[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"behavioral-variant-frontotemporal-dementia\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:behavioral-variant-frontotemporal-dementia":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,45],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100283059","diagnosing-frontotemporal-lobar-degeneration-100283059",false,"NCT02964637","Diagnosing Frontotemporal Lobar Degeneration","Multimodal Assessment for Predicting Specific Pathological Substrate in Frontotemporal Lobar Degeneration","Inclusion Criteria:\n\n* Participant must have a reliable study partner who can provide an independent evaluation of functioning.\n* Able to read, understand and speak English for neuropsychological testing.\n* All subjects must meet one of these diagnostic criteria (A) probable behavioral variant FTD, (B) MRI-supported non-fluent variant PPA; (C) MRI-supported semantic variant PPA and \\[18F\\]T807 negative (D) probable CBS: using current criteria for CBS(27); (E) PSP: inclusion criteria for PSP are based upon the National Institute of Neurological Disorders and Stroke Society of Progressive Supranuclear Palsy (NINDS-SPSP) (F) FTD-MND\n* Control subjects must have a normal neurological exam, a CDR sum of boxes = 0, and MMSE score equal to or greater than 28\n\nExclusion Criteria:\n\n* Patients with clinical, imaging or CSF A beta\u002F tau profile consistent with AD\n* History of traumatic brain injury, brain tumors, stroke or other neurological or psychiatric disorders that can explain symptoms will be excluded.\n* Premenopausal women will be asked to consent to a pregnancy test prior to each scan as pregnant women will be excluded from study because of potential harm to fetus from PET study.\n* Presence of pacemakers, aneurysm clips, artificial heart valves, ear implants, metal fragments or foreign objects in the eyes, skin or body.",true,"ALL","18 Years","90 Years",{"count":21,"type":22},100,"ESTIMATED","OBSERVATIONAL","To establish diagnostic tools to make an accurate clinical and pathological diagnosis of patients with clinical FTLD syndromes",[26,27,28,29,30,31],"Corticobasal Syndrome","Progressive Supranuclear Palsy","Behavioral Variant Frontotemporal Dementia","Semantic Dementia","Progressive Nonfluent Aphasia","Amyotrophic Lateral Sclerosis And\u002For Frontotemporal Dementia","RECRUITING","2025-03-25",{"date":35,"type":36},"2025-03-30","ACTUAL",{"date":38,"type":4},"2015-08",{"date":40,"type":22},"2026-12",{"name":42,"class":43},"University Health Network, Toronto","OTHER",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":51,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":17,"minAge":53,"maxAge":54,"enrollmentInfo":55,"targetDuration":4,"studyType":57,"phases":58,"briefSummary":60,"conditions":61,"keywords":4,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":67,"leadSponsor":69,"locationsCount":4},"100574626","the-ketogenic-diet-in-the-treatment-of-behavioral-variant-frontotemporal-dementia-100574626","NCT06761729","The Ketogenic Diet in the Treatment of Behavioral Variant Frontotemporal Dementia","An Exploratory Study for Evaluating the Efficacy, Safety and Tolerability of JT821 in the Intervention of Behavioral Variant Frontotemporal Dementia","JT821","Inclusion Criteria:\n\n1. Subject is between the ages of 45 - 70;\n2. Meetting the diagnostic criteria for \"probable bvFTD published by the International bvFTD Standards Consortium in 2011;\n3. Subjects must not undergo any drug adjustment treatment for 2 months prior to the enrollment and during the enrollment period ;\n4. Subjects must sign a written informed consent form prior to the screening visit examination. If the subject cannot sign due to limited cognitive ability or other reasons, the signature may be left blank, and the rationale must be stated. The legal guardian should provide the reason, sign the name, date, and time in the reason description area, and also sign the name, date, and time in the legal guardian column.\n\nExclusion Criteria:\n\nInclusion Criteria:\n\n1. Subject is between the ages of 45 - 70;\n2. Meetting the diagnostic criteria for \"probable bvFTD published by the International bvFTD Standards Consortium in 2011;\n3. Subjects must not undergo any drug adjustment treatment for 2 months prior to the enrollment and during the enrollment period ;\n4. Subjects must sign a written informed consent form prior to the screening visit examination. If the subject cannot sign due to limited cognitive ability or other reasons, the signature may be left blank, and the rationale must be stated. The legal guardian should provide the reason, sign the name, date, and time in the reason description area, and also sign the name, date, and time in the legal guardian column.\n\nExclusion Criteria:\n\n1. Dementia caused by other factors: Alzheimer's Disease，vascular dementia, central nervous system infections (such as AIDS, syphilis, etc.), Huntington's disease and Parkinson's disease, Lewy body dementia, traumatic brain injury dementia, other physical and chemical factors (such as drug poisoning, alcohol poisoning, carbon monoxide poisoning, etc.), significant somatic diseases (such as hepatic encephalopathy, pulmonary etc.), intracranial space-occupying lesions (such as subdural hematoma, brain tumors), endocrine system disorders (such as thyroid diseases, parathyroid diseases) and dementia caused by vitamin deficiency or any other known causes;\n2. Having a low-carb diet , ketogenic diet, or vegan diet within 3 months before the screening visit or being currently doing.