[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"behavior\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:behavior":43},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,30,0,25,[9,81,126,146,183,206,237,266,302,323,349,376,405,430,454,480,508,536,564,593,610,640,668,692,718],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":4,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":57,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":80},"100454745","interventions-in-mathematics-and-cognitive-skills-100454745",false,"NCT05201534","Interventions in Mathematics and Cognitive Skills","Interventions in Math Learning Disabilities: Cognitive and Neural Correlates","Inclusion Criteria:\n\n1. Elementary school aged children starting from first grade (6-12 years old)\n2. IQ: Participants with a Full Scale IQ \\> 70 on the Wechsler Abbreviated Scle of Intelligence (WASI-II).\n3. Identification of Mathematical Learning Disabilities: Scores below the 35th percentile percentile on symbolic number processing test in Numeracy Screener and two or more Wechsler Individual Achievement Test (WIAT-IV) math subtests\n4. Identification of typically developing children: Scores at or above the 35th percentile percentile on symbolic number processing test in Numeracy Screener and all WIAT-IV math subtests\n5. Normal or corrected-to-normal vision and no hearing impairments\n6. Inclusion in MRI scan session: Right-handed\n\nExclusion Criteria:\n\n1. History of neurological or psychiatric disorder (i.e., schizophrenia, psychosis, depression, or attention deficit hyperactivity disorder.)\n2. History of trauma involving head injury\n3. Consistent psychiatric medications\n4. Exclusion from MRI scan session: No major contraindication for magnetic resonance imaging (MRI) - braces, metal implants, pacemakers, vascular stents, metallic ear tubes, consistent exposure to metal, claustrophobia)",true,"ALL","6 Years","12 Years",{"count":22,"type":23},180,"ESTIMATED","INTERVENTIONAL",[26],"NA","The purpose of this study is to investigate neurocognitive mechanisms underlying response to intervention aimed at enhancing, and remediating weaknesses in, numerical skills in children, including those with mathematical learning disabilities (MLD).",[29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56],"Math Learning Disability","Child Development","Developmental Disability","Learning Disabilities","Learning Disabled","Learning Curve","Mathematics Disorder","Dyscalculia","Dyscalculia, Primary","Dyscalculia, Acquired","Specific Learning Disorder, With Impairment in Mathematics","Individuality","Behavior, Child","Behavior and Behavior Mechanisms","Behavior","Decision Making","Neuronal Plasticity","Cognition","Cognition Disorder","Cognitive Dysfunction","Cognitive Change","Cognitive Impairment, Mild","Cognitive Developmental Delay","Cognitive Orientation","Cognitive Delay, Mild","Cognitive Deficits, Mild","Cognitive Abnormality","Neuroscience",[58,59,60,61,62,63,64,65,66,67],"Numerical skills in children","Low math abilities","Mathematical Learning Disabilities","Mathematical Concepts","Mathematics","Transfer, Psychology","Generalization, Psychology","Early Intervention, Educational","Neural Pathways","Neural Networks, Computer","RECRUITING","2026-06-22",{"date":71,"type":72},"2026-06-25","ACTUAL",{"date":74,"type":72},"2023-05-05",{"date":76,"type":23},"2026-08-31",{"name":78,"class":79},"Stanford University","OTHER",1,{"id":82,"slug":83,"hasResults":12,"nctId":84,"briefTitle":85,"officialTitle":86,"acronym":87,"eligibilityCriteria":88,"healthyVolunteers":12,"sex":18,"minAge":89,"maxAge":90,"enrollmentInfo":91,"targetDuration":4,"studyType":24,"phases":93,"briefSummary":95,"conditions":96,"keywords":112,"overallStatus":114,"whyStopped":4,"lastUpdateSubmitDate":115,"lastUpdatePostDateStruct":116,"startDateStruct":118,"completionDateStruct":120,"leadSponsor":122,"locationsCount":125},"100637347","phase-3-a-study-of-orforglipron-ly3502970-in-participants-with-type-2-diabetes-who-observe-ramadan-fasting-100637347","NCT07613307","A Study of Orforglipron (LY3502970) in Participants With Type 2 Diabetes Who Observe Ramadan Fasting","A Phase 3b, Multicenter, Multi-Country, Open-Label, Single-Arm Study to Investigate the Efficacy and Safety of Orforglipron in Adult Participants With Type 2 Diabetes Who Observe Ramadan Fasting (ACHIEVE-RAM)","ACHIEVE-RAM","Inclusion Criteria:\n\n* Have a clinical diagnosis of T2D based on the World Health Organization (WHO) classification or other locally applicable diagnostic standards.\n* Have an HbA1c value of at least 7.0% (53 millimoles per mole (mmol\u002Fmol)) to less than 9.5% (91 mmol\u002Fmol) at screening.\n* Intend to be compliant with the fast during the Ramadan period.\n* Have had stable body weight self-reported change of 5 kilograms (kg) or lower during the 90 days prior to screening.\n* Have body mass index (BMI) of 25 kilograms per meter square (kg\u002Fm2) or higher at screening.\n\nExclusion Criteria:\n\n* Have any form of diabetes other than T2D, including type 1 diabetes (T1D), gestational diabetes, latent autoimmune diabetes, maturity-onset diabetes of the young, and medication-induced diabetes\n* Have a family (first-degree relative) or personal history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2.\n* Have a history of chronic or acute pancreatitis any time prior to screening\n* Have evidence of a significant, uncontrolled endocrine abnormality, for example, thyrotoxic or adrenal crises, in the opinion of the investigator\n* Have a history of an active or untreated malignancy or are in remission from a clinically significant malignancy for less than 5 years.\n* Have a history of cholecystectomy (surgically removed gallbladder)\n* Have New York Heart Association Functional Classification IV congestive heart-failure.","18 Years","65 Years",{"count":92,"type":23},130,[94],"PHASE3","The purpose of this study is to test the efficacy and safety of orforglipron in participants with T2D (type 2 diabetes) who participate in fasting during Ramadan. For each participant, the study will last up to 48 weeks with a minimum of 7 in clinic visits and 4 virtual visits.",[97,98,99,100,101,102,103,43,104,105,106,107,108,109,110,111],"Diabetes Mellitus, Type 2","Diabetes Melletus","Glucose Metabolism Disorders","Metabolic Disorders","Nutritional and Metabolic Diseases","Endocrine System Diseases","Feeding Behavior","Fasting","Glucagon-Like Peptide-1 Receptor","Glucagon-Like Peptide Receptors","Receptors, G-Protein-Coupled","Receptors, Cell Surface","Membrane Proteins","Proteins","Receptors, Peptide",[113,104],"Ramadan","NOT_YET_RECRUITING","2026-06-18",{"date":117,"type":72},"2026-06-23",{"date":119,"type":23},"2026-07",{"date":121,"type":23},"2027-05",{"name":123,"class":124},"Eli Lilly and Company","INDUSTRY",37,{"id":127,"slug":128,"hasResults":12,"nctId":129,"briefTitle":130,"officialTitle":130,"acronym":4,"eligibilityCriteria":131,"healthyVolunteers":17,"sex":18,"minAge":89,"maxAge":4,"enrollmentInfo":132,"targetDuration":4,"studyType":24,"phases":134,"briefSummary":135,"conditions":136,"keywords":4,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":137,"lastUpdatePostDateStruct":138,"startDateStruct":140,"completionDateStruct":142,"leadSponsor":144,"locationsCount":80},"100504471","studies-of-human-inference-using-on-line-testing-100504471","NCT05848752","Studies of Human Inference Using On-line Testing","Inclusion Criteria:\n\n* Adult Prolific participants who have a 95% approval rating and achieve a minimum score of 80% on our pre-test,\n* Speak fluent English\n* Are in the US.\n\nExclusion Criteria:\n\n* None",{"count":133,"type":23},500,[26],"The investigators will record behavioral responses from human participants on crowdsourcing platform Prolific to identify the decision strategies humans apply short-term, long-term, and multi timescale (across both timescales) inference tasks. Participants will perform a flexible decision-making task (described in Research Strategy Aim 1) in which subjects must determine which of two locations a series of evidence (package drops) came from. Subjects must 1) report the current location, 2) predict the next location. The investigators will record these responses, the number (and sequence) of evidence, and the response time (time from the end of trial until the response) for each trial. Subjects will perform all blocks (parameters and number of blocks to be determined by inference model development and testing prior to task development) so that we can compare responses at each timescale. Since participants participate voluntarily for small sums of money (around $12\u002F hour based on duration of task) and the investigators' previous studies have collected over 200 subjects in a matter of days, they will aim to record behavioral data from 1000 subjects. This number allows them to address the broad range of subject variability expected using Bayesian statistical methods such as Bayes factors.",[43],"2026-05-14",{"date":139,"type":72},"2026-05-18",{"date":141,"type":72},"2025-02-15",{"date":143,"type":23},"2028-06-30",{"name":145,"class":79},"University of Colorado, Boulder",{"id":147,"slug":148,"hasResults":12,"nctId":149,"briefTitle":150,"officialTitle":151,"acronym":152,"eligibilityCriteria":153,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":154,"enrollmentInfo":155,"targetDuration":4,"studyType":24,"phases":157,"briefSummary":158,"conditions":159,"keywords":165,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":174,"lastUpdatePostDateStruct":175,"startDateStruct":177,"completionDateStruct":179,"leadSponsor":181,"locationsCount":80},"100511439","impact-of-bright-light-therapy-on-prader-willi-syndrome-100511439","NCT05939453","Impact of Bright Light Therapy on Prader-Willi Syndrome","A Randomized, Double-Blind, Controlled Trial of Bright Light Therapy on All-Cause Excessive Daytime Sleepiness in Prader-Willi Syndrome","PWS-LT","Inclusion Criteria:\n\n* Diagnosis of PWS confirmed by genetic testing\n* Score of 12 or above on the Epworth Sleepiness Scale (ESS).