[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"benign-paroxysmal-positional-vertigo\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:benign-paroxysmal-positional-vertigo":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,52,77,106,139],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":34,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":41,"lastUpdatePostDateStruct":42,"startDateStruct":45,"completionDateStruct":47,"leadSponsor":49,"locationsCount":4},"100505635","clinical-trial-of-vit-d-and-calcium-for-recurrent-bppv-100505635",false,"NCT05863949","Clinical Trial of Vit D and Calcium for Recurrent BPPV","STOP Vertigo: Supplementation of Vitamin D for Termination of Recurrences From Benign Paroxysmal Positional Vertigo","Inclusion Criteria:\n\n* Age 18 years or older\n* 2 or more distinct episodes of benign paroxysmal positional vertigo within a 12-month period on history\n* At least 1 episode diagnosed based on physical examination by trained study personnel, meeting the diagnostic criteria of the Bárány Society\n* Episodes separated in time, with a minimum of 1 week symptom-free between episodes\n* Serum evidence of Vitamin D deficiency, as evidenced by 25-hydroxy vitamin D level of \\\u003C75 nmol\u002FL (\\\u003C30 ng\u002FmL)48\n* Subject able to provide informed consent to participate in the study\n\nExclusion Criteria:\n\nPotential subjects will be excluded if they\n\n* have another identifiable cause of vertigo identified on history or physical examination\n* have a history of allergy or medically significant adverse reaction to vitamin D or calcium carbonate\n* have a chronic medical disorder which is a contraindication to vitamin D or calcium carbonate supplementation, including uncontrolled hyperparathyroidism, nephrolithiasis, or GI malabsorption disorders\n* are on loop diuretic agents or thiazides\n* have a contraindication to routine bloodwork for study purposes, including being hospitalized with a critical illness, cellulitis at blood draw sites, or presence of vascular grafts.","ALL","18 Years",{"count":19,"type":20},860,"ESTIMATED","INTERVENTIONAL",[23],"NA","Randomized double blind placebo controlled trial of vitamin D supplements, with or without calcium supplementation, versus placebo in reduction of recurrences in BPPV.",[26,27,28,29,30,31,32,33],"BPPV","Benign Paroxysmal Positional Vertigo","Vertigo","Vertigo, Peripheral","Dizziness","Dizziness; Epidemic","Vitamin D Deficiency","Calcium Deficiency",[35,36,37,38,39],"bppv","benign paroxysmal positional vertigo","vertigo","dizziness","vitamin D","NOT_YET_RECRUITING","2025-06-20",{"date":43,"type":44},"2025-06-25","ACTUAL",{"date":46,"type":20},"2025-08",{"date":48,"type":20},"2026-09",{"name":50,"class":51},"Ottawa Hospital Research Institute","OTHER",{"id":53,"slug":54,"hasResults":11,"nctId":55,"briefTitle":56,"officialTitle":56,"acronym":4,"eligibilityCriteria":57,"healthyVolunteers":11,"sex":16,"minAge":58,"maxAge":59,"enrollmentInfo":60,"targetDuration":4,"studyType":21,"phases":62,"briefSummary":63,"conditions":64,"keywords":4,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":76},"100572865","effect-of-wii-fit-training-in-comparison-to-vestibular-rehabilitation-training-on-balance-in-patients-with-benign-paroxysmal-postional-vertigo-100572865","NCT06738823","Effect of Wii Fit Training in Comparison to Vestibular Rehabilitation Training on Balance in Patients With Benign Paroxysmal Postional Vertigo","Inclusion Criteria:\n\n* Patients diagnosed with benign paroxysmal positional vertigo.\n* Aged 30-60 years.\n* Ability to stand and walk independently.\n* Male and Female\n* Positive Dix Hallpike Test\n* DHI Scale: 36-42 (moderate Handicap)\n\nExclusion Criteria:\n\n* patients with history of vestibular surgery or cochlear implantation.\n* Patients with history of seizures or epilepsy.\n* patients with a pacemaker or implantable cardioverter-defibrillator(ICD).\n* Patients with history of severe head injury or concussion within the past year.