[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"beta-cell-function\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:beta-cell-function":41},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":4,"briefSummary":21,"conditions":22,"keywords":25,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":5},"100638518","function-of-beta-cells-in-early-onset-diabetes-mellitus-100638518",false,"NCT07574138","Function of Beta Cells in Early-onset Diabetes Mellitus","Comparison of Beta Cell Functional Changes in Patients With Early-onset Type 2 Diabetes Mellitus and Those With Typical Onset","Inclusion Criteria:\n\n* The patient is diagnosed with Type 2 Diabetes Mellitus according to the ADA 2024 criteria (Fasting Glucose ≥ 126 mg\u002Fdl, or Glucose after 2 hours of an Oral Glucose Tolerance Test ≥ 200 mg\u002Fdl, or HbA1C ≥ 6.5%, or with typical symptoms accompanied by any Glucose ≥ 200 mg\u002Fdl).\n* The duration of Type 2 Diabetes Mellitus does not exceed 10 years.\n* Classification by age of onset: Early onset group (\\\u003C 40 years) and typical onset group (≥ 40 years).\n* At least 6 months without the need for insulin and no recorded episodes of diabetic ketoacidosis since the time of diagnosis.\n* For the early-onset group: Autoantibodies (Anti-GAD, ICA) are negative and fasting C-peptide levels are \\> 0.6 nmol\u002FL.\n* The patient consents to participate in the study and signs the informed consent document.\n\nExclusion Criteria:\n\n* Pregnant women or patients with acute illnesses at the time of assessment.\n* The patient has been diagnosed with or exhibits characteristics suggestive of Type 1 Diabetes Mellitus (such as a history of ketoacidosis, C-peptide \\\u003C 0.2 nmol\u002FL).\n* Secondary diabetes mellitus due to pancreatic disorders (pancreatitis, pancreatic tumors, pancreatic resection), due to medications (glucocorticoids), or due to other endocrine disorders (Cushing's syndrome, hyperthyroidism, acromegaly).\n* Severe renal failure with an estimated glomerular filtration rate (eGFR) \\\u003C 30 mL\u002Fmin\u002F1.73 m².\n* Use of medications that affect beta cell function or complications such as prolonged high-dose corticosteroids, immunosuppressive agents, or chemotherapy.\n* Not of Vietnamese ethnicity.\n* Non-compliance with treatment guidelines or failure to attend scheduled follow-up appointments.","ALL",{"count":18,"type":19},296,"ESTIMATED","OBSERVATIONAL","* Research objectives: Evaluate and compare the clinical and paraclinical characteristics, complications, as well as the changes in beta cell function and HbA1C levels between two patient groups over a one-year follow-up period.\n\n  +Research design: This is a prospective cohort study, monitoring patients at 3, 6, 9, and 12 months.\n* Study Population and Sample Size: The study is planned to be conducted on 296 Vietnamese patients (accounting for a 20% dropout rate) who are being examined at the University of Medicine and Pharmacy Hospital in Ho Chi Minh City.\n* Key Evaluation Indicators: The function of beta cells and insulin resistance status are measured through the indices of HOMA-B, HOMA-IR, fasting C-peptide levels, and HbA1C levels.\n* Time and location: The study will be conducted from February 2025 to February 2028 at the Endocrinology Clinic, University Medical Center Ho Chi Minh City.",[23,24],"Type 2 Diabetes Mellitus (T2DM)","Beta Cell Function",[26,27,28],"Early-onset type 2 diabetes mellitus","Beta cell function","C-peptide","RECRUITING","2026-05-01",{"date":32,"type":33},"2026-05-07","ACTUAL",{"date":35,"type":33},"2025-02-24",{"date":37,"type":19},"2028-02",{"name":39,"class":40},"University Medical Center Ho Chi Minh City (UMC)","OTHER","Beta-cell Function"]