[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"bis-eeg\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:bis-eeg":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,48,77],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":28,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100053505","the-effects-of-midazolam-dexmedetomidine-and-esketamine-on-bispectral-index-and-raw-electroencephalogram-in-patients-under-propofol-remifentanil-baseline-anesthesia-100053505",false,"NCT07699523","The Effects of Midazolam, Dexmedetomidine, and Esketamine on Bispectral Index and Raw Electroencephalogram in Patients Under Propofol-Remifentanil Baseline Anesthesia","Inclusion Criteria:\n\n1. ASA physical status I-II;\n2. BMI 18-28 kg\u002Fm²;\n3. Scheduled for elective laparoscopic cholecystectomy, with an expected surgical duration from skin incision to completion of wound closure of ≥45 min;\n4. Planned to receive propofol-remifentanil total intravenous anesthesia, with routine intraoperative BIS monitoring and simultaneous acquisition of raw EEG signals;\n5. Voluntarily agrees to participate in this study, has signed the informed consent form, and is able to cooperate with the intervention and assessment procedures.\n\nExclusion Criteria:\n\n1. A confirmed history of psychiatric or neurological disorders, or use of antipsychotics, antidepressants, benzodiazepines, or other sedative-hypnotic drugs within 4 weeks before surgery;\n2. Cognitive impairment identified by Mini-Cog screening;\n3. Poorly controlled or untreated hypertension, sinus bradycardia, or severe cardiac conduction block;\n4. Acute angle-closure glaucoma;\n5. Known allergy to any required anesthetic drug;\n6. Difficulty in electrode placement or any condition that may interfere with EEG monitoring.","ALL","18 Years","65 Years",{"count":19,"type":20},120,"ESTIMATED","INTERVENTIONAL",[23],"NA","This prospective, single-center, randomized interventional study aims to investigate the effects of commonly used adjunct anesthetic drugs on the Bispectral Index (BIS) and electroencephalographic (EEG) activity during total intravenous anesthesia.\n\nBIS monitoring is widely used to estimate the depth of anesthesia. However, previous studies suggest that certain anesthetic drugs, particularly dexmedetomidine and esketamine, may alter BIS values independently of the patient's actual level of consciousness. As a result, BIS readings may not always accurately reflect anesthetic depth when multiple drugs are administered together.\n\nAdult patients undergoing elective laparoscopic cholecystectomy under standardized propofol-remifentanil anesthesia will be randomly assigned to receive one of the following adjunct drugs: midazolam, dexmedetomidine, esketamine, or no additional study drug (control group). Continuous BIS values and raw EEG signals will be recorded throughout the study period.\n\nThe primary objective is to compare changes in BIS values among different adjunct anesthetic drugs under otherwise similar anesthetic conditions. The study will also explore corresponding EEG characteristics associated with these changes. The findings are expected to improve understanding of drug-related differences in processed EEG monitoring and provide data for future development of more accurate anesthesia depth assessment methods.",[26,27],"Depth of Anesthesia Monitoring","BIS-EEG",[29,30,31,32,33,34],"Bispectral Index","Electroencephalography","Midazolam","Dexmedetomidine","Esketamine","Total Intravenous Anesthesia","NOT_YET_RECRUITING","2026-07-08",{"date":38,"type":39},"2026-07-13","ACTUAL",{"date":41,"type":20},"2026-06-30",{"date":43,"type":20},"2027-12-30",{"name":45,"class":46},"China-Japan Friendship Hospital","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":4,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":55,"targetDuration":4,"studyType":57,"phases":4,"briefSummary":58,"conditions":59,"keywords":63,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":73,"leadSponsor":75,"locationsCount":47},"100640534","comparison-of-hemodynamic-responses-during-anesthesia-induction-using-eleveld-and-schnider-100640534","NCT07586189","Comparison of Hemodynamic Responses During Anesthesia Induction Using Eleveld and Schnider","Comparison of Hemodynamic Responses During Anesthesia Induction Using Eleveld and Schnider Target-Controlled Infusion Models. A Randomized Trial","Inclusion Criteria:\n\n* Patients scheduled for elective