[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"bells-palsy\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:bells-palsy":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,40,70,97,123],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":4},"100640808","study-on-the-optimal-waveform-patterns-of-electroacupuncture-targeted-intervention-for-bells-palsy-based-on-surface-electromyography-characteristics-100640808",false,"NCT07598175","Study on the Optimal Waveform Patterns of Electroacupuncture Targeted Intervention for Bell's Palsy Based on Surface Electromyography Characteristics","Inclusion Criteria for Bell's Palsy Subjects：\n\n* Meet the above Bell's palsy diagnostic criteria;\n* Age 18-65 years, either gender;\n* Disease course in recovery phase (21 days ≤ course ≤ 6 months) and not recovered (FNGS 2.0 score \\>4);\n* Voluntarily participate in this study and sign informed consent.\n\nInclusion Criteria for Healthy Subjects：\n\n* Do not meet the above Bell's palsy diagnostic criteria;\n* Age 18-65 years, either gender, matched to Bell's palsy subjects within 5 years for age and gender;\n* Normal facial nerve function, FNGS 2.0 score = 4;\n* Voluntarily participate in this study and sign informed consent.\n\nExclusion Criteria for Bell's Palsy Subjects：\n\n* Facial trauma, skin lesions, or other diseases that may cause facial paralysis symptoms;\n* Diagnosed with Ramsay Hunt syndrome (herpes zoster oticus);\n* Bilateral facial paralysis;\n* Previous history of facial paralysis;\n* Facial synkinesis, contracture, or spasm already present;\n* History of facial surgery;\n* Uncontrolled diabetes, hypertension, severe cardiac, hepatic, or renal disease, cognitive impairment, aphasia, or mental disorders;\n* Pacemaker use;\n* Pregnant or lactating patients.\n\nExclusion Criteria for Healthy Subjects：\n\n* Facial trauma, skin lesions, or other diseases that may affect facial muscle activity;\n* Previous history of facial paralysis;\n* History of facial surgery;\n* Uncontrolled diabetes, hypertension, severe cardiac, hepatic, or renal disease, cognitive impairment, aphasia, or mental disorders;\n* Pacemaker use;\n* Pregnant or lactating patients.",true,"ALL","18 Years","65 Years",{"count":20,"type":21},100,"ESTIMATED","INTERVENTIONAL",[24],"NA","The goal of this clinical study is to find out whether different electronic acupuncture wave forms can effectively treat recovery-stage Bell's palsy in adults and evaluate their safety.\n\nThe main questions it aims to answer are:\n\n* Can targeted electronic acupuncture wave forms improve facial nerve function in patients with Bell's palsy?\n* What is the optimal electronic acupuncture waveform for different degrees of facial nerve injury?\n* What adverse events may occur during electronic acupuncture treatment? Researchers will compare low-frequency continuous wave electronic acupuncture and intermittent wave electronic acupuncture to determine which waveform works better for recovery-stage Bell's palsy.\n\nParticipants will:\n\n* Receive either low-frequency continuous wave electronic acupuncture or intermittent wave electronic acupuncture every other day for 4 weeks\n* Undergo surface sEMG and ENoG examinations at baseline, Week 2, and Week 4\n* Complete facial function assessments and safety evaluations at each clinic visit",[27],"Bell's Palsy","NOT_YET_RECRUITING","2026-05-19",{"date":31,"type":32},"2026-05-20","ACTUAL",{"date":34,"type":21},"2026-05-15",{"date":36,"type":21},"2028-11-20",{"name":38,"class":39},"The Third Affiliated hospital of Zhejiang Chinese Medical University","OTHER",{"id":41,"slug":42,"hasResults":11,"nctId":43,"briefTitle":44,"officialTitle":44,"acronym":45,"eligibilityCriteria":46,"healthyVolunteers":11,"sex":16,"minAge":47,"maxAge":48,"enrollmentInfo":49,"targetDuration":4,"studyType":51,"phases":4,"briefSummary":52,"conditions":53,"keywords":55,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":60,"lastUpdatePostDateStruct":61,"startDateStruct":63,"completionDateStruct":65,"leadSponsor":67,"locationsCount":69},"100637028","validation-of-artificial-intelligence-based-facial-paralysis-assessment-in-patients-with-bells-palsy-100637028","NCT07573358","Validation of Artificial Intelligence-Based Facial Paralysis Assessment in Patients With Bell's Palsy","AI-FACE","Inclusion Criteria:\n\n* Patients with unilateral Bell's palsy.\n* Patients must be within one month of onset of Bell's palsy symptoms at the time of enrollment.\n* Body mass index (BMI) less than 30 $kg\u002Fm\\^2$.\n* Patients must be cooperative and able to follow simple verbal instructions during facial movement tasks.\n\nExclusion Criteria:\n\n* Bilateral facial paralysis or recurrent Bell's palsy.\n* Facial nerve palsy due to known secondary causes (e.g., trauma, neoplasm, infection, stroke, Ramsay Hunt syndrome, or otitis media).\n* Facial deformities, scars, or burns that interfere with facial motion detection.