[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"bipolar\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:bipolar":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,49,81,117,158],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":29,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100632204","transcranial-photobiomodulation-for-bipolar-depression-100632204",false,"NCT07510646","Transcranial Photobiomodulation for Bipolar Depression","A Pilot Clinical Trial for the Efficacy and Safety of Transcranial Photobiomodulation (tPBM) in Improving Symptoms of Bipolar Depression","Inclusion Criteria:\n\n* • Diagnosis of bipolar depression\n\n  * Montgomery-Asberg Depression Rating Scale (MADRS) of 24 or higher\n  * Capable of providing consent\n  * Currently inpatient or outpatient\n  * Ability to communicate in spoken and written English fluently enough to complete the required study assessments\n\nExclusion Criteria:\n\n* Currently in manic or mixed episode, as measured by Young Mania Rating Scale (YMRS) more than 8-10\n\n  * Currently psychotic\n  * Judged to be at serious and imminent suicidal risk\n  * Currently has alcohol or substance use disorder (meeting criteria in the past 1 months)\n  * Unstable medical conditions\n  * Inability to consent or to complete study procedures\n  * Changes in medications or use of augmentative devices and other interventions in the 4 weeks prior to the study\n  * Participation in other clinical research trials that may influence primary outcomes or adherence to the proposed study\n  * Current pregnancy or intention to become pregnant","ALL","18 Years",{"count":19,"type":20},40,"ESTIMATED","INTERVENTIONAL",[23],"NA","This study the effectiveness and safety of light therapy device targeted at the brain using a wearable device, the Vielight RX Gamma as a treatment for bipolar depression. Up to forty patients with bipolar disorder will be enrolled into the study and will either receive active treatment with the Vielight RX Gamma or sham (inactive device). They will be administered the devices in clinic 5days\u002Fweek for 6 weeks. Changes in disease symptoms, cognitive function, pain, quality of life and rest EEG changes will be assessed.",[26,27,28],"Bipolar","Bipolar Disorder (BD)","Bipolar Disorder Depression",[30,31,32,33,34,35],"photobiomodulation","PBM","Vielight","bipolar disorder","bipolar depression","light therapy","NOT_YET_RECRUITING","2026-04-01",{"date":39,"type":40},"2026-04-03","ACTUAL",{"date":42,"type":20},"2026-07-01",{"date":44,"type":20},"2027-07-01",{"name":46,"class":47},"Vielight Inc.","INDUSTRY",1,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":55,"eligibilityCriteria":56,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":57,"targetDuration":4,"studyType":21,"phases":58,"briefSummary":59,"conditions":60,"keywords":64,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":78,"locationsCount":48},"100620556","changing-lives-and-changing-outcomes-9-at-worcester-recovery-center-and-hospital-100620556","NCT07359157","Changing Lives and Changing Outcomes-9 at Worcester Recovery Center and Hospital","Changing Lives and Changing Outcomes-9 at Worcester Recovery Center and Hospital: Implementing and Evaluating A Mental Illness and Criminal Risk Focused Intervention for People With Serious Mental Illness","CLCO-9","Inclusion Criteria:\n\n* Currently hospitalized at Worcester Recovery Center and Hospital (WRCH)\n* At least 18 years old\n* Self-reported current or past legal involvement\n* Speaks English\n* For patients without a legally authorized representative (LAR): demonstrate capacity to consent per the Capacity Assessment Record (CAR).\n* For patients with an LAR: assent to participate.