\n\nExclusion Criteria:\n\n* Subjects with an eye condition that could be negatively affected by bright light such as patients with a history of retinal damage or patients needing photosensitizing medications\n* A history of previous treatment with LT\n* Patients presenting with active psychosis or mania","88 Years",{"count":156,"type":23},50,[26],"This is a placebo controlled clinical trial to assess the utility of light therapy as a sufficient treatment for excessive daytime sleepiness in patients with Prader-Willi Syndrome",[160,161,162,163,164,43],"Prader-Willi Syndrome","Excessive Daytime Sleepiness","Hyperphagia","Body Weight","Mood",[166,167,168,169,170,171,172,173],"Light Therapy","Aberrant Behavior Checklist","Clinical Global Impression- Improvement","Fitbit","Actigraphy reports","Epworth Sleepiness Scale","Hyperphagia Questionnaire (HQCT)","Modified Overt Aggression Scale (MOAS)","2026-05-13",{"date":176,"type":72},"2026-05-15",{"date":178,"type":72},"2023-10-01",{"date":180,"type":23},"2026-12",{"name":182,"class":79},"Maimonides Medical Center",{"id":184,"slug":185,"hasResults":12,"nctId":186,"briefTitle":187,"officialTitle":187,"acronym":4,"eligibilityCriteria":188,"healthyVolunteers":17,"sex":18,"minAge":189,"maxAge":190,"enrollmentInfo":191,"targetDuration":4,"studyType":24,"phases":193,"briefSummary":194,"conditions":195,"keywords":4,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":197,"lastUpdatePostDateStruct":198,"startDateStruct":200,"completionDateStruct":202,"leadSponsor":204,"locationsCount":80},"100481060","adaptation-and-implementation-of-a-patient-navigation-program-for-cervical-cancer-screening-across-contexts-in-senegal-100481060","NCT05544084","Adaptation and Implementation of a Patient Navigation Program for Cervical Cancer Screening Across Contexts in Senegal","Inclusion Criteria:\n\nThe inclusion criteria for samples a, b, \\& c are as follows:\n\n1\\) Senegal citizen between the ages of 25 and 69, 2) willing to participate in survey assessments;\n\nThe additional criteria apply for both women and men for the follow samples:\n\nSample a: 3) an invited member of the study National Advisory Board or Regional Implementation Resource Teams as defined above; 4) able to read and write in French.\n\nSample b: 3) employed by the state at a study site health facility as a patient navigator, clinician (nurse, midwife) who treats and educates patients, or is a community health worker at the facility or community level (Bajenu Gox - women's health educator).\n\nSample c: Women: 3) a woman living with a male partner who also agrees to participate in the study, 4) eligible to seek cervical cancer prevention services at a designated health facility in Senegal. Men: 3) a man living in a household with at least one woman eligible to seek cervical cancer prevention services at a designated health facility in Senegal.\n\nExclusion Criteria:\n\n* No additional exclusion criteria exist.","25 Years","69 Years",{"count":192,"type":23},901,[26],"The goal of this project is to prevent unnecessary deaths due to cervical cancer in Senegal. This mixed methods research responds to identified intrapersonal- and community-level barriers to early cervical cancer screening uptake, follow-up, and treatment among women there. Investigators will apply the Dynamic Adaptation Process (DAP) as integrated into the Exploration, Preparation, Implementation, Sustainment (EPIS) framework to study the adaptation of an evidence-based cervical cancer patient navigation program in urban and rural contexts in Senegal, measure the intervention effectiveness, and evaluate programmatic implementation outcomes. By studying the process of adaptation of a patient navigation program in a low- and middle-income country (LMIC), investigators will build new knowledge while addressing an important public health issue. The project demonstrates innovation by advancing both adaptation and implementation process knowledge of an evidence-based patient navigation intervention in various contexts within a LMIC with a particular focus on how the adaptation responds to cancer-related stigma, misinformation, and women's autonomy in healthcare decision-making. Investigators will build knowledge through local learning which will further the long-term goal to inform the national cervical cancer prevention and control programs in two areas of Senegal and other similar LMICs.",[196,43],"Cervical Cancer","2026-05-06",{"date":199,"type":72},"2026-05-08",{"date":201,"type":72},"2023-08-01",{"date":203,"type":23},"2027-08-28",{"name":205,"class":79},"University of Illinois at Chicago",{"id":207,"slug":208,"hasResults":12,"nctId":209,"briefTitle":210,"officialTitle":211,"acronym":212,"eligibilityCriteria":213,"healthyVolunteers":17,"sex":18,"minAge":89,"maxAge":214,"enrollmentInfo":215,"targetDuration":4,"studyType":24,"phases":217,"briefSummary":218,"conditions":219,"keywords":223,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":228,"lastUpdatePostDateStruct":229,"startDateStruct":231,"completionDateStruct":233,"leadSponsor":235,"locationsCount":80},"100585905","cold-water-and-decision-making-100585905","NCT06908447","Cold Water and Decision-Making","Voluntary Cold-Water Immersion Effects on Value-Based Choice","CoVa","Inclusion Criteria:\n\n* 18-40 years of age\n* Consent to participate\n* Fluency in German\n* Physically and mentally healthy\n* BMI 18-30 kg\u002Fm2\n* Normal day-night rhythm\n\nExclusion Criteria:\n\n* Raynaud syndrome\n* Cold urticaria\n* High resting heart rate (\\>160 beats per minute)\n* Acute infection\n* Diagnosed current or former illnesses of\n\n  * Brain and mind\n  * Heart and blood circulation\n  * Gastrointestinal system\n  * Endocrine system\n  * Other serious past or present medical conditions\n* Wearing of medical devices (e.g., pacemaker)\n* Fear of blood, needles, or phlebotomy\n* Allergies to plasters, gels, and other medical equipment\n* Allergies to commercially available liquid meals (e.g., shakes, yfood Labs GmbH)\n* Recurrent intake of medication which affect metabolism\n* Regular nicotine consumption (e.g., vaping, cigarettes)\n* Excessive alcohol consumption (\\>14 servings\u002Fweek)\n* Recent illegal drug consumption (within 2 weeks prior)\n* Strong mental or physical stress\n* Excessive exercise (\\>2 h high-intensity exercise\u002Fday)\n* Pregnancy or breastfeeding\n* Inability to wear skin-exposing swimwear, e.g., for religious reasons\n* Affinity for winter swimming, cryotherapy, breathwork (\\>3 times\u002Fyear)","40 Years",{"count":216,"type":23},40,[26],"The behavioral within-subject cross-over design study \"CoVa\" aims to investigate the effect of a short-term full-body cold-water immersion vs. warm-water immersion control on value-based choice, psychological well-being, and peripheral physiology.",[43,220,221,222],"Stress","Quality of Life","Psychological Wellbeing",[224,225,220,226,227],"Decision-Making","Psychology","Cold-Exposure","Cold-Water Immersion","2026-04-17",{"date":230,"type":72},"2026-04-21",{"date":232,"type":72},"2025-08-28",{"date":234,"type":23},"2026-12-31",{"name":236,"class":79},"German Institute of Human Nutrition",{"id":238,"slug":239,"hasResults":12,"nctId":240,"briefTitle":241,"officialTitle":242,"acronym":243,"eligibilityCriteria":244,"healthyVolunteers":12,"sex":18,"minAge":89,"maxAge":4,"enrollmentInfo":245,"targetDuration":4,"studyType":24,"phases":247,"briefSummary":248,"conditions":249,"keywords":251,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":256,"lastUpdatePostDateStruct":257,"startDateStruct":259,"completionDateStruct":261,"leadSponsor":263,"locationsCount":265},"100554584","mobile-health-technology-enabled-afib-management-100554584","NCT06500988","Mobile Health Technology-Enabled AFib Management","Patient Centered Mobile Health Technology-Enabled Atrial Fibrillation Management: Phase 2","mTECH Afib","Inclusion Criteria:\n\n1. Aged 18 or older at time of consent\n2. Diagnosis of paroxysmal (Afib lasting less than 7 days) or persistent (7 days or longer) atrial fibrillation\n3. BMI (Body Mass Index) ≥ 27.0\n\nExclusion Criteria:\n\n1. Permanent Afib (decision has been made not to attempt sinus rhythm)\n2. Severe valvular disease\n3. Moderate mitral valve stenosis\n4. Prior cardiac surgery\n5. Presence of implanted cardiac device\n6. History of cardiac arrest\n7. Left ventricular ejection fraction (LVEF) ≤ 35%\n8. Life expectancy \\\u003C 1 year\n9. Non-English speaking\n10. Treating clinician deems unsafe for exercise\n11. Any other reason that makes patient unsuitable for study at the discretion of the PI",{"count":246,"type":23},248,[26],"The overall objective of this proposal is to evaluate the effect on quality of life of a comprehensive digital atrial fibrillation (AFib) management tool that will empower patients to a) take an active role in learning about AFib management options, starting and adhering to evidence-based therapies and lifestyle changes and b) to guide the patients during AFib episodes which are associated with anxiety and impairment in quality of life.