[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"behavior-problem\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:behavior-problem":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,53,86,118,149],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":29,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":41,"lastUpdatePostDateStruct":42,"startDateStruct":45,"completionDateStruct":47,"leadSponsor":49,"locationsCount":52},"100636782","phase-4-intranasal-dexmedetomidine-or-esketamine-for-negative-postoperative-behavioral-changes-in-children-100636782",false,"NCT07570160","Intranasal Dexmedetomidine or Esketamine for Negative Postoperative Behavioral Changes in Children","Exploring the Association of Perioperative Electroencephalographic Changes Following Preoperative Intranasal Dexmedetomidine or Esketamine With Negative Postoperative Behavioral Changes in Children Undergoing Day Surgery","PEDI-NPOBCs","Inclusion Criteria:\n\n1. Children aged 2 to 12 years.\n2. Scheduled to undergo elective day surgery under general anesthesia.\n3. ASA (American Society of Anesthesiologists) physical status I to III.\n\nExclusion Criteria:\n\n1. Congenital diseases or severe liver or kidney dysfunction.\n2. History of allergic reactions to study drugs.\n3. Neuromuscular diseases, cerebral palsy, epilepsy.\n4. Other psychiatric or neurological disorders.\n5. Body mass index (BMI) ≥ 30 kg\u002Fm².\n6. Severe upper respiratory tract infections prior to surgery.\n7. Use of sedatives or analgesics within 48 hours before surgery.\n8. Exposure to major life stressors within 1 month before surgery (e.g., family separation, death of a parent).\n9. Refusal to participate or failure to obtain consent from the child's legal guardian.","ALL","2 Years","12 Years",{"count":21,"type":22},342,"ESTIMATED","INTERVENTIONAL",[25],"PHASE4","The goal of this clinical trial is to learn whether intranasal dexmedetomidine or esketamine given before anesthesia can reduce negative postoperative behavioral changes in children undergoing day surgery. Negative postoperative behavioral changes may include anxiety, sleep problems, nightmares, irritability, or other unusual behaviors after surgery. This study will also examine whether changes in brain wave patterns during the perioperative period are related to these behavioral changes.\n\nThe main questions this study aims to answer are:\n\nDoes intranasal dexmedetomidine reduce negative postoperative behavioral changes in children after day surgery? Does intranasal esketamine reduce negative postoperative behavioral changes in children after day surgery? Are perioperative electroencephalographic (EEG) features associated with negative postoperative behavioral changes? Researchers will compare intranasal dexmedetomidine, intranasal esketamine, and normal saline to see whether these treatments differ in their effects on postoperative behavior and perioperative EEG features.\n\nParticipants will be randomly assigned to receive intranasal dexmedetomidine, intranasal esketamine, or intranasal normal saline about 30 minutes before anesthesia. They will receive routine perioperative monitoring, including EEG monitoring during surgery and recovery. They will also be assessed for sedation, pain, and emergence delirium. Follow-up assessments of postoperative behavioral changes will be completed on postoperative days 3, 7, and 28.",[28],"Behavior Problem",[30,31,32,33,34,35,36,37,38,39],"Dexmedetomidine","Esketamine","Intranasal Premedication","Pediatric Day Surgery","Negative Postoperative Behavioral Changes","Emergence Delirium","Perioperative Electroencephalography","General Anesthesia","Children","Randomized Controlled Trial","NOT_YET_RECRUITING","2026-04-29",{"date":43,"type":44},"2026-05-06","ACTUAL",{"date":46,"type":22},"2026-06-01",{"date":48,"type":22},"2027-11-30",{"name":50,"class":51},"Nanjing Children's Hospital","OTHER",1,{"id":54,"slug":55,"hasResults":11,"nctId":56,"briefTitle":57,"officialTitle":58,"acronym":4,"eligibilityCriteria":59,"healthyVolunteers":60,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":61,"targetDuration":4,"studyType":23,"phases":63,"briefSummary":65,"conditions":66,"keywords":68,"overallStatus":76,"whyStopped":4,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":80,"completionDateStruct":82,"leadSponsor":84,"locationsCount":52},"100529151","chicago-parent-program-for-foster-and-kinship-caregivers-100529151","NCT06170047","Chicago Parent Program for Foster and Kinship Caregivers","The Chicago Parent Program for Foster Care: A Randomized Control Trial Examining the Prevention of Behavior Problems Among Young Children in Foster Care Through Group-based Foster Caregiver Training","Inclusion Criteria:\n\n* Must be a licensed foster caregiver or kinship caregiver to a foster child between the ages of 2 and less than 9 years of age\n* Must be a licensed