\n\nExclusion Criteria:\n\n* Hospital status that does not permit group attendance (e.g., room-based seclusion)",{"count":19,"type":20},[23],"People with serious mental illness (depression, bipolar, and schizophrenia spectrum disorders) have high rates of repeated criminal legal involvement and psychiatric hospitalizations. Longstanding research shows that in addition to treating clients' symptoms of mental illness, targeting risk factors for legal involvement can help reduce their chances of future incarcerations. Because hospitals are becoming increasingly forensic, treatment programs that address both mental illness and risk factors for legal involvement may be especially helpful in a state hospital setting, like Worcester Recovery Center and Hospital (WRCH). This treatment study offers an adjunctive 9-session intervention, Changing Lives and Changing Outcomes-9 (CLCO-9), for patients at WRCH; this program is designed to help people with serious mental illness who are involved in the legal system increase their awareness of their mental health and reduce their chances of future legal involvement.\n\nThe investigators are proposing a treatment study testing the use of the CLCO-9 group intervention with patients with serious mental illness with current or previous criminal legal involvement at Worcester Recovery Center and Hospital (WRCH). The study has three aims:\n\n1. Evaluate feasibility, fidelity, and patient satisfaction during the implementation of the CLCO-9 group treatment at WRCH\n2. Evaluate CLCO-9's effectiveness on improving patient's self-reported mental health, and behavioral indicators of mental health and risk factors for legal involvement\n3. Explore changes in WRCH clinicians' knowledge and attitudes about treating risk factors for criminal legal involvement.\n\nTo test these aims, the research team will employ a two-phase study. In the first phase, the researchers will implement the intervention and make necessary adjustments to maximize the success of the implementation. In the second phase, the researchers will evaluate the treatment program's effectiveness in producing change from pre- to post-treatment.\n\nAll patient participants in this study will receive the intervention. The projected sample size is about 20 treatment completers and 4 to 8 group leaders.",[61,62,63,26],"Serious Mental Illness","Psychotic Disorder","Depression",[65,66,67,68,69,70],"serious mental illness","criminogenic risk","criminal legal involvement","treatment","forensic","state hospital","RECRUITING","2026-02-12",{"date":74,"type":40},"2026-02-17",{"date":76,"type":40},"2026-02-05",{"date":42,"type":20},{"name":79,"class":80},"Massachusetts General Hospital","OTHER",{"id":82,"slug":83,"hasResults":11,"nctId":84,"briefTitle":85,"officialTitle":85,"acronym":86,"eligibilityCriteria":87,"healthyVolunteers":11,"sex":16,"minAge":88,"maxAge":4,"enrollmentInfo":89,"targetDuration":4,"studyType":21,"phases":91,"briefSummary":92,"conditions":93,"keywords":99,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":108,"lastUpdatePostDateStruct":109,"startDateStruct":111,"completionDateStruct":113,"leadSponsor":115,"locationsCount":48},"100609222","integrated-care-for-older-adults-with-major-depression-and-physical-multimorbidity---the-i-connect-100609222","NCT07211750","Integrated Care for Older Adults With Major Depression and Physical Multimorbidity - The I-CONNECT","I-CONNECT","Inclusion Criteria:\n\n* Age 65 years or older\n* Clinical diagnosis of a mood disorder (depression or bipolar disorder)\n* Currently receiving care from a psychiatrist\n* At least two chronic physical health conditions\n* Living independently at home in the Leuven region\n* Ongoing care from both a general practitioner and a psychiatrist\n\nExclusion Criteria:\n\n* Severe cognitive impairment (e.g., advanced dementia) that prevents participation in assessments or shared decision-making\n* Inability to provide informed consent","65 Years",{"count":90,"type":20},82,[23],"The goal of this clinical trial is to learn if I-CONNECT (Integrated Care for Older Adults with Major Depression and Physical Multimorbidity) can improve the health and well-being of older adults with depression or bipolar disorder and at least two chronic physical conditions, such as diabetes or high blood pressure. It will also study if the care model improves how people experience their care, lowers treatment burden, and how well the program is delivered.