\n\nResearchers plan to evaluate the effectiveness of this novel digital toolkit in improving quality of life and decreasing AFib burden in a randomized clinical trial (RCT). A pilot study assessing feasibility and retention of the intervention was previously conducted (NCT05400837)",[250,43],"Atrial Fibrillation",[252,250,253,254,255],"Remote Patient Monitoring","Risk Factor Modification","Digital Health","Mobile Health","2026-04-15",{"date":258,"type":72},"2026-04-20",{"date":260,"type":72},"2025-06-03",{"date":262,"type":23},"2028-06",{"name":264,"class":79},"Johns Hopkins University",2,{"id":267,"slug":268,"hasResults":12,"nctId":269,"briefTitle":270,"officialTitle":271,"acronym":4,"eligibilityCriteria":272,"healthyVolunteers":12,"sex":18,"minAge":20,"maxAge":4,"enrollmentInfo":273,"targetDuration":4,"studyType":24,"phases":275,"briefSummary":276,"conditions":277,"keywords":282,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":293,"lastUpdatePostDateStruct":294,"startDateStruct":296,"completionDateStruct":298,"leadSponsor":300,"locationsCount":265},"100631882","integrating-the-youth-nominated-support-team-yst-with-cbt-for-black-youth-with-acute-suicide-risk-aim-2b-100631882","NCT07506460","Integrating the Youth Nominated Support Team (YST) With CBT for Black Youth With Acute Suicide Risk: Aim 2b","Integrating the Youth Nominated Support Team (YST) With CBT for Black Youth With Acute Suicide Risk","Youth Inclusion Criteria:\n\n* Patients that are able to provide at least one verifiable contact for emergency or tracking purposes\n* Willing to receive care at MiSide\n* Present to an acute emergency care setting with suicide risk (per protocol)\n* Self-identify as Black\n* Willing and able to complete enrollment procedures\n* Willing and able to provide signed and dated informed assent\n\nYouth Exclusion Criteria:\n\n* Unable to be consented in English\n* Do not have a parent\u002Flegal guardian available to provide consent\n* Are not able to provide informed assent or to participate in the assessment due to significant agitation, psychosis, cognitive impairment, learning disability, or medical trauma\n* Actively engaged in specialty mental health treatment\n* Participated in the Aim 2a open trial\n\nParent\u002FGuardian Inclusion Criteria:\n\n* Adults 18 years and older\n* The parent or legal guardian of a youth participating in this Aim\n* Understand written and spoken English\n* Willing and able to complete enrollment procedures\n* Willing and able to provide signed and dated informed consent\n* Need to have access to technology, either cell or an email address\n\nParent\u002FGuardian Exclusion Criteria:\n\n\\- Do not understand written and spoken English\n\nSupport Person Inclusion Criteria:\n\n* Adults 18 years and older\n* Understand written and spoken English\n* Approved to serve as a support person by the parent\u002Flegal guardian\n\nSupport Person Exclusion Criteria:\n\n* Do not understand written and spoken English\n* Not approved to serve as a support person by the parent\u002Fguardian",{"count":274,"type":23},90,[26],"This is a second pilot study being completed based on lessons learned from the Aim 2a feasibility pilot study (NCT06941311). Following modifications, the investigators are testing the acceptability, feasibility, and preliminary effectiveness of the combination of two psychosocial interventions, Cognitive Behavioral Therapy for Suicide Prevention (CBT-SP) and the computer-assisted version of the Youth-Nominated Support Team (eYST).\n\nIn this phase of the study, CBT-SP + eYST will be tested in an open trial (number of youth = 15). Investigators will recruit Black adolescents (ages 12-17) that come to an urban acute care setting for suicidal thoughts and\u002For self-injurious behaviors to receive the intervention in an outpatient community mental health agency. Participants will receive 12-14 sessions of CBT-SP in addition to YST. Participants will nominate up to 5 caring adults in their lives to serve as support persons. These support persons will attend an education\u002Forientation session to learn more about their role and how to support the youth. Support persons will have weekly contact with the youth and weekly follow up contacts from the youth's clinician\u002FYST intervention specialist.\n\nYouth will be assessed at baseline, 6 weeks, and 14 weeks. Parents will be assessed at baseline and 14 weeks. Support persons will be assessed at baseline and 14 weeks.\n\nFidelity assessments will be completed by clinicians after each session, after the YST psycho-ed session, and weekly to document contact with the support team.",[278,279,280,281,43],"Suicide Prevention","Suicide","Self-Injurious Behavior","Behavioral Symptoms",[283,284,285,286,287,288,289,290,291,292],"Black youth","Acute suicide risk","Youth Nominated Support Team","Cognitive Behavioral therapy for Suicide Prevention","Community Mental Health","Suicide prevention","Behavior Therapy","Psychotherapy","Behavioral Disciplines and Activities","Cognitive Behavioral Therapy","2026-03-26",{"date":295,"type":72},"2026-04-01",{"date":297,"type":72},"2026-03-23",{"date":299,"type":23},"2026-08",{"name":301,"class":79},"University of Michigan",{"id":303,"slug":304,"hasResults":12,"nctId":305,"briefTitle":306,"officialTitle":307,"acronym":4,"eligibilityCriteria":308,"healthyVolunteers":17,"sex":309,"minAge":89,"maxAge":4,"enrollmentInfo":310,"targetDuration":4,"studyType":24,"phases":312,"briefSummary":313,"conditions":314,"keywords":4,"overallStatus":114,"whyStopped":4,"lastUpdateSubmitDate":315,"lastUpdatePostDateStruct":316,"startDateStruct":318,"completionDateStruct":319,"leadSponsor":321,"locationsCount":4},"100629277","a-chatbot-to-reduce-chemsex-and-hiv-related-risk-behaviors-among-men-who-have-sex-with-men-100629277","NCT07472582","A Chatbot to Reduce Chemsex and HIV-related Risk Behaviors Among Men Who Have Sex With Men","A Chatbot to Reduce Chemsex and HIV-related Risk Behaviors Among Men Who Have Sex With Men: a Pilot Randomized Controlled Trial","Inclusion Criteria:\n\n* Hong Kong men aged at least 18 years\n* Able to understand Cantonese\n* Had anal intercourse with at least one man within the past six months\n* Willingness to provide contact information for follow-up\n* Having access to WhatsApp\n\nExclusion Criteria:\n\n* Self-reported a diagnosis of schizophrenia or bipolar disorder","MALE",{"count":311,"type":23},100,[26],"The goal of this clinical trial is to investigate whether receiving chatbot-delivered stage-of-change-tailored online interventions is effective in reducing chemsex among men who have sex with men in Hong Kong. The main question it aims to answer is:\n\nDoes chatbot-delivered stage-of-changed online interventions reduce chemsex among men who have sex with men\n\nEligible participants will be randomly assigned to either the intervention or the control group. The control group will watch one online video introducing chemsex-related knowledge and harm reduction skills per week for 12 weeks. On top of the interventions received by the control group, participants in the intervention group will have access to a chatbot during the 12-week intervention period. The chatbot will deliver 12 weekly episodes of interventions tailored to once's current stage-of-change related to chemsex. The chatbot will also address questions related to chemsex during the intervention period.",[43],"2026-03-13",{"date":317,"type":72},"2026-03-16",{"date":295,"type":23},{"date":320,"type":23},"2027-03-31",{"name":322,"class":79},"Chinese University of Hong Kong",{"id":324,"slug":325,"hasResults":12,"nctId":326,"briefTitle":327,"officialTitle":327,"acronym":4,"eligibilityCriteria":328,"healthyVolunteers":17,"sex":18,"minAge":329,"maxAge":20,"enrollmentInfo":330,"targetDuration":4,"studyType":24,"phases":331,"briefSummary":332,"conditions":333,"keywords":338,"overallStatus":114,"whyStopped":4,"lastUpdateSubmitDate":340,"lastUpdatePostDateStruct":341,"startDateStruct":343,"completionDateStruct":345,"leadSponsor":347,"locationsCount":80},"100621924","the-effect-of-virtual-reality-distraction-on-pain-and-discomfort-associated-with-bitewing-radiographs-in-pediatric-patients-100621924","NCT07376941","The Effect of Virtual Reality Distraction on Pain and Discomfort Associated With Bitewing Radiographs in Pediatric Patients","Inclusion Criteria:\n\n1. Healthy\n2. Cooperative children\n3. Aged 4 to 12 years\n4. Referred to the radiology department for two-bitewing radiographs.\n\nExclusion Criteria:\n\n1- Children with a history of epilepsy or anxiety disorder","4 Years",{"count":274,"type":23},[26],"This study will be conducted at King Abdulaziz University Dental Hospital (KAUDH). Ethical approval was obtained from the Research Ethics Committee of the Faculty of Dentistry at King Abdulaziz University (32-03-25).