[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"binge-eating\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:binge-eating":31},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,16,0,[8,54,81,119,150,173,207,244,267,289,314,347,375,398,423,448],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":36,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":42,"lastUpdatePostDateStruct":43,"startDateStruct":46,"completionDateStruct":48,"leadSponsor":50,"locationsCount":53},"100053868","halo-trial-high-medium-and-low-intensity-psychotherapy-for-binge-eating-disorder-100053868",false,"NCT07698132","HALO-TRIAL: High, Medium And LOw Intensity Psychotherapy for Binge Eating Disorder","HALO","Inclusion Criteria:\n\n* Binge Eating Disorder according to DSM-5 criteria\n* 18-65 years of age\n* Fluent Danish speaker\n\nExclusion Criteria:\n\n* Concurrent psychotherapeutic treatment\n* Use of weight loss medications within the last month (i.e., GLP-1 receptor antagonists)\n* Suicidal ideation or suicidality\n* Psychosis or psychotic disorders\n* Mania or bipolar disorder\n* Drug misuse disorder\n* Alcohol misuse disorder\n* Cluster B personality disorders in the severe range (diagnosed)\n* Dosage of Antidepressants, Antipsychotics and Stimulants must be stable for at least 6 months","ALL","18 Years","65 Years",{"count":20,"type":21},256,"ESTIMATED","INTERVENTIONAL",[24],"NA","The HALO trial is designed as a four-armed, assessor-blinded, fidelity-monitored randomized clinical trial. The goal of this randomized controlled study is to investigate the effectiveness of four different psychotherapy programs and to determine which one is most effective in reducing the number of binge-eating episodes in people with the eating disorder Binge Eating Disorder (BED), by directly comparing three intensities of Cognitive Behavioral Therapy-Enhanced against a manualized treatment as usual.\n\nParticipants will be asked to complete a 21-weeks randomized intervention and participate in follow up assesments.",[27,28,29,30,31,32,33,34,35],"Binge Eating Disorder","Binge Eating Episodes","Binge Eating\u002FLoss of Control Eating","Binge Eating Disorders","Binge Eating","Binge Eating Behaviour","Binge Eating Disorder Associated With Obesity","Eating Disorder Binge","Eating Disorders",[27,35,37,38,39,40],"Cognitive Behavioral Therapy","Psychotherapy","Randomized Controlled Trial","Evidence-based Psychiatry","RECRUITING","2026-07-07",{"date":44,"type":45},"2026-07-13","ACTUAL",{"date":47,"type":45},"2024-06-10",{"date":49,"type":21},"2032-12",{"name":51,"class":52},"Herlev and Gentofte Hospital","OTHER",1,{"id":55,"slug":56,"hasResults":11,"nctId":57,"briefTitle":58,"officialTitle":59,"acronym":60,"eligibilityCriteria":61,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":62,"targetDuration":4,"studyType":22,"phases":64,"briefSummary":65,"conditions":66,"keywords":67,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":53},"100626464","cor-protocol-for-the-treatment-of-binge-eating-in-chilean-adults-cor-100626464","NCT07435974","COR Protocol for the Treatment of Binge Eating in Chilean Adults (COR)","A Pilot Study on the Feasibility and Acceptability of the COR (Body Compassion-Emotional Regulation-Conscious Reconnection With Eating) Protocol for Addressing Binge Eating in Chilean Adults","COR","Inclusion Criteria:\n\n* Adults aged 18 years or older.\n* Overweight or obesity, based on self-report.\n* At least three binge-eating episodes in the past 30 days, associated with psychological distress.\n* The presence of chronic medical conditions commonly associated with overweight or obesity (e.g., hypothyroidism, hyperthyroidism, dyslipidemia, hypertension, type 2 diabetes mellitus, or polycystic ovary syndrome) is permitted, provided that such conditions are medically stable.\n* If present, chronic medical conditions must be medically stable, defined as:\n* stable medical treatment for at least 12 weeks,\n* no recent changes in medication,\n* no acute clinical decompensation or recent major cardiovascular events,\n* at least one related medical follow-up visit in the past 12 months.\n* If present, psychopharmacological treatment must be stable, defined as no changes in medication type or dosage during the 12 weeks prior to enrollment.\n* Daily access to the internet and to a computer or smartphone that allows participation in online sessions and assessments.\n\nExclusion Criteria:\n\n* Current compensatory behaviors associated with binge eating, such as self-induced vomiting and\u002For regular use of laxatives, within the past 60 days.\n\n  * Pregnancy or breastfeeding at the time of the initial assessment.\n  * History of bariatric surgery.\n  * Active suicidal ideation\n  * Current symptoms consistent with severe mental disorders, such as psychotic disorders, bipolar disorder, complex post-traumatic stress disorder, or severe personality disorders, when associated with marked functional impairment or the need for specialized or higher-intensity clinical care.\n  * Current substance use pattern that, due to its severity or functional impact, requires specialized clinical treatment.\n  * Ongoing psychological and\u002For nutritional treatment at the time of enrollment, defined as regular sessions or an active treatment plan, regardless of treatment focus or therapeutic approach.\n  * Presence of active or medically unstable conditions, characterized by clinically significant symptoms, lack of medical follow-up, or recent changes in medication, that could interfere with participation in the intervention or substantially affect eating behavior or mood.