[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"bilateral-knee-osteoarthritis\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:bilateral-knee-osteoarthritis":31},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,48],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":26,"conditions":27,"keywords":32,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100053870","phase-1-contralateral-corticosteroid-injection-in-total-knee-arthroplasty-100053870",false,"NCT06809998","COntralateral CorticoSTeroid Injection in Total Knee Arthroplasty","COSTI: COntralateral CorticoSTeroid Injection in Total Knee Arthroplasty - A Triple Blinded, Randomized Controlled Trial Pilot Study","COSTI","Inclusion Criteria:\n\n* Patients 18 years of age and older\n* Primary osteoarthritis diagnosis with indication for primary elective unilateral TKA\n* No previous contralateral knee injections (steroids\u002Fbiologics) within one year of study\n* Not scheduled for bilateral TKA or a subsequent staged contralateral TKA within the next six months\n* No previous or active infection or trauma (osseous\u002Fligamentous\u002Fextensor mechanism) on the contralateral knee\n* Contralateral knee pain \\& symptoms - defined as a VAS of \\>4\u002F10 at initial pre-op visit\n* Contralateral knee OA quantified as: Kellgren and Lawrence grade \\>2-4\n\n  * Assessed by PI (AK) who will not be contributing any patients to the study through examination of blinded knee radiographs (3 views: AP\u002Flateral\u002FSunrise)\n* Patient is able to read and understand English and provide informed consent to participation in the study\n\nExclusion Criteria:\n\n* Other aetiologies of OA that warrants TKA (inflammatory or post traumatic arthritis)\n* Cognitive impairment (dementia, Alzheimer's, uncontrolled delirium) which will prevent patients from completing primary outcome measure or comply with follow-up requirements\n* Previous TKA or ORIF or nailing on either knee\n* Previous or active knee infection or extensor mechanism disruption\n* Previous arthroscopy on either knee\n* Medical contraindication to elective TKA surgery","ALL","18 Years",{"count":20,"type":21},60,"ESTIMATED","INTERVENTIONAL",[24,25],"PHASE1","PHASE2","Through a triple-blinded randomized control trial, the primary purpose of this pilot study is to assess the efficacy of administering peri-operative contralateral corticosteroid injection in patients undergoing TKA. The secondary outcome was to assess the effect of contralateral corticosteroid injection on pain and functional outcomes of patients undergoing TKA.",[28,29,30,31],"Total Knee Anthroplasty","Osteoarthritis(Primary)","Osteoarthritis (OA) of the Knee","Bilateral Knee Osteoarthritis",[15,33,34],"Total Knee Arthroplasty","Corticosteroid Injection","RECRUITING","2026-07-09",{"date":38,"type":39},"2026-07-13","ACTUAL",{"date":41,"type":39},"2025-01-24",{"date":43,"type":21},"2027-08-30",{"name":45,"class":46},"Unity Health Toronto","OTHER",1,{"id":49,"slug":4,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":50,"targetDuration":4,"studyType":22,"phases":51,"briefSummary":26,"conditions":52,"keywords":53,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":54,"lastUpdatePostDateStruct":55,"startDateStruct":57,"completionDateStruct":58,"leadSponsor":60,"locationsCount":47},"100578338",{"count":20,"type":21},[24,25],[28,29,30,31],[15,33,34],"2026-04-29",{"date":56,"type":39},"2026-05-01",{"date":41,"type":39},{"date":59,"type":21},"2027-07-30",{"name":45,"class":46}]