\n\nInclusion criteria will include healthy and cooperative children aged 4 to 12 years who are referred to the radiology department for two-bitewing radiographs. Children with a history of epilepsy or anxiety disorder will be excluded. The study's purpose, risks, benefits, and limitations will be explained to the parents or guardians of eligible children by trained dental interns. Those who agree to participate will be asked to sign an Arabic consent form before their involvement. Additionally, an assent form will be obtained from children aged seven and older.\n\nSubjects' age, gender, previous dental experience, and behavior during previous dental visits, as assessed by Frankl's behavior rating scale , will be recorded, along with whether they own or have prior exposure to a virtual reality device. Only children with cooperative and definitely cooperative behavior will be included.\n\nA randomization sequence with an allocation ratio of 1:1 will be generated using computer software and kept with a radiology assistant who is not involved in the study to ensure allocation concealment. Due to the nature of the study, neither the subject nor the radiologist will be blinded to the group allocation. However, the statistician will be blinded to which group each subject will be allocated.\n\nBefore taking the radiographs, subjects will be asked to select a video from a list of popular cartoon shows or a video of their preference. In the test group, the subjects will wear virtual reality device goggles (LG 360 virtual reality \\[VR\\] headset, LG Electronics) connected to a mobile phone, and the chosen video will be played. In the control group, radiographs will be taken without the use of any distraction device. The sounds of the videos will be played on headphones. All bitewing radiographs will be taken by the same radiologist, following the As Low As Reasonably Achievable (ALARA) protocol and hospital guidelines. The procedure uses either size one or size two bitewing Photostimulable Phosphor digital sensors, along with a film holder and a rectangular collimator. While taking the radiographs, the Tell-Show-Do behavior management technique will be used with all participating children, and they will be recorded with a high-resolution camera.\n\nThe camera will aim toward the face and the body. Later, two trained and calibrated evaluators will independently assess the participating children's behavioral pain using the face, legs, activity, cry, and consolability (FLACC) behavioral pain assessment scale. The FLACC scale ranges from 0 to 10, with 0 indicating no pain and 10 the worst possible pain. Additionally, the behavior during the BWS will also be recorded using Frankl's behavior rating scale classification. Training and calibration for the evaluators will involve watching videos of 20 randomly selected children during their dental treatment. A stopwatch will be used to measure the chair time required to take the radiographs. In the test group, the time needed to place the VR device will be included.\n\nImmediately after taking the BWS, the subjects will be shown the Arabic version of the Wong-Baker FACES pain rating scale. They will be asked to select the face that best describes their feelings during the procedure. Finally, the satisfaction with the use of VR during BWS taking will be assessed using a five-point Likert scale, where zero indicates 'not satisfied at all' and 10 means' very satisfied'. Subjects who require repeating any of the BWS will be excluded from the study",[334,335,43,336,337],"Objective Pain and Discomfort","Subjective Pain and Discomfort","Satisfaction","Future Preferences",[339],"Satisfaction, Virtual Reality, Bitewings Radiographs","2026-01-26",{"date":342,"type":72},"2026-01-29",{"date":344,"type":23},"2026-02-01",{"date":346,"type":23},"2026-05-30",{"name":348,"class":79},"King Abdulaziz University",{"id":350,"slug":351,"hasResults":12,"nctId":352,"briefTitle":353,"officialTitle":354,"acronym":355,"eligibilityCriteria":356,"healthyVolunteers":12,"sex":18,"minAge":89,"maxAge":4,"enrollmentInfo":357,"targetDuration":4,"studyType":358,"phases":4,"briefSummary":359,"conditions":360,"keywords":362,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":366,"lastUpdatePostDateStruct":367,"startDateStruct":369,"completionDateStruct":371,"leadSponsor":373,"locationsCount":80},"100621669","physical-activity-trends-in-cancer-survivors-treated-at-the-movement-and-rehabilitation-clinic-100621669","NCT07373626","Physical Activity Trends in Cancer Survivors Treated at the 'MOvement and REhabilitation' Clinic","Prospective Study on Physical Activity Trends in Cancer Survivors Treated at the 'MOvement and REhabilitation' (MO.RE) Clinic","MOREACTIVE2025","Inclusion Criteria:\n\n* Diagnosis of cancer\n* Age over 18 years\n* Signed informed consent\n* Patients for whom a physical exercise program can be proposed\n\nExclusion Criteria:\n\n* Patients for whom the physiatric assessment identifies a need for individual rehabilitative treatment\n* Significant language barrier\n* Neuropsychological, psychiatric, or cognitive deficits, or clinical conditions that prevent participation in an independent physical activity program",{"count":156,"type":23},"OBSERVATIONAL","An active lifestyle after a cancer diagnosis can reduce the side effects of treatment and improve quality of life, mental health, and survival. Recent evidence in the literature confirms its benefits across various types and stages of cancer. However, the majority of cancer patients do not reach the recommended levels of physical activity due to physical, psychological, and logistical barriers. It is essential that healthcare professionals provide motivational support and address individual barriers to physical activity through the active involvement of patients, thus promoting the adoption and maintenance of an active lifestyle. To achieve this, personalization of physical activity programs is crucial. For this reason, the MOvement \\& REhabilitation clinic was established in 2022, where a dedicated physiotherapist provides personalized consultations and educational support to promote physical activity among cancer patients.\n\nThis study aims to evaluate the trend over time in the amount of physical activity among cancer patients attending the \"MOvement and REhabilitation\" (MO.RE) clinic. The study also seeks to assess patient engagement, the amount of resources used to help patients maintain an active lifestyle, and any barriers to physical activity.",[43,361],"Motor Activity",[363,364,365],"Physical Activity","Physical Exercise","Onco-hematological patients","2026-01-23",{"date":368,"type":72},"2026-01-28",{"date":370,"type":72},"2025-09-01",{"date":372,"type":23},"2027-02-28",{"name":374,"class":375},"Azienda USL Reggio Emilia - IRCCS","OTHER_GOV",{"id":377,"slug":378,"hasResults":12,"nctId":379,"briefTitle":380,"officialTitle":380,"acronym":381,"eligibilityCriteria":382,"healthyVolunteers":12,"sex":18,"minAge":89,"maxAge":4,"enrollmentInfo":383,"targetDuration":4,"studyType":24,"phases":385,"briefSummary":386,"conditions":387,"keywords":392,"overallStatus":114,"whyStopped":4,"lastUpdateSubmitDate":396,"lastUpdatePostDateStruct":397,"startDateStruct":399,"completionDateStruct":401,"leadSponsor":403,"locationsCount":80},"100621487","effects-of-virtual-reality-with-multisensory-stimulation-on-emotional-and-behavioral-disorders-in-individuals-with-acquired-brain-injury-and-disability-requiring-institutional-care-a-single-case-experimental-design-sced-study-100621487","NCT07371260","Effects of Virtual Reality With Multisensory Stimulation on Emotional and Behavioral Disorders in Individuals With Acquired Brain Injury and Disability Requiring Institutional Care: a Single Case Experimental Design (SCED) Study.","Rév In MAS","Inclusion Criteria:\n\n* Resident aged over 18\n* Diagnosis of stroke, traumatic brain injury, tumor, or cerebral anoxia for more than 3 years.\n* Living in a nursing home for at least 6 months\n* Presence of one or more emotional and behavioral disorders during initial assessments (NPI-ES) for at least 3 months.\n* Sufficient cognitive abilities to understand instructions and answer questions using a Likert scale.\n* Normal or corrected visual acuity\n* Resident affiliated with the social security system\n\nExclusion Criteria:\n\n* Motor or sensory disorders incompatible with the use of VR\n* Unstabilized photosensitive epilepsy or presence of a seizure in the past year\n* Change in the prescription of neuroleptic treatments, antidepressants, benzodiazepines, sedatives, anxiolytics, mood stabilizers, antiepileptics, or betablockers within the last 3 months.\n* Unstabilized major psychiatric disorders.\n* Craniectomy\n* Limited range of cervical movement due to orthopedic disorders\n* Moderate or severe hearing loss not compensated by a hearing aid\n* Anosmia\n* Asthma\n* Pregnant women or women suspected of being pregnant\n* Breastfeeding women\n* Neurocognitive disorders preventing understanding of instructions during assessments\n* The resident is included in another research protocol",{"count":384,"type":23},3,[26],"Acquired brain injuries (ABIs) frequently cause emotional and behavioral disorders that impair independence and quality of life, particularly in institutions. Virtual reality (VR), already used in various mental and neurological disorders, offers therapeutic potential that remains largely unexplored in this context.