\n  * Significant functional impairment that, in the clinical judgment of the research team, would limit the participant's ability to engage safely and consistently in the intervention.",{"count":63,"type":21},30,[24],"The goal of this clinical study is to learn whether a brief online psychological program called COR can be delivered in a feasible and acceptable way for adults who experience recurrent binge eating.\n\nThe main questions this study aims to answer are:\n\n* Is the COR program acceptable to participants, in terms of satisfaction, adherence, and dropout rates?\n* Is the COR program feasible to deliver online, including recruitment, retention, and completion of sessions and questionnaires?\n* Do participants show preliminary changes over time in binge eating-related distress and emotional well-being?\n\nParticipants in this study are adults who experience recurrent episodes of binge eating. They will take part in an individual online intervention that includes eight weekly sessions, a brief pre-session, and a follow-up session one month after the end of treatment.\n\nDuring the study, participants will:\n\n* Attend weekly online sessions focused on understanding binge eating, emotions, and the relationship with food and the body\n* Practice simple exercises to help manage emotional distress and food-related urges\n* Complete short questionnaires before, during, and after the intervention to describe their experiences\n\nThe information from this study will help researchers understand whether this type of intervention can be used in future, larger studies and in real-world clinical settings.",[27,31],[68,27,69,70,71],"Binge eating","Body compassion","Emotion regulation","Intuitive eating","2026-04-20",{"date":74,"type":45},"2026-04-22",{"date":76,"type":45},"2026-04-01",{"date":78,"type":21},"2026-07-30",{"name":80,"class":52},"Universidad Catolica de Temuco",{"id":82,"slug":83,"hasResults":11,"nctId":84,"briefTitle":85,"officialTitle":86,"acronym":87,"eligibilityCriteria":88,"healthyVolunteers":89,"sex":16,"minAge":90,"maxAge":91,"enrollmentInfo":92,"targetDuration":4,"studyType":22,"phases":94,"briefSummary":95,"conditions":96,"keywords":103,"overallStatus":108,"whyStopped":4,"lastUpdateSubmitDate":109,"lastUpdatePostDateStruct":110,"startDateStruct":112,"completionDateStruct":114,"leadSponsor":116,"locationsCount":118},"100616125","effectiveness-of-a-10-week-multicomponent-intervention-combined-with-parent-education-on-binge-eating-behavior-in-children-and-adolescents-100616125","NCT07301541","Effectiveness of a 10-week Multicomponent Intervention Combined With Parent Education on Binge Eating Behavior in Children and Adolescents","Effectiveness of a 10-week Multicomponent Intervention Combined With Parent Education on Binge Eating Behavior in Children and Adolescents: a Randomized Controlled Trial With Long-term Follow-up","STOB","Inclusion Criteria:\n\n* Attending the camp in Hobro or Fjordmark from January 2027 to December 2027\n* 7-14 years of age at recruitment\n* Participants must have written informed consent from parent\u002Fguardian before camp to participate\n* At least one parent\u002Fguardian submit written informed consent to participate in the study with their child\n\nExclusion Criteria:\n\n* A medical condition affecting dietary intake and\u002For eating behavior\n* Taking weight loss medication\n* The parent\u002Fguardian don't understand the written informed consent\n* Participant or parent\u002Fguardian are unwilling to or unable to comply with the study protocol and instructions given by the study staff.",true,"7 Years","14 Years",{"count":93,"type":21},200,[24],"The main purpose is to investigate the effectiveness of a 10-week multicomponent camp intervention to reduce BE behavior in children and adolescents and explore in a randomized controlled setting if a parent-based BED-intervention has any add-on effect, attenuating the development of BE behavior in this sample. The study will include an initial follow-up assessment scheduled 10-12 weeks after camp completion and plans for long-term follow-up assessments one, three and five years after inclusion.\n\nOverall, we hypothesize that the multicomponent camp intervention will effectively reduce BE behavior in children and adolescents. Furthermore, we hypothesize that participants whose parents are randomized to receive the parental BED intervention will show a lower prevalence of BE behavior one year after the camp intervention compared with children whose parents receive standard care.",[27,31,97,98,99,100,101,102],"Loss of Control Eating","Overweight , Obesity","Children","Childhood Obesity","Screening","BED",[68,104,105,99,106,107,102,101],"Binge eating disorder","Lifestyle intervention","Loss of control eating","Adolescents","NOT_YET_RECRUITING","2026-04-07",{"date":111,"type":45},"2026-04-13",{"date":113,"type":21},"2027-01",{"date":115,"type":21},"2036-01",{"name":117,"class":52},"University of Aarhus",2,{"id":120,"slug":121,"hasResults":11,"nctId":122,"briefTitle":123,"officialTitle":123,"acronym":124,"eligibilityCriteria":125,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":126,"targetDuration":4,"studyType":22,"phases":128,"briefSummary":129,"conditions":130,"keywords":134,"overallStatus":108,"whyStopped":4,"lastUpdateSubmitDate":141,"lastUpdatePostDateStruct":142,"startDateStruct":144,"completionDateStruct":146,"leadSponsor":148,"locationsCount":4},"100632798","sleep-optimization-to-aid-in-recovery-digital-program-100632798","NCT07518368","Sleep Optimization to Aid in Recovery Digital