spinal surgery under general anesthesia\n* Patients who will undergo surgery at the Neurosurgery Department of Istanbul University, Istanbul Faculty of Medicine\n* Patients aged 18 years or older\n* Patients who provide written informed consent to participate in the study\n\nExclusion Criteria:\n\n* Patients with uncontrolled hypertension\n* Patients with uncontrolled diabetes mellitus\n* Patients younger than 18 years of age\n* Patients who do not provide informed consent to participate in the study",{"count":56,"type":20},50,"OBSERVATIONAL","This randomized prospective study aims to compare the effects of two target-controlled infusion models, the Schnider and Eleveld models, on anesthetic depth and hemodynamic responses during anesthesia induction in adult patients undergoing spinal surgery.\n\nPatients scheduled for spinal surgery will be randomized into either the Schnider or Eleveld group. Before induction, standard monitoring will be applied, including electrocardiography, peripheral oxygen saturation, invasive arterial blood pressure monitoring, heart rate monitoring, and bispectral index monitoring. Anesthesia induction will be performed with fentanyl 2 mcg\u002Fkg, rocuronium 0.6 mg\u002Fkg, and propofol administered by target-controlled infusion with an effect-site target concentration of 3 mcg\u002FmL according to the allocated pharmacokinetic model.\n\nHemodynamic parameters and bispectral index values will be recorded before induction and at the 1st, 3rd, 5th, and 10th minutes after induction. Additional parameters, including time to BIS below 40, time to delta activity, burst suppression duration, total propofol dose during the first 5 minutes, need for additional propofol, hemodynamic response to intubation, vasopressor requirement within the first 10 minutes, and use of esmolol, will also be documented. The primary aim is to evaluate whether the Schnider and Eleveld models differ in terms of induction-related hemodynamic stability and anesthetic depth during the early induction period.",[60,34,61,62,27],"Spinal (Fusion) Surgery","Target Controlled Infusion of Propofol","Anesthesia Depth Monitoring",[64,65,66,67],"spinal surgery","total intravenous anesthesia","target controlled infusion","anesthesia depth monitoring","RECRUITING","2026-05-18",{"date":71,"type":39},"2026-05-20",{"date":69,"type":39},{"date":74,"type":20},"2026-08-30",{"name":76,"class":46},"Istanbul University",{"id":78,"slug":79,"hasResults":11,"nctId":80,"briefTitle":81,"officialTitle":82,"acronym":4,"eligibilityCriteria":83,"healthyVolunteers":84,"sex":15,"minAge":4,"maxAge":4,"enrollmentInfo":85,"targetDuration":87,"studyType":57,"phases":4,"briefSummary":88,"conditions":89,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":100,"completionDateStruct":102,"leadSponsor":104,"locationsCount":47},"100634172","deep-learning-framework-for-continuous-depth-of-anesthesia-forecasting-100634172","NCT07536230","Deep Learning Framework for Continuous Depth of Anesthesia Forecasting","Validation of a Deep Learning Framework for Continuous Forecasting of Pharmacodynamic Responses and Physiological Trajectories During General Anesthesia","Inclusion Criteria:\n\n* Patients scheduled for elective surgery requiring general anesthesia.\n* Procedures requiring continuous depth of anesthesia monitoring (BIS).\n\nExclusion Criteria:\n\n\\- Procedures where the primary anesthetic plan does not involve continuous electronic data capture.",true,{"count":86,"type":20},115,"1 Day","The integration of Artificial Intelligence (AI) in anesthesiology offers the potential to shift patient monitoring from reactive to predictive. Deep learning architectures, specifically Long Short-Term Memory (LSTM) networks, excel at processing complex, time-series data to forecast future clinical states.\n\nWhile standard PK\u002FPD models (such as the state of the art Eleveld model for Propofol and Remifentanil) estimate target-site drug concentrations (Ce), they do not account for real-time, patient-specific dynamic responses. This study aims to deploy an AI framework designed to predict future physiological states.",[90,27,91,92,93,94,95,96],"BIS","Artifical Intelligence","Intraoperative","Machine Learning","Anesthesia","Anesthesia Awareness","Predictive Model","2026-04-10",{"date":99,"type":39},"2026-04-17",{"date":101,"type":20},"2026-06-01",{"date":103,"type":20},"2026-09-01",{"name":105,"class":46},"Universitair Ziekenhuis Brussel"]