\n\nMultisensory devices offer enhanced immersion that can potentially increase the relaxation and calming effect. Their use in specialized care home (SCH) could provide additional support for care.\n\nThe main objective of the study is to measure the effect of an 8-week multisensory VR relaxation program on the most significant emotional and behavioral disorders in adults with acquired brain injury living in SCH. The SCED method with multiple baselines across subjects (ABA) is used with three adult residents with ABCI and behavioral disorders living in SCH. The study consists of three phases (baseline, intervention, follow-up), during which the three main emotional and behavioral disorders of each resident are assessed weekly based on observations made throughout the week. Additional measures include the assessment of the socio-emotional profile by the care team (ECCSEG) and the emotional distress experienced by residents (QOLIBRI), collected twice per phase. The intervention consists of eight weeks of VR relaxation (VirtySens®), with two 15-minute sessions per week.\n\nAll measurements taken during the experiment will be anonymized and used only by the investigators, who are fully aware of the European GDPR (General Data Protection Regulation) concerning the protection of personal data.",[388,389,43,390,391],"Brain Injury","Virtual Reality","Emotion","Well-being",[393,43,390,391,389,394,395],"Acquired Brain Injury","Multisensory","Specialized Care Home","2026-01-19",{"date":398,"type":72},"2026-01-27",{"date":400,"type":23},"2026-02-15",{"date":402,"type":23},"2027-02-01",{"name":404,"class":79},"Hopital La Musse",{"id":406,"slug":407,"hasResults":12,"nctId":408,"briefTitle":409,"officialTitle":410,"acronym":4,"eligibilityCriteria":411,"healthyVolunteers":12,"sex":412,"minAge":89,"maxAge":4,"enrollmentInfo":413,"targetDuration":4,"studyType":24,"phases":415,"briefSummary":416,"conditions":417,"keywords":4,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":420,"lastUpdatePostDateStruct":421,"startDateStruct":423,"completionDateStruct":425,"leadSponsor":427,"locationsCount":429},"100582352","effectiveness-of-digital-intervention-hm4mh-app-on-perinatal-psychological-wellbeing-100582352","NCT06862193","Effectiveness of Digital Intervention (HM4MH-app) on Perinatal Psychological Wellbeing","The Effectiveneness of a Digital Intervention (the HM4MH-app) on Perinatal Psychological Wellbeing: Randomized Controlled Trial","Inclusion Criteria:\n\n(i) pregnant women attending a participating maternity health care centre who (ii) have access to their own mobile phone and BankID and is (iii) currently in gestational week 8-15 and (iv) is 18 years or older.\n\nExclusion Criteria:\n\n* Previous psychotic disorder","FEMALE",{"count":414,"type":23},440,[26],"As many as 25% of pregnant women report mental health problems such as depressiveness and anxiety. This is a major concern as mental illness during pregnancy can have severe and long-lasting consequences for the pregnant woman, the baby, as well as the partner. Digital interventions (e.g., apps) have shown to be promising in promoting mental wellbeing, at scale, however, the majority of tools have been developed and evaluated in a general population rather than tailored for pregnancy. The objective of this trial is to investigate the effectiveness of a new digital tool (HealthyMoms4MentalHealth-app) on mental health outcomes during the perinatal period.",[418,43,419],"Mobile Application","Perinatal Mental Health","2025-12-15",{"date":422,"type":72},"2025-12-22",{"date":424,"type":72},"2025-03-10",{"date":426,"type":23},"2027-12-31",{"name":428,"class":79},"Karolinska Institutet",4,{"id":431,"slug":432,"hasResults":12,"nctId":433,"briefTitle":434,"officialTitle":435,"acronym":4,"eligibilityCriteria":436,"healthyVolunteers":17,"sex":18,"minAge":329,"maxAge":20,"enrollmentInfo":437,"targetDuration":4,"studyType":24,"phases":438,"briefSummary":439,"conditions":440,"keywords":442,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":446,"lastUpdatePostDateStruct":447,"startDateStruct":449,"completionDateStruct":451,"leadSponsor":453,"locationsCount":80},"100571813","impact-of-therapy-dogs-on-child-anxiety-and-behavior-during-local-anesthesia-for-dental-procedures-100571813","NCT06725134","Impact of Therapy Dogs on Child Anxiety and Behavior During Local Anesthesia for Dental Procedures","Impact of Therapy Dogs on Anxiety and Behavior of Pediatric Dental Patients During Local Anesthesia: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Age range: children aged 4- to 12-years\n* Health status: healthy children without significant medical conditions (ASA I or ASA II)\n* Dental procedure: children scheduled for at least two dental procedures requiring local anesthesia\n* Consent: written informed consent from the parent or legal guardian\n* Verbal assent from potential subjects age 4-9 years; written assent for children age 10-12 years\n\nExclusion Criteria:\n\n* Allergies: children with known allergies to dogs or animal dander\n* Children with a fear or phobia of dogs\n* Children with a behavioral disorder which may negatively impact response to the presence of a therapy dog\n* Previous exposure: children who have previously undergone dental procedures with local anesthesia in the presence of a therapy dog\n* Medical conditions: children with medical conditions that might affect their vital signs independently of the dental procedure (e.g., heart conditions)\n* Parental discomfort: cases where parents are uncomfortable with the presence of a therapy dog during the procedure\n* Advanced behavior guidance is indicated: children whose behavior for dental examination is classified as \"Definitely Negative\" (Frankl 1)",{"count":7,"type":23},[26],"Therapy dogs in dental offices might help anxious children during dental care. Therapy dogs might help children during injection of local anesthetic, when we inject numbing medication before working on the teeth. The goal of this study is to learn if having a therapy dog with a child during the injection of numbing medication helps children to be more comfortable at the dentist's office. This study is of children who need dental care using local anesthesia. Study participant's behavioral reactions and heart rate during injection of local anesthetic with and without having a therapy dog present will be recorded and children and their guardians will be asked a few short questions about the injection and therapy dog after injection.",[441,43],"Situational Anxiety",[443,444,445],"Animal assisted therapy","Pediatric dentistry","Local anesthesia","2025-11-25",{"date":448,"type":72},"2025-12-03",{"date":450,"type":72},"2024-11-01",{"date":452,"type":23},"2027-07",{"name":301,"class":79},{"id":455,"slug":456,"hasResults":12,"nctId":457,"briefTitle":458,"officialTitle":458,"acronym":4,"eligibilityCriteria":459,"healthyVolunteers":17,"sex":18,"minAge":89,"maxAge":460,"enrollmentInfo":461,"targetDuration":4,"studyType":24,"phases":463,"briefSummary":464,"conditions":465,"keywords":466,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":471,"lastUpdatePostDateStruct":472,"startDateStruct":474,"completionDateStruct":476,"leadSponsor":478,"locationsCount":80},"100540915","modulating-reward-learning-using-transcranial-magnetic-stimulation-100540915","NCT06323057","Modulating Reward Learning Using Transcranial Magnetic Stimulation","Inclusion Criteria:\n\n* Be between the ages of 18 and 55 years old.\n* Be in stable mental and physical health.\n* If female, test non-pregnant.\n* Be willing to provide informed consent.\n* Be able to comply with protocol requirements and likely to complete all study procedures.\n\nExclusion Criteria:\n\n* Contraindication to rTMS (history of neurological disorder or seizure, increased intracranial pressure, brain surgery, or head trauma with loss of consciousness for \\> 15 minutes, implanted electronic device, metal in the head, or pregnancy).\n* History of autoimmune, endocrine, viral, or vascular disorder affecting the brain.\n* Life time history of mental disorders such as: Bipolar Affective disorder (BPAD), Schizophrenia, Post-traumatic Stress disorder (PTSD) or Dementia or Major Depression.