[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"binge-alcohol-consumption\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:binge-alcohol-consumption":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,50,82],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":30,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100625085","preliminary-trial-of-an-avatar-guided-digital-intervention-for-emerging-adults-100625085",false,"NCT07418047","Preliminary Trial of an Avatar Guided Digital Intervention for Emerging Adults","Randomized Controlled Feasibility Trial of an Avatar Guided Intervention for Young Adults Seen in the Emergency Department With Alcohol Use Problems and Suicidal Thoughts","EA-Avatar","Inclusion Criteria:\n\n* (1) emergency department admission for alcohol- or suicide-related reason since turning 18, OR treated for incidental suicide risk in the emergency department\n* (2) aged 18-29\n* (3) speak, read, and understand English\n* (4) binge drinking in the past month OR alcohol use problems (Alcohol Use Disorders Identification Test score \\> 5)\n* (5) active suicidal ideation in the past month\n* (6) owning and having access to a personal smartphone\n* (7) willingness to be randomized to an avatar guided intervention for alcohol use problems and suicidal thoughts OR a freely available suicide safety planning app\n* (8) for remote MyChart-based recruitment only, have MyChart activated\n\nExclusion Criteria:\n\n* (1) severe cognitive delay, active psychosis, or heavy intoxication that precludes research participation\n* (2) imminent safety risk and have been recently unsafe to themselves or others\n* (3) prisoner or are under arrest\n* (4) not interested or not willing to be randomized to receive the avatar-guided digital intervention or safety plan app\n* (5) under the care of a legal guardian","ALL","18 Years","29 Years",{"count":21,"type":22},60,"ESTIMATED","INTERVENTIONAL",[25],"NA","The goal of this clinical trial is to learn whether a novel digital avatar (virtual coach) support program can help emerging adults ages 18-29 who present to the emergency department with suicidal thoughts and alcohol misuse (EA-Avatar). The study also aims to learn whether people find the program easy to use and whether daily surveys and the study design are able to be completed by the majority of emerging adult participants.\n\nThe main questions this study aims to answer are:\n\n* Do participants use the digital program and find it helpful?\n* Is it possible for participants to complete daily surveys for twenty-eight days and follow-up surveys over twelve weeks?\n* Are there early signs that the program may help lower alcohol use and suicidal thoughts?\n\nResearchers will compare participants who receive the new digital avatar program plus supportive text messages to participants who receive a freely available suicide safety planning app to see if there are differences in use, engagement, and early signs of benefit.\n\nParticipants will:\n\n* Receive standard care from the emergency department\n* Be randomly put into one of two groups (EA-Avatar or a free suicide prevention app)\n* Depending on their group, use a new avatar-guided digital support program with text message reminders OR use a free suicide safety planning app\n* Complete surveys at the start of the study and again at four, eight, and twelve weeks\n* Complete short daily surveys for twenty-eight days",[28,29],"Binge Alcohol Consumption","Suicidal Ideation",[31,32,33,34,35,36],"suicidal ideation","binge drinking","emerging adults","feasibility","emergency department","digital health","RECRUITING","2026-05-14",{"date":40,"type":41},"2026-05-19","ACTUAL",{"date":43,"type":22},"2026-05-18",{"date":45,"type":22},"2026-08-31",{"name":47,"class":48},"University of Massachusetts, Worcester","OTHER",2,{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":56,"eligibilityCriteria":57,"healthyVolunteers":58,"sex":17,"minAge":18,"maxAge":59,"enrollmentInfo":60,"targetDuration":4,"studyType":23,"phases":62,"briefSummary":63,"conditions":64,"keywords":68,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":81},"100637977","acute-effects-of-jgermeister-with-energy-drinks-jgermbomb-100637977","NCT07588022","Acute Effects of Jägermeister With Energy Drinks (Jägermbomb)","Acute Effects of an Explosive Cocktail With Energy Drinks That is Trendy Among Young People, the Jägerbomb","JB","Inclusion Criteria:\n\n1. Men and women between 18-45 years old with a weight between 50-90 kg for men and between 55-80 kg for women, and a body mass index (BMI) between 19-28 kg\u002Fm2. Lower or higher weights or BMIs are allowed, in the opinion of the Principal Investigator or the collaborators designated by the Principal Investigator and that do not pose a risk to the subjects and do not interfere with the objectives of the study.\n2. Alcohol consumption in the form of occasional binge drinking (≥1 time\u002Fmonth), social alcohol consumption (≥10g\u002Fday distributed weekly) and experience in alcohol intoxication.\n3. Consumption ≥7 drinks with methylxanthines (coffee, tea, chocolate, cola, BE) per week and who have consumed ED on at least one occasion.\n4. Understand and agree to the trial procedures and sign an informed consent.\n5. History and physical examination that demonstrate no organic or psychiatric disorders.\n6. The ECG and general blood and urine tests performed before the test should be within normal limits. Minor or punctual variations from the limits of normality are allowed if, at the discretion of the Principal Investigator, taking into account the state of science, they are not of clinical significance, do not pose a risk to the subjects and do not interfere with the assessment of the product. These variations and their non-relevance will be justified in writing in a specific way.