foster caregiver or kinship caregiver to a foster child in Ohio and in the custody of Hamilton County Job and Family Services, Butler County Children Services, or Montgomery County Children Services\n* Must be in good standing with the foster care agency\n* Must be English-speaking\n\nExclusion Criteria:\n\n* Not having a foster child between the ages of 2 and less than 9 years\n* The foster child not being in the custody of Ohio counties: Hamilton County Job and Family Services, Butler County Children Services, or Montgomery County Children Services\n* The foster child was placed in the home more than 45 days prior to enrollment\n* The foster child being moved out of the placement prior to the start of the intervention\n* The foster child having been previously enrolled with another caregiver\n* The caregiver having been previously enrolled with another child\n* The caregiver unable to commit to completing all study activities\n* The foster child is not enrolled in the study",true,{"count":62,"type":22},300,[64],"NA","The primary objective of this study is to test the effects of an evidence-based prevention intervention (CPP) adapted for foster and kinship caregivers of young children (FC; foster care) on caregiver competence and child behavior problems for children in foster care compared with an active comparator group that receives standard supports through the child welfare and healthcare systems (i.e., usual care).",[28,67],"Parenting",[69,70,71,72,73,74,75],"Foster care","Child behavior","Parenting skills","Behavioral health","Prevention","Parenting confidence","Parenting stress","RECRUITING","2026-03-18",{"date":79,"type":44},"2026-03-19",{"date":81,"type":44},"2024-02-02",{"date":83,"type":22},"2027-08-30",{"name":85,"class":51},"Children's Hospital Medical Center, Cincinnati",{"id":87,"slug":88,"hasResults":11,"nctId":89,"briefTitle":90,"officialTitle":91,"acronym":4,"eligibilityCriteria":92,"healthyVolunteers":11,"sex":17,"minAge":93,"maxAge":94,"enrollmentInfo":95,"targetDuration":4,"studyType":23,"phases":97,"briefSummary":98,"conditions":99,"keywords":102,"overallStatus":76,"whyStopped":4,"lastUpdateSubmitDate":109,"lastUpdatePostDateStruct":110,"startDateStruct":112,"completionDateStruct":114,"leadSponsor":116,"locationsCount":52},"100485586","emotion-focused-family-therapy-for-parents-of-children-with-mental-health-difficulties-100485586","NCT05603000","Emotion Focused Family Therapy for Parents of Children With Mental Health Difficulties","A Randomized Controlled Trial of Emotion Focused Family Therapy for Parents of Children With Mental Health Difficulties","Inclusion Criteria:\n\n* Parent of child aged 7 to 15 years old with anxiety, depression, or behavioural challenges\n* Parent of child is willing to participate in intervention\n* Parent is living at home with the child\n\nExclusion Criteria:\n\n* Parent or child not proficient enough in speaking\u002Funderstanding English to complete measures or EFFT intervention components\n* Parent or child with a severe mental health disorder (e.g., active suicidality and psychosis) is not considered suitable for the trial intervention due to the clinical need for immediate intervention\n* Parent or child is actively receiving, or due to receive, intensive psychological intervention focused on cognitive and\u002For behavioural strategies to intervene with emotional or behavioural difficulties\n* Parent or child has any disabilities in language, speech or hearing that would interfere with their completion of the EFFT and measures\n* Parent or child are allergic to adhesive electrode gel use in some tasks (i.e., sodium chloride)","7 Years","15 Years",{"count":96,"type":22},200,[64],"Emotion Focused Family Therapy (EFFT) is a promising intervention that aims to teach parents advanced skills to support their child's development of emotion skills and increase their adaptive behaviours, potentially leading to improvements in their child's psychological functioning and family functioning more broadly.\n\nThis randomized controlled trial (RCT; EFFT vs waitlist control) will (1) test the efficacy of a 6-week group EFFT program on parent and child outcomes and (2) examine maintenance of treatment gains up to four months post-intervention.",[100,101,28],"Anxiety","Depression",[103,104,105,106,107,108],"children","parents","mental health","emotion","psychotherapy","parent-child relationship","2026-01-21",{"date":111,"type":44},"2026-01-23",{"date":113,"type":44},"2022-10-11",{"date":115,"type":22},"2027-03",{"name":117,"class":51},"University of Guelph",{"id":119,"slug":120,"hasResults":11,"nctId":121,"briefTitle":122,"officialTitle":123,"acronym":124,"eligibilityCriteria":125,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":126,"enrollmentInfo":127,"targetDuration":4,"studyType":23,"phases":129,"briefSummary":130,"conditions":131,"keywords":135,"overallStatus":76,"whyStopped":4,"lastUpdateSubmitDate":139,"lastUpdatePostDateStruct":140,"startDateStruct":142,"completionDateStruct":144,"leadSponsor":146,"locationsCount":52},"100492002","psychoeducation-of-parents-to-children-with-fasd-100492002","NCT05686473","Psychoeducation of Parents to Children With FASD","Evaluation of a Treatment Program Based on Psychoeducation of Parents of Children and Adolescents With Fetal Alcohol Spectrum Disorder (FASD)","NorFASDPEdu","All children and adolescents (age 2,5-18 years) referred to the Regional Competence Centre for children with prenatal alcohol exposure in Arendal, Norway will be invited to participate in the current research project.