[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"bee-sting\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:bee-sting":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":26,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":5},"100528075","tolerance-in-beekeepers-100528075",false,"NCT06156046","Tolerance in Beekeepers","Elucidation of the Mechanism of Immune Tolerance in Beekeepers","Inclusion Criteria:\n\n\\- Group 1 inclusion criteria.\n\n* Individuals naive to beekeeping (\\\u003C2 previous bee stings, none in the last 24 months)\n* no history of anaphylaxis to stings. Group 2 inclusion criteria.\n* Beekeepers with \\> approximately 10 stings\u002Fyear who have been beekeeping for \\>3 years.\n* No history of anaphylaxis to bee venom. Group 3 inclusion criteria\n* Beekeepers with diagnosis of anaphylaxis to bee venom in the last 12 months who are sensitised to bee venom (as evidenced by positive specific IgE and positive skin test to bee venom)\n\nExclusion Criteria:\n\n* Unable to understand protocol\u002Fconsent.\n* Unable to commit to follow up visits.\n* Participants with a known history of mastocytosis or under investigation for suspected mastocytosis.\n* Participants undergoing desensitisation treatment to bee venom before the first visit.\n* Participants being treatment with immunosuppressive medications. being treatment with immunosuppressive medications.",true,"ALL","18 Years",{"count":20,"type":21},120,"ESTIMATED","OBSERVATIONAL","Beekeepers experience multiple bee stings each year. Many of these beekeepers (25-60%) become sensitized to bee venom through the production of specific antibodies that target the bee venom. Although these antibodies are important in the triggering of an allergic reaction only a small number of sensitised beekeepers go on to have an allergic reaction with symptoms away from the site of the sting. These reactions can be severe and are known as anaphylactic reactions.\n\nThe study investigates why some beekeepers develop severe allergic symptoms after bee stings while others do not.\n\nThis study will explore factors in the blood that protect sensitised individuals from having anaphylactic reactions - meaning that despite being sensitised they are tolerant and do not react to subsequent stings.",[25],"Bee Sting",[27,28,29],"Immune tolerance","Anaphylaxis","Beekeepers","RECRUITING","2025-04-29",{"date":33,"type":34},"2025-04-30","ACTUAL",{"date":36,"type":34},"2024-01-22",{"date":38,"type":21},"2027-10-01",{"name":40,"class":41},"University Hospital Plymouth NHS Trust","OTHER"]