[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"biofilms\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:biofilms":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,40,64],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":28,"lastUpdatePostDateStruct":29,"startDateStruct":32,"completionDateStruct":34,"leadSponsor":36,"locationsCount":39},"100635000","biofilm-induced-antimicrobial-resistance-risk-eradication-in-critical-care-central-venous-catheters-100635000",false,"NCT07546994","Biofilm-induced Antimicrobial Resistance RIsk ERadication in Critical Care Central Venous Catheters","BARRIER","Inclusion Criteria:\n\n* Central venous catheters (conventional central venous lines, dialysis catheters, PICC lines) showing positive microbiological culture taken from adult patients in the critical care units (intensive care units, post-operative intensive care units and post-resuscitation intensive care units)\n* Patient consent is free, informed, and non-opposition, provided after delivery of an information letter and oral explanation.\n\nExclusion Criteria:\n\n* None","ALL","18 Years",{"count":19,"type":20},150,"ESTIMATED","OBSERVATIONAL","Central venous catheter (CVC) infections are a frequent and serious nosocomial complication in critical care, leading to increased morbidity, mortality, and costs. The pathophysiology of these infections relies on the formation of a biofilm, an organized microbial structure that confers exceptional tolerance to anti-infectives and the immune system. However, data concerning the characteristics of the in vivo biofilm (kinetics, composition, endo- vs. extraluminal organization) on central venous catheters in intensive care patients are very limited, hindering the development of effective and targeted prevention strategies.\n\nThe main aim of this study is to quantify the density and describe the spatial distribution (extra- and intraluminal compartments) of the biofilm on infected or colonized central venous catheters, prospectively collected from patients in the critical care units.",[24,25,26],"Catheter-Related Infections","Biofilms","Infection Prevention","NOT_YET_RECRUITING","2026-04-16",{"date":30,"type":31},"2026-04-23","ACTUAL",{"date":33,"type":20},"2026-04",{"date":35,"type":20},"2028-04",{"name":37,"class":38},"Centre Hospitalier Universitaire de Nīmes","OTHER",2,{"id":41,"slug":42,"hasResults":11,"nctId":43,"briefTitle":44,"officialTitle":44,"acronym":45,"eligibilityCriteria":46,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":47,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":49,"conditions":50,"keywords":4,"overallStatus":54,"whyStopped":4,"lastUpdateSubmitDate":55,"lastUpdatePostDateStruct":56,"startDateStruct":58,"completionDateStruct":60,"leadSponsor":62,"locationsCount":39},"100580538","structural-and-microbiological-characterization-of-arterial-catheter-biofilm-in-icus-patients-using-optical-coherence-tomography-100580538","NCT06838598","Structural and Microbiological Characterization of Arterial Catheter Biofilm in ICU's Patients Using Optical Coherence Tomography","OCT-BIO-KTA","Inclusion Criteria:\n\n* Patient or relative informed of the study and having declared their non-objection\n* Patient over 18 years old\n* Patient hospitalized in ICU with an arterial catheter\n\nExclusion Criteria:\n\n* Patient unable to express consent\n* Patient whose collection of the arterial catheter is impossible or for whom storage at 4°C is impossible\n* Patient with arterial catheter removed outside the usual procedure of the ICU\n* Patient admitted in ICU with an arterial catheter already in place",{"count":48,"type":20},60,"29.3% of bacteremias in intensive care units (ICU) are linked to vascular devices, including 7.7% to arterial catheters, with an influence on both morbility and mortality.\n\nIt is now accepted that biofilm as a role on bacterial development on inner surface of vascular devices but there is yet a lack of clinical relevant data documenting a causal relation between biofilm formation and bacteremias.\n\nThe investigators assume that a better structural and microbiological characterization of arterial catheter biofilm in ICU patients could help preventing bacteremias or have a more specific treatment when it appears.",[25,51,52,53],"Arterial Catheterization, Peripheral","Bacteremia","Tomography, Optical Coherence","RECRUITING","2026-03-16",{"date":57,"type":31},"2026-03-18",{"date":59,"type":31},"2024-06-03",{"date":61,"type":20},"2027-12",{"name":63,"class":38},"Centre Hospitalier William Morey - Chalon sur Saône",{"id":65,"slug":66,"hasResults":11,"nctId":67,"briefTitle":68,"officialTitle":69,"acronym":4,"eligibilityCriteria":70,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":71,"targetDuration":73,"studyType":21,"phases":4,"briefSummary":74,"conditions":75,"keywords":4,"overallStatus":54,"whyStopped":4,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":82,"completionDateStruct":84,"leadSponsor":86,"locationsCount":88},"100610516","biofilm-on-chest-drains-after-thoracic-surgery-clinical-impact-and-antibiotic-resistance-100610516","NCT07228598","Biofilm on Chest Drains After Thoracic Surgery: Clinical Impact and Antibiotic Resistance","Biofilm Formation on Thoracic Drains: Clinical Significance and Association With Antibiotic Resistance","Inclusion Criteria:\n\n* Age 18 years and older\n* Undergoing elective thoracic surgery requiring chest drain placement\n* Able and willing to provide written informed consent\n\nExclusion Criteria:\n\n* Presence of active infection prior to surgery\n* Emergency thoracic surgery\n* Immunosuppressed patients (e.g., neutropenia, advanced malignancy, organ transplantation)\n* Patients receiving systemic antibiotic therapy at the time of drain removal\n* Drainage for empyema or pre-existing pleural infection\n* Presence of extrathoracic infection focus\n* Refusal or inability to provide informed consent",{"count":72,"type":20},180,"30 Days","This prospective observational study aims to investigate the frequency and clinical significance of biofilm formation on thoracic chest drains used after thoracic surgery. Biofilms are structured bacterial communities that adhere to surfaces and can promote infection and antibiotic resistance. In this study, small samples from the tips of chest drains will be collected under sterile conditions at the time of drain removal and analyzed in the microbiology laboratory.\n\nThe main objectives are to evaluate the relationship between the duration of chest drain placement and the presence of biofilm, and to identify the antibiotic resistance profiles of microorganisms isolated from these biofilms. Secondary outcomes include the association between biofilm formation, postoperative infections (such as empyema or wound infection), and the length of hospital stay.\n\nThis study will be conducted at Ondokuz Mayıs University Faculty of Medicine, Department of Thoracic Surgery, in collaboration with the Department of Microbiology. The findings are expected to contribute to better understanding of optimal drain management and infection prevention strategies after thoracic surgery.",[25,76,77,78],"Thoracic Surgery","Postoperative Infection","Antibiotic Resistance, Bacterial","2025-11-16",{"date":81,"type":31},"2025-11-19",{"date":83,"type":31},"2025-10-01",{"date":85,"type":20},"2026-07-01",{"name":87,"class":38},"Caner İşevi, MD",1]