\n* No other vestibular disorders or conditions that may affect balance.","30 Years","60 Years",{"count":61,"type":20},38,[23],"THIS STUDY IS A RANDOMIZED CONTROL TRIAL AND THE PURPOSE OF THE STUDY IS TO DETERMINE THE EFFECT OF WIIFIT TRAINING IN COMPARISON TO VESTIBULAR REHAB TRAINING ON BALANCE IN PATIENTS WITH BENIGN PAROXYSMAL POSITIONAL VERTIGO",[27,65,28],"Balance","RECRUITING","2024-12-13",{"date":69,"type":44},"2024-12-18",{"date":71,"type":44},"2024-07-20",{"date":73,"type":20},"2024-12-20",{"name":75,"class":51},"Foundation University Islamabad",1,{"id":78,"slug":79,"hasResults":11,"nctId":80,"briefTitle":81,"officialTitle":82,"acronym":4,"eligibilityCriteria":83,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":84,"enrollmentInfo":85,"targetDuration":4,"studyType":21,"phases":87,"briefSummary":88,"conditions":89,"keywords":91,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":100,"completionDateStruct":102,"leadSponsor":104,"locationsCount":76},"100571877","personalized-treatment-of-refractory-bppv-100571877","NCT06725966","Personalized Treatment of Refractory BPPV","Personalized Medicine to Treat Refractory Benign Paroxysmal Positional Vertigo, Through Computational Fluid Dynamics Analysis From Magnetic Resonance Image Reconstructions","Inclusion Criteria:\n\n* A. Diagnosed with BPPVp according to the Barany Society criteria:\n\n  1. Recurrent episodes of vertigo or positional instability, triggered by lying down or turning the head in the supine position.\n  2. Episodes lasting less than 1 minute.\n  3. Positional nystagmus observed after a latency period during the Dix-Hallpike test (DHT), with an upward vertical component and a torsional component (clockwise on the left side and counterclockwise on the right).\n  4. Symptoms not explained by any other cause.\n\n     AND\n* B. Refractory to otolith repositioning maneuvers (Epley and\u002For Semont maneuvers), with persistence of symptoms after three attempts.\n\nExclusion Criteria:\n\n* Cognitive impairment that prevents understanding of their condition and the required procedures.\n* Pathological conditions that hinder the execution of the maneuvers.\n* BPPV involving canals other than the posterior canal or bilateral posterior canal involvement.\n* Low educational level, which may impede understanding of the procedures and informed consent.","100 Years",{"count":86,"type":20},54,[23],"Background: Benign paroxysmal positional vertigo (BPPV) is the most common cause of vertigo, often effectively treated with standard canalith repositioning maneuvers (CRMs). However, approximately 12.5% of cases remain refractory, leading to persistent symptoms and increased healthcare burden. Variations in the anatomical orientation of the semicircular canals (SCCs) may explain the resistance to conventional maneuvers. This study explores a personalized medicine approach, utilizing computational fluid dynamics (CFD) based on MRI reconstructions to tailor CRMs with the help of mechanical rotation chair according to individual inner ear anatomy.\n\nMethods: The investigators conducted a randomized, multicenter, open-label study targeting patients with refractory posterior canal BPPV. Participants were allocated to either a control group (receiving repeated standard CRMs and Brandt-Daroff exercises) or an intervention group (receiving personalized CRMs based on CFD simulations derived from MRI scans). The intervention group's maneuvers were executed using a mechanical rotational chair designed for precise angulation. Primary outcomes included resolution of nystagmus and vertigo symptoms, while secondary outcomes measured the reduction in healthcare visits and improved quality of life (Dizziness Handicap Inventory score).",[27,90],"Personalized Medicine",[26,92,93,94,95,96],"Benign paroxysmal positional vertigo","Computational fluid dynamics","MRI","Canalith repositioning maneuvers","Mechanical rotation chair","2024-12-08",{"date":99,"type":44},"2024-12-10",{"date":101,"type":44},"2024-07-01",{"date":103,"type":20},"2026-12-31",{"name":105,"class":51},"Hospital Clinico Universitario de Santiago",{"id":107,"slug":108,"hasResults":11,"nctId":109,"briefTitle":110,"officialTitle":111,"acronym":112,"eligibilityCriteria":113,"healthyVolunteers":114,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":115,"targetDuration":4,"studyType":21,"phases":117,"briefSummary":118,"conditions":119,"keywords":126,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":131,"lastUpdatePostDateStruct":132,"startDateStruct":134,"completionDateStruct":136,"leadSponsor":137,"locationsCount":76},"100471855","effect-of-peripheral-vestibular-disease-location-on-outcomes-following-home-based-virtual-reality-vestibular-therapy-100471855","NCT05424302","Effect of Peripheral Vestibular Disease Location on Outcomes Following Home-based Virtual Reality Vestibular Therapy","Effect of Peripheral Vestibular Pathology Location on the Ability of Home-based Virtual Reality to Improve Symptoms of Peripheral Vestibular Disorders","VR-PVD-RCT","Inclusion Criteria:\n\n* Participants diagnosed with chronic (≥3 months) unilateral or bilateral peripheral vestibular disorders such as vestibular neuritis, labyrinthitis, Ramsay Hunt syndrome, ischemic lesion and trauma.\n* Diagnosis made using caloric testing (≥25% reduced vestibular response) and either ocular vestibular evoked myogenic potential (oVEMP) or cervical vestibular evoked myogenic potential (cVEMP) testing.