Program","SOARPilot","Inclusion Criteria:\n\n* 18 years or older,\n* Initiating treatment for an eating disorder (e.g., currently on a waitlist for eating disorder treatment, scheduled to start treatment, completed an intake, or started treatment within the past two weeks for an eating disorder),\n* Able to access the internet\n\nExclusion Criteria:\n\n* None",{"count":127,"type":21},154,[24],"The purpose of this pilot study is to evaluate the usability and feasibility of SOAR (Sleep Optimization to Aid Recovery), a brief and self-guided digital program designed to share evidence-based sleep hygiene information with individuals seeking treatment for an eating disorder. The SOAR program delivers well-established recommendations promoted by the National Sleep Foundation and other professional sleep health organizations. The purpose of this study is not to test a new treatment or intervention per se, but rather to examine how effectively this existing information can be delivered through a digital platform to people preparing for or engaged in eating disorder treatment. By providing these evidence-based strategies in a user-friendly and accessible format, SOAR aims to support healthy sleep habits that may enhance overall well-being and facilitate recovery.\n\nThe investigators will compare SOAR against a control condition, which would be no intervention (treatment-as-usual). Participants randomized to the control will receive access to SOAR after the follow-up period has ended, if they wish to use it.",[131,31,132,133],"Sleep Health","Disordered Eating","Sleep Disturbances",[135,136,68,137,138,139,140],"Eating disorders","Disordered eating","Sleep health","Sleep disturbances","waitlist","eating disorder treatment","2026-04-06",{"date":143,"type":45},"2026-04-08",{"date":145,"type":21},"2026-05",{"date":147,"type":21},"2028-03",{"name":149,"class":52},"University of Nevada, Las Vegas",{"id":151,"slug":152,"hasResults":11,"nctId":153,"briefTitle":154,"officialTitle":155,"acronym":4,"eligibilityCriteria":156,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":157,"enrollmentInfo":158,"targetDuration":4,"studyType":22,"phases":160,"briefSummary":162,"conditions":163,"keywords":4,"overallStatus":108,"whyStopped":4,"lastUpdateSubmitDate":164,"lastUpdatePostDateStruct":165,"startDateStruct":167,"completionDateStruct":169,"leadSponsor":171,"locationsCount":4},"100633006","early-phase-1-testing-an-intervention-for-college-students-with-food-insecurity-and-binge-eating-100633006","NCT07521072","Testing an Intervention for College Students With Food Insecurity and Binge Eating","Building an Intervention for College Students With Food Insecurity and Binge Eating","Inclusion Criteria:\n\n* college student status, ages 18-30 years, current food insecurity, current binge eating, and interest in changing binge eating behaviors. Food security status will be determined by 2-item the Hunger Vital Sign screening, which demonstrates high sensitivity and specificity in identifying individuals with food insecurity; scores must report mild or greater food insecurity to participate. Binge eating and related impairment will be evaluated by the Eating Disorder Diagnostic Scale and the Clinical Impairment Assessment, and the binge eating items from the Eating Disorder Examination interview. Eating behaviors must be consistent with a DSM-5-TR binge spectrum eating disorder diagnosis, whereby an individual reports binge eating episodes at minimum one time per week for the current month and at least two times per month for the prior two months, to participate. Participants will be permitted to report other mild level symptoms of psychopathology due to the high comorbidity between anxiety, depression, and binge eating among individuals with food insecurity.\n\nExclusion Criteria:\n\n* Severe levels of anxiety and depression symptoms.","30 Years",{"count":159,"type":21},10,[161],"EARLY_PHASE1","This study is being conducted to test a new intervention. We are interested in whether it is easy to use and complete and whether you find it helpful in reducing concerns about your eating.",[31],"2026-04-02",{"date":166,"type":45},"2026-04-09",{"date":168,"type":21},"2026-12-01",{"date":170,"type":21},"2028-05-01",{"name":172,"class":52},"Virginia Polytechnic Institute and State University",{"id":174,"slug":175,"hasResults":11,"nctId":176,"briefTitle":177,"officialTitle":178,"acronym":179,"eligibilityCriteria":180,"healthyVolunteers":11,"sex":16,"minAge":181,"maxAge":182,"enrollmentInfo":183,"targetDuration":4,"studyType":22,"phases":185,"briefSummary":186,"conditions":187,"keywords":191,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":198,"lastUpdatePostDateStruct":199,"startDateStruct":201,"completionDateStruct":203,"leadSponsor":205,"locationsCount":53},"100478383","early-phase-1-naltrexone-neuroimaging-in-teens-with-eating-disorders-100478383","NCT05509257","Naltrexone Neuroimaging in Teens With Eating Disorders","Development of a Pharmacodynamic Biomarker of Opioid Antagonism in Adolescents With Eating Disorders","NN-RCT","Inclusion Criteria:\n\n* Adolescents and young adults aged 13-21 years\n* Eating disorder diagnosis characterized by binge eating and\u002For purging (eg, Anorexia Nervosa-Binge\u002FPurge, Bulimia Nervosa, Binge Eating Disorder, Other Specified Feeding\u002FEating Disorder) using Diagnostic and Statistical Manual of Mental Disorders, 5th edition (DSM-V) criteria.