[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"bacterial-vaginitis\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:bacterial-vaginitis":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,42],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100536208","phase-4-refining-treatment-options-for-trichomonas-vaginalis-infection-a-comparative-analysis-of-metronidazole-and-secnidazole-100536208",false,"NCT06261840","Refining Treatment Options for Trichomonas Vaginalis Infection: A Comparative Analysis of Metronidazole and Secnidazole","Refining Treatment Options for Trichomonas Vaginalis Infection in Women and Men: A Comparative Analysis of Oral Multi-Dose Metronidazole and Single-Dose Secnidazole","Inclusion Criteria:\n\n* Women and men aged 18 years or older of any race\u002Fethnicity will be included in the study.\n* Participants must have either a positive T. vaginalis rapid antigen test (OSOM), or wet mount microscopy with motile trichomonads, or nucleic acid amplification test (NAAT) urinalysis or Pap smear positive for TV within two weeks of available results (and have not yet been treated) that is confirmed by repeat T. vaginalis NAAT testing at study enrollment,\n* Willing and able to provide and understand informed consent to comply with the study protocol,\n* Have a method of contact (either phone, email or social media),\n* Be willing to be randomized.\n\nExclusion Criteria:\n\n* Pregnant\u002Flactating or seeking to be pregnant\n* Have been treated for with a 5-nitroimidazole (i.e. Metronidazole (MTZ), tinidazole (TDZ), or secnidazole \\[SEC\\]) in the last 28 days\n* Used intravaginal boric acid or any other intravaginal treatment for T. vaginalis in the last 14 days\n* Have a history of a type 1 hypersensitivity reaction to 5-nitroimidazole medications\n* Are taking phenytoin (Dilantin) and\u002For warfarin (Coumadin) due to drug-drug interactions with oral MTZ\n* Use of medications which may alter the metabolism of MTZ including Lithium and barbiturates (amobarbital, butalbital, methohexital, phenobarbital, pentobarbital, primidone, secobarbital)\n* Have been previously enrolled in the study",true,"ALL","18 Years",{"count":20,"type":21},1200,"ESTIMATED","INTERVENTIONAL",[24],"PHASE4","This is a multi-centered, randomized, open-label, parallel, phase IV clinical trial comparing the effectiveness and cost-effectiveness of oral multi-dose metronidazole (MTZ) and oral single-dose secnidazole (SEC) for the treatment of Trichomonas vaginalis in both women and men.",[27,28],"Trichomonas Vaginitis","Bacterial Vaginitis","RECRUITING","2026-05-04",{"date":32,"type":33},"2026-05-06","ACTUAL",{"date":35,"type":33},"2025-05-06",{"date":37,"type":21},"2029-07-31",{"name":39,"class":40},"Tulane University","OTHER",4,{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":46,"acronym":4,"eligibilityCriteria":47,"healthyVolunteers":16,"sex":48,"minAge":18,"maxAge":49,"enrollmentInfo":50,"targetDuration":4,"studyType":22,"phases":52,"briefSummary":54,"conditions":55,"keywords":58,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":4},"100619395","the-effects-of-adjunctive-therapy-with-vaginal-tablets-lactobacillus-acidophilus-and-a-low-dose-estriol-gynoflor-to-prolong-pregnancy-time-in-preterm-labor-a-randomized-controlled-trial-100619395","NCT07344064","The Effects of Adjunctive Therapy With Vaginal Tablets Lactobacillus Acidophilus and a Low Dose Estriol (Gynoflor®) to Prolong Pregnancy Time in Preterm Labor, A Randomized Controlled Trial","Inclusion Criteria\n\n\\- Pregnant women diagnosed with preterm labor or threatened preterm labor, with a gestational age between 24 and 33 weeks, who are receiving tocolytic therapy.\n\nExclusion Criteria\n\n* Age under 18 years or 35 years and older\n* Incomplete course of Gynoflor® (less than 6 days of use)\n* Presence of contraindications to tocolysis\n* Preterm premature rupture of membranes (PPROM)\n* Unable to be contacted for follow-up\n* History of allergy to probiotics or Gynoflor®\n* Multiple gestation\n* History of short cervix diagnosed between 16-24 weeks of gestation\n* History of previous preterm labor (PTL)\n* Pregnancy achieved via assisted reproductive technology (ART)\n* Presence of fetal anomaly\n* History of antepartum hemorrhage\n* Substance abuse, including cigarette smoking, alcohol, cocaine, or heroin use\n* Other causes of preterm labor such as uterine overdistension (e.g., polyhydramnios, multifetal gestation), uterine abnormalities (e.g., myoma uteri), or systemic infections, except vaginitis","FEMALE","35 Years",{"count":51,"type":21},80,[53],"NA","The study aim to study The Adjunctive therapy with vaginal tablets containing Lactobacillus acidophilus KS400 and low-dose Estriol (Gynoflor®) in addition to standard tocolytic treatment administered once daily for 6 days starting the same day as tocolytic therapy, in pregnant women diagnosed with preterm labor at gestational age 24-33 weeks .Primary Outcome is the rate of pregnancy prolongation beyond 7 days after initiation of tocolytic therapy.",[56,57,28],"Threaten Preterm","Prethrem Labour",[59,60,61,62,63],"Lactobacillus","Gynoflor","Threaten preterm","Bacterial vaginitis","Probiotic","NOT_YET_RECRUITING","2026-01-07",{"date":67,"type":33},"2026-01-15",{"date":69,"type":21},"2026-02",{"date":71,"type":21},"2026-10",{"name":73,"class":40},"Queen Savang Vadhana Memorial Hospital, Thailand"]