\n* Uncooperative or cognitively impaired individuals unable to follow instructions or maintain required facial postures.","25 Years","40 Years",{"count":50,"type":21},63,"OBSERVATIONAL","This observational study aims to assess the concurrent validity of an artificial intelligence (AI)-based facial paralysis assessment system in patients with unilateral Bell's palsy. Currently, clinical assessment relies on subjective scales like the Sunnybrook Facial Grading System, which can vary between different observers. This study will compare AI-generated composite asymmetry scores-derived from real-time computer vision analysis of facial landmarks-with scores from the Sunnybrook system. The goal is to determine if AI can provide a valid, objective method for monitoring facial nerve recovery.",[27,54],"Facial Nerve Paralysis",[56,57,58,59],"Facial Asymmetry","Artificial Intelligence","Sunnybrook Facial Grading System","Computer Vision","2026-05-01",{"date":62,"type":32},"2026-05-07",{"date":64,"type":21},"2026-06-01",{"date":66,"type":21},"2026-12-01",{"name":68,"class":39},"Cairo University",1,{"id":71,"slug":72,"hasResults":11,"nctId":73,"briefTitle":74,"officialTitle":74,"acronym":4,"eligibilityCriteria":75,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":76,"targetDuration":4,"studyType":22,"phases":78,"briefSummary":79,"conditions":80,"keywords":83,"overallStatus":87,"whyStopped":4,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":69},"100634264","the-efficacy-of-intradermal-acupuncture-for-ocular-surface-diseases-after-intractable-facial-paralysis-100634264","NCT07537426","The Efficacy of Intradermal Acupuncture for Ocular Surface Diseases After Intractable Facial Paralysis","Inclusion Criteria:\n\n* 1.Male or female patients aged 18-65 years.\n* 2.Meets diagnostic criteria for intractable peripheral facial paralysis, with disease duration from 1 month to 1 year. FNGS 2.0 ≥15 points; ENoG shows the ratio of CMAP amplitude≤ 20%.\n* 3.At least one subjective ocular symptom (dryness, foreign body sensation, burning, fatigue, redness, fluctuating vision) and OSDI scores between 30 and 80.\n* 4.Voluntarily provides written informed consent and can comply with treatment and follow-up.\n\nExclusion Criteria:\n\n* 1.Other ocular diseases (glaucoma, keratitis, retinopathy, acute inflammation of conjunctiva, sclera, cornea).\n* 2\\. Intraocular surgery or laser therapy within the past 90 days.\n* 3.Use of systemic or topical antibiotics or tear-affecting drugs within 3 weeks; dry eye medications within 2 weeks.\n* 4.Lacrimal passage obstruction, dacryocystitis, punctal occlusion, or neurological impairment preventing full eyelid closure.\n* 5.Coagulation disorders, open wounds, or local infection at intervention sites.\n* 6.Allergy to press-needle materials (stainless steel, adhesive tape).\n* 7.Pregnancy or lactation.\n* 8.Severe cardiac, hepatic, renal, psychiatric disorders, or malignant tumors.\n* 9.Participation in another clinical trial within the past month.",{"count":77,"type":21},78,[24],"The purpose of this study is to explore the clinical efficacy of intradermal acupuncture in the treatment of ocular surface diseases after Intractable Facial Paralysis, and to seek effective and convenient treatment for ocular surface diseases after intractable peripheral facial paralysis. The main question it aims to answer is ： Will the intradermal acupuncture intervention effectively reduce the OSDI score ? The researchers compared the intradermal acupuncture with the placebo-needle to observe whether the intradermal acupuncture could better improve the symptoms.",[81,27,82],"Facial Paralysis, Peripheral","Ocular Surface Disease",[84,85,86],"sequelae of facial paralysis","ocular surface disease","intradermal acupuncture","RECRUITING","2026-04-12",{"date":90,"type":32},"2026-04-17",{"date":92,"type":32},"2026-04-01",{"date":94,"type":21},"2028-03-25",{"name":96,"class":39},"The First Affiliated Hospital of Zhejiang Chinese Medical University",{"id":98,"slug":99,"hasResults":11,"nctId":100,"briefTitle":101,"officialTitle":102,"acronym":4,"eligibilityCriteria":103,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":104,"enrollmentInfo":105,"targetDuration":4,"studyType":22,"phases":107,"briefSummary":108,"conditions":109,"keywords":110,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":114,"lastUpdatePostDateStruct":115,"startDateStruct":117,"completionDateStruct":119,"leadSponsor":121,"locationsCount":4},"100613441","effects-of-photobiomodulation-and-electrical-stimulation-among-bells-palsy-patients-100613441","NCT07266636","Effects of Photobiomodulation and Electrical Stimulation Among Bell's Palsy Patients","Comparative Effect of Photobiomodulation and Electrical Stimulation on Facial Disability Among Bell's Palsy Patients","Inclusion Criteria:\n\n* Participants diagnosed with idiopathic Bell's palsy by the Physicians, moderate to severe facial muscle weakness i.e. grade III-VI on the House-Brackmann scale and duration of the condition less than 2 weeks are the inclusion criteria Exclusion Criteria\n* Participants with a middle ear infection, parotid gland tumor, malignant otitis externa, tumors in the base of the lateral skull, upper motor neuron facial palsy, segmental muscle