[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"bipolar-disorder-1\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:bipolar-disorder-1":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":40,"lastUpdatePostDateStruct":41,"startDateStruct":44,"completionDateStruct":46,"leadSponsor":48,"locationsCount":5},"100451370","exercise-based-program-for-rehabilitation-of-veterans-with-severe-mental-illness-100451370",false,"NCT05157620","Exercise-based Program for Rehabilitation of Veterans With Severe Mental Illness","ESHANTI","Inclusion Criteria:\n\n* Written informed consent;\n* age 18-70 years;\n* DSM-5 diagnosis of\n\n  * schizophrenia,\n  * schizoaffective disorder,\n  * bipolar 1 disorder,\n* DSM-5 diagnosis of schizophrenia, schizoaffective disorder, or bipolar 1 disorder including those with a co-morbid\n\n  * alcohol use disorder or substance use disorder;\n  * clinically stable;\n* clinical global impression-severity (CGI-S) scores mild to moderately ill\n\nExclusion Criteria:\n\n* Unable to provide written informed consent;\n* intellectual disability (i.e., severe enough to impact understanding of yoga-based exercises) based on chart or IQ\\\u003C80 on the Wechslet Abbreviated Scale of Intelligence-II (WASI-II);\n* disability or illness precluding yoga-based exercises or wellness lifestyle program, e.g.,\n\n  * current or recent angina (\\\u003C6 months),\n  * history of myocardial infarction in the past year (unless permission is obtained from the primary care physician),\n  * uncontrolled hypertension or hypotension;\n* neurological illness complicating diagnosis \u002F cognitive evaluation, e.g.,\n\n  * dementia,\n  * stroke or head injury;\n* physical problems that preclude training for yoga-based exercises \u002F wellness lifestyle program, e.g.,\n\n  * severely impaired vision;\n  * ongoing treatment that includes more than one hour per week of relaxation and mind-body based stress reduction strategies related to yoga","ALL","18 Years","70 Years",{"count":20,"type":21},112,"ESTIMATED","INTERVENTIONAL",[24],"NA","This is a hybrid1, effectiveness-implementation study of yoga-based exercises (YE) as an adjunctive tool for rehabilitation among persons with Severe Mental Illness (SMI). The two-arm randomized controlled trial will compare the efficacy of YE compared to the Wellness Lifestyle Program (WLP). Primary outcomes of the study will be self-report and performance-based measures of community functioning, defined in the investigators study as social, leisure, employment, and life skills functioning in the community. Secondary outcomes will include cognition and physical fitness measures.",[27,28,29],"Schizophrenia","Schizoaffective","Bipolar Disorder 1",[31,32,33,34,35,36,37,38],"schizophrenia","psychotic disorders","schizoaffective","bipolar disorder 1","exercise","yoga","community function","quality of life","RECRUITING","2026-06-29",{"date":42,"type":43},"2026-07-01","ACTUAL",{"date":45,"type":43},"2022-10-24",{"date":47,"type":21},"2026-12-31",{"name":49,"class":50},"VA Office of Research and Development","FED"]