[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"biomarkers-of-b-vitamin-status-and-gut-microbiome-composition\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:biomarkers-of-b-vitamin-status-and-gut-microbiome-composition":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":40,"leadSponsor":42,"locationsCount":5},"100639993","effect-of-a-food-intervention-with-a-prebiotic-alone-or-combined-with-b-vitamins-on-gut-microbiota-diversity-inflammation-and-mental-health-outcomes-in-older-adults-gutfood-100639993",false,"NCT07592975","Effect of a Food Intervention With a Prebiotic Alone or Combined With B-vitamins on Gut Microbiota Diversity, Inflammation and Mental Health Outcomes in Older Adults (GutFood)","'GutFood' - Effect of a Food Intervention With a Prebiotic Alone or Combined With B-vitamins on Gut Microbiota Diversity, Inflammation and Mental Health Outcomes in Older Adults","Inclusion Criteria:\n\n* Community-dwelling\n* Non or low consumers (≤ 4 portions\u002Fweek) of foods\u002Fbeverages fortified with B-vitamins\n* Individuals with the capacity to provide informed consent\n\nExclusion Criteria:\n\n* B12 injection users\n* Using supplements containing the nutrients of interest (B-vitamins, inulin, probiotics)\n* Taking medications that interfere with B-vitamin metabolism\n* Currently taking antibiotics\n* GI disease (Crohn's, coeliac)\n* Serious chronic disease (e.g. cancer, liver disease)",true,"ALL","50 Years",{"count":20,"type":21},84,"ESTIMATED","INTERVENTIONAL",[24],"NA","Ageing is associated with changes in gut microbiota composition, increased inflammation, and a greater risk of poor mental health outcomes. Nutritional inadequacies, including low dietary fibre intake and suboptimal B-vitamin status, are common in older adults and may contribute to these age-related health issues. Research suggests that increasing dietary fibre intake, particularly through prebiotics such as inulin, may help to improve gut health. In addition, B-vitamins have been linked to both gut and mental health, although their combined effects with prebiotics are not well understood.\n\nWith the assistance of a food company, the investigators have developed a functional drink enriched with chicory inulin, alone or in combination with B-vitamins. Therefore, the investigators plan to conduct a 12-week randomised, double-blind, placebo-controlled trial to test the effect of this functional drink on gut health outcomes, nutritional status, inflammation, and mental health in adults aged 50 years and older.",[27],"Biomarkers of B-vitamin Status and Gut Microbiome Composition",[29,30,31,32,33],"Functional food","Healthy ageing","B-vitamin status","Gut microbes","Inulin","RECRUITING","2026-05-11",{"date":37,"type":38},"2026-05-18","ACTUAL",{"date":37,"type":21},{"date":41,"type":21},"2026-12",{"name":43,"class":44},"University of Ulster","OTHER"]