\n* uninterruptable central nervous system medication","55 Years",{"count":462,"type":23},28,[26],"Our specific aim is to examine the effects of TMS on reward processing during goal-directed behavior. In these experiments the investigators will utilize a scalp-recorded brain oscillation called frontal midline theta that is believed to index the sensitivity of the cingulate cortex to reward feedback. Here the investigators will asked whether this electrophysiological signal can be modulated up or down using TMS while participants engage in decision making tasks, and if so, whether it would affect the encoding of rewards and subsequent choices during task performance.",[43],[467,468,469,470],"transcranial magnetic stimulation","reward processing","EEG","theta","2025-11-14",{"date":473,"type":72},"2025-11-18",{"date":475,"type":72},"2024-02-14",{"date":477,"type":23},"2026-04-30",{"name":479,"class":79},"Rutgers, The State University of New Jersey",{"id":481,"slug":482,"hasResults":12,"nctId":483,"briefTitle":484,"officialTitle":485,"acronym":486,"eligibilityCriteria":487,"healthyVolunteers":17,"sex":412,"minAge":89,"maxAge":488,"enrollmentInfo":489,"targetDuration":4,"studyType":24,"phases":491,"briefSummary":492,"conditions":493,"keywords":496,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":500,"lastUpdatePostDateStruct":501,"startDateStruct":503,"completionDateStruct":505,"leadSponsor":507,"locationsCount":80},"100603208","decision-making-and-food-intake-100603208","NCT07133529","Decision-making and Food Intake","Decision-making and Food Intake (\"Buffet Study\")","Buffet","Inclusion Criteria:\n\n* Nulliparous women (age: 18-35 years) with a regular menstrual cycle (25-32 days)\n* Legally competent\u002FConsent to participate\n* Language proficiency in German (native speaker, fluent)\n* Physically and mentally healthy\n* Body mass index (BMI) of 18.5 - 30 kg\u002Fm2\n\nExclusion Criteria:\n\n* Current or use of hormonal contraceptives in the previous 6 months\n* Current use of hormonal intra-uterine devices (IUDs)\n* Previous or current pregnancy\n* Diagnosed psychological or metabolic disorder\n* Former or current illnesses of:\n\n  1. Brain or mind (including anxiety disorders, depression, eating disorders, personality disorders, alcohol, drugs or drug or non-substance dependence, neurological disorders other than occasional headache, psychiatric or neurological abnomalities)\n  2. Heart or blood circulation\u002Fcardiovascular disease (myocardial infarction, stroke, hypertension, hypotension, having a pacemaker)\n  3. Gastro-intestinal disorders (e.g. colon diseases, irritable bowel syndrome, Crohn's disease)\n  4. Endocrine disorders (e.g. thyroid disorders)\n  5. Other serious past or present medical conditions (for example, metabolic syndrome, diabetes)\n* Other serious health problems or current severe mental or physical stress.\n* Blood clotting disorder\n* Fear of drawing blood\n* Severe anemia\n* Previously diagnosed hypoglycemia episodes\n* Regular intake of medication (e.g. Antidepressant\u002Fanti-anxiety medication)\n* Blood donation within 4 weeks before the study appointment\n* Intake of anticoagulant medications\n* illegal drug consumption\n* smoking or nicotine consumption\n* extreme athletes\n* vegetarians or vegans or any other dietary restrictions due to allergies or intolerances\n* shift workers","35 Years",{"count":490,"type":23},45,[26],"The study will investigate how the expectation of food availability impacts the response to food cues, mood, interoceptive awareness, and consumption of food intake in healthy, naturally cycling women.",[43,494,220,46,495],"Hormones","Food Intake",[497,498,499],"Decision-making","Food intake","Food uncertainty","2025-08-18",{"date":502,"type":72},"2025-08-21",{"date":504,"type":72},"2025-08-04",{"date":506,"type":23},"2026-07-31",{"name":236,"class":79},{"id":509,"slug":510,"hasResults":12,"nctId":511,"briefTitle":512,"officialTitle":513,"acronym":514,"eligibilityCriteria":515,"healthyVolunteers":17,"sex":18,"minAge":516,"maxAge":517,"enrollmentInfo":518,"targetDuration":4,"studyType":24,"phases":519,"briefSummary":520,"conditions":521,"keywords":525,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":527,"lastUpdatePostDateStruct":528,"startDateStruct":530,"completionDateStruct":532,"leadSponsor":534,"locationsCount":80},"100420552","the-vespa-pilot-study-100420552","NCT04756245","The VESPA Pilot Study","The Virtually Engaging Socially With Physical Activity (VESPA) Pilot Study","VESPA","Inclusion Criteria:\n\n* Age of 45-80 years\n* Body mass index between 30-45 kg\u002Fm2\n* Low-active (30 or more minutes of moderate intensity physical activity on 2 or fewer days per week)\n* Have access to home Wi-Fi\n* Have regular access to a computer, tablet, or smartphone to receive teleconferencing calls\n* Have a clear \"VR space\" (7'x7' object-free space)\n* Have an \"Activity buddy\" (spouse, child, caregiver, etc.)\n* Modified Telephone Interview for Cognitive Status (TICS-M) score of 32 or greater\n* Consent from a physician for study participation\n* Proficient in the English language\n* Willingness to create or use existing personal Facebook account for virtual reality activities.\n\nExclusion Criteria:\n\n* Current involvement in other physical activity research studies\n* Hearing or sight impairments (significant visual or hearing impairment that cannot be corrected and results in the inability to use the telephone or hear normal conversation, colorblindness)\n* Dependence on a cane or walker\n* More than 1 fall in the past year\n* Contraindication to exercise\n* Current or recent history within the last 6 months of: symptomatic coronary heart disease, cancer, liver or renal disease, severe pulmonary disease, gross physical impairment, or uncontrolled hypertension; myocardial infarction or cardiovascular procedure within the last 3 months\n* History of or diagnosis of photosensitive epilepsy\n* Score of \"severe\" on any question in the Virtual Reality Sickness Questionnaire;\n* Unwillingness to use a head-mounted virtual reality system\n* Current severe or untreated depression","45 Years","80 Years",{"count":5,"type":23},[26],"Physical activity has been described by the US federal government as a 'best buy' for public health. Unfortunately, most adults in the United States are not sufficiently active, and this worsens with age. Low levels of participation are driven by many challenging barriers, including lack of access, few opportunities for enjoyable activity, and few supportive social relationships, which is especially important given the central role of social connection for lasting behavior change.\n\nA half-century of research in behavioral sciences has generated effective group-based physical activity programs, but these are inaccessible to most as they are often delivered in a few select research centers. Recent advances in telehealth have offered media for extending these interventions more broadly, but the experience of such programs is often hampered by technology that does not allow for a sense of physical and social presence. Fortunately, uptake of virtual reality (VR) is increasing rapidly, and the medium has a high level of potential for advancing the delivery of immersive evidence-based group interventions to those that most need it. Thus our specific aims are:\n\nSpecific aim 1: To test the feasibility and acceptability of a group-mediated physical activity intervention delivered fully via modern VR to older adults.\n\nSpecific aim 2: To examine the impact of this program on overall physical activity among older adults compared to the current standard-of-care for telehealth: the video conference meeting platform.",[522,43,523,524],"Exercise","Loneliness","Social Isolation",[526,389,363],"Telehealth","2025-07-14",{"date":529,"type":72},"2025-07-16",{"date":531,"type":72},"2020-12-17",{"date":533,"type":23},"2026-12-30",{"name":535,"class":79},"Wake Forest University",{"id":537,"slug":538,"hasResults":12,"nctId":539,"briefTitle":540,"officialTitle":541,"acronym":4,"eligibilityCriteria":542,"healthyVolunteers":17,"sex":18,"minAge":89,"maxAge":543,"enrollmentInfo":544,"targetDuration":4,"studyType":24,"phases":546,"briefSummary":547,"conditions":548,"keywords":552,"overallStatus":114,"whyStopped":4,"lastUpdateSubmitDate":555,"lastUpdatePostDateStruct":556,"startDateStruct":558,"completionDateStruct":560,"leadSponsor":562,"locationsCount":4},"100596656","omaha-system-based-health-application-on-improving-knowledge-attitude-and-behaviors-regarding-infectious-disease-prevention-in-the-community-100596656","NCT07048301","Omaha System-Based Health Application on Improving Knowledge, Attitude, and Behaviors Regarding Infectious Disease Prevention in the Community","Developing an Omaha System-Based Health Application on Improving Knowledge, Attitude, and Behaviors Regarding Infectious Disease Prevention in the Community","Inclusion criteria:\n\n* being aged between 18 and 64 years,\n* living in two container cities,\n* having a knowledge score of 'very low (1)' and 'low (2)' on the Omaha System Problem Rating Scale for Outcome for Communicable\u002F Infectious Problem Knowledge Parameter,\n* being literate,\n* owning a smartphone.\n\nExclusion criteria:\n\n* having impaired vision or hearing,\n* having a mental illness,\n* not owning a smartphone,\n* being pregnant or postpartum,\n* being participants in another scientific study,\n* refusing to participate.","64 Years",{"count":545,"type":23},112,[26],"Background: Infectious diseases remain significant public health concerns due to several factors such as climate and environmental changes and natural disasters. Mobile health applications (mHealth apps) can be an appropriate way for fostering community participation, disseminating knowledge, and promoting behavior change toward infectious disease prevention. This study aims to describe a protocol for a pilot randomized controlled study to evaluate the impact of the Omaha System-Based mHealth app (BUHOS) on improving knowledge, attitude, and behaviors (KAB) regarding infectious disease prevention in an earthquake-affected region of Türkiye.