[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"bardet-biedl-syndrome-bbs\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:bardet-biedl-syndrome-bbs":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,51],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":30,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":50},"100644723","phase-4-real-world-effects-of-mc4r-agonist-therapy-in-bbs-and-severe-genetic-obesity-100644723",false,"NCT07674290","Real-World Effects of MC4R Agonist Therapy in BBS and Severe Genetic Obesity","Real-World Effectiveness, Safety and Patient-reported Outcomes of Setmelanotide in Patients With Bardet-Biedl Syndrome: A Prospective Mono Centric Observational Interventional Study","REAL-MC4","Inclusion Criteria:\n\n* clinical phenotype corresponding to Bardet-Biedl Syndrome\n* genetic testing with notable finding\n\nExclusion Criteria:\n\n* patients younger than the age approved for treatment with setmelanotide","ALL",{"count":19,"type":20},200,"ESTIMATED","INTERVENTIONAL",[23],"PHASE4","Bardet-Biedl syndrome (BBS) and other rare disorders associated with impairment of the melanocortin-4 receptor (MC4R) pathway are characterized by severe early-onset obesity, hyperphagia, and substantial morbidity. Setmelanotide, an MC4R agonist, is approved in Europe for selected genetic obesity disorders and reimbursed in Germany for eligible patients. This study aims to evaluate the effectiveness, safety, treatment persistence, metabolic outcomes, and patient-reported outcomes of Setmelanotide under real-world conditions. The registry is designed to allow future inclusion of additional MC4R agonists as they become approved and clinically available. The study will primarily be conducted at University Hospital Essen and will collect longitudinal routine clinical data from pediatric and adult patients receiving MC4R agonist therapy according to approved indications.",[26,27,28,29],"Bardet Biedl Syndrome (BBS)","Bardet Biedl Syndrome","Bardet-Biedl Syndrome (BBS)","Alstrom Syndrome",[31,32,33,34,35,36,37],"Setmelanotide","Melanocortin-4-receptor","Melanocortin pathway","Bardet-Biedl Syndrome","Hyperphagia","Neurocognitive development","Genetic Obesity","RECRUITING","2026-06-23",{"date":41,"type":42},"2026-06-29","ACTUAL",{"date":44,"type":42},"2023-01-01",{"date":46,"type":20},"2030-12-31",{"name":48,"class":49},"Tom Hühne","OTHER",1,{"id":52,"slug":53,"hasResults":11,"nctId":54,"briefTitle":55,"officialTitle":55,"acronym":56,"eligibilityCriteria":57,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":58,"targetDuration":60,"studyType":61,"phases":4,"briefSummary":62,"conditions":63,"keywords":64,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":4},"100563349","bardet-beidle-syndrome-in-a-syrian-adolescent--a-rare-case-report-100563349","NCT06615011","Bardet Beidle Syndrome in a Syrian Adolescent : a Rare Case Report","AlBaathU","Inclusion Criteria:\n\n* any person\n\nExclusion Criteria:\n\n* any person",{"count":59,"type":20},100,"1 Year","OBSERVATIONAL","Bardet-Biedl Syndrome (BBS) is an uncommon genetic disorder that affects multiple organs. and presents with a variety of characteristics. It is caused by a dysfunction in the cilia. We present a case of bradet-biedl syndrome presenting with intellectual disabilities, post-axial polydactyly, gingival hyperplasia, and a significant family history of scleroderma. The diagnosis was determined based on clinical physical examination findings. The patient is undergoing treatment with Thyroxine. Although medical staff are incapable of treatment, systems support adjust the overall well-being and quality of life for individuals with Bardet-Biedl syndrome and their families.",[26],[65,66],"Central obesity","Postaxial Polydactyly","NOT_YET_RECRUITING","2024-09-25",{"date":70,"type":42},"2024-09-27",{"date":72,"type":20},"2024-10-12",{"date":74,"type":20},"2025-10-12",{"name":76,"class":49},"Al Baath University"]