\n\nResearchers will compare two groups:\n\nI-CONNECT group: participants receive care coordination, a personalized care plan, medication review, shared decision-making support, and regular follow-up from a care coordinator working with their GP, psychiatrist, pharmacist, and specialists.\n\nUsual care group: participants continue with their normal healthcare from their GP and psychiatrist.\n\nParticipants will:\n\nReceive either I-CONNECT or usual care, depending on their group\n\nComplete questionnaires about their mood, quality of life, and care experience\n\nHave their healthcare use (emergency visits and hospitalizations) tracked during the study",[94,95,96,97,26,98],"Multimorbidity","Older Adults (65 Years and Older)","Mood Disorders","Depression - Major Depressive Disorder","Integrated Care",[100,101,102,103,104,94,63,105,106,107],"Integrated care","Care coordination","Person-centered care","Shared decision-making","Self-management support","Bipolar disorder","Older adults","Quality of life","2025-12-11",{"date":110,"type":40},"2025-12-12",{"date":112,"type":40},"2025-10-01",{"date":114,"type":20},"2027-10-30",{"name":116,"class":80},"KU Leuven",{"id":118,"slug":119,"hasResults":11,"nctId":120,"briefTitle":121,"officialTitle":121,"acronym":122,"eligibilityCriteria":123,"healthyVolunteers":124,"sex":16,"minAge":125,"maxAge":126,"enrollmentInfo":127,"targetDuration":129,"studyType":130,"phases":4,"briefSummary":131,"conditions":132,"keywords":138,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":149,"lastUpdatePostDateStruct":150,"startDateStruct":152,"completionDateStruct":154,"leadSponsor":156,"locationsCount":48},"100591286","behavioural-development-long-term-outcomes-and-opportunities-to-optimize-youth-mental-health-trajectories-100591286","NCT06978452","Behavioural Development, Long-term Outcomes and Opportunities to Optimize Youth Mental Health Trajectories","BLOOM","Inclusion Criteria:\n\nYouth between 9 to 25 years of age at inclusion, who are able to read and understand either French or English, with at least one parent or legal guardian available to consent for those under 18 years of age.\n\nSpecific eligibility criteria:\n\nHelp-seeking group: At least one help-seeking contact made with a primary care clinical service provider or agency (e.g, paediatric\u002Ffamily physician clinic, CLSC or Aire Ouverte) for a mental health concern (i.e., clinical needs).\n\nNon help-seeking group:\n\nAt least one of the birth parents or siblings have received psychiatric care for a diagnosis of DMDs (i.e., family needs) OR Being in contact with community agencies that provide youth-centred social services for food, housing, social discrimination (e.g., racialized youth, LGBTQ2SIA+) (i.e., social needs) OR Having a diagnosed chronic physical illness that is expected to require treatment for \\>12 months (e.g., diabetes, asthma to name a few) (i.e., physical health needs)\n\nExclusion Criteria:\n\n* Due to the requirements of assessment procedures, youth who cannot communicate verbally due to known neurological conditions or intellectual disabilities will not be included. Youth who are already diagnosed with one of the DMDs by a physician and currently prescribed a treatment targeting the diagnosed condition (pharmacological or psychotherapeutic interventions), will not be eligible for inclusion.\n\nImportantly, no one will be excluded based on sex, gender, health insurance status, ethnicity, income status, ability to travel or living arrangements. If a participant initially approached through the referral pathways for non help-seeking individuals turns out to have had at least one help-seeking contact for a mental health concern (i.e., clinical needs), the participant will still be included but classified as part of the help-seeking group. We anticipate non help-seeking referrals to satisfy more than one criteria. Their occurrence and distribution will be recorded in detail as part of our assessment procedure.",true,"9 Years","25 Years",{"count":128,"type":20},560,"5 Years","OBSERVATIONAL","Behavioural Development, Long-term Outcomes and Opportunities to Optimize Youth Mental Health (BLOOM) is a project that aims to overcome age and diagnostic