\n3. Patients diagnosed with schizophrenia spectrum disorder ,bipolar disorder, moderate to severe depression or delirium according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5).\n4. Abnormal laboratory tests at screening visit and baseline: including liver function tests (alanine aminotransferase \\[ALT\\], aspartate aminotransferase \\[AST\\]) exceeding twice the upper limit of normal; and renal function (creatinine \\[Cr\\]) exceeding 1.5 times the upper limit of normal. Slight exceedances that are not clinically significance, as judged by the investigator, may not be excluded;\n5. Fasting triglycerides ≥ 5.7 mmol\u002FL or total cholesterol ≥ 10.34 mmol\u002FL at the screening visit and baseline;\n6. Presence any of the following infections at the screening visit:\n\n   Positive human immunodeficiency virus antibody (HIV Ab); Positive Treponema pallidum antibody (TP Ab);\n7. Gastrointestinal diseases that could affect the absorption or metabolism of the investigational product as judged by the investigator, within 2 months before the screening visit;\n8. Having undergone major surgeries deemed unsuitable for enrollment by the investigator within 6 months before the screening visit or those planning to undergo major surgeries during the study period (The definition of major surgeries refers to Grade 3 and Grade 4 surgeries as outlined in the \"Administrative Measures for Grading of Surgeries in Medical Institutions (Trial)\" implemented on December 6, 2022);\n9. Patients who have suffered from malignant tumors within 3 years prior to the screening visit (excluding basal cell carcinoma of the skin that has been radically cured, squamous cell carcinoma of the skin and\u002For carcinoma in situ that has been radically resected);\n10. Having a history of alcohol or drug abuse within 1 year prior to the screening visit;\n11. Known allergy to any components of the investigational product in this study;\n12. Having uncorrectable visual or auditory impairments or any other conditions that would affect the assessment of the scale;\n13. Contraindications to JT821:\n\nAbsolute contraindications:\n\n1. Type 1 diabetes\n2. Primary carnitine deficiency (Laboratory tests: Hypoglycemia with low ketone levels, elevated creatine kinase (CK), etc.)\n3. Carnitine palmitoyl transferase (CPT) I and II deficiency (Laboratory tests: Hypoglycemia with low ketone levels, elevated transaminases, CK, elevated blood ammonia, tandem mass spectrometry for measurement of blood acylcarnitine profile, etc.)\n4. Carnitine translocase deficiency (Laboratory tests: Hypoglycemia with low ketone levels, elevated transaminases, CK, elevated blood ammonia, tandem mass spectrometry for measurement of blood acylcarnitine profile, etc.)\n5. β-Oxidation disorders (Laboratory tests: Blood glucose, electrolytes, blood lipids, coagulation, liver function, kidney function)\n6. Medium-chain acyl dehydrogenase deficiency (MCAD) (Laboratory tests: Hypoglycemia with low ketone levels, elevated transaminases, CK, elevated blood ammonia, metabolic acidosis, tandem mass spectrometry for measurement of blood acylcarnitine profile, etc.)\n7. Very long-chain acyl dehydrogenase deficiency (VLCAD) (Laboratory tests: Hypoglycemia with low ketone levels, elevated transaminases, CK, elevated creatine kinase isoenzyme (CK-MB) and lactate dehydrogenase (LDH), tandem mass spectrometry for measurement of blood acylcarnitine profile)\n8. Long-chain acyl dehydrogenase deficiency (LCAD) (Laboratory tests: Hypoglycemia with low ketone levels, elevated transaminases, CK, elevated creatine kinase isoenzyme (CK-MB) and lactate dehydrogenase (LDH), tandem mass spectrometry for measurement of blood acylcarnitine profile)\n9. Short-chain acyl dehydrogenase deficiency (SCAD) (Laboratory tests: Tandem mass spectrometry for measurement of blood acylcarnitine profile, determination of SCAD enzyme activity)\n10. Long-chain 3-hydroxyacyl-CoA deficiency (Laboratory tests: Hypoglycemia with low ketone levels, elevated transaminases, CK, elevated CK-MB and LDH, analysis of blood acylcarnitine profile, etc.)\n11. Medium-chain 3-hydroxyacyl-CoA deficiency (Laboratory tests: Hypoglycemia with low ketone levels, elevated transaminases, CK, elevated CK-MB and LDH, analysis of blood acylcarnitine profile, etc.)\n12. Pyruvate carboxylase deficiency (Laboratory tests: Hypoglycemia with low ketone levels, elevated transaminases, CK, elevated CK-MB and LDH, analysis of blood acylcarnitine profile, etc.)\n13. Porphyria (Laboratory tests: Sunlight test of urinary porphobilinogen)\n14. Acute pancreatitis\n15. Liver failure\n16. Pregnancy\n\nRelative contraindications:\n\nPatients who cannot maintain adequate nutrition (Fasting blood glucose \\\u003C 2.8 mmol\u002FL, blood ketone \\> 0.5 mmol\u002FL) (15) Any other situations that the investigator considers unsuitable for participating in this study; (16)Currently participating in other investigational product\u002Fdevice for treatment or participating in other clinical trials for treatment purposes.","45 Years","70 Years",{"count":56,"type":22},3,"INTERVENTIONAL",[59],"NA","This study is an exploratory clinical research on the use of JT821 (a ketogenic diet formulation) for the treatment of patients with behavioral variant frontotemporal dementia (bvFTD), aiming to evaluate the effectiveness, safety, and tolerability of JT821 in the intervention of bvFTD.\n\nThe ketogenic diet (KD) is a low-carbohydrate, adequate protein and high-fat diet. KD was shown to be effective in treating different neurodegenerative diseases.",[28],"NOT_YET_RECRUITING","2025-02-05",{"date":65,"type":36},"2025-02-10",{"date":65,"type":22},{"date":68,"type":22},"2025-10-31",{"name":70,"class":43},"Xuanwu Hospital, Beijing"]