[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"balance-deficits\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:balance-deficits":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,47,81,108,138],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":30,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":4},"100617764","virtual-reality-based-vs-traditional-physiotherapy-for-balance-frailty-and-fall-prevention-in-adults-aged-45-years-and-older-100617764",false,"NCT07322861","Virtual Reality-Based vs Traditional Physiotherapy for Balance, Frailty, and Fall Prevention in Adults Aged 45 Years and Older","A Controlled Trial Comparing Virtual Reality-Based PABLO Training With Traditional Otago Physiotherapy for Balance, Frailty, and Fall Risk in Adults Aged 45 Years and Older","Inclusion Criteria:\n\n* Adults aged 40 years and older\n* History of at least one fall in the past 12 months OR clinical evidence of balance dysfunction\n* Ability to walk at least 10 meters, with or without an assistive device\n* Adequate cognitive function, defined as Mini-Mental State Examination (MMSE) score ≥ 24\n* Ability and willingness to provide written informed consent\n\nExclusion Criteria:\n\n* Severe cognitive impairment (MMSE \\\u003C 24)\n* Unstable cardiovascular, musculoskeletal, or neurological conditions that contraindicate exercise participation\n* Severe uncorrected visual or auditory impairment that interferes with training or assessments\n* Current participation in another structured exercise or rehabilitation program\n* Any medical condition deemed unsafe for participation by the treating physiotherapist","ALL","40 Years",{"count":19,"type":20},80,"ESTIMATED","INTERVENTIONAL",[23],"NA","This study will compare two exercise-based rehabilitation programs to improve balance and reduce fall risk in adults aged 45 years and older who have had at least one fall in the past year or have balance problems. Participants will be assigned to one of two groups: (1) a virtual reality (VR) exercise program using the PABLO system, or (2) a traditional physiotherapy program based on the Otago approach. Both programs will include balance training, strength\u002Fpower exercises, aerobic activity, and flexibility. The program will last 12 weeks, with two supervised sessions per week (about 30 minutes each). Assessments will be completed at the start of the study and again after 12 weeks. The main outcomes include frailty status, number of falls, mobility (Timed Up and Go test), and balance (Berg Balance Scale). Additional outcomes include grip strength, quality of life (SF-12), and program adherence and safety. The study will help determine whether VR-based rehabilitation improves participation and outcomes compared with traditional physiotherapy.",[26,27,28,29],"Frailty","Falls","Balance Deficits","Mobility Limitations",[31,32,33,26,34],"Virtual Reality Rehabilitation","Balance Training","Fall Prevention","Exergaming","NOT_YET_RECRUITING","2025-12-29",{"date":38,"type":39},"2026-01-07","ACTUAL",{"date":41,"type":20},"2026-01-01",{"date":43,"type":20},"2026-06-01",{"name":45,"class":46},"Umm Al-Qura University","OTHER",{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":16,"minAge":55,"maxAge":4,"enrollmentInfo":56,"targetDuration":4,"studyType":21,"phases":58,"briefSummary":59,"conditions":60,"keywords":65,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":80},"100577967","a-study-to-evaluate-the-safety-and-performance-of-a-vestibular-implant-in-adults-to-provide-balance-restoration-100577967","NCT06805175","A Study to Evaluate the Safety and Performance of a Vestibular Implant in Adults to Provide Balance Restoration","A Prospective, Multicentric, Staged Feasibility Study to Evaluate the Safety and Performance of the Second-generation Otolith Vestibular Implant in Adults With Vestibular Dysfunction to Mitigate Imbalance. BionicVEST2","BionicVEST2","Inclusion Criteria:\n\n* Adults of 18 years or older with bilateral vestibulopathy \\>1 year of evolution without benefit from conventional rehabilitation treatment. Symptoms unlikely to improve according to clinicians´ estimation.