[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"barrett-adenocarcinoma\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:barrett-adenocarcinoma":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100460527","emr-versus-esd-for-barretts-neoplasia-100460527",false,"NCT05276791","EMR Versus ESD for Barrett's Neoplasia","Endoscopic Mucosal Resection Versus Endoscopic subMucosal Dissection fOr Removal of Visible Lesions in Barrett's Esophagus With Early Neoplasia: a Randomized Controlled Trial","REMOVE-RCT","Inclusion Criteria:\n\n* Patients age: ≥ 18 years\n* Willingness to undergo both EMR or ESD\n* Ability to provide written, informed consent (approved by IRB) and understand the responsibilities of trial participation\n* BE with at least one visible lesion (\"target lesion\") with absence of signs of submucosal invasion on endoscopy, after evaluation by the adjudication committee\n* Multiple lesions are allowed as long as the lesions are considered eligible for endoscopic treatment. Only the target lesion is evaluated for the study\n* Prior endoscopic resection is allowed\n\nExclusion Criteria:\n\n* Patients with visible lesions with suspicion of submucosal invasion based on assessment of the adjudication committee\n* Patients with HGD in at least one random biopsy, before inclusion (i.e. during endoscopy in the referring center \\\u003C3 months before imaging, or during imaging endoscopy)\n* History of esophageal surgery other than fundoplication\n* History of esophageal ablation therapy\n* In case of prior endoscopic resection, the target lesion located within 1 cm of the prior resection site\n* Uncontrolled coagulopathy with INR \\>2.0, thrombocytopenia with platelet counts \\\u003C 50,000\n* Esophageal varix or varices\n* Subject has a known history of unresolved drug or alcohol dependency that would limit ability to comprehend or follow instructions related to informed consent, post-treatment instructions, or follow-up guidelines\n* Life expectancy \\\u003C2 years","ALL","18 Years",{"count":20,"type":21},331,"ESTIMATED","INTERVENTIONAL",[24],"NA","Rationale:\n\nThe optimal technique for removal of visible dysplastic lesions in Barrett's esophagus remains controversial. Endoscopic mucosal resection (EMR) is safe, effective, easy to apply, and has been the most widely used technique since 2008. Endoscopic submucosal dissection (ESD) is a more controlled dissection method with potential improved efficacy, but at the cost of higher technical complexity.\n\nObjective:\n\nThe investigators aim to compare EMR and ESD for removal of visible lesions in Barrett's esophagus.\n\nStudy design:\n\nRandomized clinical trial\n\nStudy population:\n\nPatients with Barrett's esophagus and a visible lesion with dysplasia and\u002For early cancer. Suspicion for submucosal invasion is an exclusion criterion.\n\nIntervention:\n\nPatients are randomized to receive either EMR or ESD, with follow-up and no ablation during 12 months after the resection.\n\nMain study endpoint:\n\nPrimary endpoint is the proportion of patients with no evidence of residual or local recurrent neoplasia during 12 months follow-up after baseline.",[27,28,29],"Barretts Esophagus With Dysplasia","Barrett Adenocarcinoma","Esophageal Cancer",[31,32],"Barrett's esophagus","Esophagheal adenocarcinom","RECRUITING","2026-06-24",{"date":36,"type":37},"2026-06-29","ACTUAL",{"date":39,"type":37},"2023-01-17",{"date":41,"type":21},"2028-12-01",{"name":43,"class":44},"St. Antonius Hospital","OTHER",6]