\n\nMethods: This study is a two-armed, parallel-group, randomized controlled trial design. A total of 112 eligible participants will be recruited from two separate container cities of an earthquake-affected region. These participants will be randomly allocated to either an intervention group or a control group. BUHOS will be designed based on the Omaha System, a widely recognized standardized taxonomy for the assessment, planning, and evaluation of healthcare services. BUHOS will be a two-week nursing intervention that includes monitoring KAB, employing Education, Guidance and Counseling (education videos), and Surveillance (reminder messages), and assessing the outcomes. Outcome variables will include the Problem Rating Scale for Outcomes, Community Communicable Diseases Knowledge Survey, Communicable Diseases Risk Awareness and Protection Scale and System Usability Scale. Outcome variables will be assessed on the 15th and 30th day after intervention.\n\nHypotheses:\n\nH1: Among the Omaha System Problems, the Communicable\u002F Infectious Condition Problem Knowledge score will be higher on the 15th and 30th days compared to the control group.\n\nH2: Infectious diseases risk awareness and prevention score will be higher on the 15th and 30th days compared to the control group.\n\nH3: Communicable\u002F Infectious Condition Status Behaviour Parameter score will be higher on the 15th and 30th days compared to the control group H4: The knowledge and behaviour of the communicable\u002F infectious status and the awareness and prevention of the risk of infectious diseases of the experimental group will be higher than before the intervention on the 15th and 30th days.",[549,550,43,551],"Infectious Diseases","Attitude","Knowledge",[553,554],"Omaha System","Mobile health app","2025-06-24",{"date":557,"type":72},"2025-07-02",{"date":559,"type":23},"2025-09",{"date":561,"type":23},"2026-06",{"name":563,"class":79},"Kocaeli University",{"id":565,"slug":566,"hasResults":12,"nctId":567,"briefTitle":568,"officialTitle":569,"acronym":570,"eligibilityCriteria":571,"healthyVolunteers":12,"sex":18,"minAge":89,"maxAge":4,"enrollmentInfo":572,"targetDuration":574,"studyType":358,"phases":4,"briefSummary":575,"conditions":576,"keywords":579,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":584,"lastUpdatePostDateStruct":585,"startDateStruct":587,"completionDateStruct":589,"leadSponsor":591,"locationsCount":80},"100431469","validity-and-reliability-study-of-the-pain-indicator-behavior-scale-brain-damage-escid-dc-100431469","NCT04898491","Validity and Reliability Study of the Pain Indicator Behavior Scale-Brain Damage (ESCID-DC)","Validity and Reliability Study of the Pain Indicator Behavior Scale Adapted to Measure Pain in Critically Ill Patients With Acquired Brain Damage, Non-communicative and With an Artificial Airway (ESCID-DC).","ESCID-DC","Inclusion Criteria:\n\n1. Age equal to or greater than 18 years.\n2. Inability to communicate verbally or motor.\n3. Have a artificial airway.\n4. Informed consent of the family member or representative of the patient.\n\nExclusion Criteria:\n\n1. Previous pathology of cognitive impairment.\n2. Previous brain injury.\n3. Previous psychiatric disorder.\n4. Previous dementia.\n5. Previous chronic substance abuse.\n6. Previous chronic diabetics.\n7. Previous spinal cord injury.\n8. Previous severe polyneuropathy (diagnosed or suspected).\n9. Confirmed diagnosis of brain death.\n10. Continuous infusion of muscle relaxants and \u002F or barbiturate coma.\n11. Level of deep sedation (RASS -5).",{"count":573,"type":23},300,"18 Months","A multicentre observational study to validate the adaptation of the Pain Indicator Behavior Scale (ESCID) for patients with acquired Brain Damage (ESCID-DC), as a measuring instrument.",[577,578,43],"Pain","Brain Injuries",[577,580,581,582,583],"Brain injury","Brain damage","Intensive Critical Unit","Nursing","2025-03-28",{"date":586,"type":72},"2025-04-02",{"date":588,"type":72},"2022-06-01",{"date":590,"type":23},"2025-06-30",{"name":592,"class":79},"Candelas Lopez Lopez",{"id":594,"slug":595,"hasResults":12,"nctId":596,"briefTitle":597,"officialTitle":597,"acronym":598,"eligibilityCriteria":599,"healthyVolunteers":17,"sex":412,"minAge":89,"maxAge":4,"enrollmentInfo":600,"targetDuration":4,"studyType":358,"phases":4,"briefSummary":601,"conditions":602,"keywords":4,"overallStatus":114,"whyStopped":4,"lastUpdateSubmitDate":603,"lastUpdatePostDateStruct":604,"startDateStruct":605,"completionDateStruct":606,"leadSponsor":608,"locationsCount":4},"100585345","influence-of-the-3d-sonographic-representation-of-the-fetal-face-on-the-health-conscious-behavior-of-pregnant-women-100585345","NCT06901154","Influence of the 3D-sonographic Representation of the Fetal Face on the Health-conscious Behavior of Pregnant Women","IN3D","Inclusion Criteria:\n\n* pregnant women undergoing ultrasound\n\nExclusion Criteria:\n\n* age \\\u003C18 years",{"count":156,"type":23},"Studies have shown that ultrasound examinations during pregnancy have a short-term anxiety and stress-reducing effect, without having any influence on the mother-child bond or health-conscious behavior.\n\nIt has not yet been investigated to what extent the representation of the child's face alone achieves a lasting positive effect if the representation in 3D form were permanently available.",[43],"2025-03-23",{"date":584,"type":72},{"date":584,"type":23},{"date":607,"type":23},"2025-09-30",{"name":609,"class":79},"Martin-Luther-Universität Halle-Wittenberg",{"id":611,"slug":612,"hasResults":12,"nctId":613,"briefTitle":614,"officialTitle":615,"acronym":616,"eligibilityCriteria":617,"healthyVolunteers":17,"sex":18,"minAge":20,"maxAge":618,"enrollmentInfo":619,"targetDuration":4,"studyType":24,"phases":620,"briefSummary":621,"conditions":622,"keywords":625,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":632,"lastUpdatePostDateStruct":633,"startDateStruct":635,"completionDateStruct":637,"leadSponsor":638,"locationsCount":80},"100547952","the-energyco-study-100547952","NCT06414668","The ENERGYCO Study","ENERGY Expenditure of COmmuting to School","ENERGYCO","Inclusion Criteria:\n\n1. the school has a specific space for parking bicycles and allows for their parking\n2. the school does not have a specific school bus route\n3. the school has at least two lines per class\n4. at least eight students from the school will agree to participate in the study (i.e., presenting a signed parental consent).","17 Years",{"count":573,"type":23},[26],"The aims of this school-based cycling intervention called \"ENERGY Commuting to school\" (ENERGYCO) will be divided into two phases: Phase I will aim: 1) to design, test, and validate predictive equations for the objective quantification of the energy expenditure related to different modes of commuting to school (i.e., walking, cycling, motorized-vehicle); and 2) to quantify the energy expenditure of each mode of commuting to school using indirect calorimetry in adolescents; and Phase II will aim to evaluate the effect of a school-based cycling intervention on different health-related outcomes, such as energy expenditure, resting metabolic rate, basal metabolism, physical activity levels, body composition, muscle strength, cardiorespiratory fitness, blood pressure, physical literacy, motor competence, and psychosocial outcomes on Spanish adolescents.",[623,363,43,624],"Energy Expenditure","Body Composition",[626,627,628,629,630,631],"Resting metabolic rate","Energy expenditure","Physical activity","Body composition","Cycling","School","2024-12-03",{"date":634,"type":72},"2024-12-05",{"date":636,"type":72},"2023-02-01",{"date":590,"type":23},{"name":639,"class":79},"Universidad de Granada",{"id":641,"slug":642,"hasResults":12,"nctId":643,"briefTitle":644,"officialTitle":645,"acronym":646,"eligibilityCriteria":647,"healthyVolunteers":17,"sex":18,"minAge":89,"maxAge":90,"enrollmentInfo":648,"targetDuration":4,"studyType":24,"phases":650,"briefSummary":651,"conditions":652,"keywords":656,"overallStatus":114,"whyStopped":4,"lastUpdateSubmitDate":659,"lastUpdatePostDateStruct":660,"startDateStruct":662,"completionDateStruct":664,"leadSponsor":666,"locationsCount":265},"100570279","can-computational-measures-of-task-performance-predict-psychiatric-symptoms-and-changes-in-symptom-severity-across-time-100570279","NCT06705179","Can Computational Measures of Task Performance Predict Psychiatric Symptoms and Changes in Symptom Severity Across Time","Leveraging Computationally Derived Measures of Individual Differences in Learning and Decision-making to Predict Psychiatric Diagnosis, Symptoms and Changes in Symptom Severity Across Time","CABxtime","Inclusion criteria (healthy control participants):\n\n* Age range of 18 to 65.\n* Not currently having a psychiatric diagnosis determined after psychiatric evaluation by Drs. Tadayon-Nejad and Wei (both are board certified psychiatrists).\n* Ability to understand and perform experimental tasks, i.e. basic ability to communicate and comprehend tasks.\n* Ability to give informed consent.\n\nExclusion criteria (healthy control participants):\n\n• Prior history and or current diagnosis of neurological disease.\n\nInclusion criteria (patients):\n\n* Age range of 18 to 65.\n* Psychiatric diagnosis of any type of depressive disorders, any type of anxiety disorders or obsessive-compulsive disorder.\n* Primary or comorbid bipolar disorders are allowed but only if not in the acute manic phase.