\n* Hearing impairment ranging from:\n\n  1. Early feasibility stage (first 6 subjects enrolled): moderate to severe hearing loss with PTA of 41-70 dB HL on the ear to be implanted.\n  2. Late feasibility stage (12 subjects): normal hearing to severe hearing loss with PTA ≤ 70 dB HL on the ear to be implanted.\n* Patients diagnosed with bilateral vestibulopathy or probable bilateral vestibulopathy based on the consensus document of the Barany Society on vestibular implant candidate criteria for research \\[van de Berg et al., 2020\\]:\n\n  a. Unsteadiness when walking or standing plus at least one of the following: i. Movement-induced blurred vision or ii. Oscillopsia during walking or quick head\u002Fbody movements, and\u002For iii. Worsening of unsteadiness in darkness and\u002For on uneven ground b. Symptoms greatest during head movement and not compensated after rehabilitation program. c. Bilaterally reduced or absent angular VOR function documented by at least one of the following major criteria: i. Pathological horizontal angular VOR gain ≤ 0.6 and at least one vertical angular VOR gain \\\u003C 0.7, measured by the video-HIT technique. ii. Reduced caloric response (sum of bithermal max. peak SPV on each side ≤6◦\u002Fsec for 30 sec water stimuli or \\\u003C10◦\u002Fsec for 60 sec of air stimuli). In case only one of two criteria from c. are matched, the remaining test(s) should comply with the following minor criteria: 1) Bilaterally pathological VOR gains of at least two semicircular canals \\\u003C 0.7, measured by the video- HIT or scleral-coil technique 2) Reduced caloric response (sum of bithermal max. peak SPV on each side \\\u003C10°\u002Fsec for water and air stimuli of ≥30 sec). d. Absent cVEMP and oVEMP responses in the ear to be implanted.\n* Anatomical optimal conditions for implantation evaluated by CT and MRI:\n\nvestibule permeability ascertained and present intact vestibular nerve.\n\n* Ability to use the device and follow a personalized rehabilitation program.\n* Ability to undergo the surgery.\n\nExclusion Criteria:\n\n* Dynamic Gait Index \\> 18 and Functional Gait Assessment \\> 22\n* Ossification or other inner ear anomalies that prevent full insertion of electrodes.\n* Middle ear disorders including conductive hearing loss.\n* Retro cochlear or central origins of hearing impairment.\n* Medical contraindications for surgery.\n* Chronic depression, dementia and cognitive disorders that could, at the discretion of the clinician, significantly interfere with use or evaluation of the VI.\n* Cerebellar ataxias without bilateral vestibulopathy and CANVAS.\n* Known genetical indication for ataxia.\n* Known diagnosis of DFNA9.\n* Downbeat nystagmus syndrome.\n* Persistent Postural-Perceptual Dizziness.\n* Vestibular suppressant medications.\n* Oculomotor disorders (if oscillopsia is prominent).\n* Peripheral neuropathies.\n* Central gait disorders due to normal pressure hydrocephalus, frontal gait disorders, subcortical vascular encephalopathy or multiple sclerosis.\n* Intoxications (i.e. excessive alcohol and\u002For drugs use).\n* No current psychological or psychiatric disorder that could significantly interfere with use or evaluation of the VI.\n* Unable or unwilling to comply with the requirements of the clinical investigation as determined by the Investigator.\n* Unrealistic expectations on the part of the subject, regarding the possible benefits, risks and limitations that are inherent in the procedure and prosthetic device.\n* Investigator site personnel directly affiliated with this study and\u002For their immediate families; immediate family is defined as a spouse, parent, child, or sibling.\n* Cochlear employees or employees of Contract Research Organizations or contractors engaged by Cochlear for the purposes of this investigation.\n* Pregnant or breastfeeding women.