increased mortality. One possible cause is that bacteria from the mouth and throat enter the lower airways during tracheal intubation.\n\nThe mouth and throat naturally contain many bacteria, including potentially harmful microorganisms. During general anesthesia, coughing and swallowing reflexes are reduced or absent. When a tracheal tube is inserted, secretions from the mouth and throat may be carried into the trachea. The tube may also support the movement of contaminated fluid into the lower airways.\n\nORAL-PROTECT I is a prospective, randomized, controlled study. It investigates whether simple oral hygiene before surgery can reduce the transfer of bacteria into the trachea during airway management under general anesthesia.\n\nThe study includes patients aged 60 years or older undergoing elective surgery under general anesthesia with tracheal intubation. Participants are randomly assigned to an intervention group or a control group. The intervention group performs oral hygiene immediately before anesthesia. This includes brushing the teeth and tongue for about 3 minutes, followed by rinsing and gargling for about 1 minute with a chlorhexidine antiseptic solution. The control group receives standard care without additional oral hygiene.\n\nOral, pharyngeal, and tracheal swabs will be collected at predefined time points. The primary outcome is based on the perioperative tracheal bacterial load, sampled every 30 minutes and assessed at two hours after induction of anesthesia. The co-primary outcome is based on the oral bacterial load immediately before endotracheal intubation.\n\nSecondary outcomes include changes in oral and tracheal bacterial load over time and identification of the microorganisms detected. The study aims to clarify early bacterial transfer during airway management and to evaluate whether a simple preoperative oral hygiene measure can reduce this process.",[29,71,72],"Intubation Intratracheal","Chlorhexidine",[74,75,76,77,78,79,80,81],"anesthesia, general","oral hygiene","bacterial load","oropharyngeal","respiratory mucosa","chlorhexidine","tracheal intubation","mouth rinsing","2026-06-21",{"date":45,"type":48},{"date":85,"type":20},"2026-06-20",{"date":87,"type":20},"2027-05-01",{"name":89,"class":55},"University Hospital Ulm"]