[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"bladder-hyperactivity\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:bladder-hyperactivity":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":28,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":5},"100549500","evaluation-of-autonomic-nervous-system-changes-in-response-to-stimulation-by-sacral-neuromodulation-100549500",false,"NCT06434831","Evaluation of Autonomic Nervous System Changes in Response to Stimulation by Sacral Neuromodulation","ESTIME","Inclusion Criteria:\n\n* Male of female ≥ 18 years\n* OAB syndrome\n* Indication for a two-staged SNM\n* Under general anaesthesia with Remifentanil and Propofol\n* Patient who has given written consent to participate in the trial\n* Patient willing to comply with all study procedures and duration\n\nExclusion Criteria:\n\n* Tibial neuro-stimulation (last 3 months)\n* Sacral neuromodulation (last 3 months)\n* Botulinum toxin A intra-detrusor injection (last 9 months)\n* Pregnancy in progress\n* Administrative reasons\n* Guardianship\u002Fcuratorship","ALL","18 Years",{"count":19,"type":20},40,"ESTIMATED","INTERVENTIONAL",[23],"NA","Overactive bladder syndrome (OAB) is defined by urgent and frequent urges to urinate associated with frequent night-time urination and sometimes urinary incontinence. Sacral neuromodulation (SNM) is now one of the second-line treatments for OAB.\n\nThe mode of action of SNM is still poorly understood but a number of data from recent scientific literature suggest that SNM may act, among other things, by altering the balance of the autonomic nervous system (ANS) - located at the interface between the urinary tract and the brain structures regulating the functioning of the urinary tract.\n\nThe aim of this study would therefore be to develop a predictive tool for the effectiveness of SNM.",[26,27],"Bladder Hyperactivity","Sacral Neuromodulation",[29,30,31,32,33],"Bladder hyperactivity","autonomic nervous system","sacral neuromodulation","urodynamic assessment","heart rate variability","RECRUITING","2026-04-29",{"date":37,"type":38},"2026-05-06","ACTUAL",{"date":40,"type":38},"2024-02-14",{"date":42,"type":20},"2026-12-02",{"name":44,"class":45},"University Hospital, Lille","OTHER"]