\n* Stable medication regimen (no dose or drug changes in the past 4 weeks)\n* Participant and parent\u002Flegal guardian (if under 18 years) are willing and able to provide informed permission\u002Fassent\u002Fconsent for the study\n\nExclusion Criteria:\n\n* Pregnant (via UCG)\n* Prior hypersensitivity reaction to naltrexone (e.g., anaphylaxis)\n* Non-removable metal in the body that is magnetic resonance imaging incompatible\n* Current naltrexone use\n* Self-reported opioid use in the past 7 days\n* A language barrier (e.g., non-English speaking) for the participant that precludes communication and\u002For ability to complete all study-related requirements.","13 Years","21 Years",{"count":184,"type":21},60,[161],"Using a randomized, placebo-controlled, crossover study, this study will evaluate functional magnetic resonance imaging (fMRI) as a pharmacodynamic biomarker of opioid antagonism in adolescents with eating disorders. The hypothesis is that fMRI will be able to detect acute reward pathway modulation by naltrexone (an opioid antagonist) in pre-defined regions of interest (anterior cingulate cortex, nucleus accumbens, dorsolateral prefrontal cortex).",[35,31,188,189,190],"Purging (Eating Disorders)","Bulimia Nervosa","Anorexia Nervosa, Atypical",[192,193,194,195,196,197],"Pediatric","Adolescent","Eating Disorder","Neuroimaging","Naltrexone","Pharmacodynamic Biomarker","2025-11-20",{"date":200,"type":45},"2025-11-25",{"date":202,"type":45},"2022-09-17",{"date":204,"type":21},"2027-06",{"name":206,"class":52},"Children's Mercy Hospital Kansas City",{"id":208,"slug":209,"hasResults":11,"nctId":210,"briefTitle":211,"officialTitle":212,"acronym":213,"eligibilityCriteria":214,"healthyVolunteers":11,"sex":215,"minAge":17,"maxAge":4,"enrollmentInfo":216,"targetDuration":4,"studyType":22,"phases":218,"briefSummary":219,"conditions":220,"keywords":223,"overallStatus":108,"whyStopped":4,"lastUpdateSubmitDate":235,"lastUpdatePostDateStruct":236,"startDateStruct":238,"completionDateStruct":240,"leadSponsor":242,"locationsCount":53},"100609689","testing-shape-a-single-session-intervention-targeting-binge-eating-in-women-through-assessment-and-values-based-strategies-100609689","NCT07217847","Testing SHAPE: A Single-Session Intervention Targeting Binge Eating in Women Through Assessment and Values-Based Strategies","Testing a Single-session Consultation for Reducing Binge Eating","SHAPE","Inclusion Criteria:\n\n* ≥ 18 years old\n* Identify as cisgender female\n* self-reported BMI ≥ 18.5 kg\u002Fm²\n* Rate the extent to which their weight or shape influences how they feel about themselves as a \"4\" or higher on a 7-point Likert scale on screening measures\n* ≥1 binge eating episode every 2 weeks (i.e., ≥ six episodes over 3 months) at the time of screening\n\nExclusion Criteria:\n\n* \\\u003C 18 years old\n* Assigned male at birth\n* Gender identity different from biological sex indicated on birth certificate\n* Purging behaviors (i.e., self-induced vomiting, laxative misuse, or diuretic misuse) ≥ 1x\u002Fweek in the last 3 months at the time of screening.\n* Engaged in structured psychological therapy or counseling (defined as attending sessions \\> 1x\u002Fmonth in the past 3 months)\n* Prior participation in studies that include administration of the EDE interview at Ohio University (IRB-FY24-403, IRB-FY25-330, and IRB-21-F-14).","FEMALE",{"count":217,"type":21},56,[24],"The goal of this controlled trial is to learn whether a brief single-session intervention (SSI) can reduce binge eating symptoms by targeting overvaluation of weight\u002Fshape in women with recurrent binge eating.\n\nThe main questions it aims to answer are:\n\n* Does assessment alone reduce binge eating severity and overvaluation of weight\u002Fshape compared to a control group undergoing minimal assessment?\n* Does adding a values-based reflection and goal-setting component (the full SHAPE intervention) add benefits beyond the assessment alone?\n\nResearchers will compare three groups:\n\n1. assessment-only,\n2. full SHAPE intervention, and\n3. minimal assessment control to see if both active conditions outperform the control, and whether the full intervention adds any benefits beyond the assessment itself\n\nParticipants will:\n\n* Complete a semi-structured eating disorder assessment (Eating Disorder Examination)\n* Depending on assignment, also complete a values-based reflection and goal-setting exercise with psychoeducation\n* Complete follow-up assessments evaluating binge eating severity, overvaluation of weight\u002Fshape, clinical impairment, binge frequency, and related outcomes.",[31,32,29,221,222],"Body Image","Body Image Disturbance",[224,225,226,227,228,229,230,231,232,233,234],"single session","single-session consultation","single-session intervention","binge eating","disordered eating","binge-spectrum disorder","body image","body image concerns","weight\u002Fshape concerns","overvaluation","loss of control eating","2025-10-14",{"date":237,"type":45},"2025-10-20",{"date":239,"type":21},"2025-10",{"date":241,"type":21},"2027-05",{"name":243,"class":52},"Taylor Rezeppa",{"id":245,"slug":246,"hasResults":11,"nctId":247,"briefTitle":248,"officialTitle":249,"acronym":4,"eligibilityCriteria":250,"healthyVolunteers":89,"sex":215,"minAge":17,"maxAge":4,"enrollmentInfo":251,"targetDuration":4,"studyType":22,"phases":252,"briefSummary":253,"conditions":254,"keywords":4,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":258,"lastUpdatePostDateStruct":259,"startDateStruct":261,"completionDateStruct":263,"leadSponsor":265,"locationsCount":53},"100492573","treating-binge-eating-and-obesity-digitally-in-black-women-100492573","NCT05693896","Treating Binge Eating and Obesity Digitally in Black Women","Treating