[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"basal-ganglia-hemorrhage\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:basal-ganglia-hemorrhage":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,49],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":31,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100608723","rainbow-ich-trial-of-ai-guided-minimally-invasive-neurosurgery-for-ich-100608723",false,"NCT07205263","RAINBOW-ICH Trial of AI Guided Minimally Invasive Neurosurgery for ICH","A Multicenter, Randomized, Controlled, Umbrella Trial for Minimally Invasive Neurosurgery With Al-assisted Robotic Guidance for Hemorrhagic Stroke (RAINBOW-ICH)","RAINBOW-ICH","Umbrella Trial Inclusion Criteria:\n\n1. Age ≥18 years；\n2. Clinical diagnosis of spontaneous hemorrhagic stroke；\n\nUmbrella Trial Exclusion Criteria:\n\n1\\. Radiologically diagnosed cerebrovascular abnormalities, as well as ischemic infarction converting to intracerebral hemorrhage, or recent (within 1 year) recurrence of intracerebral hemorrhage；\n\nEach substudy will specify additional inclusion and exclusion criteria in the respective Substudy-specific Registration. Patients who fulfill the overall umbrella trial criteria will be assessed for enrollment into each substudy.","ALL","18 Years",{"count":20,"type":21},1000,"ESTIMATED","INTERVENTIONAL",[24],"NA","Intracerebral hemorrhage (ICH) is one of the most devastating forms of stroke, with high rates of death and disability worldwide. Despite advances in medical and surgical care, effective therapeutic options remain limited. To address this gap, the RAINBOW-ICH trial has been designed as a nationwide, multicenter, randomized umbrella trial evaluating the efficacy and safety of AI-assisted, robotic-guided minimally invasive neurosurgery compared with conventional strategies across major ICH subtypes.\n\nUnder a single master protocol, RAINBOW-ICH incorporates multiple parallel randomized controlled substudies, each targeting a distinct ICH population-large basal ganglia hemorrhage, moderate basal ganglia hemorrhage, intraventricular hemorrhage, and brainstem hemorrhage. This umbrella design allows efficient use of resources while generating high-quality evidence tailored to the specific needs of different ICH subgroups, thereby supporting a more patient-centered approach to care.",[27,28,29,30],"Basal Ganglia Hemorrhage","Intraventricular Hemorrhage","Brainstem Stroke","Intracranial Hemorrhage, Spontaneous",[32,33,29,34,27,35],"Umbrella Trial","Intraventricular hemorrhage","Robotic-guided","Minimally invasive surgery","RECRUITING","2026-01-06",{"date":39,"type":40},"2026-01-08","ACTUAL",{"date":42,"type":40},"2025-09-30",{"date":44,"type":21},"2027-12",{"name":46,"class":47},"Second Affiliated Hospital, School of Medicine, Zhejiang University","OTHER",1,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":55,"eligibilityCriteria":56,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":57,"targetDuration":4,"studyType":22,"phases":59,"briefSummary":60,"conditions":61,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":62,"startDateStruct":63,"completionDateStruct":64,"leadSponsor":66,"locationsCount":48},"100551871","a-trial-for-minimally-invasive-neurosurgery-with-ai-assisted-robotic-guidance-for-moderate-basal-ganglia-hemorrhage-rainbow-mbh-100551871","NCT06465719","A Trial for Minimally Invasive Neurosurgery With AI-assisted Robotic Guidance for Moderate Basal Ganglia Hemorrhage (RAINBOW-MBH)","A Multicenter, RAndomlzed, coNtrolled, umBrella Trial fOr Minimally Invasive Neurosurgery With Al-assisted Robotic Guidance for Moderate Basal Ganglia Hemorrhage (RAINBOW-MBH)","RAINBOW-MBH","Inclusion Criteria:\n\n1. Age ≥18 years at randomization\n2. Hypertensive basal ganglia hemorrhage confirmed by CT\u002FCTA\n3. Hematoma volume 15-30 mL (excluding 30 mL)\n4. Functional impairment (aphasia, hemiparesis with strength ≤3, or NIHSS ≥15)\n5. CT shows stable hematoma (≥6h interval, change \\\u003C5 mL)\n6. GCS ≥9\n7. Surgery feasible within 72h after onset\n8. Pre-ICH mRS ≤1\n9. Informed consent obtained according to laws and ethics\n\nExclusion Criteria:\n\n1. Hematoma involving the thalamus, midbrain, or other areas\n2. Radiologically diagnosed cerebrovascular abnormalities, as well as ischemic infarction converting to intracerebral hemorrhage, or recent (within 1 year) recurrence of intracerebral hemorrhage\n3. Signs of impending brain herniation, such as midline shift \\>1 cm or changes in the ipsilateral pupil;\n4. Any irreversible coagulopathy disorders or known coagulation system disease; platelet count \\\u003C100,000; INR \\>1.4; use of anticoagulants within 7 days prior to this hemorrhage;\n5. Pregnant or possibly pregnant\n6. Patients with severe concomitant diseases that may interfere with outcome assessment\n7. Poor compliance or follow-up difficulties",{"count":58,"type":21},330,[24],"A nationwide, prospective, multicenter randomized controlled clinical trial to evaluate the therapeutic effects of the fiber tract-based artificial intelligence (AI) Robot Guiding System on the perioperative and long-term recovery of patients with moderate-volume basal ganglion hemorrhage.",[27],{"date":39,"type":40},{"date":42,"type":40},{"date":65,"type":21},"2027-12-31",{"name":46,"class":47}]