\n\nExclusion Criteria:\n\n1. Not meeting the inclusion criteria.\n2. History or clinical evidence of gastrointestinal, liver, renal or other disorders that may involve an alteration in the absorption, distribution, metabolism or excretion of the drug, or that are suggestive of gastrointestinal irritation by drugs.\n3. Current history of substance use disorder according to DSM-V (except nicotine). A previous history of mild substance use disorder (corresponding to substance abuse according to DSM-IV criteria) is admitted.\n4. History or clinical evidence of psychiatric disorders, alcoholism, abuse of drugs or other drugs or habitual consumption of psychoactive drugs.\n5. Have participated in clinical trials with drugs or nutraceuticals in the previous 12 weeks.\n\n5\\) Have suffered any organic disease or major surgery in the three months prior to the start of the study.\n\n6\\) Subjects who have an intolerance or have had serious adverse reactions to alcohol. The inclusion of subjects of oriental origin who do not have an intolerance to alcohol will be allowed.\n\n7\\) Have taken medication regularly in the month prior to the study sessions, with the exception of vitamins, herbal remedies, or dietary supplements that, in the judgment of the Principal Investigator or collaborators designated by the Principal Investigator, do not pose a risk to the subjects and do not interfere with the objectives of the study. Treatment with single doses of symptomatic medication in the week prior to study sessions will not be grounds for exclusion if it is assumed to have been completely eliminated on the day of the experimental session.\n\n8\\) Smokers of \\>5 cigarettes a day. 9) Consumption of more than 20 g of alcohol daily in women and more than 40 g in men.\n\n10\\) Consumers of more than 5 coffees, teas, colas, or other stimulant or xanthine beverages daily in the 3 months prior to the start of the study.\n\n11\\) Subjects who are not able to understand the nature of the trial and the procedures they are asked to follow.\n\n12\\) Subjects with positive serology for hepatitis B, C or HIV. 13) Women who are pregnant or breastfeeding, or who use hormonal contraceptives or do not use reliable contraceptive measures during the study (such as abstinence, intrauterine devices, barrier methods or with a vasectomized partner).\n\n14\\) Women with amenorrhea or premenstrual syndrome of severe intensity.",true,"45 Years",{"count":61,"type":22},24,[25],"The main objective of this study is to compare the acute effects of drinking Jägerbombs with drinking alcohol alone during a binge-drinking episode, which involves consuming a large amount of alcohol in a short period of time to become intoxicated. Secondary objectives are to assess whether Jägerbombs produce prototypical alcohol effects, increase stimulation and rewarding effects, affect coordination, time reaction and vision, change stress-related hormone responses, and cause hangover symptoms.",[65,66,28,67],"Alcohol Drinking","Healthy Adult Participants","Energy Drinks",[69,70,71,72],"Binge drinking","Jägerbomb","Alcohol","Psychomotor performance","2026-05-08",{"date":38,"type":41},{"date":76,"type":41},"2026-02-18",{"date":78,"type":22},"2027-06",{"name":80,"class":48},"Fundació Institut Germans Trias i Pujol",1,{"id":83,"slug":84,"hasResults":11,"nctId":85,"briefTitle":86,"officialTitle":87,"acronym":4,"eligibilityCriteria":88,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":89,"targetDuration":4,"studyType":23,"phases":91,"briefSummary":92,"conditions":93,"keywords":95,"overallStatus":100,"whyStopped":4,"lastUpdateSubmitDate":101,"lastUpdatePostDateStruct":102,"startDateStruct":104,"completionDateStruct":106,"leadSponsor":108,"locationsCount":4},"100607782","peer-led-intervention-to-reduce-alcohol-binge-drinking-among-university-students-in-romania-100607782","NCT07193030","Peer-Led Intervention To Reduce Alcohol Binge Drinking Among University Students In Romania","Peer-Led Intervention To Reduce Alcohol Binge Drinking Among University Students In Romania- A Pilot Study Of The Implementation Processes","Inclusion Criteria:\n\n* University students currently enrolled in full-time undergraduate or postgraduate programs at Babeș-Bolyai University in Romania\n* Able to provide informed consent\n* Willing to participate in an in-person session\n* Alcohol status: AUDIT-C scoring 3 or above in females, 4 or above in males\n\nExclusion Criteria:\n\n* Students currently receiving treatment for alcohol dependence or any other substance use disorder\n* Students with a diagnosed severe mental health condition that may impair participation\n* Participation in any similar alcohol reduction program in the past 6 months.\n* Abstinent from alcohol consumption.",{"count":90,"type":22},120,[25],"The goal of this clinical trial is to learn if a behavioural intervention to change binge drinking habits in university students in Romania is feasible. The main research question is:\n\nIs a peer-led Alcohol Brief Intervention feasible to be implemented in a Romanian University to reduce binge drinking among students?\n\nResearchers will compare brief intervention (counselling) to no intervention.\n\nStudent participants will:\n\n1. Receive brief counselling for 15-20 minutes by their peers who were trained.\n2. Report their alcohol consumption levels in three surveys conducted over three months.",[28,94],"Binge Drinking",[69,96,97,98,99],"Alcohol Brief Intervention","Behaviour change wheel","University students","Romania","NOT_YET_RECRUITING","2025-09-25",{"date":103,"type":41},"2025-10-01",{"date":105,"type":22},"2026-03-01",{"date":107,"type":22},"2026-10-30",{"name":109,"class":48},"International Agency for Research on Cancer"]