Binge Eating and Obesity Digitally in Black Women: A Feasibility Study","Inclusion Criteria:\n\n* Over 18 years of age,\n* BMI ≥ 30 kg\u002Fm\\^2,\n* have and regularly use a Bluetooth-enabled smartphone,\n* report at least one binge eating episode weekly,\n* work or live within 30 miles of Kannapolis, NC,\n* complete the screening questionnaire\n\nExclusion Criteria:\n\n* currently pregnant,\n* in substance abuse treatment,\n* involved in another weight reduction program,\n* have a history of anorexia,\n* are purging,\n* currently in treatment for eating difficulties,\n* are concurrent intravenous drug users\n* consume \\>4 alcoholic beverages\u002Fday",{"count":184,"type":21},[24],"More than 30% of Black women with obesity binge eat. Binge eating may increase the risk for the development of metabolic syndrome and binge-eating-disorder (BED), which is associated with severe obesity. Though several effective treatments for binge eating exist, Black women have not fared well. Not only has their inclusion in treatment trials been limited, but when participating, they are more likely to drop out, and\u002For lose less weight, compared to their White counterparts. Furthermore, treatment for binge eating is often not available in primary care and community-based settings places where Black women are more likely to receive treatment for their eating and weight-related concerns. Currently, there is scant intervention research to treat binge eating in Black women. With the highest rates of obesity (57%) nationally, Black women are in need of culturally-relevant treatments for binge eating and weight gain prevention. Given the established relationship between frequent binge eating and subsequent weight gain, addressing binge eating among Black women with obesity is imperative.",[31,255,256,257],"Binge-Eating Disorder","Weight Gain Prevention","Obesity","2025-08-20",{"date":260,"type":45},"2025-08-27",{"date":262,"type":45},"2025-01-15",{"date":264,"type":21},"2026-12",{"name":266,"class":52},"University of North Carolina, Chapel Hill",{"id":268,"slug":269,"hasResults":11,"nctId":270,"briefTitle":271,"officialTitle":272,"acronym":4,"eligibilityCriteria":273,"healthyVolunteers":89,"sex":215,"minAge":17,"maxAge":274,"enrollmentInfo":275,"targetDuration":4,"studyType":22,"phases":277,"briefSummary":278,"conditions":279,"keywords":4,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":281,"lastUpdatePostDateStruct":282,"startDateStruct":284,"completionDateStruct":286,"leadSponsor":288,"locationsCount":53},"100581279","preventing-type-2-diabetes-in-black-emergent-adult-100581279","NCT06848244","Preventing Type 2 Diabetes in Black Emergent Adult","Preventing Type 2 Diabetes in Black Emergent Adult Women At-Risk for Binge-Eating Disorder","Inclusion Criteria:\n\n* Black women\n* between 18-25 years of age\n* BMI ≥ 25 kg\u002Fm\\^2\n* At least one binge eating episode weekly\n* Prediabetic\n* Have access to a smartphone\n\nExclusion Criteria:\n\n* Have no internet access\n* Currently type 2 diabetic\n* Currently pregnant\n* Are in substance use treatment\n* Have received prior or planned bariatric surgery","25 Years",{"count":276,"type":21},100,[24],"Black Americans are disproportionately affected by diabetes, with nearly double the rates of type 2 diabetes mellitus (T2DM), compared to non-Hispanic White adults. Though numerous factors affect these disparities, one modifiable risk factor may be that of binge eating (BE), which increases risk for binge-eating disorder (BED), which is associated with severe obesity, and often precedes a T2DM diagnosis, beginning in childhood or adolescence. Nearly 30% of Black women with obesity report binge eating episodes. Furthermore, given that binge and overeating may disparately increase the odds of obesity in Black adults (15-fold increase vs. 6-fold increase in White adults), reducing this behavior will be critical to prevent continued disparities in T2DM diagnosis. Given that Black women have the highest rates of obesity in the nation (57%), report disparate rates of weight gain between young adulthood and mid adulthood, and report disparate rates of emotional eating in adolescence, which is a risk factor for BE, one pathway to reducing disparities in T2DM risk in Black women may be to reduce binge eating and prevent weight gain in emerging adulthood (ages 18-25).",[280,255,31,257],"Type 2 Diabetes Mellitus","2025-07-28",{"date":283,"type":45},"2025-07-30",{"date":285,"type":45},"2025-06-30",{"date":287,"type":21},"2030-12",{"name":266,"class":52},{"id":290,"slug":291,"hasResults":11,"nctId":292,"briefTitle":293,"officialTitle":294,"acronym":4,"eligibilityCriteria":295,"healthyVolunteers":89,"sex":16,"minAge":17,"maxAge":296,"enrollmentInfo":297,"targetDuration":4,"studyType":22,"phases":298,"briefSummary":299,"conditions":300,"keywords":302,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":306,"lastUpdatePostDateStruct":307,"startDateStruct":309,"completionDateStruct":311,"leadSponsor":313,"locationsCount":118},"100496199","improving-appetite-self-regulation-in-african-american-adults-with-type-2-diabetes-100496199","NCT05741125","Improving Appetite Self-Regulation in African American Adults With Type 2 Diabetes","Improving Appetite Self-Regulation in African American Adults With Type 2 Diabetes: A Digital Intervention","Inclusion Criteria:\n\nIndividuals are eligible if they\n\n* identify as a Non-Hispanic, AA\n* are over 18 years of age\n* have an A1c value \\> 7.5\n* have a working Smartphone\n* complete binge eating screening\n\nExclusion Criteria:\n\nIndividuals will