\n* Current participation, or participation in another interventional clinical study\u002Ftrial in the past 30 days, involving an investigational drug or device (unless determined by the investigator or Sponsor to not impact this investigation).","18 Years",{"count":57,"type":20},18,[23],"The main aim of this study is to understand if an experimental vestibular implant system can improve balance performance. The system consists of a vestibular implant combined with a cochlear implant sound processor and programming software. The implant is designed to preserve hearing in the implanted ear. The vestibular implant is surgically placed under the skin just behind the ear in the mastoid bone and has an electrode that stimulates the vestibular nerve. A sound processor is worn behind the ear and powers the implant via the coil. The study will be conducted in adults with bilateral vestibulopathy (BVP) who have normal to severe hearing loss in the inner ear. The study participants will undergo a series of tests that include evaluations of their balance and hearing and self-reported questionnaires on their balance and general health.",[61,62,63,28,64],"Vestibulopathy","Moderate to Severe Hearing Loss","Normal Hearing","Vestibular Abnormality",[66,67,68],"vestibular implant","vestibulopathy","cochlear implant","RECRUITING","2025-11-23",{"date":72,"type":39},"2025-11-25",{"date":74,"type":39},"2025-09-18",{"date":76,"type":20},"2026-10",{"name":78,"class":79},"Cochlear","INDUSTRY",3,{"id":82,"slug":83,"hasResults":11,"nctId":84,"briefTitle":85,"officialTitle":85,"acronym":86,"eligibilityCriteria":87,"healthyVolunteers":11,"sex":16,"minAge":55,"maxAge":88,"enrollmentInfo":89,"targetDuration":4,"studyType":21,"phases":91,"briefSummary":92,"conditions":93,"keywords":4,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":98,"lastUpdatePostDateStruct":99,"startDateStruct":101,"completionDateStruct":103,"leadSponsor":105,"locationsCount":107},"100601634","neuromodulation-enhanced-use-of-robotic-balance-training-to-improve-balance-function-in-individuals-with-stroke-100601634","NCT07113041","Neuromodulation-Enhanced Use of RObotic BALANCE Training to Improve Balance Function in Individuals With Stroke","NEUROBALANCE","Inclusion Criteria:\n\n1. Aged between 18-75 years\n2. Diagnosed with a cortical\u002Fsubcortical ischemic stroke at least 6 months before the screening, as confirmed by the neurological exam or an MRI.\n3. Have complaints of impaired balance and poor postural control determined by a BBS score of ≤50.\n4. Ability to stand upright with or without support for at least 20 seconds\n5. Ability to walk with or without a walking aid for at least ten meters\n6. Not planning to change medication in the next four months\n7. Minimum Cognitive Ability to understand the verbal instructions and comply with the study procedures, as determined by the University of California, San Diego, Brief Assessment of Capacity to Consent Instrument (UBACC).\n\nExclusion Criteria:\n\n1. Currently undergoing any regular physical therapy program or research studies focusing on balance functions.\n2. Having a brainstem stroke.\n3. Contraindication for MRI scan (presence of metal implants, claustrophobia)\n4. Affected by the peripheral nerve injury, neuromuscular conditions, or orthopedic issues of lower limbs before stroke, or have any persistent pain or difficulty maintaining blood pressure while upright.\n5. Have a scalp or skin condition (e.g., psoriasis or eczema) \\* on the scalp near the stimulation site\n6. Having severe visual impairment (e.g., spatial neglect) or hearing problems that may affect study compliance\n7. Any other neurological injury or psychiatric conditions (e.g., severe anxiety or schizophrenia etc.)\n8. Contraindications to MRI, including the presence of non-titanium metallic implants, claustrophobia, etc.