[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"benign-prostatic-hyperplasia-with-outflow-obstruction\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:benign-prostatic-hyperplasia-with-outflow-obstruction":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,50,72,95,120],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":29,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100635459","feasibility-and-utility-of-a-prehabilitation-program-for-use-in-patients-with-benign-prostatic-hyperplasia-who-have-elected-to-undergo-holmium-laser-enucleation-of-the-prostate-holep-100635459",false,"NCT07552961","Feasibility and Utility of a Prehabilitation Program for Use in Patients With Benign Prostatic Hyperplasia Who Have Elected to Undergo Holmium Laser Enucleation of the Prostate (HoLEP).","Evaluating the Feasibility of a Comprehensive Prehabilitation Program for Use in Benign Prostatic Hyperplasia Patients Undergoing Holmium Laser Enucleation of the Prostate","Inclusion Criteria:\n\n1. Opting to undergo HoLEP procedure for the treatment of BPH\n2. Estimated prostate size (\\>60 ml)\n3. Have received permission to exercise from their primary care provider\n4. Access to a computer\u002F smartphone and internet access to complete associated questionnaires and access online educational resource\n\nExclusion Criteria:\n\n1\\. Other medical or psychiatric conditions which preclude the ability to participate in exercise or utilize the online education module","MALE","18 Years",{"count":19,"type":20},40,"ESTIMATED","INTERVENTIONAL",[23],"NA","Benign prostatic hyperplasia (BPH) is a debilitating condition which is highly prevalent in older males, up to 45% of those over the age of 45 are affected and 80% of those over the age of 70 are affected. While not all men with BPH experience problematic symptoms, many will experience lower urinary tract symptoms (LUTS) including difficulty passing urine, recurrent urinary tract infections, bladder stones, and hematuria. Holmium Laser Enucleation of the Prostate (HoLEP) is the gold standard in terms of surgical BPH management and is associated with a low risk for requiring repeat interventions. However, in the weeks following HoLEP procedures many men will experience transient urinary incontinence which can be distressing to patients.\n\nIn the setting of prostate cancer, exercise and mental health supports prior to surgery has been shown to improve incontinence and post-surgical recovery. This is often termed prehabilitation and consists of programming done in the months before surgery. The objective of this study is to assess the safety and feasibility of prehabilitation programming prior to HoLEP procedures for men with BPH.\n\nThe investigators will be randomizing 40 patients into 2 groups, one receiving standard of care interventions prior to their HoLEP surgery and one receiving at least 12 weeks of comprehensive prehabilitation programming including: pelvic floor physiotherapy, access to additional informational resources, and access to mental health supports including individual and couples counselling. In both groups the investigators will be collecting key demographics and clinical information from patients as well as assessing their urinary function through several questionnaires before prehabilitation, immediately before surgery, and up to 1 year after surgery.\n\nThe investigators hope to establish that prehabilitation is a safe and feasible option for these patients. Secondarily investigators hope to provide evidence that prehabilitation improves incontinence faster following HoLEP procedures and improves post-surgical recovery.",[26,27,28],"Benign Prostatic Hyperplasia","Benign Prostatic Hyperplasia With Lower Urinary Tract Symptoms","Benign Prostatic Hyperplasia With Outflow Obstruction",[30,31,32,33,34,35,36],"Prehabilitation","Exercise Therapy","Holmium Laser Enucleation of the Prostate","Mental Health Support","Safety","Feasibility","Incontinence","NOT_YET_RECRUITING","2026-04-22",{"date":40,"type":41},"2026-04-27","ACTUAL",{"date":43,"type":20},"2026-06-01",{"date":45,"type":20},"2027-11-01",{"name":47,"class":48},"University of Calgary","OTHER",1,{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":4,"eligibilityCriteria":56,"healthyVolunteers":11,"sex":16,"minAge":57,"maxAge":58,"enrollmentInfo":59,"targetDuration":4,"studyType":21,"phases":61,"briefSummary":55,"conditions":62,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":4},"100624496","short-term-outcomes-of-bipolar-prostate-resection-bpr-versus-diode-laser-ablation-versus-holmium-laser-enucleation-of-prostate-above-80-grams-with-minimum-one-year-follow-up-duration-100624496","NCT07410390","Short Term Outcomes Of Bipolar Prostate Resection (BPR) Versus Diode Laser Ablation Versus Holmium Laser Enucleation Of Prostate Above 80 Grams With Minimum One Year Follow Up Duration.","Randomized Controlled Study Comparing Safety, Efficacy and Short Term Outcomes Of Bipolar Prostate Resection (BPR) Versus Diode Laser Ablation Versus Holmium Laser Enucleation Of Prostate Above 80 Grams With Minimum One Year Follow Up Duration.","Inclusion Criteria:\n\n* Refractory LUTS secondary to benign prostatic hyperplasia (BPH)\n* Acute retention secondary to BPH who failed medical treatment\n* Prostate size above 80 gm in Pelvi-Abdominal ultrasound or Trans-Rectal ultrasound\n\nExclusion Criteria:\n\n* Suspected Neurogenic bladder.