be excluded if they:\n\n* have major end-organ type 2 diabetes mellitus complications\n* have a history of weight loss surgery\n* are currently pregnant\n* in substance use treatment or are involved in another weight reduction program.","75 Years",{"count":184,"type":21},[24],"The purpose of this 6-month randomized clinical trial is to examine the feasibility of recruitment, attendance, retention, program adherence, and satisfaction of a digital application designed, Centering Appetite to improve glucose scores (HbA1c) and binge eating in African American adults with type 2 diabetes. Intervention participants will receive type 2 diabetes education and web-based lessons on appetite self-regulation. Participants will also receive a Fitbit to monitor daily physical activity. The investigators will follow up with participants at six months.",[301,31],"Type 2 Diabetes",[303,301,304,305],"Bing Eating","African Americans","Digital","2025-06-13",{"date":308,"type":45},"2025-06-17",{"date":310,"type":45},"2025-01-22",{"date":312,"type":21},"2026-02-01",{"name":266,"class":52},{"id":315,"slug":316,"hasResults":11,"nctId":317,"briefTitle":318,"officialTitle":319,"acronym":4,"eligibilityCriteria":320,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":321,"targetDuration":4,"studyType":22,"phases":323,"briefSummary":324,"conditions":325,"keywords":327,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":338,"lastUpdatePostDateStruct":339,"startDateStruct":341,"completionDateStruct":343,"leadSponsor":345,"locationsCount":53},"100517015","enhanced-cue-exposure-therapy-for-negative-emotional-eating-100517015","NCT06012045","Enhanced Cue Exposure Therapy for Negative Emotional Eating","A Randomized Controlled Trial of Enhanced Cue Exposure Therapy for Negative Emotional Eating","Inclusion Criteria:\n\n* aged 18 or over\n* a score \\>3.25 on the emotional eating subscale of the Dutch Eating Behavioural Questionnaire lasting for three months or longer\n* confirmed to have, on average, two or more NEE episodes per week using ecological momentary assessments (EMAs)\n\nExclusion Criteria:\n\n* active suicidal intent or plan\n* psychiatric illnesses except mood disorders, anxiety disorders, and eating disorders because mood and anxiety disorders and symptoms are common in those with NEE\n* currently receiving psychotherapy, or adjusting to changing psychiatric medication\n* substance abuse\n* any conditions or circumstances that prevent the participant from receiving all treatment sessions",{"count":322,"type":21},138,[24],"The current study aims to evaluate the efficacy of Enhanced Cue Exposure Therapy (E-CET) in reducing negative emotional eating (NEE), compared to an active control intervention, behavioral lifestyle intervention (BLI), in a parallel-group, participant-blinded, randomized controlled trial. The secondary aim is to evaluate whether changes in conditioned stimulus-unconditioned stimulus (CS-US) expectancies mediate the changes in NEE.",[326,31],"Disordered Eating Behaviors",[328,329,330,331,332,333,334,335,336,337],"emotional eating","eating disorders","obesity","exposure and response prevention","behavioral therapy","randomized controlled trial","violation of expectancy","inhibitory learning","habituation","mechanism of change","2025-04-03",{"date":340,"type":45},"2025-04-06",{"date":342,"type":45},"2023-12-21",{"date":344,"type":21},"2026-03-02",{"name":346,"class":52},"The University of Hong Kong",{"id":348,"slug":349,"hasResults":11,"nctId":350,"briefTitle":351,"officialTitle":352,"acronym":353,"eligibilityCriteria":354,"healthyVolunteers":89,"sex":16,"minAge":17,"maxAge":355,"enrollmentInfo":356,"targetDuration":4,"studyType":22,"phases":358,"briefSummary":359,"conditions":360,"keywords":362,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":366,"lastUpdatePostDateStruct":367,"startDateStruct":369,"completionDateStruct":371,"leadSponsor":373,"locationsCount":53},"100566039","transcranial-magnetic-stimulation-and-inhibitory-control-training-to-reduce-binge-eating-brain-and-behavioral-changes-100566039","NCT06649994","Transcranial Magnetic Stimulation and Inhibitory Control Training to Reduce Binge Eating: Brain and Behavioral Changes","Transcranial Magnetic Stimulation and Inhibitory Control Training to Reduce Binge Eating: Brain and Behavioral Changes (BE-NEMOIC)","BE-NEMOIC","Inclusion Criteria:\n\n* BMI between 20 and 39.9\n* Age between 18 and 60 years\n* Two or more binge eating episodes in the past month (assessed with the Binge Eating Scale)\n* Proficiency in the Spanish language\n* Right lateral dominance to avoid differential effects due to cortical hemispheric specialization\n\nExclusion Criteria:\n\n* Traumatic, digestive, metabolic or systemic disorders that affect the central nervous system, autonomic or endocrine\n* Psychopathological disorders or presence of severe symptoms in the Depression Anxiety and Stress Scale-21 (DASS-21)\n* Eeating disorders other than Binge Eating Disorder, or severe or extreme Binge Eating Disorder (8 or more binges per week)\n* Contraindication for performing functional magnetic resonance imaging (pregnancy, metal implants, etc.) or iTBS (tinnitus, dizziness, surgical interventions, diseases or drugs that affect the central nervous system, etc.).","60 Years",{"count":357,"type":21},150,[24],"People with BE are characterized by high impulsivity, high levels of craving for high-calorie foods, deficits in inhibitory control, and maladaptive decision making. These characteristics are related, at brain level, to alterations in the activation of areas such as the