\n9. Not be pregnant or thinking of becoming pregnant\n10. Diagnosed with alcohol or substance abuse in the last 3 years\n11. Contraindications to TMS, including the presence of metallic implants in the head and a history of seizures or medication-resistant epilepsy or ongoing use of anti-seizure\u002Fseizure threshold-lowering medications.","75 Years",{"count":90,"type":20},45,[23],"Our proposed study, \"NEUROBALANCE Stroke,\"; aims to evaluate the effectiveness of a combined intervention involving robotic balance training and noninvasive brain stimulation in improving balance function and postural control in individuals with chronic stroke. The study will recruit 45 participants who have had a stroke at least 6 months before enrolment and experience persistent balance and gait deficits. Participants will be randomized into three groups: (1) robotic balance training with active brain stimulation, (2) robotic balance training with sham brain stimulation, and (3) standard-of-care rehabilitation.\n\nThe study will involve 15 training sessions over 5 weeks, with assessments conducted at baseline, post-training, and two months post-training to evaluate balance recovery and retention. The primary focus is understanding how this intervention affects brain and muscle activity during balance tasks and how these changes translate into functional improvements in clinical outcome measures of balance function. Additionally, participant feedback on brain stimulation and exercise engagement will be collected to inform future studies.\n\nThe findings may guide the development of personalized training protocols and contribute to broader rehabilitation strategies.",[94,95,96,97,28],"Stroke","Stroke (CVA) or Transient Ischemic Attack","Stroke Ischemic","Stroke Gait Rehabilitation","2025-08-01",{"date":100,"type":39},"2025-08-08",{"date":102,"type":39},"2025-06-01",{"date":104,"type":20},"2029-08-31",{"name":106,"class":46},"Kessler Foundation",1,{"id":109,"slug":110,"hasResults":11,"nctId":111,"briefTitle":112,"officialTitle":113,"acronym":4,"eligibilityCriteria":114,"healthyVolunteers":11,"sex":16,"minAge":115,"maxAge":4,"enrollmentInfo":116,"targetDuration":4,"studyType":21,"phases":118,"briefSummary":120,"conditions":121,"keywords":123,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":129,"lastUpdatePostDateStruct":130,"startDateStruct":132,"completionDateStruct":134,"leadSponsor":136,"locationsCount":107},"100575969","early-phase-1-examining-the-effects-of-theta-burst-tms-on-brain-connectivity-and-balance-ability-in-older-adults-with-balance-problems-100575969","NCT06779188","Examining the Effects of Theta Burst TMS on Brain Connectivity and Balance Ability in Older Adults With Balance Problems","Treating Balance Impairment of the Elderly With TMS-induced Brain Connectivity","Inclusion Criteria:\n\na) Able to provide informed consent b) All ethnic groups c) \\>65 years of age d) ≥2 non-injury falls or ≥1 injury fall in the past year \\[17\\]-\\[21\\] e) Absence of dementia\u002Funcontrolled psychiatric disorder h) Able to walk and stand for 5 min continuously independently without assistance (i.e., cane, walker, ankle foot orthotics, electric scooter).\n\ni) Willingness to undergo MRI, participate in the 4-weeks intervention AND in the laboratory studies before, immediately-after, and 3-month after the intervention.\n\nExclusion Criteria:\n\n1. Inability to provide informed consent.\n2. Non-English speaking.\n3. Have contraindications to TMS based on TMS Adult Safety Screen (e.g., pregnancy, metal in the brain\u002Fskull, neurostimulator, pacemaker, infusion device, medication to treat mental illness)\n4. Unintentional weight loss of ≥10 pounds over the past year.\n5. Severe uncontrolled hypertension, or uncontrolled diabetes.\n6. Poor cognitive status (Montreal Cognitive Assessment (MoCA) score ≥ 26)\n7. Untreated depression or Geriatric Depression Scale score on 15 item scale \\>7\n8. History of limb amputation (upper or lower extremity)\n9. Planned surgery in the next 3 months.\n10. History of chemotherapy or planned chemotherapy in the next 6 months or active malignancy.\n11. Severe osteoporosis, defined by diagnosis of osteoporosis with fracture.