\n* Suspected Prostatic adenocarcinoma (either by digital rectal examination or high PSA level)\n* Urinary bladder carcinoma\n* urethral stricture. previous bladder, urethral or prostate surgery.\n* Bleeding tendency.\n* Uncontrolled bleeding disorders.","55 Years","85 Years",{"count":60,"type":20},105,[23],[28],"2026-02-08",{"date":65,"type":41},"2026-02-13",{"date":67,"type":20},"2026-02-20",{"date":69,"type":20},"2026-12-30",{"name":71,"class":48},"Ain Shams University",{"id":73,"slug":74,"hasResults":11,"nctId":75,"briefTitle":76,"officialTitle":76,"acronym":4,"eligibilityCriteria":77,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":78,"targetDuration":4,"studyType":21,"phases":80,"briefSummary":81,"conditions":82,"keywords":4,"overallStatus":85,"whyStopped":4,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":89,"completionDateStruct":91,"leadSponsor":93,"locationsCount":49},"100529890","preoperative-pelvic-floor-physical-therapy-to-minimize-stress-urinary-incontinence-after-holmium-laser-enucleation-of-the-prostate-100529890","NCT06179654","Preoperative Pelvic Floor Physical Therapy to Minimize Stress Urinary Incontinence After Holmium Laser Enucleation of the Prostate","Inclusion Criteria:\n\n1. Age: \\>=18 years of age\n2. Sex: male sex assigned at birth (needs to have a prostate)\n3. BMI: all BMI\n4. Ethnic background: all ethnicities\n5. Medical history: patients scheduled to undergo HoLEP for BPH\u002FLUTS and associated complications (i.e. gross hematuria, retention, etc.).\n\nExclusion Criteria:\n\n1. Neurological disorders: patients with a history of a neurologic disorder that could affect muscle function, neurogenic bladder, lumbosacral spine pathology\n2. Specific urologic conditions: patients with pre-operative indwelling catheter, urethral stricture greater than 1 centimeter in length or requiring dilation\u002Fincision, indwelling ureteral stent\n3. History of pelvic radiation: patient with prior pelvic radiation will be excluded\n4. Patients unable to give consent\n5. Non-English speaking patients given the need for multiple surveys and telephone follow-ups.",{"count":79,"type":20},36,[23],"The purpose of this study is to allow us to assess the effectiveness (or success) of starting pelvic floor physical therapy (i.e. exercises for your pelvic muscles) prior to HoLEP (holmium laser enucleation of the prostate) surgery for enlarged prostates in order to manage or prevent urinary incontinence (i.e. leaking) after surgery (i.e. post-operatively). Your pelvic floor refers to the muscles under your bladder along your pelvic bones that prevent you from leaking urine or stool. Traditionally, pelvic floor physical therapy is started after surgery and continued until urinary continence (i.e. no leaking of urine) is regained. We want to assess if beginning pelvic floor physical therapy prior to surgery (and continuing afterwards) reduces the time required to regain urinary continence following HoLEP.",[28,83,84],"Urinary Retention","Lower Urinary Tract Symptoms","RECRUITING","2025-08-20",{"date":88,"type":41},"2025-08-21",{"date":90,"type":41},"2023-11-29",{"date":92,"type":20},"2026-10-31",{"name":94,"class":48},"The Cleveland Clinic",{"id":96,"slug":97,"hasResults":11,"nctId":98,"briefTitle":99,"officialTitle":100,"acronym":4,"eligibilityCriteria":101,"healthyVolunteers":102,"sex":16,"minAge":103,"maxAge":104,"enrollmentInfo":105,"targetDuration":4,"studyType":21,"phases":107,"briefSummary":108,"conditions":109,"keywords":4,"overallStatus":85,"whyStopped":4,"lastUpdateSubmitDate":111,"lastUpdatePostDateStruct":112,"startDateStruct":114,"completionDateStruct":116,"leadSponsor":118,"locationsCount":49},"100536491","association-of-urine-bdnf-and-ngf-with-lower-urinary-system-parameters-100536491","NCT06265519","Association of Urine BDNF and NGF With Lower Urinary System Parameters","The Association of Urinary BDNF and NGF With Lower Urinary System Parameters in Patients With Bladder Outlet Obstruction Secondary to Benign Prostate Hyperplasia","Inclusion Criteria:\n\n1. 