dorsolateral prefrontal cortex (DLPFC) and ventromedial prefrontal cortex (vmPFC) among other brain areas and their connectivity. The investigators propose an intervention that seeks to target these issues. Thus, the present study aims to characterize the effects of neuromodulation with intermittent theta burst stimulation (iTBS) of the DLPFC or the vmPFC in combination with inhibitory control training to produce brain, cognitive and behavioral changes, and modify altered biological parameters in people with BE. Participants will be randomly allocated to one of three groups: 1) a group that will receive active iTBS of the DLPFC together with inhibitory control training with a food Go\u002FNoGo paradigm, and 2) a group that will receive active iTBS of the vmPFC together with inhibitory control training with a food Go\u002FNoGo paradigm, and 3) an active control group that will receive sham iTBS together with inhibitory control training with a food Go\u002FNoGo paradigm. The investigators hypothesized that neuromodulation with iTBS applied to DLPFC or vmPFC will modify the dynamics of different brain circuits associated with binge eating. Neuromodulation of the DLPFC or vmPFC in combination with inhibitory control training, will be associated with: (i) decreased appraisal of unhealthy foods, (ii) reduced food craving, (iii) improved eating behavior, (iv) modified brain connectivity and activation both at rest and linked to task performance with food stimuli, (v) a decrease in the frequency and intensity of binge eating, (vi) improved emotional symptoms and emotional eating (depression, anxiety, emotional regulation, emotional eating, reward-related eating, non-homeostatic eating), (vii) improved cognitive abilities (motor and cognitive inhibition, delay of gratification, impulsivity, working memory, cognitive flexibility and decision making), (viii) changes in biological parameters associated to the interventions (plasma and microbiota), and (ix) advantages in cost-effectiveness and cost-utility based on economic evaluation analyses.",[31,361],"Inhibition, Psychological",[227,363,364,365],"rTMS","inhibitory control","training","2025-03-24",{"date":368,"type":45},"2025-03-25",{"date":370,"type":45},"2024-04-29",{"date":372,"type":21},"2026-12-31",{"name":374,"class":52},"Raquel Vilar López",{"id":376,"slug":377,"hasResults":11,"nctId":378,"briefTitle":379,"officialTitle":380,"acronym":4,"eligibilityCriteria":381,"healthyVolunteers":89,"sex":16,"minAge":17,"maxAge":382,"enrollmentInfo":383,"targetDuration":4,"studyType":22,"phases":385,"briefSummary":386,"conditions":387,"keywords":4,"overallStatus":108,"whyStopped":4,"lastUpdateSubmitDate":389,"lastUpdatePostDateStruct":390,"startDateStruct":392,"completionDateStruct":394,"leadSponsor":396,"locationsCount":4},"100541149","brief-binge-eating-and-drinking-online-intervention-100541149","NCT06326099","Brief Binge Eating and Drinking Online Intervention","A Mobile-Based Intervention to Address Heavy Drinking and Binge Eating in College Students","Inclusion Criteria:\n\n* full time undergraduate student at the study site\n* between the ages of 18 and 24\n* ability to speak and read English\n* at least two occasions of binge drinking (5 or more drinks in a row for males, 4 (i.e., an objectively large amount of food with a self-reported loss of control) in the past 28 days\n* at least two occasions of binge eating (i.e., an objectively large amount of food with a self-reported loss of control)151 in the past 28 days\n* no receipt of mental health or substance use care in the past month.\n\nExclusion Criteria:\n\n* not meeting eligibility criteria","24 Years",{"count":384,"type":21},300,[24],"This pilot project targets both binge drinking and binge eating behavior in college students through a mobile-based online program that provides students with evidence-based intervention material designed to reduce the incidence of both behaviors and encourage students to seek more formal in-person counseling.",[31,388],"Binge Drinking","2025-03-05",{"date":391,"type":45},"2025-03-10",{"date":393,"type":21},"2025-05-01",{"date":395,"type":21},"2026-04-30",{"name":397,"class":52},"University of Southern California",{"id":399,"slug":400,"hasResults":11,"nctId":401,"briefTitle":402,"officialTitle":403,"acronym":4,"eligibilityCriteria":404,"healthyVolunteers":89,"sex":215,"minAge":17,"maxAge":355,"enrollmentInfo":405,"targetDuration":4,"studyType":22,"phases":407,"briefSummary":408,"conditions":409,"keywords":410,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":414,"lastUpdatePostDateStruct":415,"startDateStruct":417,"completionDateStruct":419,"leadSponsor":421,"locationsCount":53},"100568609","emote-a-smartphone-application-for-binge-eating-based-on-dbt-skills-100568609","NCT06683456","EMOTE: a Smartphone Application for Binge Eating Based on DBT Skills","EMOTE: a Smartphone Application for Binge Eating Based on DBT Skills: a Randomized Controlled Trial","Inclusion Criteria:\n\n* female;\n* aged 18 years or older;\n* self-report at least one binge eating episode over the past four weeks;\n* owned a smartphone;\n* fluent in Portuguese.\n\nExclusion Criteria:\n\n* attending psychotherapy (face-to-face or digital) or another clinical trial;\n* body mass index below 18.5;\n* self-report an average of eight or more episodes of binge eating or inappropriate compensatory behaviours per week;\n* being pregnant;\n* self-report bipolar disorder, psychotic disorder, substance abuse, suicidal ideation or borderline personality disorder.",{"count":406,"type":21},68,[24],"Binge eating, whether formally diagnosed or occurring at subthreshold levels, is associated with adverse health consequences and decreased quality of life.