\n12. Pregnant or have a chance of being pregnant.\n13. Chronic inflammatory condition, autoimmune disease or infectious processes such as active tuberculosis, Human Immunodeficiency Virus, Rheumatoid arthritis, systemic lupus erythematosus, acute or chronic hepatitis B or C.\n14. Illicit drug use\n15. Use of medications that may increase the risk of falling:\n\n    * Sedatives\n    * Hypnotics\n    * Anti-cholinergic\n    * Benzodiazepines\n    * Anti-depressants\n16. Intracranial bleeds visible on their most recent CT or MRI scans.","65 Years",{"count":117,"type":20},30,[119],"EARLY_PHASE1","The goal of this study is to learn if manipulating the brain using magnets works to treat balance impairment, a major cause of falls, in older adults with balance problems. The technique to manipulate the brain using magnets is known as transcranial magnetic stimulation or TMS.\n\nThe main questions this study aims to answer are:\n\n* How does TMS change communication between brain areas?\n* Does TMS improve balance ability in older adults with balance problems? Researchers will compare the TMS group to a placebo group to see if manipulating the brain using magnets works to treat balance impairment.\n\nParticipants will:\n\n* Receive TMS or placebo stimulation for 4 weeks.\n* Visit the laboratory for checkups and tests 3 times.",[122,28],"Aging",[124,125,126,127,128],"TMS","Balance","Brain stimulation","Elderly","Treatment","2025-05-14",{"date":131,"type":39},"2025-05-15",{"date":133,"type":39},"2025-05-06",{"date":135,"type":20},"2026-05-31",{"name":137,"class":79},"Weinberg Medical Physics LLC",{"id":139,"slug":140,"hasResults":11,"nctId":141,"briefTitle":142,"officialTitle":143,"acronym":4,"eligibilityCriteria":144,"healthyVolunteers":11,"sex":16,"minAge":55,"maxAge":145,"enrollmentInfo":146,"targetDuration":4,"studyType":21,"phases":147,"briefSummary":148,"conditions":149,"keywords":154,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":165,"lastUpdatePostDateStruct":166,"startDateStruct":168,"completionDateStruct":170,"leadSponsor":172,"locationsCount":107},"100568606","effectiveness-of-vestaid-app-100568606","NCT06683417","Effectiveness of VestAid App","Vestibular Rehabilitation Aid (VestAid)","Inclusion:\n\n* Snellen visual acuity (corrected) greater than 20\u002F40\n* No more than 25dB hearing loss at 500,1000, 2000, and 4000 Hz\n* Ability to detect 4.31 using Semmes-Weinstein monofilament at the lower extremity\n* At least 40 degrees of neck yaw motion with only mild to moderate pain (6 or under on 0-10 numeric pain scale)\n* Internet access at home\n* No significant residual from past musculoskeletal or neuromuscular conditions\n* Ability ambulates unassisted\n* Diagnosed with a concussion or inner ear problem the last 30 days\n* Between 18-60 years of age\n* Can read and understand English\n* Has complaints of dizziness\n\nExclusion criteria:\n\n* Greater then 30 days since diagnosis of concussion\u002FmTBI or inner ear problem\n* No access to internet at home\n* Younger than 18 years of age or older than 60 years of age\n* Cannot read or understand English\n* No complaints of dizziness and\u002For balance deficits\n* Have significant neuropathy\n* Cannot see tablet clearly at 1 meter\n* Neck pain \\>5 on a 10-point pain scale.","60 Years",{"count":19,"type":20},[23],"This multi-center randomized trial (MCRT) will investigate the effectiveness of the VestAid application to provide equivalent or faster recovery from dizziness compared to standard-of-care delivery of vestibular rehabilitation exercises.",[150,151,28,152,153],"MTBI - Mild Traumatic Brain Injury","Vestibular Disease","Vestibular Disorders","Dizziness",[155,156,157,158,159,160,161,162,163,164],"mTBI","vestibular rehabilitation","vestibular disorder","technology","application","dizziness","balance disorder","image processing","eye gaze compliance","VOR","2024-11-08",{"date":167,"type":39},"2024-11-12",{"date":169,"type":20},"2025-01-15",{"date":171,"type":20},"2025-12-30",{"name":173,"class":79},"BlueHalo"]