[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"bd\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:bd":86},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,55],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":32,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":43,"lastUpdatePostDateStruct":44,"startDateStruct":47,"completionDateStruct":49,"leadSponsor":51,"locationsCount":54},"100622473","high-intensity-focused-ultrasound-vs-cryotherapy-in-the-treatment-of-basal-cell-carcinomas-and-bowens-disease-in-adults-100622473",false,"NCT07384078","High Intensity Focused Ultrasound vs. Cryotherapy in the Treatment of Basal Cell Carcinomas and Bowen's Disease in Adults","HIFU vs. CRYO - High Intensity Focused Ultrasound vs. Cryotherapy in the Treatment of Basal Cell Carcinomas and Bowen's Disease - a Randomized Controlled Trial","HIFUvsCRYO","Inclusion Criteria:\n\n* age 18 years or older at the time of informed consent\n* ability to give informed consent and comply with the treatment protocol and follow-up plan\n* study lesion located between neck and knees\n* one of following histologically confirmed diagnosis: Superficial BCC with maximum diameter of 2.0 cm \u002F Nodular BCC with max. diameter of 1.5 cm \u002F BD with max. diameter of 2.0 cm\n\nExclusion Criteria:\n\n* Study lesion location in face, head, genitals, hands, or below the knee\n* Clinical\u002Fdermoscopical\u002Fhistological feature for high-risk\u002Faggressive BCC\n* Clinical\u002Fhistological sign for hypertrophic BD\n* Clinical\u002Fdermoscopical\u002Fhistological feature for Squamous cell carcinoma\n* Gorlin Golz syndrome\n* Pregnancy or breastfeeding","ALL","18 Years",{"count":20,"type":21},294,"ESTIMATED","INTERVENTIONAL",[24],"NA","This prospective, randomized, controlled, and single-blinded non-inferiority clinical trial compare the efficacy and tolerability of high intensity focused ultrasound (HIFU) to standard cryotherapy in the treatment of low-risk basal cell carcinomas (BCCs) and Bowen's disease (BD) in adults. The main questions it aims to answer are:\n\n* Is HIFU an efficient treatment option for BCCs and BD?\n* What medical problems do participants get after HIFU?\n\nResearchers will compare HIFU to standard cryotherapy with liquid nitrogen to see if the ultrasound works to treat these local and low-risk non-melanosytic skin cancers.\n\nParticipants will:\n\n* Be treated either with HIFU (intervention) or cryotherapy (control).\n* Visit the clinic 4 weeks, 1-, 3- and 5 years after the treatment for check-ups, tests and survey questions.",[27,28,29,30,31],"Superficial Basal Cell Carcinoma","Nodular Basal Cell Carcinoma","Bowen's Disease","BCC","BD",[33,34,35,36,37,38,39,40,41],"HIFU","cryo","cryotherapy","high intensity focused ultrasound","basal cell carcinoma","Bowen's disease","superficial basal cell carcinoma","nodular basal cell carcinoma","non-surgical treatment","NOT_YET_RECRUITING","2026-01-26",{"date":45,"type":46},"2026-02-03","ACTUAL",{"date":48,"type":21},"2026-04-01",{"date":50,"type":21},"2032-12-31",{"name":52,"class":53},"Jussi Salonen","OTHER",1,{"id":56,"slug":57,"hasResults":11,"nctId":58,"briefTitle":59,"officialTitle":60,"acronym":61,"eligibilityCriteria":62,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":63,"targetDuration":4,"studyType":22,"phases":65,"briefSummary":66,"conditions":67,"keywords":69,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":80,"completionDateStruct":82,"leadSponsor":84,"locationsCount":54},"100596011","a-novel-psychological-intervention-for-adults-with-bipolar-disorder-and-attention-deficit-hyperactivity-disorder-comorbidity-vector-100596011","NCT07039903","A Novel Psychological Intervention for Adults With Bipolar Disorder and Attention Deficit Hyperactivity Disorder Comorbidity (VECTOR)","Bridging the Gap in the Study of Bipolar Disorder and Attention Deficit Hyperactivity Disorder: Impact of cognitiVE Reserve and funCtioning in a Newly Designed Treatment intervenTion for comORbidity (VECTOR)","VECTOR","Inclusion Criteria:\n\n* Fulfill DSM-5 criteria for BDI or BDII and ADHD using the Structured Clinical Interview for DSM-5 and the Conners' Adult ADHD Diagnostic Interview (CAARS)\n* Aged ≥18\n* Stable pharmacological treatment for at least the past three months.\n* Being in full or partial remission Young Mania Rating Scale (YMRS) ≤ 10, Hamilton Depression Rating Scale (HDRS) ≤ 14) at the time of the inclusion and assessment\n* ADHD rating scale≥24\n\nExclusion Criteria:\n\n* Any comorbid psychiatric condition\n* Diagnosis of substance abuse disorder in the past 12 months\n* Intellectual disability (intelligence quotient \\\u003C 70)\n* Having any Central Nervous System illness, independent of primary psychiatric diagnosis, hampering neuropsychological performance\n* Participation in a structured psychological intervention during the study period.",{"count":64,"type":21},68,[24],"Cognitive dysfunctions are present in Bipolar Disorder (BD) and Attention Deficit Hyperactivity Disorder (ADHD) and may negatively impact psychosocial functioning. Further, comorbid BD and ADHD (BD-ADHD) is prevalent, associated with an earlier BD onset and a less favorable prognosis. Nevertheless, there is a paucity of research dedicated to the characterization and treatment of comorbid BD-ADHD.\n\nThis study aims to develop and evaluate the effectiveness of a novel psychological group intervention (VECTOR) for adults with BD-ADHD. VECTOR integrates elements from Cognitive Behavioral Therapy (CBT) for ADHD and Functional Remediation (FR) for BD.\n\nEighty patients will be randomized (1:1) to receive either the VECTOR program (12 weekly group sessions) or treatment as usual (TAU).\n\nIt is expected that the VECTOR program will result in greater improvements in functioning and symptom reduction compared to TAU.",[68,31],"ADHD",[70,71,72,73,74,31,75,68,76],"clinical trial","Cognitive Behavioral Therapy","Psychological treatment","Bipolar Disorder","Bipolar and Related Disorders","Attention-Deficit Hyperactivity Disorder","Functional remediation","2025-06-18",{"date":79,"type":46},"2025-06-26",{"date":81,"type":21},"2025-09-01",{"date":83,"type":21},"2027-12-31",{"name":85,"class":53},"Hospital Universitari Vall d'Hebron Research Institute",""]