\n\nAccess to accessible, cost-effective interventions that effectively address binge eating episodes is critical for individuals with this condition, and smartphone applications have demonstrated promise in treating binge eating and related disorders.\n\nThis study aims to evaluate the efficacy of eMOTE, a novel smartphone application for binge eating based on Dialectical Behavior Therapy (DBT) skills. For this purpose, a randomized controlled trial will be conducted in which women who self-report binge eating episodes will be randomly assigned to the app intervention group or a waiting list group.",[31],[411,31,412,413],"DBT","Feeding and Eating Disorders","Application","2024-11-08",{"date":416,"type":45},"2024-11-12",{"date":418,"type":45},"2024-04-01",{"date":420,"type":21},"2025-03-15",{"name":422,"class":52},"Universidade do Porto",{"id":424,"slug":425,"hasResults":11,"nctId":426,"briefTitle":427,"officialTitle":428,"acronym":429,"eligibilityCriteria":430,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":431,"targetDuration":4,"studyType":22,"phases":432,"briefSummary":433,"conditions":434,"keywords":436,"overallStatus":108,"whyStopped":4,"lastUpdateSubmitDate":440,"lastUpdatePostDateStruct":441,"startDateStruct":443,"completionDateStruct":445,"leadSponsor":446,"locationsCount":4},"100554171","integrative-intervention-strategies-for-binge-eating-in-patients-with-overweight-or-obesity-100554171","NCT06495619","Integrative Intervention Strategies for Binge Eating in Patients With Overweight or Obesity","Effectiveness of Integrative Intervention Strategies for Binge Eating in Patients With Overweight or Obesity: A Multidisciplinary Approach","BE-side","Inclusion Criteria:(1) age 18-65 years; (2) BMI≥25 kg\u002Fm2; (3) ability to read and write in Italian; (4) Binge Eating Disorder (BED) or subthreshold BED status.\n\n\\-\n\nExclusion Criteria: (1) current treatment for BE with a registered psychologist; (2) severe psychiatric disorders; (4) cognitive impairment; (5) pregnancy; (6) severe medical comorbidity.\n\n\\-",{"count":276,"type":21},[24],"The main goal of the clinical trial is to compare the short- and long-term outcomes of three 12-week interventions among outpatients with overweight\u002Fobesity and binge eating (BE):\n\n1. treatment-as-usual for weight loss (TAU);\n2. combined TAU and guided self-help for improving eating behaviors (TAU+GSH);\n3. combined TAU, GSH, and biofeedback (TAU+GSH+BF). The primary outcomes will be self-reported reduction of days with objective BE episodes (OBEs).\n\nThe secondary outcomes will be impulsivity, emotion dysregulation, interoceptive awareness, distress, physiological correlates of arousal (skin conductance and heart rate variability), and inflammatory biomarkers.\n\nThe TAU+GSH arm is expected to be comparable to the TAU+GSH+BF arm in reducing the number of days with OBEs but is expected to be significantly less effective in improving secondary outcomes (impulsivity, emotional dysregulation, interoceptive awareness, distress, physiological inflammatory markers). The TAU arm is expected to show significant inferiority regarding the primary and secondary outcomes and cost-effectiveness compared to the TAU+GSH and TAU+GSH+BF conditions.",[31,435],"Overweight and Obesity",[31,437,257,438,439],"Overweight","Guided Self-Help","Biofeedback","2024-07-03",{"date":442,"type":45},"2024-07-11",{"date":444,"type":21},"2024-08-01",{"date":285,"type":21},{"name":447,"class":52},"G. d'Annunzio University",{"id":449,"slug":450,"hasResults":11,"nctId":451,"briefTitle":452,"officialTitle":453,"acronym":4,"eligibilityCriteria":454,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":455,"enrollmentInfo":456,"targetDuration":4,"studyType":22,"phases":457,"briefSummary":458,"conditions":459,"keywords":4,"overallStatus":108,"whyStopped":4,"lastUpdateSubmitDate":460,"lastUpdatePostDateStruct":461,"startDateStruct":463,"completionDateStruct":465,"leadSponsor":467,"locationsCount":4},"100550979","feasibility-of-a-digital-therapeutic-for-adults-with-binge-eating-and-obesity-100550979","NCT06454123","Feasibility of a Digital Therapeutic for Adults With Binge Eating and Obesity","A Feasibility Study of a Digital Therapeutic for Adults With Recurrent Binge Eating and Obesity","Inclusion Criteria:\n\n1. English speaking male or female patients, 18-70 years\n2. Patients with recurrent binge eating (≥12 episodes in 3 months) and obesity (BMI ≥30)\n3. Understand written and spoken English\n4. Own an iPhone with iOS 11 or higher, or Android with OS 8.1 or higher\n5. Willing and able to complete enrollment procedures\n6. Able to understand the nature of the study and provide written informed consent\n\nExclusion Criteria:\n\n1. Patients with active psychosis\n2. Patients who are acutely intoxicated at the time of enrollment\n3. Currently enrolled in other treatment studies for the symptoms and behaviors targeted\n4. Patients who are cognitively impaired\n5. Patients who, in the judgment of the investigator, would have an unfavorable risk\u002Fbenefit profile with respect to the digital therapeutic","70 Years",{"count":63,"type":21},[24],"The primary objective of this study is to test the feasibility of a digital therapeutic to address comorbid binge eating and obesity in adults.",[31,257],"2024-06-06",{"date":462,"type":45},"2024-06-12",{"date":464,"type":21},"2024-09",{"date":466,"type":21},"2025-06",{"name":468,"class":469},"Oui Therapeutics, Inc.","INDUSTRY"]