\n* Comorbidity with autism spectrum disorder (ASD) and attention-deficit\u002Fhyperactivity disorder (ADHD) are allowed.\n* Ability to understand and perform experimental tasks, i.e. basic ability to communicate and comprehend tasks.\n* Ability to give informed consent.\n\nExclusion criteria (patients):\n\n* Prior history and or current diagnosis of neurological disease.\n* History or current diagnosis of psychotic disorders.\n* Currently active substance use disorder.",{"count":649,"type":23},1100,[26],"This study investigates the computational mechanisms associated with psychiatric disease dimensions. The study will characterize the relationship between computational parameter estimates of task performance and psychiatric symptoms and diagnoses with a longitudinal approach over a 12 month interval. Participants will be healthy participants recruited through Prolific an on-line crowdsourcing service, and psychiatric patients and healthy participants recruited via UCLA Psychiatry Clinics and UCLA's STAND Program",[43,653,654,655],"Depressive Disorder","Anxiety Disorders","Obsessive Compulsive Disorder (OCD)",[657,658],"Computational Psychiatry","Behavioral task battery","2024-11-21",{"date":661,"type":72},"2024-11-26",{"date":663,"type":23},"2025-01-01",{"date":665,"type":23},"2029-12-31",{"name":667,"class":79},"California Institute of Technology",{"id":669,"slug":670,"hasResults":12,"nctId":671,"briefTitle":672,"officialTitle":673,"acronym":674,"eligibilityCriteria":675,"healthyVolunteers":12,"sex":18,"minAge":89,"maxAge":4,"enrollmentInfo":676,"targetDuration":4,"studyType":24,"phases":678,"briefSummary":679,"conditions":680,"keywords":4,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":683,"lastUpdatePostDateStruct":684,"startDateStruct":686,"completionDateStruct":688,"leadSponsor":690,"locationsCount":384},"100561703","pilot-trial-of-the-rubi-program-for-autistic-adults-100561703","NCT06593613","Pilot Trial of the RUBI Program for Autistic Adults","Pilot Randomized Trial of the RUBI Program for Families of Autistic Adults","RUBI-A","Inclusion Criteria:\n\n* Autistic adults will:\n\n  1. be age ≥ 18 years;\n  2. live at home with their parent and be able to attend each session;\n  3. have a community diagnosis of autism (confirmed through record documentation) and Social Communication Questionnaire (SCQ) total score \\> 15;\n  4. have a parent rated 24-item EDI Reactivity Score \\> 50 percentile, which reflects mild to moderate challenging behaviors (e.g., outbursts; verbal aggression);\n  5. have receptive language \\> 18 months as measured on the Mullen Scales of Early Learning (MSEL) Receptive Language subtest or similar measure of receptive language;\n  6. have a stable educational\u002Fvocational plan and be medication free or on stable medication (no changes in prior 6 weeks or planned changes for 16 weeks). Individuals on stable medication will be included as this enhances sample representativeness.\n* Parents\u002FLegally Authorized Representatives will be able to:\n\n  1. attend each session.\n\nExclusion Criteria:\n\n* Autistic adults with: (1) serious medical conditions requiring immediate care (e.g., uncontrolled seizures) or (2) serious behavioral challenges where safety to self and\u002For others is of concern and that warrant more immediate or intensive treatment (e.g., self-injurious behaviors or aggression resulting in tissue damage). This will be evaluated through case panel with study site Principal Investigators.\n* Parents\u002FLegally Authorized Representatives where they are unable to attend weekly virtual or in person sessions over the course of 20 weeks.",{"count":677,"type":23},80,[26],"The goal of this clinical trial is to evaluate if a redesigned version of the RUBI parenting intervention can reduce challenging behaviors and improve adaptive skills in autistic adults with co-occurring challenging behaviors. The main questions it aims to answer are:\n\n* Is the redesigned RUBI intervention feasible and acceptable for autistic adults and their families?\n* Does the redesigned RUBI intervention reduce challenging behaviors and enhance the quality of life for autistic adults?\n* Researchers will compare the redesigned RUBI intervention to an active control group, Introduction to the Science and Lived Experience of Autism (ISLEA), to see if RUBI is more effective in improving outcomes for autistic adults and their families.\n\nParticipants will:\n\n* Attend sessions where they receive either the RUBI intervention or the ISLEA program.\n* Engage in activities designed to promote communication, co-regulation, and autonomy in the context of supporting autistic adults.\n* Complete assessments at the start, throughout, and at the end of the 20-week trial to evaluate outcomes such as challenging behaviors, adaptive skills, and quality of life.",[681,43,682],"Autism Spectrum Disorder","Parenting","2024-09-09",{"date":685,"type":72},"2024-09-19",{"date":687,"type":72},"2024-09-01",{"date":689,"type":23},"2024-12-31",{"name":691,"class":79},"Seattle Children's Hospital",{"id":693,"slug":694,"hasResults":12,"nctId":695,"briefTitle":696,"officialTitle":697,"acronym":698,"eligibilityCriteria":699,"healthyVolunteers":17,"sex":18,"minAge":89,"maxAge":516,"enrollmentInfo":700,"targetDuration":4,"studyType":24,"phases":701,"briefSummary":702,"conditions":703,"keywords":704,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":710,"lastUpdatePostDateStruct":711,"startDateStruct":713,"completionDateStruct":715,"leadSponsor":717,"locationsCount":80},"100555717","exogenous-ketones-and-behavior-100555717","NCT06515717","Exogenous Ketones and Behavior","Exogenous Ketones and Behavior (ExoKet)","ExoKet","Inclusion Criteria:\n\n* Consent to participate\n* Fluent in German\n* Physically healthy. No regular medication\n* No drug use 1 week prior to the study\n* BMI 18-31 kg\u002Fm2\n\nExclusion Criteria:\n\n* Former or current illnesses of:\n* Brain or mind (including eating disorders, personality disorders, alcohol, drugs or drug dependence, neurological disorders other than occasional headache; depression or anxiety disorder excluded)\n* Heart or blood circulation\n* Gastro-intestinal or endocrine disorders\n* Liver or kidney disorders\n* Electrolyte imbalance\n* Other serious past or present medical conditions (for example, metabolic syndrome, diabetes, cancer)\n* Pregnancy\n* Extreme athletes (\\>2h\u002Fday intense work-out; casual cycling or walking is ok)\n* Menopause (post menopause is ok)\n* Ketogenic diet, ketogenic supplement intake, intermittent fasting or calorie restricted diet during preceding 4 weeks of study participation\n* Fear of blood draw",{"count":490,"type":23},[26],"The study will examine the effect of exogenous ketone ester on behavior and metabolism using Virtual Reality and computerizes behavioral tasks.",[43],[705,706,707,708,709],"ketones","human cognition","metabolism","anxiety","intervention","2024-07-26",{"date":712,"type":72},"2024-07-29",{"date":714,"type":23},"2024-07-18",{"date":716,"type":23},"2025-06-23",{"name":236,"class":79},{"id":719,"slug":720,"hasResults":12,"nctId":721,"briefTitle":722,"officialTitle":723,"acronym":724,"eligibilityCriteria":725,"healthyVolunteers":12,"sex":18,"minAge":4,"maxAge":4,"enrollmentInfo":726,"targetDuration":4,"studyType":24,"phases":727,"briefSummary":728,"conditions":729,"keywords":4,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":733,"lastUpdatePostDateStruct":734,"startDateStruct":736,"completionDateStruct":737,"leadSponsor":738,"locationsCount":80},"100500201","monitoring-sedentary-behavior-and-light-physical-activity-in-patients-with-stroke-100500201","NCT05793177","MONitoring Sedentary Behavior and Light Physical Activity in Patients With Stroke","Monitoring Sedentary Behavior and Light Physical Activity in Patients With Stroke","MONSS","Inclusion Criteria:\n\n* Verified ischemic stroke or intracerebral hemorrhage\n* Modified rankin score (mRS) 1-3 at discharge\n* Discharged with at rehabilitation plan within 1-14 hospitalization days\n* Able to ambulate independently\n* Speak and understand Danish\n\nExclusion Criteria:\n\n* Aphasia\n* Unable to give informed consent\n* Unable to ambulate independently\n* Mental illness\n* Other co-morbidity like terminal cancer.",{"count":311,"type":23},[26],"This randomized control trial (RCT) aims to test the effect of a 12 weeks tailored behavioral intervention on stroke survivors living in the community and compare the results to a control group of stroke survivors participating in standard care. The intervention's purpose is to lower the time spend with sedentary behavior and raise the level of physical activity in stroke survivors throughout their everyday life. The intervention contains two motivational interviews with a focus on goal setting, action planning, motivation, fatigue management, and general information on life after stroke. The primary outcome for behavior change is objectively measured physical activity using an activity tracker (ActivPal4 Micro) and secondary glycohemoglobin and changes in quality of life.",[730,43,731,732],"Stroke, Acute","Physical Inactivity","Sedentary Behavior","2024-07-24",{"date":735,"type":72},"2024-07-25",{"date":178,"type":72},{"date":689,"type":23},{"name":739,"class":79},"Zealand University Hospital"]