[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"biventricular-pacing\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:biventricular-pacing":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,46],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100534655","csp-versus-bivp-for-heart-failure-patients-with-rvp-upgraded-to-cardiac-resynchronization-therapy-100534655",false,"NCT06241651","CSP Versus BiVP for Heart Failure Patients With RVP Upgraded to Cardiac Resynchronization Therapy","Conduction System Pacing Versus Biventricular Pacing for Heart Failure Patients With Right Ventricular Pacing Upgraded to Cardiac Resynchronization Therapy: a Prospective Multicenter Non-inferiority Randomized Controlled Study","CSP-UPGRADE","Inclusion Criteria:\n\n1. Patients with symptomatic heart failure (LVEF \\\u003C50%) after right ventricular pacing for at least 3 months;\n2. NYHA class II-IV;\n3. NT-proBNP \\>125pg\u002FmL in patients with sinus rhythm, NT-proBNP \\>250pg\u002FmL in patients with atrial fibrillation;\n4. Right ventricular pacing percentage \\>40%;\n5. Adult patients aged 18-80;\n6. With informed consent signed.\n\nExclusion Criteria:\n\n1. History of acute myocardial infarction within 3 months before enrollment;\n2. Frequent premature ventricular contraction (\\>15%) or malignant ventricular arrhythmia which is difficult to control;\n3. History of valvular heart disease intervention within 3 months before enrollment;\n4. After mechanical tricuspid valve replacement;\n5. Ventricular septal hypertrophy (≥15mm during diastole);\n6. Complex congenital heart disease;\n7. History of heart transplantation;\n8. Enrollment in any other study;\n9. Pregnant or with child-bearing plan;\n10. A life expectancy of less than 12 months.","ALL","18 Years","80 Years",{"count":21,"type":22},66,"ESTIMATED","INTERVENTIONAL",[25],"NA","The present study is a prospective, multicenter, non-inferiority, randomized controlled trail. It aims to investigate whether the efficacy of conduction system pacing (CSP) is non-inferior to biventricular pacing (BiVP) in patients with heart failure and right ventricular pacing (RVP) requiring upgrading to cardiac resynchronization therapy (CRT).",[28,29,30,31,32],"Conduction System Pacing","Biventricular Pacing","Cardiac Resynchronization Therapy","Right Ventricular Pacing","Heart Failure","RECRUITING","2026-05-11",{"date":36,"type":37},"2026-05-14","ACTUAL",{"date":39,"type":37},"2024-01-01",{"date":41,"type":22},"2027-03",{"name":43,"class":44},"The First Affiliated Hospital with Nanjing Medical University","OTHER",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":52,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":54,"targetDuration":4,"studyType":23,"phases":56,"briefSummary":57,"conditions":58,"keywords":62,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":45},"100597365","uhf-ecg-in-lbbb-and-response-to-crt-prediction-100597365","NCT07057544","UHF ECG in LBBB and Response to CRT Prediction","The Role of Ultra-high-frequency ECG in the Localization of Left Ventricular Conduction Disorders and Prediction of Response to Resynchronization Therapy","UHF BLOCK","Inclusion Criteria:\n\n* HF due to ischemic or non-ischemic cardiomyopathy\n* known coronary angiography\n* NYHA II-IV\n* LVEF ≤40%\n* non-RBBB QRSd lasting \\>130 ms (by automated measurement)\n* proximal LBBB proved by an invasive EP study or non-invasive dyssynchrony assessment in case such a method is confirmed to be non-inferior to an invasive EP study during the project\n\nExclusion Criteria:\n\n* Age ˂18 years\n* heart failure from reversible causes\n* Moderate to severe aortic stenosis\n* pregnancy\n* active myocarditis\n* hypertrophic cardiomyopathy\n* cardiac valve surgery in the last three months\n* myocardial infarction, PCI, or CABG in the last three months\n* severe valvular disease requiring intervention\n* severe atherosclerotic disease of the aorta and\u002For femoral arteries\n* life expectancy ˂1 year\n* known medical condition or contraindication causing potential complications for EP study",{"count":55,"type":22},200,[25],"The main objective of the project is to demonstrate that in patients with heart failure and QRS complex of nonRBBB morphology lasting over 130 ms, UHF-ECG can differentiate patients with trueLBBB from IVCD better than existing approaches based on the assessment of QRS complex morphology and duration from 12-lead ECG.\n\nAnother goal of the proposed study is to demonstrate that trueLBBB patients will benefit more from CRT using left bundle branch pacing than from CRT using biventricular pacing.\n\nThe final aim of the project is to demonstrate that the echocardiographic and clinical response in patients with intraventricular conduction disturbance will be dependent on the degree of reduction in ventricular dyssynchrony after CRT.",[59,60,29,61],"Left Bundle Branch Block","Left Bundle Branch Area Pacing","Intraventricular Conduction Delay",[63,64,65,66,67],"left bundle branch block","resynchronization therapy","intraventricular conduction delay","left bundle branch pacing","biventricular pacing","2025-07-09",{"date":70,"type":37},"2025-07-14",{"date":72,"type":37},"2024-05-01",{"date":74,"type":22},"2027-12-31",{"name":76,"class":77},"Faculty Hospital Kralovske Vinohrady","OTHER_GOV"]