\n\nInclusion criteria:\n\n* Valid information about alcohol exposure in fetal life. Exceptions to this inclusion criterion are children who have been adopted and with dysmorphic features that are consistent with full Fetal Alcohol Syndrome.\n\nExclusion Criteria:\n\n* Children with known genetic syndromes, progressive brain and neuromuscular diseases or major sensory defects (blindness or deafness).","18 Years",{"count":128,"type":22},75,[64],"By longitudinal, prospective research in children and adolescents with Fetal Alcohol Spectrum Disorders (FASD) and their parents to explore the beneficial effects of participating in a standardized intervention program in order to treat and reduce the consequences of early brain damage. By using elements from international programs based on psychoeducation and parent training, the investigators aim to help parents to better understand and respond to the neurodevelopmental disabilities of their children, and thereby improving behavioral problems and self-regulation deficits.",[132,28,133,134],"Fetal Alcohol Spectrum Disorders","Adaptive Behavior","Learning Disorders",[136,137,67,138],"FASD","Psychoeducation","Information program","2025-05-16",{"date":141,"type":44},"2025-05-21",{"date":143,"type":44},"2025-05-01",{"date":145,"type":22},"2026-12",{"name":147,"class":148},"Sorlandet Hospital HF","OTHER_GOV",{"id":150,"slug":151,"hasResults":11,"nctId":152,"briefTitle":153,"officialTitle":154,"acronym":4,"eligibilityCriteria":155,"healthyVolunteers":11,"sex":17,"minAge":156,"maxAge":93,"enrollmentInfo":157,"targetDuration":4,"studyType":23,"phases":159,"briefSummary":160,"conditions":161,"keywords":162,"overallStatus":76,"whyStopped":4,"lastUpdateSubmitDate":169,"lastUpdatePostDateStruct":170,"startDateStruct":172,"completionDateStruct":174,"leadSponsor":176,"locationsCount":52},"100560652","phase-4-effects-of-esketamine-on-postoperative-behavioral-changes-in-children-undergoing-tonsillectomy-andor-adenoidectomy-100560652","NCT06579937","Effects of Esketamine on Postoperative Behavioral Changes in Children Undergoing Tonsillectomy and\u002For Adenoidectomy","Esketamine for the Prevention of Postoperative Behavioral Changes in Children Undergoing Tonsillectomy and\u002For Adenoidectomy: a Randomized Controlled Trial","Inclusion Criteria:\n\n* American society of Aneshesiologists physical status I or II;\n* Aged 3-7 years;\n* Scheduled for elective tonsillectomy and (or) adenoidectomy.\n\nExclusion Criteria:\n\n* Parents refusing to allow their children to participate;\n* Intake of sedative or analgesic medication within 48 hours before surgery;\n* Developmental delay;\n* Psychosis;\n* Body mass index \\> 30 kg\u002Fm2;\n* Allergy to study drugs;\n* Major life changes 1 month before the operation, such as the divorce of parents, death of parents, moving to a new home, changing to a new kindergarten, etc.;\n* Any other conditions that precluded study inclusion.","3 Years",{"count":158,"type":22},172,[25],"The goal of this clinical trial is to learn the effect of intravenous esketamine in postoperative negative behavior changes in children compared to placebo (a look-alike substance that contains no drug). It will also learn about the effect of esketamine in emergence delirium. The main questions are:\n\nDose esketamine lower the incidence of postoperative negative behavior changes compared to placebo? Dose esketamine lower the incidence of emergence delirium compared to placebo? Researchers will compare esketamine to placebo to see if esketamine works to treat postoperative negative behavior change and emergence delirium.\n\nParticipants will:\n\nReceive intravenous esketamine or placebo (a look-alike substance that contains no drug) during anesthesia induction; Fill in the Post hospitalization behavior questionnaire for ambulatory surgery postoperative 1, 7, and 30",[28],[163,164,165,166,167,168],"esketamine","postoperative negative behavioral change","pediatrics","emergence delirium","tonsillectomy","adenoidectomy","2024-09-27",{"date":171,"type":44},"2024-10-01",{"date":173,"type":44},"2024-09-02",{"date":175,"type":22},"2025-10-30",{"name":177,"class":51},"Fujian Provincial Hospital"]