boundaries to generate person-specific longitudinal profiles of mental health in youth aged 9 to 25. The overarching objective is to lay the informational foundation to accurately predict both clinical outcomes and opportunities to optimize health trajectories. This project will recruit youth in need without any mental health diagnosis and follow them annually for 5 years. The present study includes assessment of antecedents, opportunities and outcomes that will establish eligibility for preventive interventions",[97,26,133,134,135,136,137],"Psychosis","Eating Disorder NOS","ADHD","Substance Use Disorder (SUD)","OCD",[139,140,141,142,143,144,145,146,147,148],"antecedents","mental health prevention","resilience","access to care","help-seeking","youth in needs","biomarker","speech","language","cognition","2025-05-11",{"date":151,"type":40},"2025-05-18",{"date":153,"type":40},"2024-07-01",{"date":155,"type":20},"2029-07-01",{"name":157,"class":80},"Douglas Mental Health University Institute",{"id":159,"slug":160,"hasResults":11,"nctId":161,"briefTitle":162,"officialTitle":163,"acronym":164,"eligibilityCriteria":165,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":166,"enrollmentInfo":167,"targetDuration":4,"studyType":21,"phases":169,"briefSummary":170,"conditions":171,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":178,"lastUpdatePostDateStruct":179,"startDateStruct":181,"completionDateStruct":183,"leadSponsor":185,"locationsCount":48},"100573625","effect-of-blue-light-blocking-on-reducing-manic-symptoms-in-bipolar-disorder-100573625","NCT06748716","Effect of Blue Light Blocking on Reducing Manic Symptoms in Bipolar Disorder","Effect of Blue Light Blocking on Reducing Manic Symptoms in Bipolar Disorder: a Randomized Placebo-controlled Trial BLUME (Blue Light Filtering in Manic Episodes)","BLUME","Inclusion Criteria:\n\n* Patients hospitalized with manic symptoms in HUG\n* Diagnostic of Bipolar Disorder according to the Diagnostic and Statistical Manual of Mental Disorders, 5th edition (DSM-5) criteria\n* aged 18-70 years\n\nExclusion Criteria:\n\n* previous knowledge of blue-blocking glasses\n* not consenting to participate\n* severe eye disease or traumatic injury affecting both eyes.\n* withdrawal symptoms from any drug or alcohol at the time of admission (the start of the intervention will be delayed until withdrawal symptoms have ceased)","70 Years",{"count":168,"type":20},96,[23],"This study will be a randomized controlled trial (RCT) measuring the efficacy of wearing blue-blocking glasses (orange glasses) on manic symptoms in a population of patients suffering from Bipolar Disorder (BD), hospitalized for a manic episode on 10 days compared to non-filtering glasses (clear glasses, placebo) in addition to pharmacological treatment as usual.\n\nThe primary objective of this study is to evaluate the efficacity of orange glasses on improving manic symptoms in adult patients presenting BD in comparison with placebo. The primary outcome will be the change of total score of the Young Mania Rating Scale (YMRS) from baseline to day 10. Secondary objectives will be change in sleep quality, in motor activity (patterns of activity and rest), impact on psychotics symptoms, kinetics of the decrease of the manic symptoms from inclusion to the study and impact on maximal administered antipsychotic medication dosage ; they will be explored.\n\nThe investigators hypothesize that orange glasses is more effective than placebo in improving manic symptoms as an adjuvant treatment.\n\nThis project will take place in Alizé unit which is a newly conceived specialized ward dedicated to treating BD, at the HUG. The methodology has been developed in collaboration with the center of clinical research (CRC). The study will be conducted in accordance with established ethical and data management\u002Fprotection practices.",[26,172,27,173,174,175,176,177],"Manic","Dark Therapy","Actigraphy","Mania","RCT","Virtual Darkness","2024-12-18",{"date":180,"type":40},"2024-12-27",{"date":182,"type":20},"2025-04-01",{"date":184,"type":20},"2028-04-01",{"name":186,"class":80},"Rayan NASSERDINE"]