weakness, recurrent episodes of facial paralysis, polyneuropathies and Ramsay Hunt Syndrome will be excluded from the study.","64 Years",{"count":106,"type":21},34,[24],"Despite promising evidence supporting both photobiomodulation (PBM) and electrical stimulation (ES) in Bell's palsy rehabilitation, key gaps remain in the literature. Few studies have directly compared these modalities under standardized conditions, especially while keeping facial exercises constant across groups. Inconsistent treatment parameters such as variations in PBM wavelength or ES intensity limit the comparability and replication of existing findings. Additionally, many studies rely on subjective outcome measures and lack structured timelines for assessing facial symmetry, neuromuscular coordination, or long-term recovery, including complications like synkinesis. These limitations highlight the need for a well-controlled comparative study to determine the more effective modality when paired with consistent facial rehabilitation exercises.",[27],[111,112,113],"Photobiomodulation","Electrical Muscle Stimulation","Facial Exercises","2025-11-24",{"date":116,"type":32},"2025-12-05",{"date":118,"type":21},"2025-11-25",{"date":120,"type":21},"2026-05-25",{"name":122,"class":39},"Lahore University of Biological and Applied Sciences",{"id":124,"slug":125,"hasResults":11,"nctId":126,"briefTitle":127,"officialTitle":128,"acronym":129,"eligibilityCriteria":130,"healthyVolunteers":11,"sex":16,"minAge":131,"maxAge":132,"enrollmentInfo":133,"targetDuration":4,"studyType":22,"phases":135,"briefSummary":136,"conditions":137,"keywords":141,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":144,"lastUpdatePostDateStruct":145,"startDateStruct":147,"completionDateStruct":149,"leadSponsor":151,"locationsCount":69},"100557759","safety-and-effectiveness-of-the-blinker-system-in-participants-with-facial-nerve-palsy-100557759","NCT06542289","Safety and Effectiveness of the BlinkER System in Participants With Facial Nerve Palsy","Single-Arm, Multicenter Study to Evaluate the Safety and Effectiveness of the BlinkER System in Participants With Facial Nerve Palsy","Paralysis","Inclusion Criteria:\n\n22 years of age or older\n\n* Unilateral facial palsy due to any of the following: Bell's palsy, Ramsay Hunt syndrome, malignant or benign tumor resection, Lyme disease, cerebrovascular accident (hemorrhagic or ischemic), or trauma\n* A deficit in eye closure during blinking, defined as a mean blink score ≤2.0 in the study eye on the scale by Mäkelä, et al, as graded by the investigator.\n* Willing and able to comply with the study procedures and follow-up\n* Willing and able to provide informed consent\n* English, Spanish, or Hebrew, Arabic -speaking\n* In a trial with the BlinkER System, the device produces blinks sufficient to cover the pupil in the study eye, defined as a mean grade ≥ 3.0 on the Mäkelä scale, as graded by the investigator.\n* Participant successfully completes BlinkER System training and certification\n\nExclusion Criteria:\n\n* Bilateral facial paralysis (for example Parkinson's Disease)\n* History of prior intervention that is providing closure of the eyelids (e.g., facial reanimation, complete tarsorrhaphy surgery, etc.)\n* Has an implanted eyelid weight in the study eyelid.\n* History of diabetic neuropathy, unstable cardiovascular disease, neurologic disease causing severe cognitive or motor impairment, severe immunological deficiency, or malignant diseases that are not in remission\n* Signs of corneal infection, severe ocular surface inflammation, or significant periorbital skin inflammation\u002Finfection\n* Suspected or diagnosed epilepsy.\n* Cancerous lesions in the area where the BlinkER system electrodes will be applied.\n* Cardiac demand pacemaker, implanted defibrillator or other implanted electronic device\n* Cornea or iris abnormalities that preclude visualization of the pupil\n* Cranial nerve V palsy or neurotrophic keratitis\n* Synkinesis that results in eyelid closure\n* Known allergy to any of the patient-contacting materials of the BlinkeER electrode (i.e. polyethylene (PET) film tape or hydrogel)\n* Participants who are pregnant or nursing.\n* Participation in another ophthalmic clinical trial within one year prior to enrollment. Participant must also be willing to refrain from another ophthalmic study for the duration of the study.\n* Co-existing condition, either ocular or non-ocular that, in the judgement of the investigator could affect the safety or effectiveness of treatment or the compliance of the participant to the protocol.","22 Years","120 Years",{"count":134,"type":21},80,[24],"Prospective, single-arm, multicenter, single-masked, pivotal study to Evaluate the Safety and Effectiveness of the Blinker system in Participants with Facial Nerve Palsy.",[27,138,139,140],"Ramsay Hunt Syndrome","Lyme Disease","Facial Palsy",[142,143],"BlinkER System","BlinkER","2025-06-08",{"date":146,"type":32},"2025-06-10",{"date":148,"type":21},"2025-10-01",{"date":150,"type":21},"2026-11-30",{"name":152,"class":153},"Neurotrigger Ltd","INDUSTRY"]