\n* Participants prescribed vestibular rehabilitation\n* Participants ≥18 years of age\n* Access to an android or iOS smart phone\n\nExclusion Criteria:\n\n* Pregnant participants\n* Participant diagnosed with a central vestibular disorder",true,{"count":116,"type":20},50,[23],"This parallel-group randomized controlled trial aims to determine if the location of the lesion(s) in the vestibular system (unilateral versus bilateral, lateral semi-circular canal versus otolith) impacts the effectiveness of adjunct take-home head-mounted display (HMD) virtual reality (VR) therapy in improving patient symptomatology. Fifty patients meeting inclusion criteria will be recruited from the principal investigator's neurotology clinic. Baseline symptomatology questionnaires will be completed, followed by random allocation to virtual reality and control groups. Vestibular rehabilitation and virtual reality protocols will be adhered to for 4 to 8 weeks, followed by symptomatology questionnaires. Data analysis will be conducted to answer the study's objectives.",[120,27,121,122,123,124,125],"Peripheral Vestibular Disorder","Meniere Disease","Vestibular Neuritis","Vestibular Neuronitis","Labyrinthitis","Herpes Zoster Oticus",[127,128,129,92,130,122,123,124,125],"Virtual reality","Video games","Peripheral vestibular disorders","Meniere disease","2024-08-13",{"date":133,"type":44},"2024-08-15",{"date":135,"type":44},"2024-06-01",{"date":48,"type":20},{"name":138,"class":51},"University of British Columbia",{"id":140,"slug":141,"hasResults":11,"nctId":142,"briefTitle":143,"officialTitle":144,"acronym":4,"eligibilityCriteria":145,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":146,"enrollmentInfo":147,"targetDuration":4,"studyType":21,"phases":149,"briefSummary":150,"conditions":151,"keywords":4,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":152,"lastUpdatePostDateStruct":153,"startDateStruct":155,"completionDateStruct":157,"leadSponsor":159,"locationsCount":76},"100516171","head-acupuncture-treat-residual-symptoms-after-canalith-repositioning-procedure-for-bppv-100516171","NCT06001047","Head Acupuncture Treat Residual Symptoms After Canalith Repositioning Procedure for BPPV","Effect of Head Acupuncture on Residual Symptoms After Canalith Repositioning Procedure for Benign Paroxysmal Positional Vertigo: a Single-center Randomized Controlled Trial.","Inclusion Criteria:\n\n1. According to the diagnostic criteria and therapeutic efficacy evaluation for benign paroxysmal positional vertigo (BPPV) formulated by the Otolaryngology-Head and Neck Surgery Branch of the Chinese Medical Association, the patient was confirmed as having BPPV and the repositioning maneuver was successful.\n2. After the maneuver, the patient's clinical symptoms were relieved, with no sense of rotation or dizziness, but residual symptoms such as discomfort and unsteady gait persisted.\n3. There were no obvious communication barriers or visual impairments.\n4. The patient and their family members agreed to the treatment plan.\n\nExclusion Criteria:\n\n* Patients with other ear diseases, history of head trauma or surgery;\n\n  * Patients who are weak and unable to tolerate, pregnant women;\n\n    * Patients who have undergone vestibular rehabilitation training before this treatment; ④ Patients with joint diseases that affect balance and walking; ⑤ Patients with a history of brain organic diseases (such as tumors, stroke, cerebral hemorrhage) or severe neurological diseases; ⑥ Patients with incomplete data or who withdraw from treatment midway.","65 Years",{"count":148,"type":20},120,[23],"Benign paroxysmal positional vertigo (BPPV) is the most common peripheral vestibular disorder, and currently, manual repositioning techniques are often used for treatment. However, up to 30%-50% of patients may experience residual symptoms such as non-rotational dizziness, heaviness, instability, and emotional disturbances even after successful repositioning, which significantly impacts their daily functioning and quality of life. Electroacupuncture therapy has been proven to be an effective treatment for dizziness and has been applied to various vestibular disorder patients. However, the efficacy of electroacupuncture on the residual effects of successfully repositioned BPPV patients remains unclear. This study aims to explore the effectiveness of three regimens: electroacupuncture, betahistine in patients with residual symptoms after successful manual repositioning.",[27],"2023-12-08",{"date":154,"type":44},"2023-12-15",{"date":156,"type":44},"2023-11-01",{"date":158,"type":20},"2026-11-01",{"name":160,"class":161},"Xi'an No.3 Hospital","OTHER_GOV"]