[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"bilateral-vestibular-deficiency\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:bilateral-vestibular-deficiency":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,60],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":35,"overallStatus":47,"whyStopped":4,"lastUpdateSubmitDate":48,"lastUpdatePostDateStruct":49,"startDateStruct":52,"completionDateStruct":54,"leadSponsor":56,"locationsCount":59},"100554583","long-term-outcomes-after-vestibular-implantation-100554583",false,"NCT06500975","Long Term Outcomes After Vestibular Implantation","Inclusion Criteria\n\n* Adults older than 22 years old who\n* have previously been enrolled in Johns Hopkins University Institutional Review Board protocol NA\\_00051349, IRB00335294 or IRB00346924 and\n* have previously been implanted with a vestibular implant under FDA IDE G150198","ALL","22 Years","90 Years",{"count":19,"type":20},32,"ESTIMATED","INTERVENTIONAL",[23],"NA","Although cochlear implants can restore hearing to individuals who have lost cochlear hair cell function, there is no widely available, adequately effective treatment for individuals suffering chronic imbalance, postural instability and unsteady vision due to bilateral vestibular hypofunction. Prior research focused on ototoxic cases has demonstrated that electrical stimulation of the vestibular nerve via a chronically implanted multichannel vestibular implant can partially restore vestibular reflexes that normally maintain steady posture and vision; improve performance on objective measures of postural stability and gait; and improve patient-reported disability and health-related quality of life. This single-arm open-label study extends that research to evaluate outcomes for up to 8 individuals with non-ototoxic bilateral vestibular hypofunction, yielding a total of fifteen adults (age 22-90 years at time of enrollment) divided as equally as possible between ototoxic and non-ototoxic cases.",[26,27,28,29,30,31,32,33,34],"Bilateral Vestibular Hypofunction","Bilateral Vestibular Deficiency","Bilateral Vestibulopathy","Gentamicin Ototoxicity","Aminoglycoside Toxicity","Vestibular Diseases","Sensation Disorders","Labyrinth Diseases","Other Disorders of Vestibular Function",[36,37,38,39,40,41,42,43,44,45,46],"Vestibular","Implant","Prosthesis","Labyrinth","Ototoxicity","Gentamicin","Oscillopsia","Disequilibrium","Dizziness","Vestibulopathy","Inner Ear","RECRUITING","2026-03-05",{"date":50,"type":51},"2026-03-09","ACTUAL",{"date":53,"type":51},"2024-12-01",{"date":55,"type":20},"2029-12",{"name":57,"class":58},"Johns Hopkins University","OTHER",1,{"id":61,"slug":62,"hasResults":11,"nctId":63,"briefTitle":64,"officialTitle":64,"acronym":4,"eligibilityCriteria":65,"healthyVolunteers":11,"sex":15,"minAge":66,"maxAge":17,"enrollmentInfo":67,"targetDuration":69,"studyType":70,"phases":4,"briefSummary":71,"conditions":72,"keywords":4,"overallStatus":47,"whyStopped":4,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":59},"100367949","correlation-of-radiological-lesions-with-vestibular-function-in-patients-with-bilateral-vestibulopathy-100367949","NCT04070937","Correlation of Radiological Lesions With Vestibular Function in Patients With Bilateral Vestibulopathy","Inclusion Criteria:\n\n* must meet the Barany criteria for bilateral vestibulopathy: bilaterally pathological horizontal angu- lar VOR gain \\\u003C0.6, measured by the video-HIT5 or scleral-coil technique and\u002For\n* reduced caloric response6 (sum of bither- mal max. peak SPV on each side \\\u003C6◦\u002Fsec7) and\u002For\n* reduced horizontal angular VOR gain \\\u003C0.1 upon sinusoidal stimulation on a rota- tory chair (0.1 Hz, Vmax = 50◦ \u002Fsec) and a phase lead \\>68 degrees (time constant \\\u003C5 sec).\n* must be 18 or older\n\nExclusion Criteria:\n\n* \\\u003C 18 y\n* does not meet Barany criteria for BV\n* contraindication for CT and MR imaging","18 Years",{"count":68,"type":20},40,"2 Years","OBSERVATIONAL","In 2014 radiologic lesions were detected at one or more semicircular canals using CT and MR imaging of temporal bone in subjects carrying the p.P51S mutation in COCH. These lesions are believed to present at more advanced stages of the hearing and vestibular deterioration. Since then, other authors have described similar lesions in advanced non-genetic hearing and vestibular impairment as well.\n\nThe purpose of this study is therefore to assess the radiologic investigation using CT and MR imaging of temporal bone to all subjects presenting with bilateral vestibulopathy, using the Barany criteria, compared to the p.P51S population.",[73,27,74,75],"Hearing Loss, Sensorineural","DFNA9","Radiology","2021-08-24",{"date":78,"type":51},"2021-08-25",{"date":80,"type":51},"2019-09-01",{"date":82,"type":20},"2026-10-30",{"name":84,"class":58},"Jessa Hospital"]