50-80 years Male\n2. Patients with bladder outlet obstruction secondary to benign prostate hyperplasia\n\nExclusion Criteria:\n\n1. Known neurological disease\n2. Diabetes\n3. Urinary tract infection\n4. Previous prostate surgery\n5. Spinal Cord Trauma\n\n7-Bladder stone 8-Cerebrovascular disease 9-Chronic Renal Failure 10-Ureteral stenosis",true,"50 Years","80 Years",{"count":106,"type":20},70,[23],"Histologically, BPH is a benign proliferative process involving both epithelial and stromal elements and is characterised by progressive enlargement of the prostate. Symptom complex including increased frequency of urination, sudden feeling of urge to urinate, nocturia, difficulty in urinating, feeling of incomplete emptying of the bladder, decreased flow rate and intermittent urination are called lower urinary tract symptoms (LUTS). The most important cause of LUTS in men is BPH. Many structural and physiological changes occur in the lower urinary system with bladder outlet obstruction. Detrusor hypertrophy and bladder hyperactivity may occur due to bladder outlet obstruction. Although the density of afferent and efferent nerves in the bladder decreases after urethral obstruction, enlargement of their trunks indicates that changes occur in these nerves. In addition, changes also occur in the neural pathways of the central nervous system following lower urinary tract obstruction. Nerve growth factor (NGF) and brain derived neurotropin factor (BDNF) are trophic proteins that act as retrograde messengers between peripheral effector tissue and the nerves that innervate it. In peripheral tissues, the source of NGF and BDNF is presumed to be the target tissues innervated by nerves. Smooth muscle cells, fibroblasts, astrocytes and other cells synthesise NGF and BDNF in culture medium. Many potential stimuli that increase NGF in the lower urinary system have been identified. These are denervation, inflammation and mechanical tension. This information has led to the idea that autonomic innervation changes in the bladder may be related with changing NGF levels. Altered afferent and adrenergic innervation in the obstructed bladder increases the possibility that NGF plays an important role in this neural growth because this type of nerves are highly sensitive to this neurotrophin.\n\nIn this study, we investigated NGF ve BDNF levels in urine samples obtained before surgery (Transurethral Prostate Resection, Prostate Enucleation with Holmium Laser and Prostate Enucleation with Thulium Fibre Laser) and after removal of obstruction in patients with bladder outlet obstruction secondary to benign prostatic enlargement using ELISA method, We aimed to determine the role of NGF and BDNF in bladder outlet obstruction and bladder changes secondary to obstruction by comparing with control patients without obstruction.",[28,110],"Lower Urinary Tract Obstructive Syndrome","2025-08-18",{"date":113,"type":41},"2025-08-22",{"date":115,"type":41},"2024-02-01",{"date":117,"type":20},"2026-07-01",{"name":119,"class":48},"Marmara University",{"id":121,"slug":122,"hasResults":11,"nctId":123,"briefTitle":124,"officialTitle":125,"acronym":126,"eligibilityCriteria":127,"healthyVolunteers":11,"sex":16,"minAge":103,"maxAge":104,"enrollmentInfo":128,"targetDuration":4,"studyType":21,"phases":130,"briefSummary":131,"conditions":132,"keywords":135,"overallStatus":85,"whyStopped":4,"lastUpdateSubmitDate":139,"lastUpdatePostDateStruct":140,"startDateStruct":142,"completionDateStruct":144,"leadSponsor":146,"locationsCount":49},"100591670","bipolar-resection-vs-enucleation-of-prostate-100591670","NCT06983444","Bipolar Resection vs Enucleation of Prostate","Bipolar Trans Urethral Resection of the Prostate (TURP) Versus Bipolar Enucleation of the Prostate in Treatment of Benign Prostatic Hyperplasia (BPH): A Prospective Randomized Comparative Clinical Study","TURP vs BiTUEP","Inclusion Criteria:\n\n1. Patients with lower urinary tract symptoms (LUTS) due to BPH.\n2. Patients with international prostate score system (IPSS) more than 8.\n3. Patients with maximal urinary flow rate (Qmax) less than 10ml\u002Fsecond.\n4. Patients with Prostatic volume (60 - 100 gm).\n5. Patient with indication for surgical intervention.\n6. Patient age (50-80 years old)\n\nExclusion Criteria:\n\n1. Prostatic cancer.\n2. Bladder cancer.\n3. Urethral stricture.\n4. Neurogenic bladder.",{"count":129,"type":20},100,[23],"The aim of this study is to evaluate efficacy and safety of transurethral resection of the prostate and bipolar enucleation of the prostate.",[133,28,134,27],"Benign Prostatic Hyperplasia (BPH) Requiring Surgical Resection","Benign Prostatic Hyperplasia With Symptomatic Lower Urinary Tract Symptoms",[136,137,138],"TURP","TUEP","BPH","2025-05-17",{"date":141,"type":41},"2025-05-21",{"date":143,"type":20},"2025-06-01",{"date":145,"type":20},"2026-07",{"name":147,"class":48},"South Valley University"]